BR112015005887A2 - quantificação de tiroglobulina por espectroscopia de massa - Google Patents

quantificação de tiroglobulina por espectroscopia de massa

Info

Publication number
BR112015005887A2
BR112015005887A2 BR112015005887A BR112015005887A BR112015005887A2 BR 112015005887 A2 BR112015005887 A2 BR 112015005887A2 BR 112015005887 A BR112015005887 A BR 112015005887A BR 112015005887 A BR112015005887 A BR 112015005887A BR 112015005887 A2 BR112015005887 A2 BR 112015005887A2
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BR
Brazil
Prior art keywords
thyroglobulin
peptide
amount
sample
ion
Prior art date
Application number
BR112015005887A
Other languages
English (en)
Other versions
BR112015005887B1 (pt
Inventor
J Clarke Nigel
E Reitz Richard
Zhang Yanni
Original Assignee
Quest Diagnostics Invest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Inc filed Critical Quest Diagnostics Invest Inc
Publication of BR112015005887A2 publication Critical patent/BR112015005887A2/pt
Publication of BR112015005887B1 publication Critical patent/BR112015005887B1/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/046—Thyroid disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

abstract provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. the methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample. tradução do resumo resumo patente de invenção para: "quantificação de tiroglobulina por espectroscopia de massa." são fornecidos métodos para a determinação da quantidade de tiroglobulina em uma amostra usando várias etapas de purificação seguidas por espectrometria de massa, os métodos geralmente envolvem purificação de tiroglobulina em uma amostra de teste, digestão de tiroglobulina para formar o peptídeo t129, purificação do peptídeo t129, ionização do peptídeo t129, detecção da quantidade de íon de peptídeo t129 gerada, e relacionam-se com a quantidade de íon de peptídeo t129 para a quantidade de tiroglobulina originalmente presente na amostra.
BR112015005887-6A 2012-09-20 2013-09-19 Método para a determinação da quantidade de tiroglobulina em uma amostra de teste BR112015005887B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703721P 2012-09-20 2012-09-20
US61/703,721 2012-09-20
PCT/US2013/060659 WO2014047316A1 (en) 2012-09-20 2013-09-19 Thyroglobulin quantitation by mass spectroscopy

Publications (2)

Publication Number Publication Date
BR112015005887A2 true BR112015005887A2 (pt) 2017-08-08
BR112015005887B1 BR112015005887B1 (pt) 2022-04-19

Family

ID=50341936

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015005887-6A BR112015005887B1 (pt) 2012-09-20 2013-09-19 Método para a determinação da quantidade de tiroglobulina em uma amostra de teste

Country Status (7)

Country Link
US (5) US9012394B2 (pt)
EP (2) EP3392344B1 (pt)
JP (2) JP5902357B2 (pt)
CN (2) CN104797715A (pt)
BR (1) BR112015005887B1 (pt)
CA (1) CA2885542C (pt)
WO (1) WO2014047316A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972868B2 (en) 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
US8030084B2 (en) 2007-12-06 2011-10-04 Quest Diagnostics Investments Incorporated Thyroglobulin quantitation by mass spectrometry
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
CA2783797C (en) 2009-12-11 2021-06-08 Quest Diagnostics Investments Incorporated Mass spectrometric determination of non-derivatized, non-metabolized vitamin d
CN102812356B (zh) 2009-12-11 2017-08-08 奎斯特诊断投资公司 多重样品中的甾族化合物的质谱法
BR112015005887B1 (pt) 2012-09-20 2022-04-19 Quest Diagnostics Investments Incorporated Método para a determinação da quantidade de tiroglobulina em uma amostra de teste
CA2896539C (en) * 2012-12-26 2018-07-03 Quest Diagnostics Investments Incorporated C peptide detection by mass spectrometry
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
TWI682176B (zh) * 2017-09-18 2020-01-11 國立臺灣大學 用於甲狀腺癌預後之生物標記
WO2019155836A1 (ja) * 2018-02-09 2019-08-15 浜松ホトニクス株式会社 試料支持体、イオン化法及び質量分析方法
CA3094080A1 (en) * 2018-03-16 2019-09-19 Quest Diagnostics Investments Llc Methods for detecting chromogranin a by mass spectrometry
WO2023164672A2 (en) * 2022-02-24 2023-08-31 Venn Biosciences Corporation Sample preparation for glycoproteomic analysis that includes diagnosis of disease

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US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
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US20050064422A1 (en) 2001-11-29 2005-03-24 Barnidge David R Polypeptide quantitation
AU2003287017B2 (en) * 2002-10-03 2011-10-06 Norman Leigh Anderson High sensitivity quantitation of peptides by mass spectrometry
US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
CA2608796C (en) 2005-03-31 2013-09-03 Georgetown University Free thyroxine and free triiodothyronine analysis by mass spectrometry
US20070105179A1 (en) 2005-11-09 2007-05-10 Dionex Corporation Methods of detecting N-and O-linked oligosaccharides in glycoproteins
US7855057B2 (en) 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
JP2010502425A (ja) 2006-08-30 2010-01-28 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 膜を評価するシステム及び方法並びに膜濾過装置
US7807172B2 (en) 2007-06-13 2010-10-05 University Of Washington Methods and compositions for detecting thyroglobulin in a biological sample
US8030084B2 (en) * 2007-12-06 2011-10-04 Quest Diagnostics Investments Incorporated Thyroglobulin quantitation by mass spectrometry
EP2548015A1 (en) * 2010-03-15 2013-01-23 Anderson Forschung Group, Inc. Improved mass spectrometric assays for peptides
WO2012111249A1 (ja) * 2011-02-14 2012-08-23 学校法人麻布獣医学園 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法
US9140695B2 (en) * 2012-01-18 2015-09-22 University Of Utah Research Foundation Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems
BR112015005887B1 (pt) * 2012-09-20 2022-04-19 Quest Diagnostics Investments Incorporated Método para a determinação da quantidade de tiroglobulina em uma amostra de teste

Also Published As

Publication number Publication date
JP2015529342A (ja) 2015-10-05
JP5902357B2 (ja) 2016-04-13
US20170176452A1 (en) 2017-06-22
EP3392344A1 (en) 2018-10-24
US20180196062A1 (en) 2018-07-12
US20140093899A1 (en) 2014-04-03
US10718779B2 (en) 2020-07-21
CN118393051A (zh) 2024-07-26
US9580740B2 (en) 2017-02-28
BR112015005887B1 (pt) 2022-04-19
US20160053297A1 (en) 2016-02-25
US9012394B2 (en) 2015-04-21
JP2016165284A (ja) 2016-09-15
EP2898088A1 (en) 2015-07-29
EP2898088A4 (en) 2016-04-20
US10191064B2 (en) 2019-01-29
WO2014047316A1 (en) 2014-03-27
EP3392344B1 (en) 2021-10-27
CN104797715A (zh) 2015-07-22
CA2885542A1 (en) 2014-03-27
JP6678046B2 (ja) 2020-04-08
CA2885542C (en) 2023-01-24
US9915663B2 (en) 2018-03-13
US20190145984A1 (en) 2019-05-16

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/09/2013, OBSERVADAS AS CONDICOES LEGAIS.