HRP20211053T1 - Modificirani fgf-21 polipeptidi i njihove primjene - Google Patents
Modificirani fgf-21 polipeptidi i njihove primjene Download PDFInfo
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- HRP20211053T1 HRP20211053T1 HRP20211053TT HRP20211053T HRP20211053T1 HR P20211053 T1 HRP20211053 T1 HR P20211053T1 HR P20211053T T HRP20211053T T HR P20211053TT HR P20211053 T HRP20211053 T HR P20211053T HR P20211053 T1 HRP20211053 T1 HR P20211053T1
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- Prior art keywords
- polypeptide
- use according
- once
- patient
- liver
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- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title claims 7
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title claims 7
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- -1 poly(ethylene glycol) Polymers 0.000 claims 12
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 8
- 206010016654 Fibrosis Diseases 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 230000004761 fibrosis Effects 0.000 claims 5
- 208000019425 cirrhosis of liver Diseases 0.000 claims 4
- 210000004185 liver Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 102000011690 Adiponectin Human genes 0.000 claims 2
- 108010076365 Adiponectin Proteins 0.000 claims 2
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000007882 cirrhosis Effects 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 238000012317 liver biopsy Methods 0.000 claims 2
- 238000002595 magnetic resonance imaging Methods 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 238000010254 subcutaneous injection Methods 0.000 claims 2
- 239000007929 subcutaneous injection Substances 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (20)
1. Modificirani FGF-21 polipeptid koji sadrži polipeptid sa SEQ ID NO:201 pri čemu je njegov paraacetil-fenilalanin ostatak povezan sa poli(etilen glikol) segmentom, za primjenu u postupku liječenja bolesti koja je u vezi sa fibrozom odabranom od bezalkoholnog steatohepatitisa (NASH), fibroze jetre, i ciroze kod pacijenta.
2. Modificirani FGF-21 polipeptid koji sadrži polipeptid sa SEQ ID NO:201 pri čemu je njegov paraacetil-fenilalanin ostatak povezan sa poli(etilen glikol) segmentom, za primjenu u postupku liječenja ili sprječavanja NASH kod pacijenta.
3. Polipeptid za primjenu iz patentnog zahtjeva 2, pri čemu se liječi NASH.
4. Polipeptid za primjenu iz patentnog zahtjeva 1, pri čemu navedena bolest koja je povezana sa fibrozom je ciroza.
5. Polipeptid za primjenu iz patentnog zahtjeva 1, pri čemu navedena bolest koja je povezana sa fibrozom je fibroza jetre.
6. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-5, pri čemu navedeni poli(etilen glikol) ima molekulsku masu između oko 0.1 kDa i oko 100 kDa.
7. Polipeptid za primjenu iz patentnog zahtjeva 6, pri čemu navedeni poli(etilen glikol) ima molekulsku masu između oko 10 kDa i 40 kDa.
8. Polipeptid za primjenu iz patentnog zahtjeva 7, pri čemu navedeni poli(etilen glikol) ima molekulsku masu od oko 30 kDa.
9. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-8, koji dovodi do jedne ili više smanjenih frakcija masti u jetri i povećanih nivoa adiponektina kod navedenog pacijenta.
10. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-8, pri čemu prije liječenja pacijent iskazuje indeks masne jetre od najmanje oko 60.
11. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-8, pri čemu prije liječenja pacijent iskazuje postotak frakcije masti u jetri od najmanje 10%, što se po izboru određuje pomoću magnetnog rezonantnog snimanja.
12. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-8, pri čemu prije liječenja pacijent iskazuje NASH CRN fibrozni stadij 1-3, što je po izboru NASH CRN fibrozni stadij 1-3 određen pomoću biopsije jetre.
13. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-12, pri čemu je navedeni modificirani FGF-21 polipeptid namijenjen za administriranje supkutanom injekcijom.
14. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-13, pri čemu je navedeni modificirani FGF-21 polipeptid namijenjen za administriranje pri učestalosti od oko jednom dnevno; oko jednom tjedno; oko dva puta tjedno; oko jednom na dva tjedna; oko jednom na tri tjedna; ili jednom na četiri tjedna.
15. Polipeptid za primjenu iz bilo kojeg od patentnih zahtjeva 1-14, pri čemu je navedeni modificirani FGF-21 polipeptid namijenjen za administriranje u dozi od između oko 0.05 mg/kg i oko 1 mg/kg tjelesne težine pacijenta.
16. Polipeptid za primjenu iz patentnog zahtjeva 3, pri čemu navedeni poli(etilen glikol) ima molekulsku masu od oko 30 kDa, i navedeni modificirani FGF-21 polipeptid je namijenjen za administriranje supkutanom injekcijom pri učestalosti od oko jednom dnevno; oko jednom tjedno; oko dva puta tjedno; oko jednom na dva tjedna; oko jednom na tri tjedna; ili jednom na četiri tjedna u dozi od između oko 0.05 mg/kg i oko 1 mg/kg tjelesne težine pacijenta.
17. Polipeptid za primjenu iz patentnog zahtjeva 16, koji dovodi do jedne ili više smanjenih frakcija masti u jetri i povećanih nivoa adiponektina kod navedenog pacijenta.
18. Polipeptid za primjenu iz patentnog zahtjeva 16, pri čemu prije liječenja pacijent iskazuje indeks masne jetre od najmanje oko 60.
19. Polipeptid za primjenu iz patentnog zahtjeva 16, pri čemu prije liječenja pacijent iskazuje postotak frakcije masti u jetri od najmanje 10%, što se po izboru određuje magnetnim rezonantnim snimanjem.
20. Polipeptid za primjenu iz patentnog zahtjeva 16, pri čemu prije liječenja pacijent iskazuje NASH CRN fibrozni stadij 1-3, koji je po izboru NASH CRN fibrozni stadij 1-3 određen biopsijom jetre.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462068296P | 2014-10-24 | 2014-10-24 | |
US201462068534P | 2014-10-24 | 2014-10-24 | |
US201462068523P | 2014-10-24 | 2014-10-24 | |
US201462068514P | 2014-10-24 | 2014-10-24 | |
US201462068526P | 2014-10-24 | 2014-10-24 | |
US201562141383P | 2015-04-01 | 2015-04-01 | |
US201562141337P | 2015-04-01 | 2015-04-01 | |
EP18177893.7A EP3412302B1 (en) | 2014-10-24 | 2015-10-23 | Modified fgf-21 polypeptides and uses thereof |
Publications (1)
Publication Number | Publication Date |
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HRP20211053T1 true HRP20211053T1 (hr) | 2021-10-01 |
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ID=54397031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20211053TT HRP20211053T1 (hr) | 2014-10-24 | 2021-07-02 | Modificirani fgf-21 polipeptidi i njihove primjene |
Country Status (27)
Country | Link |
---|---|
US (6) | US9434778B2 (hr) |
EP (3) | EP3209316A2 (hr) |
JP (2) | JP6702962B2 (hr) |
KR (2) | KR20240024362A (hr) |
CN (6) | CN107108710B (hr) |
AU (3) | AU2015335603B2 (hr) |
BR (1) | BR112017008157A2 (hr) |
CA (1) | CA2965502A1 (hr) |
CL (1) | CL2017000999A1 (hr) |
CO (1) | CO2017004489A2 (hr) |
CY (1) | CY1124309T1 (hr) |
DK (1) | DK3412302T3 (hr) |
EA (1) | EA036697B1 (hr) |
ES (1) | ES2874331T3 (hr) |
HR (1) | HRP20211053T1 (hr) |
HU (1) | HUE055311T2 (hr) |
IL (2) | IL251795B (hr) |
LT (1) | LT3412302T (hr) |
MX (1) | MX2017004947A (hr) |
PE (1) | PE20170950A1 (hr) |
PL (1) | PL3412302T3 (hr) |
PT (1) | PT3412302T (hr) |
SG (2) | SG11201702824UA (hr) |
SI (1) | SI3412302T1 (hr) |
TW (2) | TWI705071B (hr) |
UY (1) | UY36370A (hr) |
WO (1) | WO2016065326A2 (hr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140012199A (ko) | 2007-03-30 | 2014-01-29 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
JP6712230B2 (ja) | 2014-03-11 | 2020-06-17 | ノバルティス アーゲー | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
KR20240024362A (ko) | 2014-10-24 | 2024-02-23 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
KR102668200B1 (ko) | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
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