DK0819133T3 - Kovalent koblede oligonukleotid-(minor groove-binder)-konjugater - Google Patents

Kovalent koblede oligonukleotid-(minor groove-binder)-konjugater

Info

Publication number
DK0819133T3
DK0819133T3 DK96910723T DK96910723T DK0819133T3 DK 0819133 T3 DK0819133 T3 DK 0819133T3 DK 96910723 T DK96910723 T DK 96910723T DK 96910723 T DK96910723 T DK 96910723T DK 0819133 T3 DK0819133 T3 DK 0819133T3
Authority
DK
Denmark
Prior art keywords
conjugates
minor groove
primers
short
cdpi3
Prior art date
Application number
DK96910723T
Other languages
English (en)
Inventor
Igor V Kutyavin
Eugeny A Lukhtanov
Howard B Gamper
Rich B Meyer Jr
Original Assignee
Epoch Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epoch Biosciences Inc filed Critical Epoch Biosciences Inc
Application granted granted Critical
Publication of DK0819133T3 publication Critical patent/DK0819133T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
DK96910723T 1995-04-03 1996-04-03 Kovalent koblede oligonukleotid-(minor groove-binder)-konjugater DK0819133T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/415,370 US5801155A (en) 1995-04-03 1995-04-03 Covalently linked oligonucleotide minor grove binder conjugates
PCT/US1996/004559 WO1996032496A2 (en) 1995-04-03 1996-04-03 Covalently linked oligonucleotide minor groove binder conjugates

Publications (1)

Publication Number Publication Date
DK0819133T3 true DK0819133T3 (da) 2008-05-13

Family

ID=23645421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96910723T DK0819133T3 (da) 1995-04-03 1996-04-03 Kovalent koblede oligonukleotid-(minor groove-binder)-konjugater

Country Status (12)

Country Link
US (6) US5801155A (da)
EP (1) EP0819133B1 (da)
JP (1) JP4948690B2 (da)
CN (3) CN1187363C (da)
AT (1) ATE382627T1 (da)
AU (1) AU716108B2 (da)
CA (1) CA2223678C (da)
DE (1) DE69637389T2 (da)
DK (1) DK0819133T3 (da)
ES (1) ES2300106T3 (da)
PT (1) PT819133E (da)
WO (1) WO1996032496A2 (da)

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US20110275070A1 (en) 2011-11-10
ES2300106T3 (es) 2008-06-01
US6084102A (en) 2000-07-04
PT819133E (pt) 2008-04-07
JPH11504626A (ja) 1999-04-27
EP0819133A2 (en) 1998-01-21
CA2223678C (en) 2009-09-08
CA2223678A1 (en) 1996-10-17
AU716108B2 (en) 2000-02-17
DE69637389D1 (de) 2008-02-14
CN1187363C (zh) 2005-02-02
CN1644585A (zh) 2005-07-27
CN1186496A (zh) 1998-07-01
DE69637389T2 (de) 2008-12-18
WO1996032496A3 (en) 1996-11-28
US5801155A (en) 1998-09-01
JP4948690B2 (ja) 2012-06-06
US6486308B2 (en) 2002-11-26
AU5384296A (en) 1996-10-30
US20090048427A1 (en) 2009-02-19
US20020052482A1 (en) 2002-05-02
ATE382627T1 (de) 2008-01-15
CN101914099A (zh) 2010-12-15
US6426408B1 (en) 2002-07-30
EP0819133B1 (en) 2008-01-02
US7794945B2 (en) 2010-09-14
US8465921B2 (en) 2013-06-18

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