KR101173510B1 - 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 - Google Patents

에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 Download PDF

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KR101173510B1
KR101173510B1 KR1020057003043A KR20057003043A KR101173510B1 KR 101173510 B1 KR101173510 B1 KR 101173510B1 KR 1020057003043 A KR1020057003043 A KR 1020057003043A KR 20057003043 A KR20057003043 A KR 20057003043A KR 101173510 B1 KR101173510 B1 KR 101173510B1
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heteroatoms selected
heteroaryl
alkyl
aryl
compound
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Korean (ko)
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KR20050083652A (ko
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사무엘 제이. 다니쉐프스키
알렉세이 리브킨
후미히코 요시무라
아나 에스테르 가바르다 오르테가
영신 조
팅-차오 추
후아진 돈짐
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슬로안-케테링인스티튜트퍼캔서리서치
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Priority claimed from US10/402,004 external-priority patent/US6921769B2/en
Priority claimed from US10/435,408 external-priority patent/US7649006B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020057003043A 2002-08-23 2003-08-22 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 Expired - Fee Related KR101173510B1 (ko)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US40582302P 2002-08-23 2002-08-23
US60/405,823 2002-08-23
US40858902P 2002-09-06 2002-09-06
US60/408,589 2002-09-06
US42312902P 2002-11-01 2002-11-01
US60/423,129 2002-11-01
US45615903P 2003-03-20 2003-03-20
US60/456,159 2003-03-20
US10/402,004 2003-03-28
US10/402,004 US6921769B2 (en) 2002-08-23 2003-03-28 Synthesis of epothilones, intermediates thereto and analogues thereof
US10/435,408 2003-05-09
US10/435,408 US7649006B2 (en) 2002-08-23 2003-05-09 Synthesis of epothilones, intermediates thereto and analogues thereof
US49674103P 2003-08-21 2003-08-21
US60/496,741 2003-08-21

Publications (2)

Publication Number Publication Date
KR20050083652A KR20050083652A (ko) 2005-08-26
KR101173510B1 true KR101173510B1 (ko) 2012-08-21

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KR1020057003043A Expired - Fee Related KR101173510B1 (ko) 2002-08-23 2003-08-22 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도

Country Status (18)

Country Link
US (1) US7875638B2 (https=)
EP (3) EP1767535B1 (https=)
JP (2) JP4791183B2 (https=)
KR (1) KR101173510B1 (https=)
CN (2) CN102532120A (https=)
AT (2) ATE450534T1 (https=)
AU (1) AU2003260002B2 (https=)
CA (1) CA2496477C (https=)
DE (2) DE60330407D1 (https=)
DK (2) DK1506203T3 (https=)
ES (2) ES2281692T3 (https=)
IL (1) IL167046A (https=)
MX (1) MXPA05002113A (https=)
NZ (1) NZ538522A (https=)
PH (1) PH12012501351A1 (https=)
PT (2) PT1767535E (https=)
SI (1) SI1767535T1 (https=)
WO (1) WO2004018478A2 (https=)

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