KR100869409B1 - (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도 - Google Patents

(1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도 Download PDF

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KR100869409B1
KR100869409B1 KR1020067001821A KR20067001821A KR100869409B1 KR 100869409 B1 KR100869409 B1 KR 100869409B1 KR 1020067001821 A KR1020067001821 A KR 1020067001821A KR 20067001821 A KR20067001821 A KR 20067001821A KR 100869409 B1 KR100869409 B1 KR 100869409B1
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alkyl
formula
compound
amino
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KR20060014459A (ko
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글렌 어니스트 윌콕스
크리스찬 코에처
톤 브라이스
마크 에드워드 플라나간
마이클 존 먼치호프
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화이자 프로덕츠 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020067001821A 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도 Expired - Lifetime KR100869409B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29477501P 2001-05-31 2001-05-31
US60/294,775 2001-05-31
US34104801P 2001-12-06 2001-12-06
US60/341,048 2001-12-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7015681A Division KR20040003037A (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020087018519A Division KR100926875B1 (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR1020067025590A Division KR20060133117A (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도

Publications (2)

Publication Number Publication Date
KR20060014459A KR20060014459A (ko) 2006-02-15
KR100869409B1 true KR100869409B1 (ko) 2008-11-21

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ID=26968730

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020067001821A Expired - Lifetime KR100869409B1 (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR1020077025832A Expired - Lifetime KR100868814B1 (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR10-2003-7015681A Ceased KR20040003037A (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR1020087018519A Expired - Lifetime KR100926875B1 (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR1020067025590A Ceased KR20060133117A (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020077025832A Expired - Lifetime KR100868814B1 (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR10-2003-7015681A Ceased KR20040003037A (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR1020087018519A Expired - Lifetime KR100926875B1 (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도
KR1020067025590A Ceased KR20060133117A (ko) 2001-05-31 2002-05-29 (1-벤질-4-메틸피페리딘-3-일)-메틸아민의 광학 분할, 및단백질 키나아제 억제제로서의 피롤로 2,3-피리미딘유도체의 제조를 위한 이들의 용도

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US (2) US7301023B2 (https=)
EP (3) EP1666481B9 (https=)
JP (1) JP4381137B2 (https=)
KR (5) KR100869409B1 (https=)
CN (1) CN1729192A (https=)
AP (1) AP1859A (https=)
AR (2) AR037321A1 (https=)
AT (1) ATE519741T1 (https=)
AU (2) AU2002304401C1 (https=)
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ATE423120T1 (de) * 2000-06-26 2009-03-15 Pfizer Prod Inc Pyrroloä2,3-düpyrimidin verbindungen als immunosuppressive wirkstoffe
PY0228255A (es) 2001-12-06 2004-06-01 Pfizer Prod Inc Compuestos cristalinos novedosos
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
HRP20050089B1 (hr) 2002-07-29 2015-06-19 Rigel Pharmaceuticals Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
ATE402700T1 (de) * 2002-08-27 2008-08-15 Merck Patent Gmbh Glycinamid-derivate als raf-kinase-hemmer
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WO2005012294A1 (en) 2003-07-30 2005-02-10 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
AU2005237254B2 (en) * 2004-05-03 2010-02-04 Novartis Ag Combinations comprising a S1P receptor agonist and a JAK3 kinase inhibitor
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CA2448281C (en) 2009-05-05
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US7432370B2 (en) 2008-10-07
AR037321A1 (es) 2004-11-03
KR20060133117A (ko) 2006-12-22
ZA200307982B (en) 2004-10-14
AU2002304401B2 (en) 2008-04-17
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EE200300594A (et) 2004-04-15
HRP20030943B1 (hr) 2011-11-30
US20040229923A1 (en) 2004-11-18
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PA8546301A1 (es) 2003-05-14
OA12612A (en) 2006-06-09
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AP1859A (en) 2008-07-02
GT200200100A (es) 2003-02-11
EA007251B1 (ru) 2006-08-25
ES2369226T3 (es) 2011-11-28
SK288192B6 (sk) 2014-06-03
ECSP034865A (es) 2004-01-28
EP1392694A1 (en) 2004-03-03
EA200301193A1 (ru) 2004-04-29
AU2008203170A1 (en) 2008-08-07
US20030073719A1 (en) 2003-04-17
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NO328578B1 (no) 2010-03-22
FR17C1031I1 (fr) 2017-10-13
ATE519741T1 (de) 2011-08-15
US7301023B2 (en) 2007-11-27
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PT1666481E (pt) 2012-12-03
AP2002002550A0 (en) 2002-06-30
AR045680A2 (es) 2005-11-09
FR17C1031I2 (fr) 2018-11-02
CU23337B7 (es) 2009-01-20
AU2002304401C1 (en) 2009-03-05
SK288199B6 (sk) 2014-06-03
JP2004534047A (ja) 2004-11-11
CA2448281A1 (en) 2002-12-05
CZ20033260A3 (en) 2004-03-17
PL409305A1 (pl) 2014-12-22
EP1666481A2 (en) 2006-06-07
TNSN03128A1 (fr) 2005-12-23
NO20093135L (no) 2003-11-24
BG108389A (bg) 2005-01-31
NO20035201L (no) 2003-11-24
SI1666481T1 (sl) 2012-11-30
HRP20030943A2 (en) 2005-08-31
KR100868814B1 (ko) 2008-11-14
EP1666481A3 (en) 2006-11-29
EA012666B1 (ru) 2009-12-30
PL367945A1 (en) 2005-03-07
RS52144B (sr) 2012-08-31
MA27029A1 (fr) 2004-12-20
KR20060014459A (ko) 2006-02-15
NL300887I2 (nl) 2017-08-31
UA80093C2 (uk) 2007-08-27
CL2008000762A1 (es) 2008-07-04
TWI316061B (en) 2009-10-21
NZ540332A (en) 2007-05-31
EP1666481B1 (en) 2012-09-19
CZ304366B6 (cs) 2014-04-02
KR100926875B1 (ko) 2009-11-16
IS3023B (is) 2020-08-15
BR0209246A (pt) 2004-06-15
LUC00031I2 (https=) 2017-10-11
EE05332B1 (et) 2010-08-16
NO2017047I1 (no) 2017-09-08
IS6993A (is) 2003-10-13
CY2017028I1 (el) 2018-02-14
NO20035201D0 (no) 2003-11-24
HUP0400152A2 (en) 2007-07-30
KR20080083028A (ko) 2008-09-12
HUS1900008I1 (hu) 2020-02-28
CR10177A (es) 2008-08-19

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