AR027687A1 - Procedimiento para preparar camptotecina - Google Patents
Procedimiento para preparar camptotecinaInfo
- Publication number
- AR027687A1 AR027687A1 ARP010101292A ARP010101292A AR027687A1 AR 027687 A1 AR027687 A1 AR 027687A1 AR P010101292 A ARP010101292 A AR P010101292A AR P010101292 A ARP010101292 A AR P010101292A AR 027687 A1 AR027687 A1 AR 027687A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- camptothecin
- camptotechine
- prepare
- methoxycamptothecin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Se refiere a la produccion a gran escala de camptotecina, que es el compuesto de partida del hidrocloruro de irinotecan y diversos derivados decamptotecina, a bajo costo y con facilidad. Se provee un procedimiento para preparar camptotecina, que comp rende las siguientes etapas: (a) la etapa dehidrolizar 9-metoxicamptotecina o un material natural que contiene 9-metoxicamptotecina; (b) la etapa de convertir 9-hidroxicamptotecina obtenida en la etapa(a) en camptotecina mediante 9-O-perfluoro-alquil o inferior-sulfonilacion o 9-O-feniltetrazolilacion, seguida de hidrogenolisis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000079385 | 2000-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR027687A1 true AR027687A1 (es) | 2003-04-09 |
Family
ID=18596639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010101292A AR027687A1 (es) | 2000-03-22 | 2001-03-20 | Procedimiento para preparar camptotecina |
Country Status (14)
Country | Link |
---|---|
US (1) | US6743918B2 (es) |
EP (1) | EP1270579B1 (es) |
JP (1) | JP4624633B2 (es) |
KR (1) | KR100757463B1 (es) |
CN (1) | CN1228341C (es) |
AR (1) | AR027687A1 (es) |
AT (1) | ATE327995T1 (es) |
AU (2) | AU4273501A (es) |
BR (1) | BR0109343A (es) |
CA (1) | CA2402364C (es) |
DE (1) | DE60120139T2 (es) |
MX (1) | MXPA02009203A (es) |
TW (1) | TWI287016B (es) |
WO (1) | WO2001070747A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
TWI396690B (zh) | 2006-04-27 | 2013-05-21 | Yakult Honsha Kk | 喜樹鹼衍生物的製造方法 |
CN108570057A (zh) * | 2017-03-13 | 2018-09-25 | 烟台药物研究所 | 一种合成7-乙基-10-羟基喜树碱的方法 |
CN113880855A (zh) * | 2021-09-02 | 2022-01-04 | 兰州大学 | 一种9-氟喜树碱衍生物的制备及其在抗肿瘤方面的用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
US4496555A (en) * | 1983-07-19 | 1985-01-29 | Wayne State University | Compounds and compositions for inhibiting estrogen sulfotransferase transferase activity, process and novel intermediates therein |
US4568673A (en) * | 1984-03-20 | 1986-02-04 | Wayne State University | Compositions inhibiting murine MXT ductal carcinoma |
JPS6185319A (ja) * | 1984-10-03 | 1986-04-30 | Yakult Honsha Co Ltd | 抗腫瘍剤 |
EP0254737B1 (en) * | 1986-01-16 | 1990-07-25 | Schering Corporation | Fused benzazepines |
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
JP2538792B2 (ja) | 1987-06-25 | 1996-10-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
US4868291A (en) * | 1987-08-20 | 1989-09-19 | Bristol-Myers Company | 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
JPH0873461A (ja) | 1994-09-06 | 1996-03-19 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤 |
JP4094710B2 (ja) | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
-
2001
- 2001-03-20 AR ARP010101292A patent/AR027687A1/es active IP Right Grant
- 2001-03-21 AU AU4273501A patent/AU4273501A/xx active Pending
- 2001-03-21 WO PCT/JP2001/002216 patent/WO2001070747A1/ja active IP Right Grant
- 2001-03-21 CA CA002402364A patent/CA2402364C/en not_active Expired - Fee Related
- 2001-03-21 CN CNB018070167A patent/CN1228341C/zh not_active Expired - Fee Related
- 2001-03-21 BR BR0109343-6A patent/BR0109343A/pt not_active Application Discontinuation
- 2001-03-21 TW TW090106620A patent/TWI287016B/zh not_active IP Right Cessation
- 2001-03-21 EP EP01915660A patent/EP1270579B1/en not_active Expired - Lifetime
- 2001-03-21 KR KR1020027011699A patent/KR100757463B1/ko not_active IP Right Cessation
- 2001-03-21 MX MXPA02009203A patent/MXPA02009203A/es active IP Right Grant
- 2001-03-21 DE DE60120139T patent/DE60120139T2/de not_active Expired - Lifetime
- 2001-03-21 JP JP2001568948A patent/JP4624633B2/ja not_active Expired - Fee Related
- 2001-03-21 AT AT01915660T patent/ATE327995T1/de not_active IP Right Cessation
- 2001-03-21 US US10/239,113 patent/US6743918B2/en not_active Expired - Fee Related
- 2001-03-21 AU AU2001242735A patent/AU2001242735B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP1270579B1 (en) | 2006-05-31 |
EP1270579A1 (en) | 2003-01-02 |
DE60120139T2 (de) | 2007-04-12 |
JP4624633B2 (ja) | 2011-02-02 |
CA2402364C (en) | 2008-07-08 |
DE60120139D1 (de) | 2006-07-06 |
KR20020087071A (ko) | 2002-11-21 |
KR100757463B1 (ko) | 2007-09-11 |
CN1228341C (zh) | 2005-11-23 |
ATE327995T1 (de) | 2006-06-15 |
WO2001070747A1 (fr) | 2001-09-27 |
BR0109343A (pt) | 2002-12-17 |
US6743918B2 (en) | 2004-06-01 |
CA2402364A1 (en) | 2001-09-27 |
CN1419558A (zh) | 2003-05-21 |
TWI287016B (en) | 2007-09-21 |
AU2001242735B2 (en) | 2005-05-26 |
AU4273501A (en) | 2001-10-03 |
US20040087609A1 (en) | 2004-05-06 |
EP1270579A4 (en) | 2004-07-07 |
MXPA02009203A (es) | 2004-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |