KR100905676B1 - 티오에스테르-종결된 수용해성 중합체, 및 그에 의한폴리펩티드의 n-말단 변형 방법 - Google Patents
티오에스테르-종결된 수용해성 중합체, 및 그에 의한폴리펩티드의 n-말단 변형 방법 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/688—Polyesters containing atoms other than carbon, hydrogen and oxygen containing sulfur
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Description
Claims (28)
- 제 1 항에 있어서, 각각의 X 는 H 또는 C1-C6 알킬인 반응성 중합체.
- 제 2 항에 있어서, 각각의 X 는 H 또는 메틸인 반응성 중합체.
- 제 1 항에 있어서, Y 가 O 또는 S 인 반응성 중합체.
- 제 1 항에 있어서, Q 가 화학식 -S-R1 [식중, R1 은 수소, 알킬, 치환된 알킬, 시클로알킬, 치환된 시클로알킬, 아릴, 치환된 아릴, 헤테로아릴, 치환된 헤테로아릴, 헤테로사이클 및 치환된 헤테로사이클로 이루어진 군으로부터 선택된다] 을 갖는 반응성 중합체.
- 제 5 항에 있어서, R1 이 페놀, 니트로페놀, 벤조산, 피리딘, 피리딘카르복실산 및 니트로피리딘으로 이루어진 군으로부터 선택되는 반응성 중합체.
- 제 5 항에 있어서, R1 이 치환 또는 비치환된 피리딘인 반응성 중합체.
- 제 1 항에 있어서, a 가 1 이고, Z 가 -O-, -S-, -NHCO-, -CONH-, -O2C-, -NHCO2- 및 -O2CNH- 로 이루어진 군으로부터 선택되는 반응성 중합체.
- 제 1 항에 있어서, 중합체 골격이 폴리(알킬렌 글리콜), 폴리(옥시에틸화 폴리올), 폴리(올레핀성 알콜), 폴리(비닐피롤리돈), 폴리(α-히드록시산), 폴리(비닐알콜), 폴리포스파젠, 폴리옥사졸린, 폴리(N-아크릴로일모르폴린), 폴리아크릴레이트, 폴리아크릴아미드, 폴리사카라이드, 및 이의 공중합체, 삼원중합체 및 혼합물로 이루어진 군으로부터 선택되는 반응성 중합체.
- 제 1 항에 있어서, 상기 수용해성의 비펩티드성 중합체 골격이 폴리(에틸렌 글리콜), 폴리(프로필렌 글리콜), 및 에틸렌 글리콜과 프로필렌 글리콜의 공중합체로 이루어진 군으로부터 선택되는 반응성 중합체.
- 제 1 항에 있어서, 상기 중합체 골격이 약 100 Da 내지 약 100,000 Da 의 수평균 분자량을 갖는 폴리(에틸렌 글리콜)인 반응성 중합체.
- 제 1 항에 있어서, m 이 1 내지 약 4 인 반응성 중합체.
- 제 13 항에 있어서, R 이 알콕시, 알킬, 벤질, 아릴, 아릴옥시, 히드록실, 활성 에스테르, 활성 카보네이트, 아세탈, 알데히드, 알데히드 히드레이트, 알케닐, 아크릴레이트, 메타크릴레이트, 아크릴아미드, 활성 술폰, 아민, 히드라지드, 티올, 카르복실산, 이소시아네이트, 이소티오시아네이트, 말레이미드, 비닐술폰, 디티오피리딘, 비닐피리딘, 요오도아세트아미드, 에폭시드, 글리옥살, 디온, 메실레이트, 토실레이트, 트레실레이트 및 -(Z)a-(CXH)m-CO-S-R1 으로 이루어진 군으로부터 선택되는 반응성 중합체.
- 제 13 항에 있어서, POLY 가 폴리(에틸렌 글리콜)인 반응성 중합체.
- 제 16 항에 있어서, POLY 가 폴리(에틸렌 글리콜)인 반응성 중합체.
- 제 16 항에 있어서, R' 가 폴리올, 폴리아민, 및 알콜과 아민기의 조합을 갖는 분자로 이루어진 군으로부터 선택된 분자의 잔기인 반응성 중합체.
- 제 16 항에 있어서, R' 가 글리세롤, 글리세롤 올리고머, 펜타에리트리톨, 소르비톨 및 리신으로 이루어진 군으로부터 선택된 분자의 잔기인 반응성 중합체.
- 제 20 항에 있어서, 중합체 골격이 폴리(에틸렌 글리콜)인 중합체 공액체.
- 제 20 항에 있어서, POLYPEPTIDE 가 단백질, 단백질-리간드, 효소, 시토카인, 헤마토포이에틴, 성장 인자, 호르몬, 항원, 항체, 항체 절편, 수용체 및 단백질 절편인 중합체 공액체.
- 제 20 항에 있어서, POLYPEPTIDE 가 인터페론 분자인 중합체 공액체.
- 하기 단계를 포함하는, N-말단에서 시스테인 또는 히스티딘 잔기를 갖는 폴리펩티드에 중합체 유도체를 공액시키는 방법:N-말단에 시스테인 또는 히스티딘 잔기를 갖는 폴리펩티드를 제공하는 단계;하기의 구조에 결합하는 하나 이상의 말단을 갖는 수용해성의 비펩티드성 중 합체 골격을 포함하는, 티오에스테르-종결된 중합체를 제공하는 단계:[식중,L 은 중합체 골격에 결합하는 지점이고;Z 는 연결자이고;m 은 0 내지 약 12 이고;Y 는 헤테로원자이고;각각의 X 는 H 및 알킬로부터 독립적으로 선택되고;a 는 0 또는 1 이고;Q 는 황 함유 이탈기이다];상기 폴리펩티드와 티오에스테르-종결된 중합체를 반응시켜 하기의 구조를 갖는 공액체를 형성하는 단계:[식중,POLYPEPTIDE 는 폴리펩티드 분자이고;
- 제 24 항에 있어서, 폴리펩티드 골격이 폴리(에틸렌 글리콜)인 방법.
- 제 24 항에 있어서, POLYPEPTIDE 가 단백질 리간드, 효소, 시토카인, 헤마토포이에틴, 성장 인자, 호르몬, 항원, 항체, 항체 절편, 수용체 및 단백질 절편으로 이루어진 군으로부터 선택되는 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/973,318 | 2001-10-09 | ||
US09/973,318 US6908963B2 (en) | 2001-10-09 | 2001-10-09 | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
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KR20050035143A KR20050035143A (ko) | 2005-04-15 |
KR100905676B1 true KR100905676B1 (ko) | 2009-07-03 |
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KR1020047005261A KR100905676B1 (ko) | 2001-10-09 | 2004-04-09 | 티오에스테르-종결된 수용해성 중합체, 및 그에 의한폴리펩티드의 n-말단 변형 방법 |
Country Status (10)
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US (6) | US6908963B2 (ko) |
EP (1) | EP1434589B1 (ko) |
JP (2) | JP4474521B2 (ko) |
KR (1) | KR100905676B1 (ko) |
AT (1) | ATE416773T1 (ko) |
AU (1) | AU2002360257B2 (ko) |
CA (1) | CA2463072C (ko) |
DE (1) | DE60230300D1 (ko) |
MX (1) | MXPA04003340A (ko) |
WO (1) | WO2003031581A2 (ko) |
Families Citing this family (183)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4187277B2 (ja) * | 1997-04-30 | 2008-11-26 | エンゾン ファーマシューティカルズ, インコーポレイテッド | グリコシル化し得る抗原結合単鎖タンパク質、それらの生成および使用 |
US6908963B2 (en) * | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
EP1465933B1 (en) * | 2002-01-16 | 2007-08-29 | Biocompatibles UK Limited | Polymer conjugates |
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
RS20050502A (en) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polymer conjugates of interferon- beta with enhanced biological potency |
RS20050501A (en) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polymer conjugates of cytokines,chemokines,growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
WO2004065412A1 (en) * | 2003-01-18 | 2004-08-05 | Pegsphere Co., Ltd. | Peptides having protected amines of untargeted sites, methods for production thereof and of specifically conjugated peg peptides using the same |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
JP4464395B2 (ja) * | 2003-03-05 | 2010-05-19 | ヘイローザイム インコーポレイテッド | 可溶性ヒアルロニダーゼ糖タンパク質(sHASEGP)、その調製プロセス、使用およびそれを含む薬学的組成物 |
US7871607B2 (en) * | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
CA2529819A1 (en) * | 2003-06-30 | 2004-09-23 | Domantis Limited | Pegylated single domain antibodies |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
US20050106577A1 (en) * | 2003-11-17 | 2005-05-19 | Hashem Akhavan-Tafti | Cleavable solid phases for isolating nucleic acids |
SG10201404273QA (en) | 2003-12-23 | 2014-10-30 | Genentech Inc | Novel anti-il 13 antibodies and uses thereof |
JP4726128B2 (ja) * | 2003-12-24 | 2011-07-20 | 塩野義製薬株式会社 | タンパク質のポリマー複合体の製造方法 |
US20050170457A1 (en) * | 2003-12-31 | 2005-08-04 | Chadler Pool | Novel recombinant proteins with N-terminal free thiol |
AU2005319099B2 (en) | 2004-02-02 | 2010-09-16 | Ambrx, Inc. | Modified human growth hormone |
GB2429207A (en) | 2004-02-02 | 2007-02-21 | Ambrx Inc | Modified human interferon polypeptides and their uses |
ES2390885T3 (es) * | 2004-03-11 | 2012-11-19 | Fresenius Kabi Deutschland Gmbh | Conjugados de hidroxialquilalmidón y una proteína |
WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
KR101699142B1 (ko) * | 2004-06-18 | 2017-01-23 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
EP1771573A4 (en) * | 2004-07-21 | 2009-02-18 | Ambrx Inc | BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS |
US8303973B2 (en) | 2004-09-17 | 2012-11-06 | Angiotech Pharmaceuticals (Us), Inc. | Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use |
US20060060268A1 (en) * | 2004-09-17 | 2006-03-23 | Tad Machrowicz | Method of making high strength bainite article, and article made thereby |
US7816320B2 (en) | 2004-12-22 | 2010-10-19 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 |
EP1836298B1 (en) | 2004-12-22 | 2012-01-18 | Ambrx, Inc. | COMPOSITIONS OF AMINOACYL-tRNA SYNTHETASE AND USES THEREOF |
US8080391B2 (en) | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
EP1861125A2 (en) * | 2005-03-23 | 2007-12-05 | Nektar Therapeutics Al, Corporation | Conjugates of an hgh moiety and peg derivatives |
ATE529442T1 (de) | 2005-06-03 | 2011-11-15 | Ambrx Inc | Verbesserte humane interferon-moleküle und ihre verwendungen |
AU2006289328A1 (en) * | 2005-09-07 | 2007-03-15 | Dsm Ip Assets B.V. | Polymers comprising thioester bonds |
EP1762250A1 (en) | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
PT2339014E (pt) | 2005-11-16 | 2015-10-13 | Ambrx Inc | Métodos e composições compreendendo aminoácidos não-naturais |
PT1960430E (pt) | 2005-12-09 | 2015-01-05 | Ucb Pharma Sa | Moléculas de anticorpo com especificidade para il-6 humana |
US20070190526A1 (en) * | 2006-02-16 | 2007-08-16 | Nexgen Diagnostics Llc | Methods of extracting nucleic acids |
KR100886783B1 (ko) * | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
JP2009541333A (ja) | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
EP2049151A4 (en) | 2006-07-17 | 2010-03-24 | Quintessence Biosciences Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
WO2008030613A2 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Hybrid suppressor trna for vertebrate cells |
DK2615108T3 (en) * | 2006-09-08 | 2017-01-30 | Ambrx Inc | Modified human plasma polypeptide or fc scaffolds and their applications |
WO2008030614A2 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Suppressor trna transcription in vertebrate cells |
GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
JP5615558B2 (ja) * | 2007-02-28 | 2014-10-29 | セリナ・セラピユーテイツクス・インコーポレーテツド | 活性ポリオキサゾリンおよびそれを含む組成物 |
KR20140012199A (ko) | 2007-03-30 | 2014-01-29 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
CN103965347B (zh) | 2007-05-02 | 2017-07-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
AU2008326324B9 (en) | 2007-11-20 | 2012-11-15 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
DK3042922T3 (en) | 2008-01-11 | 2017-10-23 | Serina Therapeutics Inc | MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COLPOLYMERS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME |
US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
EP3103880A1 (en) | 2008-02-08 | 2016-12-14 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
EP2268673B1 (en) * | 2008-03-28 | 2017-10-25 | The Regents of The University of California | Polypeptide-polymer conjugates and methods of use thereof |
EP2285402A2 (en) | 2008-04-14 | 2011-02-23 | Halozyme, Inc. | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
GB0807413D0 (en) | 2008-04-23 | 2008-05-28 | Ucb Pharma Sa | Biological products |
TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
UA118536C2 (uk) | 2008-07-23 | 2019-02-11 | Амбркс, Інк. | Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування |
EP3216800A1 (en) | 2008-09-26 | 2017-09-13 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
MX348657B (es) | 2008-09-26 | 2017-06-21 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
EP2334695B1 (en) | 2008-10-01 | 2015-12-23 | Quintessence Biosciences, Inc. | Therapeutic ribonucleases |
DK3037529T3 (da) | 2008-12-09 | 2019-05-20 | Halozyme Inc | Udvidede opløselige ph20-polypeptider og anvendelse deraf |
EP2199281A1 (en) * | 2008-12-19 | 2010-06-23 | DSM IP Assets B.V. | Thioic acids as building block for polythioesters |
JP5782385B2 (ja) | 2009-02-17 | 2015-09-24 | ユーシービー ファーマ ソシエテ アノニム | ヒトox40に対する特異性を有する抗体分子 |
EP2403538B1 (en) | 2009-03-04 | 2017-10-04 | Polytherics Limited | Conjugated proteins and peptides |
GB0904214D0 (en) | 2009-03-11 | 2009-04-22 | Ucb Pharma Sa | Biological products |
EP2475682B1 (en) | 2009-09-10 | 2018-01-31 | UCB Biopharma SPRL | Multivalent antibodies |
JP5734985B2 (ja) | 2009-09-17 | 2015-06-17 | バクスター・ヘルスケヤー・ソシエテ・アノニムBaxter Healthcare SA | ヒアルロニダーゼおよび免疫グロブリンの安定な共製剤およびそれらの使用方法 |
US9315860B2 (en) | 2009-10-26 | 2016-04-19 | Genovoxx Gmbh | Conjugates of nucleotides and method for the application thereof |
GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
GB0920324D0 (en) | 2009-11-19 | 2010-01-06 | Ucb Pharma Sa | Antibodies |
JP6184695B2 (ja) | 2009-12-04 | 2017-08-23 | ジェネンテック, インコーポレイテッド | 多重特異性抗体、抗体アナログ、組成物、及び方法 |
CN102753573A (zh) | 2009-12-21 | 2012-10-24 | Ambrx公司 | 经过修饰的牛促生长素多肽和其用途 |
NZ600363A (en) | 2009-12-21 | 2014-07-25 | Ambrx Inc | Modified porcine somatotropin polypeptides and their uses |
GB201000467D0 (en) | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
CN102892786B (zh) | 2010-03-11 | 2016-03-16 | Ucb医药有限公司 | Pd-1抗体 |
GB201005064D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
TR201903279T4 (tr) | 2010-03-25 | 2019-03-21 | Ucb Biopharma Sprl | Disülfür stabilize edilmiş DVD-IG molekülleri. |
US9878046B2 (en) | 2010-07-20 | 2018-01-30 | Halozyme, Inc. | Adverse side-effects associated with administration of an anti-hyaluronan agent and methods for ameliorating or preventing the side-effects |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
BR112013003522B1 (pt) | 2010-08-17 | 2021-05-25 | Ambrx, Inc. | polipeptídeos relaxina modificados compreendendo um aminoácido não codificado naturalmente, seu método de preparação e seu uso, bem como ácido nucleico e célula hospedeira |
GB201014033D0 (en) | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
RS56298B1 (sr) | 2011-01-14 | 2017-12-29 | Ucb Biopharma Sprl | Antitelo koje vezuje il-17a i il-17f |
WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
CN103889443A (zh) | 2011-06-17 | 2014-06-25 | 哈洛齐梅公司 | 使用透明质酸降解酶的持续皮下胰岛素输注法 |
US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
US20130071394A1 (en) | 2011-09-16 | 2013-03-21 | John K. Troyer | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use |
EP2758432B1 (en) | 2011-09-16 | 2019-03-06 | UCB Biopharma SPRL | Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile |
AU2012328880B2 (en) | 2011-10-24 | 2017-02-23 | Halozyme, Inc. | Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof |
UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
IL298330A (en) | 2011-12-30 | 2023-01-01 | Halozyme Inc | Ph20 polypeptide variants, formulations and uses thereof |
GB201203071D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
GB201203051D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
EP2634179A1 (en) * | 2012-02-28 | 2013-09-04 | Sanofi | Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging |
EA031986B1 (ru) | 2012-04-04 | 2019-03-29 | Галозим, Инк. | Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию |
GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
EP3505534A1 (en) | 2012-06-08 | 2019-07-03 | Sutro Biopharma, Inc. | Antibodies comprising sitespecific nonnatural amino acid residues, methods of their preparation and methods of their use |
ES2611788T3 (es) | 2012-06-26 | 2017-05-10 | Sutro Biopharma, Inc. | Proteínas de Fc modificadas que comprenden residuos de aminoácidos no naturales específicos del sitio, conjugados de las mismas, métodos para su preparación y métodos para su uso |
BR112015004022B1 (pt) | 2012-08-31 | 2023-04-25 | Sutro Biopharma, Inc | Aminoácidos modificados compreendendo um grupo azido |
US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
GB201223276D0 (en) | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
US9764039B2 (en) | 2013-07-10 | 2017-09-19 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
GB201315487D0 (en) | 2013-08-30 | 2013-10-16 | Ucb Pharma Sa | Antibodies |
KR102332302B1 (ko) | 2013-09-13 | 2021-12-01 | 제넨테크, 인크. | 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법 |
EP3683232A1 (en) | 2013-09-13 | 2020-07-22 | F. Hoffmann-La Roche AG | Methods and compositions comprising purified recombinant polypeptides |
WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
GB201320066D0 (en) | 2013-11-13 | 2013-12-25 | Ucb Pharma Sa | Biological products |
US11299528B2 (en) | 2014-03-11 | 2022-04-12 | D&D Pharmatech Inc. | Long acting TRAIL receptor agonists for treatment of autoimmune diseases |
WO2015175774A1 (en) | 2014-05-14 | 2015-11-19 | Trustees Of Dartmouth College | Deimmunized lysostaphin and methods of use |
GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
GB201411320D0 (en) | 2014-06-25 | 2014-08-06 | Ucb Biopharma Sprl | Antibody construct |
GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
HUE043847T2 (hu) | 2014-08-28 | 2019-09-30 | Halozyme Inc | Hialuronán-lebontó enzimmel és egy immun checkpoint inhibitorral végzett kombinációs terápia |
EA201700181A1 (ru) | 2014-10-14 | 2017-09-29 | Галозим, Инк. | Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования |
EP3220961B1 (en) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
KR20240024362A (ko) | 2014-10-24 | 2024-02-23 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
GB201506869D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
TW201702271A (zh) | 2015-04-30 | 2017-01-16 | 哈佛大學校長及研究員協會 | 治療代謝病症之抗-ap2抗體及抗原結合劑 |
GB201508180D0 (en) | 2015-05-13 | 2015-06-24 | Ucb Biopharma Sprl | Antibodies |
EA039951B1 (ru) | 2015-05-27 | 2022-03-31 | Юсб Биофарма Спрл | Ингибитор активности csf-1r, предназначенный для лечения или профилактики эпилепсии или болезни паркинсона, и фармацевтическая композиция на его основе |
UA124616C2 (uk) | 2015-07-06 | 2021-10-20 | Юсб Біофарма Срл | Зв'язуюче тау-білок антитіло |
GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
MX2018005031A (es) | 2015-10-27 | 2018-06-13 | Ucb Biopharma Sprl | Metodos de tratamiento con anticuerpos anti interleucina 17a/17f (il-17a/f). |
GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
US10765759B2 (en) | 2015-12-09 | 2020-09-08 | The Regents Of The University Of California | Methods of treating an ocular disease or disorder |
CA3008392C (en) | 2015-12-17 | 2021-11-09 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
CA3020339C (en) | 2016-04-07 | 2022-05-03 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
US11534496B2 (en) | 2016-06-07 | 2022-12-27 | The Brigham And Women's Hospital, Inc. | Compositions and methods relating to T peripheral helper cells in autoantibody-associated conditions |
GB201610198D0 (en) | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
JP2020500834A (ja) | 2016-08-26 | 2020-01-16 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | マクロファージ刺激タンパク質受容体(又はRON(Recepteur d′Origine Nantais))抗体及びその使用 |
GB201616596D0 (en) | 2016-09-29 | 2016-11-16 | Nascient Limited | Epitope and antibodies |
GB201621635D0 (en) | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Crystal structure |
CN110637027A (zh) | 2017-02-08 | 2019-12-31 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
WO2018183366A1 (en) | 2017-03-28 | 2018-10-04 | Syndax Pharmaceuticals, Inc. | Combination therapies of csf-1r or csf-1 antibodies and a t-cell engaging therapy |
JP2020520943A (ja) | 2017-05-19 | 2020-07-16 | シンダックス ファーマシューティカルズ, インコーポレイテッド | 併用療法 |
US10781435B2 (en) | 2017-06-22 | 2020-09-22 | Catalyst Biosciences, Inc. | Modified membrane type serine protease 1 (MTSP-1) polypeptides and methods of use |
GB201802486D0 (en) | 2018-02-15 | 2018-04-04 | Ucb Biopharma Sprl | Methods |
WO2019222435A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
US20220056093A1 (en) | 2018-09-11 | 2022-02-24 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
MX2021004351A (es) | 2018-10-16 | 2021-05-31 | UCB Biopharma SRL | Metodo para el tratamiento de miastenia grave. |
EP3867265A1 (en) | 2018-10-19 | 2021-08-25 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates, dimers thereof, and their uses |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
EP3902913A1 (en) | 2018-12-28 | 2021-11-03 | Catalyst Biosciences, Inc. | Modified urokinase-type plasminogen activator polypeptides and methods of use |
BR112021015832A2 (pt) | 2019-02-12 | 2022-01-18 | Ambrx Inc | Composições que contêm conjugados de anticorpo-agonista de tlr, métodos e usos dos mesmos |
AU2020247175A1 (en) | 2019-03-26 | 2021-10-14 | Aslan Pharmaceuticals Pte Ltd | Treatment employing anti-IL-13R antibody or binding fragment thereof |
GB201919062D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Antibody |
GB201919061D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibody |
GB201919058D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibodies |
GB202001447D0 (en) | 2020-02-03 | 2020-03-18 | Ucb Biopharma Sprl | Antibodies |
KR20220151202A (ko) | 2020-03-11 | 2022-11-14 | 암브룩스, 인코포레이티드 | 인터류킨-2 폴리펩타이드 접합체 및 그의 사용 방법 |
US11767353B2 (en) | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
JP2023538071A (ja) | 2020-08-20 | 2023-09-06 | アンブルックス,インコーポレイテッド | 抗体-tlrアゴニストコンジュゲート、その方法及び使用 |
US20230374148A1 (en) | 2020-10-15 | 2023-11-23 | UCB Biopharma SRL | Binding molecules that multimerise cd45 |
AU2020475443A1 (en) | 2020-11-02 | 2023-06-01 | UCB Biopharma SRL | Use of anti-trem1 neutralizing antibodies for the treatment of motor neuron neurodegenerative disorders |
WO2022122652A1 (en) | 2020-12-07 | 2022-06-16 | UCB Biopharma SRL | Antibodies against interleukin-22 |
MX2023006650A (es) | 2020-12-07 | 2023-06-21 | UCB Biopharma SRL | Anticuerpos multiespecificos y combinaciones de anticuerpos. |
WO2022186772A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
WO2022186773A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF IN AN ALLERGIC POPULATION |
EP4067381A1 (en) | 2021-04-01 | 2022-10-05 | Julius-Maximilians-Universität Würzburg | Novel tnfr2 binding molecules |
CA3213805A1 (en) | 2021-04-03 | 2022-10-06 | Feng Tian | Anti-her2 antibody-drug conjugates and uses thereof |
IL308100A (en) | 2021-05-03 | 2023-12-01 | UCB Biopharma SRL | Antibodies |
GB202111905D0 (en) | 2021-08-19 | 2021-10-06 | UCB Biopharma SRL | Antibodies |
WO2023048650A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF PRURITIS EMPLOYING ANTI-IL13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
WO2023048651A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | Method for treatment of moderate to severe atoptic dematitis |
GB202115122D0 (en) | 2021-10-21 | 2021-12-08 | Dualyx Nv | Binding molecules targeting IL-2 receptor |
TW202333784A (zh) | 2021-10-29 | 2023-09-01 | 新加坡商亞獅康私人有限公司 | 抗il13r抗體調配物 |
WO2023140780A1 (en) | 2022-01-24 | 2023-07-27 | Aslan Pharmaceuticals Pte Ltd. | Method of treating inflammatory disease |
TW202337905A (zh) | 2022-02-23 | 2023-10-01 | 新加坡商亞獅康私人有限公司 | 抗il13r抗體之糖基化形式 |
GB202210679D0 (en) | 2022-07-21 | 2022-09-07 | Dualyx Nv | Binding molecules targeting il-12rb2 |
WO2024043837A1 (en) | 2022-08-26 | 2024-02-29 | Aslan Pharmaceuticals Pte Ltd | High concentration anti-il13r antibody formulation |
WO2024054157A1 (en) | 2022-09-06 | 2024-03-14 | Aslan Pharmaceuticals Pte Ltd | Treatment for sleep loss or sleep disturbance in patients with dermatitis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
FR2658521B1 (fr) * | 1990-02-19 | 1994-01-21 | Serbioo | Bipeptides symetriques comportant un reste polyalkyleneglycol, procede de preparation et utilisation dans le dosage des proteases. |
US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5614549A (en) | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
JPH09504174A (ja) * | 1993-10-29 | 1997-04-28 | インサイト ファーマシューティカルズ,インク. | プロテアーゼネキシン1変異体を含むキメラ蛋白 |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
WO1996041813A2 (en) | 1994-11-09 | 1996-12-27 | Offord Robin E | Functionalized polymers for site-specific attachment |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US6184344B1 (en) * | 1995-05-04 | 2001-02-06 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
EP0832096B1 (en) * | 1995-05-04 | 2001-07-18 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
DK1568772T3 (da) * | 1995-09-21 | 2010-10-18 | Genentech Inc | Varianter af humant væksthormon |
JPH09255979A (ja) | 1996-03-21 | 1997-09-30 | Sony Corp | 潤滑剤、これを用いた磁気記録媒体及び磁気ヘッド |
JP2001511162A (ja) | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして/又は除去された付着基を有するポリペプチド−ポリマー結合体 |
EP1012184B1 (en) * | 1997-07-14 | 2007-10-10 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
US6953675B2 (en) | 1997-11-06 | 2005-10-11 | Immunomedics, Inc. | Landscaped antibodies and antibody fragments for clinical use |
JP2001525470A (ja) * | 1997-12-12 | 2001-12-11 | マクロメド・インコーポレーテッド | タンパク修飾のためのヘテロ官能化星形ポリ(エチレングリコール) |
EP1062230B1 (en) | 1998-03-05 | 2004-10-13 | Chiron Corporation | Method for increasing the serum half-life of a biologically active molecule |
US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
-
2001
- 2001-10-09 US US09/973,318 patent/US6908963B2/en not_active Expired - Lifetime
-
2002
- 2002-10-09 US US10/269,028 patent/US7078496B2/en not_active Expired - Lifetime
- 2002-10-09 CA CA2463072A patent/CA2463072C/en not_active Expired - Lifetime
- 2002-10-09 JP JP2003534552A patent/JP4474521B2/ja not_active Expired - Lifetime
- 2002-10-09 MX MXPA04003340A patent/MXPA04003340A/es active IP Right Grant
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Patent Citations (1)
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US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
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JP2005505662A (ja) | 2005-02-24 |
US20120065330A1 (en) | 2012-03-15 |
AU2002360257B2 (en) | 2006-07-27 |
WO2003031581A3 (en) | 2003-10-16 |
DE60230300D1 (de) | 2009-01-22 |
US20030105224A1 (en) | 2003-06-05 |
US6908963B2 (en) | 2005-06-21 |
US20110065862A1 (en) | 2011-03-17 |
CA2463072C (en) | 2010-08-24 |
KR20050035143A (ko) | 2005-04-15 |
US7511095B2 (en) | 2009-03-31 |
WO2003031581A2 (en) | 2003-04-17 |
JP2010090387A (ja) | 2010-04-22 |
US20030158333A1 (en) | 2003-08-21 |
EP1434589A4 (en) | 2006-06-21 |
US20060178505A1 (en) | 2006-08-10 |
CA2463072A1 (en) | 2003-04-17 |
EP1434589B1 (en) | 2008-12-10 |
EP1434589A2 (en) | 2004-07-07 |
US7834088B2 (en) | 2010-11-16 |
MXPA04003340A (es) | 2004-11-29 |
US8329876B2 (en) | 2012-12-11 |
ATE416773T1 (de) | 2008-12-15 |
US8071678B2 (en) | 2011-12-06 |
US7078496B2 (en) | 2006-07-18 |
JP4474521B2 (ja) | 2010-06-09 |
US20100069571A1 (en) | 2010-03-18 |
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