JPS6019790A - 新規なカンプトテシン誘導体 - Google Patents

新規なカンプトテシン誘導体

Info

Publication number
JPS6019790A
JPS6019790A JP58126946A JP12694683A JPS6019790A JP S6019790 A JPS6019790 A JP S6019790A JP 58126946 A JP58126946 A JP 58126946A JP 12694683 A JP12694683 A JP 12694683A JP S6019790 A JPS6019790 A JP S6019790A
Authority
JP
Japan
Prior art keywords
title compound
solvent
substituted
alkyl
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58126946A
Other languages
English (en)
Japanese (ja)
Other versions
JPH034077B2 (enExample
Inventor
Sada Miyasaka
宮坂　貞
Seigo Sawada
誠吾 沢田
Kenichiro Nogata
野方　健一郎
Eiichi Sugino
杉野　栄一
Masahiko Mutai
務台　方彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP58126946A priority Critical patent/JPS6019790A/ja
Priority to CA000458228A priority patent/CA1235415A/en
Priority to US06/627,980 priority patent/US4604463A/en
Priority to AT84108257T priority patent/ATE33839T1/de
Priority to DE198484108257T priority patent/DE137145T1/de
Priority to EP84108257A priority patent/EP0137145B1/en
Priority to DE8484108257T priority patent/DE3470744D1/de
Publication of JPS6019790A publication Critical patent/JPS6019790A/ja
Publication of JPH034077B2 publication Critical patent/JPH034077B2/ja
Priority to LU90074C priority patent/LU90074I2/fr
Priority to NL980026C priority patent/NL980026I2/nl
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP58126946A 1983-07-14 1983-07-14 新規なカンプトテシン誘導体 Granted JPS6019790A (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP58126946A JPS6019790A (ja) 1983-07-14 1983-07-14 新規なカンプトテシン誘導体
CA000458228A CA1235415A (en) 1983-07-14 1984-07-05 Camptothecin derivatives and process for preparing same
US06/627,980 US4604463A (en) 1983-07-14 1984-07-05 Camptothecin derivatives and process for preparing same
EP84108257A EP0137145B1 (en) 1983-07-14 1984-07-13 New camptothecin derivatives and process for preparing same
DE198484108257T DE137145T1 (de) 1983-07-14 1984-07-13 Camptothecin-derivate und verfahren zu deren herstellung.
AT84108257T ATE33839T1 (de) 1983-07-14 1984-07-13 Neue camptothecin-derivate und verfahren zu deren herstellung.
DE8484108257T DE3470744D1 (en) 1983-07-14 1984-07-13 New camptothecin derivatives and process for preparing same
LU90074C LU90074I2 (fr) 1983-07-14 1997-06-04 Chlorhydrate d'irinotécan trihydraté et ses dérivés pharmaceutiquement acceptables (Campto)
NL980026C NL980026I2 (nl) 1983-07-14 1998-09-17 Nieuwe camptothecinederivaten en werkwijze voor debereiding hiervan.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58126946A JPS6019790A (ja) 1983-07-14 1983-07-14 新規なカンプトテシン誘導体

Publications (2)

Publication Number Publication Date
JPS6019790A true JPS6019790A (ja) 1985-01-31
JPH034077B2 JPH034077B2 (enExample) 1991-01-22

Family

ID=14947803

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58126946A Granted JPS6019790A (ja) 1983-07-14 1983-07-14 新規なカンプトテシン誘導体

Country Status (8)

Country Link
US (1) US4604463A (enExample)
EP (1) EP0137145B1 (enExample)
JP (1) JPS6019790A (enExample)
AT (1) ATE33839T1 (enExample)
CA (1) CA1235415A (enExample)
DE (2) DE137145T1 (enExample)
LU (1) LU90074I2 (enExample)
NL (1) NL980026I2 (enExample)

Cited By (12)

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US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
US6562834B2 (en) 2000-10-27 2003-05-13 Aventis Pharma S. A. Combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6664242B2 (en) 2000-02-28 2003-12-16 Aventis Pharma S.A. Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer
US6960596B2 (en) 2000-03-17 2005-11-01 Aventis Pharma S.A. Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer
WO2006038526A1 (ja) * 2004-10-01 2006-04-13 Kabushiki Kaisha Yakult Honsha イリノテカン酸付加塩
JP2008529991A (ja) * 2005-02-08 2008-08-07 フェルミオン オサケ ユキチュア ［１，４’］ビピペリジニル−１’−カルボニルクロリドまたはその塩酸塩の製造方法
JP2009529546A (ja) * 2006-03-10 2009-08-20 シャンハイ インスティテュート オブ マテリア メディカ チャイニーズ アカデミー オブ サイエンシーズ カンプトテシン誘導体及びその応用
JP2013511540A (ja) * 2009-11-18 2013-04-04 ネクター セラピューティックス マルチアームポリマー−薬物コンジュゲートの塩形態
JP2013527228A (ja) * 2010-06-01 2013-06-27 アポセンス リミテッド 新規な医薬化合物
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
WO2019178433A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
US10501523B2 (en) 2014-07-18 2019-12-10 Sanofi IL-8 level based method of predicting the outcome of colon cancer treatment

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* Cited by examiner, † Cited by third party
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US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
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US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
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US6228855B1 (en) * 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
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CA1235415A (en) 1988-04-19
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ATE33839T1 (de) 1988-05-15
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US4604463A (en) 1986-08-05
DE137145T1 (de) 1985-11-21
EP0137145B1 (en) 1988-04-27
LU90074I2 (fr) 1997-08-21
JPH034077B2 (enExample) 1991-01-22
NL980026I2 (nl) 1999-02-01

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