JPS57209297A - Modified nucleotide, manufacture and use - Google Patents

Modified nucleotide, manufacture and use

Info

Publication number
JPS57209297A
JPS57209297A JP57064611A JP6461182A JPS57209297A JP S57209297 A JPS57209297 A JP S57209297A JP 57064611 A JP57064611 A JP 57064611A JP 6461182 A JP6461182 A JP 6461182A JP S57209297 A JPS57209297 A JP S57209297A
Authority
JP
Japan
Prior art keywords
deazapurine
purine
attached
pyrimidine
linkage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57064611A
Other languages
English (en)
Other versions
JPH0375559B2 (ja
Inventor
Shii Uoodo Deibido
Aaru Rangaa Penina
Ei Uorudorotsupu Z Areguzandaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22967380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS57209297(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yale University filed Critical Yale University
Publication of JPS57209297A publication Critical patent/JPS57209297A/ja
Publication of JPH0375559B2 publication Critical patent/JPH0375559B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP57064611A 1981-04-17 1982-04-16 Modified nucleotide, manufacture and use Granted JPS57209297A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25522381A 1981-04-17 1981-04-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010469A Division JPH03261798A (ja) 1981-04-17 1990-01-18 変性ヌクレオチド

Publications (2)

Publication Number Publication Date
JPS57209297A true JPS57209297A (en) 1982-12-22
JPH0375559B2 JPH0375559B2 (ja) 1991-12-02

Family

ID=22967380

Family Applications (6)

Application Number Title Priority Date Filing Date
JP57064611A Granted JPS57209297A (en) 1981-04-17 1982-04-16 Modified nucleotide, manufacture and use
JP62083703A Expired - Lifetime JPH0694474B2 (ja) 1981-04-17 1987-04-03 修飾されたヌクレオチドおよびその調製法およびその使用
JP2010469A Pending JPH03261798A (ja) 1981-04-17 1990-01-18 変性ヌクレオチド
JP4166268A Expired - Lifetime JPH0880B2 (ja) 1981-04-17 1992-06-24 修飾されたヌクレオチドおよびその調製法およびその使用
JP11100397A Expired - Lifetime JP3279503B2 (ja) 1981-04-17 1997-04-28 修飾ヌクレオチドおよびその調製法およびその使用法
JP11100297A Expired - Lifetime JP3279502B2 (ja) 1981-04-17 1997-04-28 修飾ヌクレオチドおよびその調製法およびその使用

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP62083703A Expired - Lifetime JPH0694474B2 (ja) 1981-04-17 1987-04-03 修飾されたヌクレオチドおよびその調製法およびその使用
JP2010469A Pending JPH03261798A (ja) 1981-04-17 1990-01-18 変性ヌクレオチド
JP4166268A Expired - Lifetime JPH0880B2 (ja) 1981-04-17 1992-06-24 修飾されたヌクレオチドおよびその調製法およびその使用
JP11100397A Expired - Lifetime JP3279503B2 (ja) 1981-04-17 1997-04-28 修飾ヌクレオチドおよびその調製法およびその使用法
JP11100297A Expired - Lifetime JP3279502B2 (ja) 1981-04-17 1997-04-28 修飾ヌクレオチドおよびその調製法およびその使用

Country Status (8)

Country Link
EP (1) EP0063879B1 (ja)
JP (6) JPS57209297A (ja)
AT (1) ATE167189T1 (ja)
AU (1) AU560651B2 (ja)
CA (1) CA1219824A (ja)
DE (2) DE3280032D1 (ja)
DK (3) DK164407B (ja)
IL (1) IL65447A (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5962600A (ja) * 1982-06-23 1984-04-10 エンゾ・バイオケム・インコ−ポレ−テツド 修飾ヌクレオチド
JPS59148798A (ja) * 1983-02-14 1984-08-25 Wakunaga Seiyaku Kk ビオチンヌクレオチド誘導体
JPS6039565A (ja) * 1983-07-14 1985-03-01 バイエル・コーポレーシヨン 標識核酸プローブおよびそれらの調製用付加物
JPS60500717A (ja) * 1982-09-30 1985-05-16 シンジーン，インコーポレイテッド リポ−タ−グル−プを含んでいる一定配列の１本鎖オリゴヌクレオチド、およびその化学的合成法
JPS60220860A (ja) * 1984-01-16 1985-11-05 カリフオルニア・インステイテユ−ト・オブ・テクノロジ− オリゴヌクレオチドの分析法
JPS617469A (ja) * 1983-05-31 1986-01-14 オルジエニツクス　リミテツド 分子遺伝プロ−ブ及びその形成方法及び検査方法及び分子遺伝プロ−ブを使用する方法
JPS6160697A (ja) * 1984-08-28 1986-03-28 ベーリンガー・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法
JPH0386897A (ja) * 1983-02-22 1991-04-11 Molecular Biosyst Inc 検出可能な１本鎖オリゴヌクレオチドの化学的合成に有用な化合物
JPH1033199A (ja) * 1981-04-17 1998-02-10 Univ Yale 修飾ヌクレオチドおよびその調製法およびその使用
US5821058A (en) * 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
USRE43096E1 (en) 1984-01-16 2012-01-10 California Institute Of Technology Tagged extendable primers and extension products

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
DK105582A (da) * 1982-03-11 1983-09-12 Nordisk Insulinlab Fremgangsmaade til bestemmelse af humane hla-d(r) vaevstyper og gensonde til brug ved fremgangsmaaden
US5260433A (en) * 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides
US4689295A (en) * 1983-01-20 1987-08-25 Integrated Genetics, Inc. Test for Salmonella
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
CA1309672C (en) * 1983-01-27 1992-11-03 Jannis G. Stavrianopoulos Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
US4605735A (en) * 1983-02-14 1986-08-12 Wakunaga Seiyaku Kabushiki Kaisha Oligonucleotide derivatives
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
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NO841725L (no) * 1983-05-02 1984-11-05 Enzo Biochem Inc Fremgangsmaate og stoffer til bruk ved analyse og paavisning av genetisk materiale
CA1228811A (en) * 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
US5221609A (en) * 1983-05-31 1993-06-22 Orgenics Ltd. Molecular genetic probe, and method of forming same, assay technique and kit using said molecular genetic probe
US4959309A (en) * 1983-07-14 1990-09-25 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4623627A (en) 1983-08-19 1986-11-18 Cetus Corporation Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same
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US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
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US4617261A (en) * 1984-03-21 1986-10-14 Cetus Corporation Process for labeling nucleic acids and hybridization probes
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US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
NZ211888A (en) * 1984-05-10 1987-08-31 Abbott Lab Biotin-antibiotin immunoassay for detecting ligands
CA1253777A (en) * 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
JPH0658368B2 (ja) * 1984-06-28 1994-08-03 株式会社日立製作所 核酸塩基検出装置
JP2648082B2 (ja) * 1984-06-28 1997-08-27 株式会社日立製作所 核酸塩基検出方法
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JP3279502B2 (ja) * 1981-04-17 2002-04-30 エール・ユニバーシティ 修飾ヌクレオチドおよびその調製法およびその使用
JP3279503B2 (ja) * 1981-04-17 2002-04-30 エール・ユニバーシティ 修飾ヌクレオチドおよびその調製法およびその使用法
JPH1052271A (ja) * 1981-04-17 1998-02-24 Univ Yale 修飾ヌクレオチドおよびその調製法およびその使用法
JPH1033199A (ja) * 1981-04-17 1998-02-10 Univ Yale 修飾ヌクレオチドおよびその調製法およびその使用
JPS5962600A (ja) * 1982-06-23 1984-04-10 エンゾ・バイオケム・インコ−ポレ−テツド 修飾ヌクレオチド
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DK171382A (da) 1982-10-18
DE3280032D1 (en) 1989-12-28
DK171822B1 (da) 1997-06-23
JP3279503B2 (ja) 2002-04-30
IL65447A (en) 1987-01-30
AU8257382A (en) 1982-10-21
JPH0880B2 (ja) 1996-01-10
DK160591A (da) 1991-09-16
AU560651B2 (en) 1987-04-16
JPH03261798A (ja) 1991-11-21
JPH1033199A (ja) 1998-02-10
CA1219824A (en) 1987-03-31
DE3280478T2 (de) 1999-02-18
DK160591D0 (da) 1991-09-16
EP0063879B1 (en) 1989-11-23
JP3279502B2 (ja) 2002-04-30
DK46797A (da) 1997-04-28
DK164407B (da) 1992-06-22
IL65447A0 (en) 1982-07-30
EP0063879A2 (en) 1982-11-03
JPH0694474B2 (ja) 1994-11-24
EP0063879A3 (en) 1983-08-10
JPH0375559B2 (ja) 1991-12-02
JPH1052271A (ja) 1998-02-24
DE3280478D1 (de) 1998-07-16
ATE167189T1 (de) 1998-06-15
JPH07107998A (ja) 1995-04-25
JPS6399093A (ja) 1988-04-30

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