JPH10512165A - 気体スプリングを有する医療用注入システム - Google Patents
気体スプリングを有する医療用注入システムInfo
- Publication number
- JPH10512165A JPH10512165A JP52172796A JP52172796A JPH10512165A JP H10512165 A JPH10512165 A JP H10512165A JP 52172796 A JP52172796 A JP 52172796A JP 52172796 A JP52172796 A JP 52172796A JP H10512165 A JPH10512165 A JP H10512165A
- Authority
- JP
- Japan
- Prior art keywords
- piston
- gas spring
- nozzle assembly
- plunger
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F41—WEAPONS
- F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
- F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
- F41B11/60—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas
- F41B11/64—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F41—WEAPONS
- F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
- F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
- F41B11/60—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas
- F41B11/64—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot
- F41B11/642—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot the piston being spring operated
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F41—WEAPONS
- F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
- F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
- F41B11/60—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas
- F41B11/64—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot
- F41B11/642—Compressed-gas guns, e.g. air guns; Steam guns characterised by the supply of compressed gas having a piston effecting a compressor stroke during the firing of each shot the piston being spring operated
- F41B11/646—Arrangements for putting the spring under tension
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F41—WEAPONS
- F41B—WEAPONS FOR PROJECTING MISSILES WITHOUT USE OF EXPLOSIVE OR COMBUSTIBLE PROPELLANT CHARGE; WEAPONS NOT OTHERWISE PROVIDED FOR
- F41B11/00—Compressed-gas guns, e.g. air guns; Steam guns
- F41B11/80—Compressed-gas guns, e.g. air guns; Steam guns specially adapted for particular purposes
- F41B11/81—Compressed-gas guns, e.g. air guns; Steam guns specially adapted for particular purposes for ejecting powder, e.g. pepper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2044—Separating means having slits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.医薬製品を注入するための装置であって: 医薬製品を保持するためのアンプル室、前記医薬製品を通すために該アンプ ル室と流体連通したノズルアセンブリーのオリフィス、および前記アンプル室内 で移動可能に配設された圧力壁部材を有するノズルアセンブリーと; 前記圧力壁部材に選択的に結合するための構成および寸法を有し、実質的に 均一な圧力下で前記アンプル室から医薬製品を噴出させるエネルギー機構とを具 備し、該エネルギー機構は気体スプリングを具備してなる装置。 2.請求項1に記載の装置であって、前記気体スプリングは、摺動可能にその中 に延出したピストンを有し、且つ加圧気体を含んでいる密閉された気体スプリン グ圧力室を具備し、 当該装置は、更に、前記ピストンと機能的かつ選択的に係合および脱係合し て、気体スプリングをロックされた圧縮状態に選択的に維持し、また気体スプリ ングをその弛緩状態へと選択的に開放するためのトリガー機構と、前記ピストン の基端部に連結されて前記トリガー機構に収容される気体スプリング連結機構を 具備し、 前記ノズルアセンブリーおよび前記気体スプリングは、ハウジング部材の中 に機能的に配置されている装置。 3.請求項2に記載の装置であって、前記ピストンの先端部は基端部よりも大き く、前記圧力室が弛緩状態にあるときに、少なくとも基端部の一部は圧力室内に 配置され、また前記先端が前記室の中に移動するときに圧力室内の加圧ガスは更 に圧縮され、 前記エネルギー機構は、更に、前記ハウジング部材に移動可能に結合された 駆動部材を具備し、該駆動部材は前記気体スプリング圧力室に対して長手方向に 移動可能であり、また前記駆動部材はピストンの先端を圧力室の中に動かすこと ができ、前記気体スプリングを圧縮状態に保持するために気体スプリング連結機 構を前記トリガー機構に連結することができる装置。 4.請求項3に記載の装置であって、前記ノズルアセンブリーは取り外し可能に 前記ハウジング部材に連結され、前記ピストンは取り外し可能且つ機能的にプ ランジャーである前記圧力壁部材に連結され、また前記ピストンと前記プランジ ャーとの間に空運動連結機構が設けられていて、前記ピストンが前記プランジャ ーに接触する前に所定の距離に沿って移動する装置。 5.請求項4に記載の装置であって、前記空運動連結機構は、長手方向のスロッ トを限定し且つ前記ピストンに連結されたラムを具備し、前記プランジャーは更 に、機能的で摺動可能に前記スロット内に収容され、且つ前記プランジャーの一 端と前記ラムの一端との間に所定の隙間を与えるような所定の長さを有するコネ クターシャフトを含み、前記ラムの一端は前記隙間を横切って移動した後に前記 プランジャーに係合する装置。 6.請求項4に記載の装置であって、前記空運動連結機構は、前記プランジャー と前記ピストンとの間に形成された弾性の迅速放出コネクタを具備し、該迅速放 出コネクタは前記プランジャーから延出し、且つ複数の弾性ツメを有し、前記ピ ストンに配置された拡大ヘッドは前記弾性ツメによって摺動可能に収容され、夫 々のツメは半径方向内側に延出したタブを有していて、前記拡大ヘッドの長手方 向の移動を制限し、前記プランジャーが前記アンプル室の内部に収容されると、 前記ツメは半径方向外側に拡張するのを妨げられて、前記拡大ヘッドを前記迅速 放出コネクタ内に保持し、 前記ノズルアセンブリーが前記装置から除去されると、前記ツメが使用者の 操作に曝されて、前記プランジャーを前記ピストンから分離できる装置。 7.請求項4に記載の装置であって、前記ノズルアセンブリーは前記医薬製品を 予め充填され、前記ノズルアセンブリーもしくは前記プランジャーまたはこれら の両者はステンレス鋼、ポリカーボネート、ポリカーボネート、ポリプロピレン およびこれらの誘導体、または前記医薬製品に適合し且つそこに加わる圧力およ びストレスに耐えることができる他の適切なプラスチック、ガラスもしくは複合 体で製造される装置。 8.請求項2に記載の装置であって、前記シールされた気体スプリング圧力室は 管状スリーブと該スリーブを密封して閉鎖する一対の末端プラグとによって定義 され、また前記ピストンはこれら末端プラグの間に摺動可能に収容される装置。 9.請求項1に記載の装置であって、更に、医薬供給瓶を前記ノズルアセンブリ ーに連結するための連結装置を具備し、該連結装置は、 基端部および先端部を有する一般に中空の本体と; 前記基端部と先端部との間に配置された分割壁であって、基端側面および先 端側面、並びに該分割壁に定義された孔とを有する分割壁と; 前記分割壁の先端側面から前記本体の先端方向に向けて軸方向に延出し、前 記プローブが前記本体内に残るように前記本体内で終端した中空プローブであっ て、該プローブは前記孔に対して整列し、これとの間での液体流通を可能にする 中空プローブと; 前記供給瓶が前記瓶コネクタの中に挿入され、その後は供給瓶の除去が阻止 されるように、前記本体の先端に形成された医薬品供給瓶コネクタと; 前記基端部に形成されたノズルコネクタであって、該ノズルコネクタは前記コ ネクタが前記ノズルアセンブリーに向けて動いた後に前記ノズルアセンブリーの 一部を連結することができ、また十分な分離力が適用されたときに前記ノズルア センブリーから離すことができる複数の迅速解除部材を有し、また前記供給瓶の 前記ノズルコネクタへの連結に際して前記プローブが前記供給瓶のシールを穿刺 するようなノズルコネクタとを具備した装置。 10.請求項9に記載の装置であって、前記連結装置は、更に、前記壁の基端部側 面に隣接した伸長可能な膜シール部材であって、一般には前記孔に対して整列し た開いたホールまたはゼロ直径ホールを有する膜シール部材と; 前記シール部材に隣接するリングであって、その挿入を可能にする前記ノズ ルアセンブリーの構造を具備するリングと; 前記基端部を保護および閉鎖するための保護キャップであって、前記迅速放 出部材に係合するための少なくとも一つの適合膜とを具備する装置。 11.請求項9に記載の装置であって、前記医薬供給瓶コネクタは、前記壁に向け て延出する少なくとも一つの可撓性の歯を具備し、該歯の自由端は前記供給瓶の 一部と係合し、前記瓶部分は前記歯と共働して前記供給瓶の取り外しを妨げる手 段を有し; ノズルコネクタ上の前記迅速解除部材は、実質的に前記本体の軸方向に延出 しており、また前記迅速解除部材が前記ノズルから半径方向に拡張することを可 能にし且つ完全に取り付けられたらその元の位置へと実質的に復帰するような弾 性を有しており; 前記解除部材の夫々は半径方向内側へ突出したタブを有しており、該タブは 、前記ノズルアセンブリーと共働して前記連結装置の取付けを可能にする装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/369,812 US5599302A (en) | 1995-01-09 | 1995-01-09 | Medical injection system and method, gas spring thereof and launching device using gas spring |
US369,812 | 1995-01-09 | ||
PCT/US1996/000086 WO1996021482A2 (en) | 1995-01-09 | 1996-01-11 | Medical injection system comprising a gas spring |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10512165A true JPH10512165A (ja) | 1998-11-24 |
Family
ID=23457035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52172796A Ceased JPH10512165A (ja) | 1995-01-09 | 1996-01-11 | 気体スプリングを有する医療用注入システム |
Country Status (8)
Country | Link |
---|---|
US (4) | US5599302A (ja) |
EP (1) | EP0802809B1 (ja) |
JP (1) | JPH10512165A (ja) |
AT (1) | ATE237380T1 (ja) |
AU (1) | AU4693596A (ja) |
DE (1) | DE69627474D1 (ja) |
TW (1) | TW387814B (ja) |
WO (1) | WO1996021482A2 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003033434A (ja) * | 2001-07-23 | 2003-02-04 | Shimadzu Corp | 針無注射器 |
JP2003529417A (ja) * | 2000-03-23 | 2003-10-07 | アンタレス・ファーマ・インコーポレーテッド | 1回限り使用の使い捨て型ジェット注射器 |
JP2006297100A (ja) * | 2004-05-25 | 2006-11-02 | Tecpharma Licensing Ag | 保護されたプライミング装置を備える投与装置 |
JP2009539436A (ja) * | 2006-06-07 | 2009-11-19 | アキュショット インク | 無針注射器用の充薬機構 |
JP2010527639A (ja) * | 2007-02-14 | 2010-08-19 | デピュー ミテック インコーポレイテッド | 損傷した骨組織を修復するために骨プラグを採取および移植するための外科用工具として特に有用な、工具を方向付けるための器具 |
JP2012035099A (ja) * | 2004-12-01 | 2012-02-23 | Acushot Inc | 無針注射装置 |
WO2016163348A1 (ja) * | 2015-04-10 | 2016-10-13 | 株式会社ダイセル | 注射器 |
JP2016221342A (ja) * | 2011-01-10 | 2016-12-28 | ゾゲニクス インコーポレーティッド | 改善された無針注射器 |
WO2020138476A1 (ja) * | 2018-12-27 | 2020-07-02 | 株式会社ダイセル | 無針注射器 |
Families Citing this family (619)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2212040T3 (es) * | 1993-07-31 | 2004-07-16 | Aradigm Corporation | Inyector sin aguja. |
FR2718357B1 (fr) * | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Perfectionnements apportés à un dispositif d'injection par jet sans aiguille. |
US6474369B2 (en) | 1995-05-26 | 2002-11-05 | Penjet Corporation | Apparatus and method for delivering a lyophilized active with a needle-less injector |
US5899879A (en) * | 1995-12-19 | 1999-05-04 | Genesis Medical Technologies, Inc. | Spring-actuated needleless injector |
US5921967A (en) | 1996-02-29 | 1999-07-13 | Medi-Ject Corporation | Plunger for nozzle assembly |
US5800388A (en) | 1996-02-29 | 1998-09-01 | Medi-Ject Corporation | Plunger/ram assembly adapted for a fluid injector |
US5769138A (en) * | 1996-04-01 | 1998-06-23 | Medi-Ject Corporation | Nozzle and adapter for loading medicament into an injector |
US6374255B1 (en) | 1996-05-21 | 2002-04-16 | Immersion Corporation | Haptic authoring |
US6458574B1 (en) | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
US5875976A (en) * | 1996-12-24 | 1999-03-02 | Medi-Ject Corporation | Locking mechanism for nozzle assembly |
US7347840B2 (en) * | 2000-03-02 | 2008-03-25 | Pyng Medical Corp. | Patch for locating a target zone for penetration |
US6761726B1 (en) * | 1998-05-15 | 2004-07-13 | Pyng Medical Corp. | Method and apparatus for the intraosseous introduction of a device such as an infusion tube |
US5911703A (en) * | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
US6030399A (en) * | 1997-06-04 | 2000-02-29 | Spectrx, Inc. | Fluid jet blood sampling device and methods |
US5947928A (en) * | 1997-06-19 | 1999-09-07 | Mile Creek Capital, Llc | Drug delivery system |
US6004287A (en) * | 1997-09-23 | 1999-12-21 | Loomis; Dale J | Biolistic apparatus for delivering substances into cells and tissues |
US6071272A (en) * | 1997-10-28 | 2000-06-06 | Hoffman; Alan S. | Method for treating erectile dysfunctionality |
US6256011B1 (en) | 1997-12-03 | 2001-07-03 | Immersion Corporation | Multi-function control device with force feedback |
US6610042B2 (en) | 1997-12-05 | 2003-08-26 | Felton Medical, Inc. | Disposable unit-dose jet-injection syringe for pre-filled and/or transfilled liquid injectable medical drug or vaccine products and method thereof |
AU767122B2 (en) * | 1998-06-10 | 2003-10-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6123684A (en) * | 1998-07-27 | 2000-09-26 | Medi-Ject Corporation | Loading mechanism for medical injector assembly |
ATE342079T1 (de) * | 1998-07-27 | 2006-11-15 | Antares Pharma Inc | Injektionshilfstorpedo für ein medizinisches injektionssystem |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
JP2000107289A (ja) * | 1998-10-05 | 2000-04-18 | Showa Yakuhin Kako Kk | カートリッジ式歯科用注射器ユニット |
US6506177B2 (en) * | 1998-10-14 | 2003-01-14 | Sergio Landau | Needle-less injection system |
US6406455B1 (en) * | 1998-12-18 | 2002-06-18 | Biovalve Technologies, Inc. | Injection devices |
DE19859137C1 (de) * | 1998-12-21 | 2000-05-18 | Ferton Holding Sa | Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit |
US6258062B1 (en) | 1999-02-25 | 2001-07-10 | Joseph M. Thielen | Enclosed container power supply for a needleless injector |
US7060048B1 (en) * | 1999-04-16 | 2006-06-13 | Powerject Research Limited | Needleless syringe |
US6689095B1 (en) * | 1999-04-22 | 2004-02-10 | Gilbert Garitano | Needleless permanent makeup and tattoo device |
US7171264B1 (en) * | 1999-05-10 | 2007-01-30 | Genetronics, Inc. | Intradermal delivery of active agents by needle-free injection and electroporation |
US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
EP1754488A1 (en) | 1999-05-24 | 2007-02-21 | Introgen Therapeutics, Inc. | Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US7074210B2 (en) * | 1999-10-11 | 2006-07-11 | Felton International, Inc. | Universal protector cap with auto-disable features for needle-free injectors |
ES2237476T3 (es) | 1999-10-11 | 2005-08-01 | Felton International, Inc. | Protector universal contra infecciones para inyectores sin aguja. |
US20020193740A1 (en) | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
US6382204B1 (en) | 1999-10-14 | 2002-05-07 | Becton Dickinson And Company | Drug delivery system including holder and drug container |
US6843781B2 (en) * | 1999-10-14 | 2005-01-18 | Becton, Dickinson And Company | Intradermal needle |
US20020198509A1 (en) * | 1999-10-14 | 2002-12-26 | Mikszta John A. | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
US6776776B2 (en) * | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
US6673035B1 (en) * | 1999-10-22 | 2004-01-06 | Antares Pharma, Inc. | Medical injector and medicament loading system for use therewith |
AU784838B2 (en) | 1999-10-22 | 2006-07-06 | Antares Pharma, Inc. | Medical injector and medicament loading system for use therewith |
US6391003B1 (en) | 1999-10-25 | 2002-05-21 | Antares Pharma, Inc. | Locking mechanism for a jet injector |
US7029457B2 (en) * | 1999-11-23 | 2006-04-18 | Felton International, Inc. | Jet injector with hand piece |
US6770054B1 (en) | 1999-11-23 | 2004-08-03 | Felton International, Inc. | Injector assembly with driving means and locking means |
US7887506B1 (en) | 1999-11-23 | 2011-02-15 | Pulse Needlefree Systems, Inc. | Safety mechanism to prevent accidental patient injection and methods of same |
US6693626B1 (en) | 1999-12-07 | 2004-02-17 | Immersion Corporation | Haptic feedback using a keyboard device |
WO2001051109A1 (en) * | 2000-01-07 | 2001-07-19 | Biovalve Technologies, Inc. | Injection device |
CA2331030A1 (en) * | 2000-02-16 | 2001-08-16 | Roche Diagnostics Gmbh | Hypodermic needleless injection system |
US6689092B2 (en) * | 2000-03-03 | 2004-02-10 | Boehringer International Gmbh | Needle-less injector of miniature type |
GB0008494D0 (en) | 2000-04-07 | 2000-05-24 | Secr Defence | Microprojectile delivery system |
US10293056B1 (en) | 2000-05-24 | 2019-05-21 | Board Of Regents, The University Of Texas System | Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases |
US6629958B1 (en) | 2000-06-07 | 2003-10-07 | Ronald P. Spinello | Leak sealing needle |
US6406456B1 (en) | 2000-06-08 | 2002-06-18 | Avant Drug Delivery Systems, Inc. | Jet injector |
AU2001271950A1 (en) * | 2000-07-10 | 2002-01-21 | Peter M. Wild | Woody plant injection method and apparatus |
US6695817B1 (en) | 2000-07-11 | 2004-02-24 | Icu Medical, Inc. | Medical valve with positive flow characteristics |
DE10034270A1 (de) * | 2000-07-14 | 2002-02-14 | Disetronic Licensing Ag | Vorratsbehältnis mit einer Dosiereinrichtung zur dosierten Abgabe eines injizierbaren Produkts an ein Injektionsgerät |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
US6610033B1 (en) * | 2000-10-13 | 2003-08-26 | Incept, Llc | Dual component medicinal polymer delivery system and methods of use |
US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
AU2003222427B8 (en) * | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
KR20030071780A (ko) * | 2000-11-30 | 2003-09-06 | 바이오밸브 테크놀로지스, 인코포레이티드 | 주입기 |
CA2429769C (en) * | 2000-12-07 | 2016-04-26 | Board Of Regents, The University Of Texas System | Methods of treatment involving human mda-7 |
US9302903B2 (en) | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
EP1361890B1 (en) | 2001-02-23 | 2011-03-30 | GlaxoSmithKline Biologicals s.a. | Influenza vaccine formulations for intradermal delivery |
EP1368104A1 (en) | 2001-03-14 | 2003-12-10 | PenJet Corporation | System and method for removing dissolved gas from a solution |
GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
US6613010B2 (en) | 2001-04-13 | 2003-09-02 | Penjet Corporation | Modular gas-pressured needle-less injector |
US20050192530A1 (en) * | 2001-04-13 | 2005-09-01 | Penjet Corporation | Method and apparatus for needle-less injection with a degassed fluid |
WO2002087663A2 (en) | 2001-04-27 | 2002-11-07 | Penjet Corporation | Method and apparatus for filling or refilling a needle-less injector |
US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
US6752781B2 (en) * | 2001-06-08 | 2004-06-22 | Sergio Landau | Durable hypodermic jet injector apparatus and method |
DE10129583A1 (de) * | 2001-06-20 | 2003-01-09 | Disetronic Licensing Ag | Vorrichtung und Verfahren zu Injektion |
US20060018877A1 (en) * | 2001-06-29 | 2006-01-26 | Mikszta John A | Intradermal delivery of vacccines and therapeutic agents |
AU2002327412A1 (en) | 2001-08-02 | 2003-02-17 | Institut Clayton De La Recherche | Methods and compositions relating to improved lentiviral vector production systems |
EP1420838A4 (en) | 2001-08-17 | 2007-01-10 | Antares Pharma Inc | INSULIN ADMINISTRATION BY DERMO-JET INJECTION |
GB2379390B (en) * | 2001-09-11 | 2005-01-26 | Caretek Medical Ltd | A novel drug delivery technology |
US7615234B2 (en) | 2001-09-11 | 2009-11-10 | Glide Pharmaceutical Technologies Limited | Drug delivery technology |
GB2391480B (en) * | 2002-08-05 | 2007-02-28 | Caretek Medical Ltd | Drug delivery system |
WO2003024507A2 (en) * | 2001-09-19 | 2003-03-27 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
AU2002330083A1 (en) * | 2001-09-21 | 2003-04-01 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
EP1480712A2 (en) * | 2001-09-28 | 2004-12-01 | BioValve Technologies, Inc. | Switchable microneedle arrays and systems and methods relating to same |
AU2002337788A1 (en) * | 2001-09-28 | 2003-04-07 | Biovalve Technologies, Inc. | Microneedle with membrane |
NZ532060A (en) * | 2001-10-02 | 2005-11-25 | Inst Clayton De La Rech | Methods and compositions relating to restricted expression lentiviral vectors and their applications |
EP2223932A1 (en) | 2001-10-19 | 2010-09-01 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
US6824526B2 (en) | 2001-10-22 | 2004-11-30 | Penjet Corporation | Engine and diffuser for use with a needle-less injector |
GB0125506D0 (en) | 2001-10-24 | 2001-12-12 | Weston Medical Ltd | Needle free injection method and apparatus |
US6607510B2 (en) * | 2001-11-09 | 2003-08-19 | Bioject Medical Technologies Inc. | Disposable needle-free injection apparatus and method |
US20030130614A1 (en) * | 2002-01-09 | 2003-07-10 | Johnson Lanny L. | Device for delivering liquid medications or nutrients and gases to local tissue |
GB2384527B (en) * | 2002-01-23 | 2004-07-14 | Bespak Plc | Dispensing device |
US6875205B2 (en) | 2002-02-08 | 2005-04-05 | Alaris Medical Systems, Inc. | Vial adapter having a needle-free valve for use with vial closures of different sizes |
EP1476210B1 (en) | 2002-02-11 | 2008-09-24 | Antares Pharma, Inc. | Intradermal injector |
US20040009939A1 (en) * | 2002-03-05 | 2004-01-15 | Board Of Regent, The University Of Texas System | Methods of enhancing immune induction involving MDA-7 |
US6904823B2 (en) | 2002-04-03 | 2005-06-14 | Immersion Corporation | Haptic shifting devices |
AU2003237798A1 (en) | 2002-04-05 | 2003-10-27 | Board Of Regents, The University Of Texas System | Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions |
AU2003228722B2 (en) | 2002-04-25 | 2009-06-25 | Takeda Pharmaceutical Company Limited | Treatment of alpha-galactosidase A deficiency |
DK1499736T3 (da) * | 2002-04-26 | 2009-06-08 | Inst Nat Sante Rech Med | Forbedrede kimære glycoproteiner og pseudotypet lentovirale vektorer |
US20040025420A1 (en) * | 2002-05-09 | 2004-02-12 | Peter M. Wild | Injection needle for injecting woody plants |
US6942638B1 (en) * | 2002-05-30 | 2005-09-13 | Kerry Quinn | Needleless injector and ampule system |
US9314228B2 (en) | 2002-05-31 | 2016-04-19 | Vidacare LLC | Apparatus and method for accessing the bone marrow |
US8142365B2 (en) * | 2002-05-31 | 2012-03-27 | Vidacare Corporation | Apparatus and method for accessing the bone marrow of the sternum |
US8641715B2 (en) * | 2002-05-31 | 2014-02-04 | Vidacare Corporation | Manual intraosseous device |
US8668698B2 (en) | 2002-05-31 | 2014-03-11 | Vidacare Corporation | Assembly for coupling powered driver with intraosseous device |
US7850620B2 (en) * | 2002-05-31 | 2010-12-14 | Vidacare Corporation | Biopsy devices and related methods |
US7951089B2 (en) | 2002-05-31 | 2011-05-31 | Vidacare Corporation | Apparatus and methods to harvest bone and bone marrow |
US11298202B2 (en) | 2002-05-31 | 2022-04-12 | Teleflex Life Sciences Limited | Biopsy devices and related methods |
EP2039298B1 (en) * | 2002-05-31 | 2017-10-25 | Vidacare LLC | Apparatus to access bone marrow |
US20070049945A1 (en) | 2002-05-31 | 2007-03-01 | Miller Larry J | Apparatus and methods to install, support and/or monitor performance of intraosseous devices |
US10973532B2 (en) | 2002-05-31 | 2021-04-13 | Teleflex Life Sciences Limited | Powered drivers, intraosseous devices and methods to access bone marrow |
US7811260B2 (en) * | 2002-05-31 | 2010-10-12 | Vidacare Corporation | Apparatus and method to inject fluids into bone marrow and other target sites |
US8690791B2 (en) | 2002-05-31 | 2014-04-08 | Vidacare Corporation | Apparatus and method to access the bone marrow |
US11337728B2 (en) | 2002-05-31 | 2022-05-24 | Teleflex Life Sciences Limited | Powered drivers, intraosseous devices and methods to access bone marrow |
US10973545B2 (en) | 2002-05-31 | 2021-04-13 | Teleflex Life Sciences Limited | Powered drivers, intraosseous devices and methods to access bone marrow |
US9072543B2 (en) | 2002-05-31 | 2015-07-07 | Vidacare LLC | Vascular access kits and methods |
US20040079169A1 (en) * | 2002-07-03 | 2004-04-29 | Peter Wild | Plant injection method and apparatus |
ES2444699T3 (es) | 2002-08-12 | 2014-02-26 | Jennerex, Inc. | Virus vaccinia para uso en el tratamiento del cáncer |
GB2410995B (en) | 2002-10-15 | 2007-05-09 | Immersion Corp | Products and processes for providing force sensations in a user interface |
JP2006504482A (ja) * | 2002-11-01 | 2006-02-09 | アンタレス・ファーマ・インコーポレーテッド | 噴射式注射によるインスリン投薬 |
CA2506798C (en) * | 2002-11-22 | 2013-01-22 | Institut Clayton De La Recherche | Compositions and systems for the regulation of genes |
CA2814774C (en) | 2003-01-31 | 2016-03-22 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
BRPI0408063A (pt) * | 2003-03-03 | 2006-02-14 | Univ Texas | métodos e composições envolvendo mda-7 |
US6802455B1 (en) * | 2003-03-26 | 2004-10-12 | Willie V. Evans | Atomizer |
FR2853837B1 (fr) * | 2003-04-16 | 2006-01-13 | Crossject | Dispositif de liaison d'un reservoir de principe actif sur une buse d'injection dans un dispositif d'injection dudit principe actif |
WO2004110533A1 (ja) * | 2003-05-09 | 2004-12-23 | Anges Mg, Inc. | 薬剤が収容された針無注射器 |
WO2005026375A2 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
US9504477B2 (en) | 2003-05-30 | 2016-11-29 | Vidacare LLC | Powered driver |
WO2004111819A1 (en) | 2003-06-09 | 2004-12-23 | Immersion Corporation | Interactive gaming systems with haptic feedback |
HU225252B1 (hu) * | 2003-08-21 | 2006-08-28 | S Istvan Lindmayer | Tû nélküli injekciós berendezés |
WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
US8034790B2 (en) * | 2003-12-01 | 2011-10-11 | Introgen Therapeutics | Use of MDA-7 to inhibit pathogenic infectious organisms |
ES2397077T3 (es) | 2004-01-26 | 2013-03-04 | Vidacare Corporation | Dispositivo manual interóseo |
US7815642B2 (en) * | 2004-01-26 | 2010-10-19 | Vidacare Corporation | Impact-driven intraosseous needle |
WO2005070483A1 (en) * | 2004-01-26 | 2005-08-04 | The Medical House Plc | Needle-free injection device |
US20070281041A1 (en) * | 2004-03-02 | 2007-12-06 | Introgen Therapeutics, Inc. | Compositions and Methods Involving MDA-7 for the Treatment of Cancer |
DE102004017971A1 (de) * | 2004-04-12 | 2005-10-27 | Leica Microsystems (Schweiz) Ag | Stativ, insbesondere für Operationsmikroskope, mit einem Kraftspeicherelement |
DE102004017970A1 (de) * | 2004-04-12 | 2005-10-27 | Leica Microsystems (Schweiz) Ag | Stativ, insbesondere für Operationsmikroskope, mit einem Kraftspeicherelement |
GB2414400B (en) * | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
US7717874B2 (en) * | 2004-05-28 | 2010-05-18 | Bioject, Inc. | Needle-free injection system |
GB2414399B (en) * | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
GB2414402B (en) * | 2004-05-28 | 2009-04-22 | Cilag Ag Int | Injection device |
GB2414406B (en) | 2004-05-28 | 2009-03-18 | Cilag Ag Int | Injection device |
GB2414403B (en) * | 2004-05-28 | 2009-01-07 | Cilag Ag Int | Injection device |
GB2414405B (en) * | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
GB2414775B (en) * | 2004-05-28 | 2008-05-21 | Cilag Ag Int | Releasable coupling and injection device |
GB2414409B (en) * | 2004-05-28 | 2009-11-18 | Cilag Ag Int | Injection device |
GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
GB2414401B (en) | 2004-05-28 | 2009-06-17 | Cilag Ag Int | Injection device |
JP2008506447A (ja) * | 2004-07-14 | 2008-03-06 | バイ−パス, インコーポレイテッド | 材料送達システム |
US7615041B2 (en) | 2004-07-29 | 2009-11-10 | Boston Scientific Scimed, Inc. | Vial adaptor |
JP4059238B2 (ja) * | 2004-09-16 | 2008-03-12 | ソニー株式会社 | デジタル信号処理装置及びデジタル信号処理方法 |
JP2008513406A (ja) | 2004-09-22 | 2008-05-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
US20060089593A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device for individual users |
US20060089594A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device |
WO2007001448A2 (en) * | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
MX2007005324A (es) | 2004-11-05 | 2007-06-25 | Icu Medical Inc | Conector medico de agarre suave. |
US8998848B2 (en) | 2004-11-12 | 2015-04-07 | Vidacare LLC | Intraosseous device and methods for accessing bone marrow in the sternum and other target areas |
JP4960252B2 (ja) | 2004-11-22 | 2012-06-27 | インテリジェクト,インコーポレイテッド | 薬剤送達用の装置、システム、および方法 |
WO2006079064A1 (en) * | 2005-01-24 | 2006-07-27 | Antares Pharma, Inc. | Prefilled needle assisted jet injector |
MX2007009152A (es) | 2005-02-01 | 2008-03-06 | Intelliject Llc | Dispositivos, sistema y metodos para el suministro de medicamentos. |
GB2422784A (en) * | 2005-02-07 | 2006-08-09 | Caretek Medical Ltd | Disposable assembly comprising a needle or stylet |
US20070009484A1 (en) * | 2005-02-08 | 2007-01-11 | Board Of Regents, The University Of Texas System | Compositions and methods involving MDA-7 for the treatment of cancer |
EP1863529A1 (en) | 2005-03-23 | 2007-12-12 | GlaxoSmithKline Biologicals S.A. | Novel composition |
BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
GB2425062B (en) * | 2005-04-06 | 2010-07-21 | Cilag Ag Int | Injection device |
GB2424835B (en) * | 2005-04-06 | 2010-06-09 | Cilag Ag Int | Injection device (modified trigger) |
GB2424836B (en) * | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
GB2424838B (en) * | 2005-04-06 | 2011-02-23 | Cilag Ag Int | Injection device (adaptable drive) |
GB2427826B (en) * | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
GB2424837B (en) * | 2005-04-06 | 2010-10-06 | Cilag Ag Int | Injection device |
US7618393B2 (en) * | 2005-05-03 | 2009-11-17 | Pharmajet, Inc. | Needle-less injector and method of fluid delivery |
US20070027428A1 (en) * | 2005-05-03 | 2007-02-01 | Pharmajet, Inc. | Vial system and method for needle-less injector |
US7699802B2 (en) * | 2005-05-03 | 2010-04-20 | Pharmajet, Inc. | Needle-less injector |
EP3782655A1 (en) | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
WO2007016643A2 (en) * | 2005-08-01 | 2007-02-08 | Mount Sinai School Of Medicine Of New York University | A method for extending longevity using npc1l1 antagonists |
US8962278B2 (en) | 2005-08-03 | 2015-02-24 | Ibio Inc. | Compositions and methods for production of immunoglobulins |
US20070055200A1 (en) * | 2005-08-10 | 2007-03-08 | Gilbert Scott J | Needle-free jet injection drug delivery device |
EP1759729B1 (en) * | 2005-08-30 | 2009-12-23 | Cilag GmbH International | Needle assembly for a prefilled syringe system |
KR101772375B1 (ko) | 2005-09-07 | 2017-08-29 | 신라젠(주) | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법 |
US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
US20110098656A1 (en) | 2005-09-27 | 2011-04-28 | Burnell Rosie L | Auto-injection device with needle protecting cap having outer and inner sleeves |
CA2876618C (en) * | 2005-10-13 | 2018-07-17 | Argos Therapeutics, Inc. | Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
WO2007070682A2 (en) * | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
DE102005062220B3 (de) * | 2005-12-20 | 2007-02-15 | Primojex Gmbh | System zur Injektion durch oder in die menschliche Haut |
WO2007075677A2 (en) * | 2005-12-20 | 2007-07-05 | Antares Pharma, Inc. | Needle-free injection device |
NO346529B1 (no) | 2005-12-22 | 2022-09-26 | Glaxosmithkline Biologicals Sa | Bruk av et immunogenpreparat for småbarn, omfattende 22F sakkaridkonjugat |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
US20080161755A1 (en) * | 2006-01-27 | 2008-07-03 | Bioject Inc. | Needle-free injection device and priming system |
WO2007092944A2 (en) * | 2006-02-08 | 2007-08-16 | Introgen Therapeutics, Inc. | Compositions and methods involving gene therapy and proteasome modulation |
US8277816B2 (en) * | 2006-02-13 | 2012-10-02 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
KR20080106433A (ko) * | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | 인플루엔자 항원, 백신 조성물 및 관련 방법 |
EP1984388B1 (en) * | 2006-02-13 | 2016-07-06 | iBio, Inc. | Hpv antigens, vaccine compositions, and related methods |
EP1998684A4 (en) * | 2006-03-10 | 2014-09-17 | Massachusetts Inst Technology | CONJUGATES AND NANOSYSTEMS WITH TRIGGERED SELF ASSEMBLY |
CA2681668C (en) * | 2006-03-23 | 2014-04-01 | Michael S. Singer | Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat |
BRPI0710210A2 (pt) | 2006-03-30 | 2011-05-24 | Glaxomithkline Biolog S A | composição imunogênica, vacina, métodos para preparar a vacina, e para prevenir ou tratar infecção estafilocócica, uso da composição imunogênica, e, processo para conjugar oligassacarìdeo ou polissacarìdeo capsular |
WO2008105773A2 (en) | 2006-03-31 | 2008-09-04 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
US20090325944A1 (en) * | 2006-04-12 | 2009-12-31 | Suzanne Walker Kahne | Methods and Compositions for Modulating Glycosylation |
US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9144648B2 (en) * | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
WO2007137117A2 (en) * | 2006-05-17 | 2007-11-29 | Massachusetts Institute Of Technology | Aptamer-directed drug delivery |
GB2438591B (en) * | 2006-06-01 | 2011-07-13 | Cilag Gmbh Int | Injection device |
GB2438590B (en) | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
GB2438593B (en) | 2006-06-01 | 2011-03-30 | Cilag Gmbh Int | Injection device (cap removal feature) |
AU2007256780B2 (en) * | 2006-06-02 | 2013-08-29 | President And Fellows Of Harvard College | Protein surface remodeling |
US9381477B2 (en) | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
WO2008001377A2 (en) * | 2006-06-28 | 2008-01-03 | Perf-Action Technologies Ltd. | Needleless injections for administering compositions to the skin |
DK2422810T3 (da) | 2006-07-17 | 2014-11-24 | Glaxosmithkline Biolog Sa | Influenzavaccine |
US9115358B2 (en) * | 2006-08-11 | 2015-08-25 | President And Fellows Of Harvard College | Moenomycin biosynthesis-related compositions and methods of use thereof |
US20090269342A1 (en) * | 2006-08-14 | 2009-10-29 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
KR20090050056A (ko) * | 2006-08-14 | 2009-05-19 | 메사츄세츠 인스티튜트 어브 테크놀로지 | 헤마글루티닌 폴리펩티드 및 시약 그리고 방법 |
EP2068743B1 (en) | 2006-09-12 | 2017-03-15 | Vidacare LLC | Medical procedures trays, kits and related methods |
US8944069B2 (en) | 2006-09-12 | 2015-02-03 | Vidacare Corporation | Assemblies for coupling intraosseous (IO) devices to powered drivers |
EP2073728B1 (en) | 2006-09-12 | 2018-11-07 | Teleflex Medical Devices S.à.r.l. | Biopsy device |
EP3167813B1 (en) | 2006-09-12 | 2019-11-13 | Teleflex Medical Devices S.à.r.l. | Bone marrow aspiration devices |
KR101541549B1 (ko) | 2006-09-13 | 2015-08-03 | 임머숀 코퍼레이션 | 카지노 게이밍 햅틱을 위한 시스템 및 방법 |
JP5606067B2 (ja) | 2006-09-15 | 2014-10-15 | オタワ ホスピタル リサーチ インスティテュート | 腫瘍崩壊性ラブドウイルス |
US7547293B2 (en) * | 2006-10-06 | 2009-06-16 | Bioject, Inc. | Triggering mechanism for needle-free injector |
JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
WO2008043774A1 (en) | 2006-10-12 | 2008-04-17 | Glaxosmithkline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
PL2086582T3 (pl) | 2006-10-12 | 2013-04-30 | Glaxosmithkline Biologicals Sa | Kompozycja zawierająca adiuwant w postaci emulsji typu olej w wodzie |
US7780201B2 (en) | 2006-10-13 | 2010-08-24 | Medela Holding Ag | Tube connector with three part construction and latching component |
DE602007014252D1 (de) | 2006-10-25 | 2011-06-09 | Icu Medical Inc | Medizinischer verbinder |
US8974410B2 (en) | 2006-10-30 | 2015-03-10 | Vidacare LLC | Apparatus and methods to communicate fluids and/or support intraosseous devices |
US20100303723A1 (en) * | 2006-11-20 | 2010-12-02 | Massachusetts Institute Of Technology | Drug delivery systems using fc fragments |
MX2009005727A (es) | 2006-12-01 | 2009-08-27 | Anterios Inc | Nanoparticulas de entidad anfifilica. |
WO2008073856A2 (en) * | 2006-12-08 | 2008-06-19 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
US20080140001A1 (en) * | 2006-12-12 | 2008-06-12 | By-Pass Inc. | Fluid Delivery Apparatus And Methods |
RU2506256C2 (ru) | 2006-12-26 | 2014-02-10 | Лантеус Медикал Имэджинг, Инк. | Лиганды для визуализации иннервации сердца |
CA2939778C (en) | 2007-01-31 | 2019-01-29 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
US9217129B2 (en) * | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
DE102007008597A1 (de) | 2007-02-19 | 2008-08-21 | Primojex Gmbh | System zur Injektion eines Fluids durch oder in die menschliche Haut |
US7744563B2 (en) * | 2007-02-23 | 2010-06-29 | Bioject, Inc. | Needle-free injection devices and drug delivery systems therefor |
WO2008115433A1 (en) | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
EP2508531B1 (en) * | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ(アミノ酸)ターゲッティング部分 |
WO2008124463A2 (en) * | 2007-04-04 | 2008-10-16 | Vidacare Corporation | Powered drivers, intraosseous devices and methods to access bone marrow |
WO2008134643A2 (en) * | 2007-04-28 | 2008-11-06 | Fraunhofer Usa, Inc. | Trypanosoma antigens, vaccine compositions, and related methods |
WO2008152639A2 (en) * | 2007-06-12 | 2008-12-18 | Bypass, Inc. | Pressure pulse actuating device for delivery systems |
NZ580603A (en) * | 2007-06-14 | 2013-02-22 | Crucell Switzerland Ag | Intradermal influenza vaccine |
WO2008156676A1 (en) | 2007-06-15 | 2008-12-24 | President And Fellows Of Harvard College | Methods and compositions for detecting and modulating o-glycosylation |
SI2167121T1 (sl) | 2007-06-26 | 2015-12-31 | Glaxosmithkline Biologicals S.A. | Cepivo, ki obsega kapsularne polisaharidne konjugate Streptococcusa pneumoniae |
CA2692933C (en) | 2007-07-11 | 2016-10-18 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
US20110059130A1 (en) * | 2007-08-20 | 2011-03-10 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods |
CA2704933A1 (en) | 2007-08-21 | 2009-02-26 | Yukon Medical, Llc | Vial access and injection system |
US8604004B2 (en) * | 2007-10-04 | 2013-12-10 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
US8172797B2 (en) * | 2007-10-10 | 2012-05-08 | Shl Group Ab | Medical delivery device |
MX350501B (es) | 2007-10-12 | 2017-09-07 | Massachusetts Inst Technology | Nanotecnologia de vacuna. |
WO2009086250A1 (en) * | 2007-12-21 | 2009-07-09 | Aesthetic Sciences Corporation | Self-contained pressurized injection device |
WO2009089119A2 (en) * | 2008-01-03 | 2009-07-16 | Massachusetts Institute Of Technology | Decoy influenza therapies |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
DE102008008023A1 (de) | 2008-02-04 | 2009-08-13 | Primojex Gmbh | System zur Injektion eines Fluids durch oder in die menschlische Haut |
US9486292B2 (en) | 2008-02-14 | 2016-11-08 | Immersion Corporation | Systems and methods for real-time winding analysis for knot detection |
TW201006515A (en) * | 2008-03-07 | 2010-02-16 | Pharmajet Inc | Intradermal injector and uses thereof |
JP5731829B2 (ja) | 2008-03-10 | 2015-06-10 | アンタレス・ファーマ・インコーポレーテッド | 注射器安全装置 |
US9117870B2 (en) * | 2008-03-27 | 2015-08-25 | Lam Research Corporation | High throughput cleaner chamber |
US8936571B2 (en) * | 2008-03-31 | 2015-01-20 | Laura Devega | Illuminated syringe |
EP2271387B1 (en) * | 2008-04-01 | 2016-06-15 | Yukon Medical, LLC | Dual container fluid transfer device |
JP5637982B2 (ja) * | 2008-04-09 | 2014-12-10 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 脂肪酸アミド加水分解酵素の阻害剤 |
KR20110009157A (ko) | 2008-04-16 | 2011-01-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
CN102066405B (zh) * | 2008-04-28 | 2015-09-30 | 哈佛大学校长及研究员协会 | 用于细胞穿透的超荷电蛋白 |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
CA3070644C (en) | 2008-05-20 | 2022-09-13 | Avant Medical Corp. | Autoinjector system |
GB2461086B (en) * | 2008-06-19 | 2012-12-05 | Cilag Gmbh Int | Injection device |
GB2461085B (en) * | 2008-06-19 | 2012-08-29 | Cilag Gmbh Int | Injection device |
GB2461084B (en) * | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Fluid transfer assembly |
GB2461087B (en) * | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
GB2461088B (en) * | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
GB2461089B (en) * | 2008-06-19 | 2012-09-19 | Cilag Gmbh Int | Injection device |
JP2011526302A (ja) | 2008-06-26 | 2011-10-06 | アンテリオス, インコーポレイテッド | 経皮送達 |
WO2010009271A2 (en) | 2008-07-15 | 2010-01-21 | Academia Sinica | Glycan arrays on ptfe-like aluminum coated glass slides and related methods |
EP2356139A4 (en) | 2008-07-23 | 2013-01-09 | Harvard College | LIGATURE OF STAPLED POLYPEPTIDES |
CA2734991A1 (en) * | 2008-07-23 | 2010-01-28 | Massachusetts Institute Of Technology | Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival |
US20100021472A1 (en) * | 2008-07-25 | 2010-01-28 | Geetha Srikrishna | Methods for diagnosing and treating cancer |
EP2318075B1 (en) | 2008-08-05 | 2019-05-22 | Antares Pharma, Inc. | Multiple dosage injector |
US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
US8343497B2 (en) * | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
WO2010057197A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
EP2376619A4 (en) | 2008-12-15 | 2012-07-04 | Greenlight Biosciences Inc | METHODS FOR CONTROLLING FLOWS IN METABOLIC PATHWAYS |
CN105132387A (zh) * | 2008-12-22 | 2015-12-09 | 绿光生物科学公司 | 用于制造化合物的组合物和方法 |
JP5732039B2 (ja) | 2009-03-20 | 2015-06-10 | アンタレス・ファーマ・インコーポレーテッド | 危険有害性薬剤の注入システム |
US8454579B2 (en) | 2009-03-25 | 2013-06-04 | Icu Medical, Inc. | Medical connector with automatic valves and volume regulator |
US20100252373A1 (en) * | 2009-04-02 | 2010-10-07 | Innovative Office Products, Inc. | Friction device for a spring cylinder |
US8546564B2 (en) | 2009-04-07 | 2013-10-01 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
WO2010118159A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
WO2010118283A1 (en) | 2009-04-09 | 2010-10-14 | Amicus Therapeutics, Inc. | Methods for preventing and/or treating lysosomal storage disorders |
EP2419071B1 (en) | 2009-04-14 | 2016-11-02 | Yukon Medical, LLC | Fluid transfer device |
WO2010129023A2 (en) | 2009-04-28 | 2010-11-11 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
US8927551B2 (en) * | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US9149465B2 (en) * | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US8765735B2 (en) * | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US9104791B2 (en) | 2009-05-28 | 2015-08-11 | Immersion Corporation | Systems and methods for editing a model of a physical system for a simulation |
EP2438046A4 (en) | 2009-06-01 | 2013-04-17 | Harvard College | O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF |
AU2010273220B2 (en) | 2009-07-13 | 2015-10-15 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
AU2010291901C1 (en) | 2009-09-14 | 2016-03-03 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus combination cancer therapy |
CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
WO2011041391A1 (en) | 2009-09-29 | 2011-04-07 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
CN105193802A (zh) | 2009-10-19 | 2015-12-30 | 阿米库斯治疗学公司 | 用于预防和/或治疗溶酶体贮积失调的新颖组合物 |
WO2011049736A1 (en) | 2009-10-19 | 2011-04-28 | Amicus Therapeutics, Inc. | Novel compositions for preventing and/or treating degenerative disorders of the central nervous system |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
CA2836117C (en) | 2009-12-10 | 2017-08-15 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
US9180127B2 (en) | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
JP6210685B2 (ja) | 2010-01-27 | 2017-10-11 | マサチューセッツ インスティテュート オブ テクノロジー | 標的化された広域スペクトルのインフルエンザ中和のための操作されたポリペプチド剤 |
US9034849B2 (en) * | 2010-02-03 | 2015-05-19 | Infinity Pharmaceuticals, Inc. | Fatty acid amide hydrolase inhibitors |
CA2789484C (en) | 2010-03-08 | 2019-10-22 | Sloan-Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
WO2011119549A1 (en) | 2010-03-22 | 2011-09-29 | President And Fellows Of Harvard College | Trioxacarcins and uses thereof |
USD644731S1 (en) | 2010-03-23 | 2011-09-06 | Icu Medical, Inc. | Medical connector |
US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
DK2566953T3 (en) | 2010-05-07 | 2019-04-15 | Greenlight Biosciences Inc | METHODS OF MANAGING THE POWER BY METABOLIC ROADS USING ENZYMOUS LOCATION |
EP2569019B1 (en) | 2010-05-11 | 2019-10-02 | Lantheus Medical Imaging, Inc. | Compositions, methods and systems for the synthesis and use of imaging agents |
US8758306B2 (en) | 2010-05-17 | 2014-06-24 | Icu Medical, Inc. | Medical connectors and methods of use |
USD655017S1 (en) | 2010-06-17 | 2012-02-28 | Yukon Medical, Llc | Shroud |
US9193989B2 (en) | 2010-06-18 | 2015-11-24 | Taiho Pharmaceutical Co., Ltd. | PRPK-TPRKB modulators and uses thereof |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
JP2013535514A (ja) | 2010-08-13 | 2013-09-12 | エイルロン セラピューティクス,インコーポレイテッド | ペプチド模倣大環状分子 |
KR101988063B1 (ko) | 2010-08-31 | 2019-09-30 | 그린라이트 바이오사이언시스, 아이엔씨. | 프로테아제 조작을 통한 대사 경로에서 유동의 제어 방법 |
EP2640405A4 (en) | 2010-09-21 | 2015-04-15 | Massachusetts Inst Technology | TREATMENT AND / OR CHARACTERIZATION OF INFLUENZA; POLYPEPTIDES HA ADAPTED TO MAN |
US8957026B2 (en) | 2010-09-22 | 2015-02-17 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
DK3590949T3 (da) | 2010-10-01 | 2022-07-11 | Modernatx Inc | Ribonukleinsyrer indeholdende n1-methyl-pseudouracil og anvendelse heraf |
SG10201709806VA (en) | 2010-10-04 | 2017-12-28 | Massachusetts Inst Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
CN103298474B (zh) | 2010-11-10 | 2016-06-29 | 无限药品股份有限公司 | 杂环化合物及其用途 |
KR101950522B1 (ko) * | 2010-11-19 | 2019-02-20 | 바이엘 컨수머 케어 악티엔게젤샤프트 | 클릭 펜 어플리케이터 장치 및 이를 이용하는 방법 |
KR101224581B1 (ko) | 2010-12-10 | 2013-01-21 | 주식회사 모리스 | 튜브 용기의 자동 밀폐 구조형 마개 |
GB201021716D0 (en) * | 2010-12-22 | 2011-02-02 | Owen Mumford Ltd | Autoinjectors |
CN103429258B (zh) | 2011-01-04 | 2016-03-09 | 新罗杰公司 | 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性 |
CA2824197C (en) | 2011-01-10 | 2020-02-25 | Michael Martin | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
EP3378480A1 (en) | 2011-01-19 | 2018-09-26 | Topokine Therapeutics, Inc. | Methods and compositions for treating obesity |
CN106924216A (zh) | 2011-01-24 | 2017-07-07 | 安特里奥公司 | 纳米颗粒组合物、其制剂和它们的用途 |
EP2667854B1 (en) | 2011-01-24 | 2019-01-16 | Anterios, Inc. | Nanoparticle compositions |
US20120328549A1 (en) | 2011-01-24 | 2012-12-27 | Anterios, Inc. | Oil compositions |
JP2014518609A (ja) | 2011-03-03 | 2014-08-07 | テルサス ファーマシューティカルズ リミテッド ライアビリティ カンパニー | C16:1n7−パルミトレアートを含む組成物および方法 |
GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
EP2691396B1 (en) | 2011-03-30 | 2016-08-10 | Brown University | Enopeptins, uses thereof, and methods of synthesis thereto |
US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
JP6026501B2 (ja) * | 2011-04-04 | 2016-11-16 | イデー インターナショナル アールアンドディー インコーポレイテッドIdee International R&D Inc. | 無針注射器のワンドアセンブリー |
CA2833850A1 (en) * | 2011-04-19 | 2012-10-26 | Invisiderm, Llc | Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof |
PL2699293T3 (pl) | 2011-04-20 | 2019-08-30 | Amgen Inc. | Urządzenie do wstrzykiwania automatycznego |
AR086405A1 (es) | 2011-05-17 | 2013-12-11 | Glaxosmithkline Biolog Sa | Vacuna de streptococcus pneumoniae |
ES2627529T3 (es) | 2011-06-08 | 2017-07-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Composiciones para tratamiento de glioblastoma |
AU2012272815B2 (en) | 2011-06-22 | 2017-09-07 | The General Hospital Corporation | Treatment of proteinopathies |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
JP6027610B2 (ja) | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環式化合物及びその使用 |
CN103946226A (zh) | 2011-07-19 | 2014-07-23 | 无限药品股份有限公司 | 杂环化合物及其应用 |
DK2734510T3 (en) | 2011-07-22 | 2019-03-04 | Massachusetts Inst Technology | CLASS I-HISTONDEACETYLASES (HDAC) ACTIVATORS AND APPLICATIONS THEREOF |
US9408972B2 (en) | 2011-08-02 | 2016-08-09 | Pharmajet, Inc. | Needle-free injection device |
TW201311663A (zh) | 2011-08-29 | 2013-03-16 | Infinity Pharmaceuticals Inc | 雜環化合物及其用途 |
USD681230S1 (en) | 2011-09-08 | 2013-04-30 | Yukon Medical, Llc | Shroud |
CN104159890B (zh) | 2011-09-09 | 2018-04-10 | 蓝瑟斯医学影像公司 | 用于合成和使用显像剂的组合物、方法和系统 |
KR20150010932A (ko) | 2011-09-09 | 2015-01-29 | 그린라이트 바이오사이언시스, 아이엔씨. | 카바페넴의 무세포 제조법 |
EP3384938A1 (en) | 2011-09-12 | 2018-10-10 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
MX358886B (es) | 2011-10-18 | 2018-08-31 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos. |
WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
EP2790755B1 (en) | 2011-12-13 | 2021-08-11 | Pharmajet Inc. | Needle-free intradermal injection device |
US20130156849A1 (en) | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
AU2012352025B2 (en) | 2011-12-16 | 2018-01-18 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
US8242158B1 (en) | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
US10130800B2 (en) | 2012-01-27 | 2018-11-20 | Invisiderm, Llc | Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof |
CN108912211A (zh) | 2012-02-15 | 2018-11-30 | 爱勒让治疗公司 | 三唑交联的和硫醚交联的拟肽大环化合物 |
BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US20150090741A1 (en) * | 2012-03-23 | 2015-04-02 | Ddps Global, Llc | Compression Spring and Pump for Dispensing Fluid |
CA2868459A1 (en) | 2012-03-27 | 2013-10-03 | Amicus Therapeutics, Inc. | Polymorphs of (3r,4r,5s)-5-(difluoromethyl)piperidine-3,4-diol fumarate and uses thereof |
US9273084B2 (en) | 2012-04-06 | 2016-03-01 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
WO2013152323A1 (en) | 2012-04-06 | 2013-10-10 | Wotton Paul K | Needle assisted jet injection administration of testosterone compositions |
US10106833B2 (en) | 2012-04-06 | 2018-10-23 | President And Fellows Of Harvard College | Methods and compounds for identifying glycosyltransferase inhibitors |
WO2013152279A1 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Chemoenzymatic methods for synthesizing moenomycin analogs |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
USD808010S1 (en) | 2012-04-20 | 2018-01-16 | Amgen Inc. | Injection device |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
WO2013169804A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9683030B2 (en) | 2012-05-10 | 2017-06-20 | Massachusetts Institute Of Technology | Agents for influenza neutralization |
USD769444S1 (en) | 2012-06-28 | 2016-10-18 | Yukon Medical, Llc | Adapter device |
UA114108C2 (uk) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
KR101711765B1 (ko) * | 2012-07-12 | 2017-03-02 | 안타레스 팔마, 인코퍼레이티드 | 액체 전달 어댑터의 경사구조 스파이크 |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
JP2015525794A (ja) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乳児においてrsv及び百日咳菌に対する免疫応答を惹起するための方法 |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
CA2880701A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
ES2874525T3 (es) | 2012-09-26 | 2021-11-05 | Harvard College | Péptidos grapados bloqueados con prolina y usos de los mismos |
US20150225471A1 (en) | 2012-10-01 | 2015-08-13 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
EP2909204B1 (en) | 2012-10-12 | 2018-12-05 | The Broad Institute, Inc. | Gsk3 inhibitors and methods of use thereof |
WO2014063068A1 (en) | 2012-10-18 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
JP6584952B2 (ja) | 2012-11-01 | 2019-10-02 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | Pi3キナーゼアイソフォームモジュレーターを用いる癌の治療 |
EP2917203B1 (en) | 2012-11-02 | 2019-04-03 | Dana-Farber Cancer Institute, Inc. | Method for identifying myc inhibitors |
US8778981B2 (en) | 2012-11-21 | 2014-07-15 | Topokine Therapeutics, Inc. | Methods and compositions for locally increasing body fat |
US9775915B2 (en) | 2012-11-26 | 2017-10-03 | President And Fellows Of Harvard College | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof |
RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
CA2894126A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
EP2935241A1 (en) | 2012-12-21 | 2015-10-28 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
DK2935222T3 (en) | 2012-12-21 | 2019-01-07 | Epizyme Inc | PRMT5 INHIBITORS AND APPLICATIONS THEREOF |
EP2935243B1 (en) | 2012-12-21 | 2018-03-14 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
US20140200261A1 (en) | 2013-01-17 | 2014-07-17 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
EP4272750A3 (en) | 2013-02-07 | 2024-01-24 | Children's Medical Center, Corp. | Protein antigens that provide protection against pneumococcal colonization and/or disease |
AU2014214754B2 (en) | 2013-02-07 | 2018-07-12 | Massachusetts Institute Of Technology | Human adaptation of H5 influenza |
EP2953667B1 (en) | 2013-02-11 | 2019-10-23 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
WO2014127478A1 (en) | 2013-02-21 | 2014-08-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Vaccine composition |
JP6030803B2 (ja) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | ピニオンシステムを有する用量注射器 |
WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
KR20150131244A (ko) | 2013-03-13 | 2015-11-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스테이플드 및 스티치드 폴리펩티드 및 그의 용도 |
US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
US9866924B2 (en) | 2013-03-14 | 2018-01-09 | Immersion Corporation | Systems and methods for enhanced television interaction |
EP2970194A1 (en) | 2013-03-15 | 2016-01-20 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
TWI639449B (zh) | 2013-03-15 | 2018-11-01 | 美商安美基公司 | 用於注射器之匣盒 |
WO2014144096A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
SG11201508113SA (en) | 2013-04-03 | 2015-10-29 | Allertein Therapeutics Llc | Novel nanoparticle compositions |
CA3130061C (en) | 2013-04-04 | 2024-05-28 | President And Fellows Of Harvard College | Macrolides and methods of their preparation and use |
ES2774330T3 (es) | 2013-04-09 | 2020-07-20 | Massachusetts Inst Technology | Polímero de suministro de fármaco y usos del mismo |
WO2014179464A1 (en) | 2013-04-30 | 2014-11-06 | Massachusetts Institute Of Technology | Human adaptation of h3 influenza |
US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
NO2753788T3 (ja) | 2013-05-10 | 2018-06-16 | ||
DK3003309T3 (da) | 2013-05-30 | 2020-12-14 | Infinity Pharmaceuticals Inc | Behandling af cancer med PI3-kinase-isoform modulatorer |
US10526375B2 (en) | 2013-06-05 | 2020-01-07 | Massachusetts Institute Of Technology | Human Adaptation of H7 HA |
GB2515039B (en) | 2013-06-11 | 2015-05-27 | Cilag Gmbh Int | Injection Device |
GB2515032A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Guide for an injection device |
GB2517896B (en) | 2013-06-11 | 2015-07-08 | Cilag Gmbh Int | Injection device |
GB2515038A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Injection device |
CA2914815A1 (en) | 2013-06-11 | 2014-12-18 | Kala Pharmaceuticals, Inc. | Urea derivatives and uses thereof |
BR112015031277A2 (pt) | 2013-06-14 | 2017-09-19 | Harvard College | Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos |
WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
EP3013347B1 (en) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glycan conjugates and use thereof |
BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
CN105658807A (zh) | 2013-08-05 | 2016-06-08 | 绿光生物科技股份有限公司 | 具有蛋白酶切割位点的工程化蛋白 |
CA2919773A1 (en) | 2013-08-05 | 2015-02-12 | Glaxosmithkline Biologicals S.A. | Combination immunogenic compositions |
US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
CA2925944C (en) | 2013-10-04 | 2023-01-10 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9265881B2 (en) * | 2013-10-14 | 2016-02-23 | Medtronic Minimed, Inc. | Therapeutic agent injection device |
US9982009B2 (en) | 2013-10-15 | 2018-05-29 | Massachusetts Institute Of Technology | Methods for treating polycystic kidney disease and polycystic liver disease |
US9902986B2 (en) | 2013-10-16 | 2018-02-27 | Massachusetts Institute Of Technology | Enterobactin conjugates and uses thereof |
CA2927917C (en) | 2013-10-18 | 2022-08-09 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9458169B2 (en) | 2013-11-01 | 2016-10-04 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CA2932124C (en) | 2013-12-11 | 2023-05-09 | Icu Medical, Inc. | Check valve |
CN110183461A (zh) | 2013-12-24 | 2019-08-30 | 哈佛学院院长等 | 皮质抑素类似物及其合成和用途 |
CN106459920B (zh) | 2014-01-16 | 2020-10-30 | 中央研究院 | 治疗及检测癌症的组合物及方法 |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
EA201691603A1 (ru) | 2014-02-12 | 2016-11-30 | Амикус Терапьютикс, Инк. | Производные сахаров, содержащие серосодержащие фрагменты, способы их получения и способы их применения для лечения mps iiic |
WO2015134920A1 (en) | 2014-03-07 | 2015-09-11 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Non-narcotic crmp2 peptides targeting sodium channels for chronic pain |
SG10201808053XA (en) | 2014-03-19 | 2018-10-30 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015148915A1 (en) | 2014-03-27 | 2015-10-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
WO2015149016A2 (en) | 2014-03-28 | 2015-10-01 | University Of Washington Through Its Center For Commercialization | Breast and ovarian cancer vaccines |
US9675627B2 (en) | 2014-04-14 | 2017-06-13 | Amicus Therapeutics, Inc. | Dosing regimens for treating and/or preventing cerebral amyloidoses |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
WO2015168380A1 (en) | 2014-04-30 | 2015-11-05 | Massachusetts Institute Of Technology | Siderophore-based immunization against gram-negative bacteria |
US10195113B2 (en) | 2014-04-30 | 2019-02-05 | Massachusetts Institute Of Technology | Adaptor for removal of fluid from vial using a needle-free syringe |
IL288147B2 (en) | 2014-05-21 | 2024-03-01 | Harvard College | RAS inhibitory peptides and their uses |
US20150344585A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
KR102576850B1 (ko) | 2014-05-27 | 2023-09-11 | 아카데미아 시니카 | 박테로이드 기원의 푸코시다제 및 이의 사용 방법 |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-her2 글리코항체 및 이의 용도 |
US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
MX2016016533A (es) | 2014-06-13 | 2017-05-01 | Glaxosmithkline Biologicals Sa | Combinaciones inmunogenas. |
CN110526912B (zh) | 2014-06-19 | 2023-02-14 | 武田药品工业株式会社 | 用于激酶抑制的杂芳基化合物 |
WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
US10759836B2 (en) | 2014-07-18 | 2020-09-01 | University Of Washington | Cancer vaccine compositions and methods of use thereof |
EP3984572A1 (en) | 2014-08-10 | 2022-04-20 | Antares Pharma, Inc. | A syringe shock absorber for use in an injection device |
US10736966B2 (en) | 2014-08-12 | 2020-08-11 | Massachusetts Institute Of Technology | Brush-poly (glycoamidoamine)-lipids and uses thereof |
CN204033941U (zh) * | 2014-08-27 | 2014-12-24 | 北京快舒尔医疗技术有限公司 | 一种具有电动功能的无针注射器 |
US9879042B2 (en) | 2014-09-08 | 2018-01-30 | Academia Sinica | Human iNKT cell activation using glycolipids |
US10905739B2 (en) | 2014-09-24 | 2021-02-02 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP3209647B1 (en) | 2014-10-21 | 2020-06-03 | ARIAD Pharmaceuticals, Inc. | Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl]pyrimidine-2,4-diamine |
US20180015101A1 (en) | 2014-10-28 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for antigen-specific tolerance |
WO2016077125A1 (en) | 2014-11-10 | 2016-05-19 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules containing reduced uracil content and uses thereof |
US10253045B2 (en) | 2014-11-26 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
USD786427S1 (en) | 2014-12-03 | 2017-05-09 | Icu Medical, Inc. | Fluid manifold |
USD793551S1 (en) | 2014-12-03 | 2017-08-01 | Icu Medical, Inc. | Fluid manifold |
US10174022B2 (en) | 2014-12-10 | 2019-01-08 | Kala Pharmaceuticals, Inc. | 1-amino-triazolo(1,5-A)pyridine-substituted urea derivative and uses thereof |
CA2972266C (en) | 2014-12-23 | 2023-05-09 | Sloan-Kettering Institute For Cancer Research | Polymorph of granaticin b |
WO2016105528A2 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
TWI736523B (zh) | 2015-01-24 | 2021-08-21 | 中央研究院 | 新穎聚醣結合物及其使用方法 |
CA2979847A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
EP3273966B1 (en) | 2015-03-27 | 2023-05-03 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
JP6843065B2 (ja) | 2015-03-30 | 2021-03-17 | グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. | リボ核酸の無細胞生産 |
JP2018515475A (ja) | 2015-04-27 | 2018-06-14 | ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. | 代謝的にプログラムされた金属キレーターおよびその使用 |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
PT3310764T (pt) | 2015-06-19 | 2023-07-11 | Massachusetts Inst Technology | 2,5-piperazinadionas substituídas por alquenilo e o seu uso em composições para entregar um agente a um sujeito ou célula |
WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US10179128B2 (en) | 2015-08-31 | 2019-01-15 | Amicus Therapeutics, Inc. | Regimens for treating and preventing lysosomal disorders and degenerative disorders of the central nervous system |
EP3347018B1 (en) | 2015-09-09 | 2021-09-01 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | Mcl−1のモジュレーターとしてのペプチド模倣大環状分子 |
EP3736261B1 (en) | 2015-09-17 | 2023-10-11 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
EP4101930A1 (en) | 2015-09-17 | 2022-12-14 | ModernaTX, Inc. | Polynucleotides containing a stabilizing tail region |
EP3355882A1 (en) | 2015-10-01 | 2018-08-08 | Kythera Biopharmaceuticals, Inc. | Compositions comprising a statin for use in methods of adipolysis |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
CN108884159A (zh) | 2015-11-07 | 2018-11-23 | 茂体外尔公司 | 用于癌症治疗的包含肿瘤抑制基因治疗和免疫检查点阻断的组合物 |
ES2913626T3 (es) | 2015-12-22 | 2022-06-03 | Modernatx Inc | Compuestos y composiciones para la administración intracelular de agentes |
JP2019511483A (ja) | 2016-03-02 | 2019-04-25 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 免疫療法のためのsting活性化ナノワクチン |
US10336784B2 (en) | 2016-03-08 | 2019-07-02 | Academia Sinica | Methods for modular synthesis of N-glycans and arrays thereof |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
US10954541B2 (en) | 2016-04-06 | 2021-03-23 | Greenlight Biosciences, Inc. | Cell-free production of ribonucleic acid |
BR112018075078A2 (pt) | 2016-06-03 | 2019-03-06 | Sanofi Pasteur Inc. | modificação de polipeptídeos da hemaglutinina do influenza manipulados |
WO2017214337A1 (en) | 2016-06-07 | 2017-12-14 | Massachusetts Institute Of Technology | Drug delivery polymers and uses thereof |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
AU2017286606A1 (en) | 2016-06-14 | 2018-12-13 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
NL2017294B1 (en) | 2016-08-05 | 2018-02-14 | Univ Erasmus Med Ct Rotterdam | Natural cryptic exon removal by pairs of antisense oligonucleotides. |
KR102437120B1 (ko) | 2016-08-05 | 2022-08-25 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
EA039427B1 (ru) | 2016-08-05 | 2022-01-26 | Санофи Пастер Инк. | Поливалентная пневмококковая полисахаридно-белковая конъюгатная композиция |
WO2018035429A1 (en) | 2016-08-18 | 2018-02-22 | Wisconsin Alumni Research Foundation | Peptides that inhibit syndecan-1 activation of vla-4 and igf-1r |
CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
US10030933B2 (en) * | 2016-08-25 | 2018-07-24 | Thomas Gore Living Trust | Gas spring assembly and a catch therefor |
KR101838631B1 (ko) * | 2016-11-03 | 2018-04-26 | 서울대학교 산학협력단 | 반복 분사에 따른 젯의 분사 속도 저하를 방지하고 약물의 자동 충전이 가능한 마이크로젯 약물 주입 장치 |
US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
KR101863355B1 (ko) * | 2016-12-01 | 2018-06-01 | 한국기계연구원 | 인젝션 량이 가변조절되는 증압식 무침주사기 |
WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
JP2020510624A (ja) | 2016-12-12 | 2020-04-09 | マルチビア インコーポレイテッド | がんおよび感染性疾患の治療および予防のための、ウイルス遺伝子治療および免疫チェックポイント阻害剤を含む方法および組成物 |
EP4371554A2 (en) | 2016-12-31 | 2024-05-22 | BioXcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
PL3596041T3 (pl) | 2017-03-15 | 2023-03-06 | Modernatx, Inc. | Związek i kompozycje do dokomórkowego dostarczania środków terapeutycznych |
JP7332478B2 (ja) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子製剤 |
WO2018175324A1 (en) | 2017-03-20 | 2018-09-27 | The Broad Institute, Inc. | Compounds and methods for regulating insulin secretion |
EP3606528B1 (en) | 2017-04-05 | 2023-10-18 | The Broad Institute, Inc. | Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof |
US20200085891A1 (en) | 2017-04-21 | 2020-03-19 | Sillajen, Inc | Oncolytic vaccinia virus and checkpoint inhibitor combination therapy |
KR20190134807A (ko) | 2017-04-25 | 2019-12-04 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 중추 신경계의 퇴행성 질환 및/또는 리소솜 저장병을 예방 및/또는 치료하기 위한 신규한 조성물 |
US20210198200A1 (en) | 2017-06-14 | 2021-07-01 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
KR20200041311A (ko) | 2017-06-23 | 2020-04-21 | 노소코미얼 백신 코포레이션 | 면역원성 조성물 |
WO2019013790A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | ANTIMICROBIAL COMPOUNDS AND USES THEREOF |
WO2019013789A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | ANTIMICROBIAL COMPOUNDS |
US11305273B2 (en) | 2017-07-27 | 2022-04-19 | Biomerieux, Inc. | Isolation tube with a rheological control member and a plunger |
WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
SG11202003192UA (en) | 2017-10-11 | 2020-05-28 | Greenlight Biosciences Inc | Methods and compositions for nucleoside triphosphate and ribonucleic acid production |
WO2019109079A1 (en) | 2017-12-01 | 2019-06-06 | North Carolina State University | Fibrin particles and methods of making the same |
WO2019124852A1 (ko) | 2017-12-19 | 2019-06-27 | 조민수 | 무침주사기 |
GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
JP2021509815A (ja) | 2018-01-05 | 2021-04-08 | オタワ ホスピタル リサーチ インスティチュート | 改変ワクシニアベクター |
JP2021518408A (ja) | 2018-03-19 | 2021-08-02 | マルチビア インコーポレイテッド | 癌治療のための、癌抑制遺伝子治療法及びcd122/cd132アゴニストを含む、方法及び組成物 |
CN115154440A (zh) | 2018-06-27 | 2022-10-11 | 比奥克斯塞尔医疗股份有限公司 | 含右美托咪定的膜制剂及其制造方法 |
EP3853202A1 (en) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
US11160791B2 (en) | 2018-11-01 | 2021-11-02 | Medefil, Inc. | Dexmedetomidine injection premix formulation in ready to use (RTU) bags |
CA3126815A1 (en) | 2019-01-16 | 2020-07-23 | Curza Global, Llc | Antimicrobial compounds and methods |
CA3126798A1 (en) | 2019-01-16 | 2020-07-23 | Curza Global, Llc | Antimicrobial compounds and methods |
CN111481774B (zh) * | 2019-01-25 | 2023-06-09 | 凯联医疗科技(上海)有限公司 | 一种微量药物无针注射器 |
BR112021014845A2 (pt) | 2019-01-31 | 2021-11-03 | Modernatx Inc | Métodos de preparação de nanopartículas lipídicas |
WO2020168466A1 (en) | 2019-02-19 | 2020-08-27 | Stemirna Therapeutics Co., Ltd. | Modified nucleoside and synthetic methods thereof |
CA3145388A1 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
MX2022001241A (es) | 2019-07-31 | 2022-04-20 | Sanofi Pasteur Inc | Composiciones de conjugados neumococicos multivalentes polisacarido - proteina y metodos para usar los mismos. |
CA3149386A1 (en) | 2019-07-31 | 2021-02-04 | Modernatx, Inc. | Compositions and methods for delivery of rna interference agents to immune cells |
KR102269721B1 (ko) * | 2019-08-13 | 2021-06-28 | 주식회사 쿼드메디슨 | 내시경용 마이크로니들 불릿 주입장치 |
EP4058146A1 (en) | 2019-11-13 | 2022-09-21 | Curza Global LLC | Antimicrobial compounds and methods |
WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
US11752269B2 (en) * | 2019-12-18 | 2023-09-12 | Integrimedical Llc | Spring loaded medical needle-free injection system |
WO2021155274A1 (en) | 2020-01-31 | 2021-08-05 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
US11642407B2 (en) | 2020-02-28 | 2023-05-09 | Massachusetts Institute Of Technology | Identification of variable influenza residues and uses thereof |
JP7386857B2 (ja) * | 2020-04-30 | 2023-11-27 | ベイジン キューエス メディカル テクノロジー カンパニー,リミテッド | 無針注射器の注射ヘッド、無針注射器の本体と無針注射器 |
WO2021231729A1 (en) | 2020-05-13 | 2021-11-18 | Sanofi | Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza |
EP4238979A1 (en) | 2020-10-30 | 2023-09-06 | Xeno-Interface Inc. | Beta-strand type crosslinked peptide |
JPWO2022092294A1 (ja) | 2020-10-30 | 2022-05-05 | ||
AR124267A1 (es) | 2020-12-09 | 2023-03-01 | Genentech Inc | Métodos de alto rendimiento para preparar nanopartículas lipídicas y sus usos |
US20220287983A1 (en) | 2021-03-09 | 2022-09-15 | Massachusetts Institute Of Technology | Branched poly(-amino esters) for the delivery of nucleic acids |
TW202313065A (zh) | 2021-05-28 | 2023-04-01 | 美商季卡尼醫療公司 | 用於治療遺傳疾病之化合物 |
CN113318301A (zh) * | 2021-06-28 | 2021-08-31 | 北京科技大学 | 一种大剂量多孔无针注射器 |
WO2023018817A1 (en) | 2021-08-11 | 2023-02-16 | Sanofi Pasteur Inc. | Truncated influenza neuraminidase and methods of using the same |
US20230233667A1 (en) | 2021-09-08 | 2023-07-27 | Affinivax, Inc. | Coronavirus vaccine |
KR20240076825A (ko) | 2021-10-08 | 2024-05-30 | 사노피 파스퇴르 인크 | 다가 인플루엔자 백신 |
CN118201635A (zh) | 2021-11-05 | 2024-06-14 | 圣诺菲·帕斯图尔公司 | 包含重组血凝素和神经氨酸酶的多价流感疫苗及其使用方法 |
WO2023079113A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi | Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same |
WO2023114889A1 (en) | 2021-12-16 | 2023-06-22 | Modernatx, Inc. | Processes for preparing lipid nanoparticles |
GB2614309A (en) | 2021-12-24 | 2023-07-05 | Stratosvir Ltd | Improved vaccinia virus vectors |
CA3240195A1 (en) | 2021-12-30 | 2023-07-06 | Paul R. Sebahar | Antimicrobial compounds and methods |
WO2023144206A1 (en) | 2022-01-27 | 2023-08-03 | Sanofi Pasteur | Modified vero cells and methods of using the same for virus production |
WO2023144393A1 (en) | 2022-01-28 | 2023-08-03 | Fundació Centre De Regulació Genòmica | Therapeutic cytokines and methods |
US11524105B1 (en) * | 2022-03-03 | 2022-12-13 | Hetaida Technology Co., Ltd. | Nasal aspirator capable of effectively preventing backflow and control method thereof |
WO2023177577A1 (en) | 2022-03-14 | 2023-09-21 | Sanofi Pasteur Inc. | Machine-learning techniques in protein design for vaccine generation |
WO2023193002A1 (en) | 2022-04-01 | 2023-10-05 | Modernatx, Inc. | Cross mixers for lipid nanoparticle production, and methods of operating the same |
WO2023235380A1 (en) | 2022-06-01 | 2023-12-07 | Zikani Therapeutics, Inc. | Macrolides for treating genetic diseases |
CN114870163B (zh) * | 2022-06-06 | 2023-12-19 | 江苏乐聚医药科技有限公司 | 气簧混动型无针注射器 |
WO2023250513A1 (en) | 2022-06-24 | 2023-12-28 | Zikani Therapeutics, Inc. | 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation |
WO2024026475A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
WO2024026482A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising surface lipid derivatives and related uses |
WO2024026487A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising phospholipid derivatives and related uses |
WO2024049994A1 (en) | 2022-09-01 | 2024-03-07 | Zikani Therapeutics, Inc. | Treatment of familial adenomatous polyopsis using a 13-membered macrolide |
CN115429974B (zh) * | 2022-09-07 | 2023-09-15 | 北京快舒尔医疗技术有限公司 | 无针注射器 |
WO2024091918A2 (en) | 2022-10-25 | 2024-05-02 | Modernatx, Inc. | Methods of lipid nanoparticle production in cross-mixers |
WO2024121380A1 (en) | 2022-12-08 | 2024-06-13 | Pierre Fabre Medicament | Vaccinal composition and adjuvant |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Family Cites Families (176)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US489757A (en) * | 1893-01-10 | eeilly | ||
US396107A (en) * | 1889-01-15 | Fluid speed-regulator for elevators | ||
US489727A (en) * | 1893-01-10 | Suspender-end | ||
US2704543A (en) * | 1955-03-22 | Hypo jet injector | ||
US3123070A (en) * | 1964-03-03 | Multidose jet injector | ||
US1567517A (en) * | 1924-10-20 | 1925-12-29 | Roy D Kisbey | Shock absorber |
US1973706A (en) * | 1928-11-30 | 1934-09-18 | Hawley Jones Corp | Shock absorber |
US2322244A (en) * | 1940-03-18 | 1943-06-22 | Marshall L Lockhart | Hypodermic injector |
US2390246A (en) * | 1940-10-18 | 1945-12-04 | Marvin L Folkman | Syringe |
US2322245A (en) * | 1943-05-20 | 1943-06-22 | Marshall L Lockhart | Ypodermic injector and method of use thereof |
US2380534A (en) * | 1941-04-26 | 1945-07-31 | Marshall L Lockhart | Hypodermic injector |
US2413303A (en) * | 1944-01-17 | 1946-12-31 | Marvin L Folkman | Syringe |
US2459875A (en) * | 1944-09-11 | 1949-01-25 | Marvin L Folkman | Syringe and ampoule |
US2398544A (en) * | 1945-01-06 | 1946-04-16 | Marshall L Lockhart | Hypodermic injector |
US2450527A (en) * | 1945-10-27 | 1948-10-05 | P & V Quicklocking Co | Semiautomatic coupling |
US2800903A (en) * | 1947-07-30 | 1957-07-30 | Becton Dickinson Co | Injection apparatus |
US2605763A (en) * | 1948-01-31 | 1952-08-05 | Becton Dickinson Co | Injection device |
US2547099A (en) * | 1948-03-11 | 1951-04-03 | Becton Dickinson Co | Injection device and ampoule |
US2704542A (en) * | 1949-02-21 | 1955-03-22 | Scherer Corp R P | Jet therapy method |
US2688968A (en) * | 1949-05-14 | 1954-09-14 | Scherer Corp R P | Hypo jet ampoule |
US2902994A (en) * | 1949-05-21 | 1959-09-08 | Scherer Corp R P | Hypo jet injector |
US2699166A (en) * | 1949-07-29 | 1955-01-11 | Becton Dickinson Co | Hypodermic injection unit |
US2737946A (en) * | 1949-09-01 | 1956-03-13 | Jr George N Hein | Hypodermic injection apparatus |
US2798485A (en) * | 1949-09-01 | 1957-07-09 | Jr George N Hein | Ampule |
US2653602A (en) * | 1950-06-17 | 1953-09-29 | Becton Dickinson Co | Injection device |
US2671347A (en) * | 1950-06-24 | 1954-03-09 | Scherer Corp R P | Latch structure |
US2754818A (en) * | 1950-06-24 | 1956-07-17 | Scherer Corp R P | Hypo jet injector |
US2681653A (en) * | 1950-09-06 | 1954-06-22 | Becton Dickinson Co | Hypodermic injection orifice structure and method of making same |
US2670121A (en) * | 1951-01-31 | 1954-02-23 | Scherer Corp R P | Flexible follower for metal ampoules |
US2764977A (en) * | 1951-05-24 | 1956-10-02 | Becton Dickinson Co | Hypodermic injection mechanism |
US2635602A (en) * | 1951-11-21 | 1953-04-21 | Jr George N Hein | Hypodermic injection apparatus |
US2821193A (en) * | 1952-07-22 | 1958-01-28 | Geoffrey W Walker | Multiple injection inoculator instrument |
US2789839A (en) * | 1952-08-27 | 1957-04-23 | Bissell Carpet Sweeper Co | Spring detent engaging means for carpet sweeper sectional handle |
US2717597A (en) * | 1952-12-04 | 1955-09-13 | Jr George N Hein | Injection apparatus |
GB766431A (en) * | 1953-02-11 | 1957-01-23 | Nat Res Dev | Improvements relating to hypodermic injection apparatus |
FR1067076A (fr) * | 1953-12-16 | 1954-06-11 | Hygiene Scient Hygiscient Lab | Perfectionnements aux appareils à injection parentérale sans aiguille |
US2820655A (en) * | 1953-12-18 | 1958-01-21 | Collins Radio Co | Tenacious fastener |
US2798486A (en) * | 1953-12-21 | 1957-07-09 | Jr George N Hein | Injection assembly |
US2714887A (en) * | 1954-04-26 | 1955-08-09 | Scherer Corp R P | Intradermal injector |
US2816544A (en) * | 1954-07-12 | 1957-12-17 | Scherer Corp R P | Hypodermic injector |
US2816543A (en) * | 1954-07-12 | 1957-12-17 | Scherer Corp R P | Hypodermic injector |
US2821981A (en) * | 1954-07-21 | 1958-02-04 | Geoffrey W Walker | Multi-shot inoculant injector instrument with adjustable ejection pressure control |
US2825332A (en) * | 1954-08-20 | 1958-03-04 | Howard Johnson Electrostatics | Hypodermic syringe with magnetically actuated piston and needle |
US2762370A (en) * | 1954-09-07 | 1956-09-11 | Scherer Corp R P | Hypodermic injector |
US2762369A (en) * | 1954-09-07 | 1956-09-11 | Scherer Corp R P | Hypodermic injector with adjustable impact plunger |
US3147967A (en) * | 1956-06-27 | 1964-09-08 | Bougeard Arthur | Pneumatic shock absorber |
NL106573C (ja) * | 1957-05-31 | |||
US2928390A (en) * | 1957-07-15 | 1960-03-15 | Scherer Corp R P | Multi-dose hypodermic injector |
US3057349A (en) * | 1959-12-14 | 1962-10-09 | Ismach Aaron | Multi-dose jet injection device |
GB964585A (ja) * | 1960-03-23 | |||
GB995605A (en) * | 1960-08-04 | 1965-06-23 | Amalgamated Dental Co Ltd | Improvements relating to hypodermic injection apparatus |
NL133848C (ja) * | 1960-08-15 | |||
FR1072399A (fr) * | 1961-01-07 | 1954-09-13 | Injecteur intra-dermique | |
US3138157A (en) * | 1961-05-12 | 1964-06-23 | Z & W Mfg Corp | Inoculant injector instrument |
US3167071A (en) * | 1961-07-17 | 1965-01-26 | Scherer Corp R P | Apparatus for administering intradermal injections |
US3115133A (en) * | 1962-05-15 | 1963-12-24 | Morando Emilio Donald | Needleless prefilled disposable hypodermic injector |
NL296017A (ja) * | 1962-08-03 | 1900-01-01 | ||
BE643768A (ja) * | 1963-02-18 | |||
US3140713A (en) * | 1963-03-25 | 1964-07-14 | Ismach Aaron | Intradermal nozzle for jet injection devices |
US3202151A (en) * | 1963-04-08 | 1965-08-24 | Scherer Corp R P | Multidose jet injector |
US3330276A (en) * | 1963-10-07 | 1967-07-11 | Scherer Corp R P | Hypodermic jet injector |
US3245703A (en) * | 1963-10-28 | 1966-04-12 | Robert S Manly | Quick detachable pipe coupling |
US3335722A (en) * | 1963-11-01 | 1967-08-15 | Olin Mathieson | Hypodermic device |
US3308818A (en) * | 1964-07-24 | 1967-03-14 | Eugene V Rutkowski | Injection cartridge |
US3330277A (en) * | 1964-08-17 | 1967-07-11 | Scherer Corp R P | Multidose hypodermic injector |
US3292622A (en) * | 1964-09-21 | 1966-12-20 | Oscar H Banker | Power operated inoculator |
US3406684A (en) * | 1964-09-28 | 1968-10-22 | Yuryo Kikakuhin Kenkyusho Kk | Jet type, medical injection instrument |
US3399759A (en) * | 1964-11-19 | 1968-09-03 | Express Injector Company Ltd | Protecting holders |
US3353537A (en) * | 1965-08-11 | 1967-11-21 | George W Knox | Automatic multi-dosage inoculating instrument |
US3424154A (en) * | 1965-11-08 | 1969-01-28 | Charles W Kinsley | Injection system |
US3461867A (en) * | 1966-03-14 | 1969-08-19 | Mizzy Inc | Needleless injector |
US3526225A (en) * | 1967-03-31 | 1970-09-01 | Tokyo Sokuhan Kk | Jet-type hypodermic injection device |
US3527212A (en) * | 1967-09-13 | 1970-09-08 | Wesley D Clark | Disposable needleless hypodermic injector |
US3521633A (en) * | 1967-11-13 | 1970-07-28 | Scherer Corp R P | Brake device for hypodermic jet injector |
US3476110A (en) * | 1967-11-13 | 1969-11-04 | Scherer Corp R P | Crank for loading hypodermic jet injector |
US3490451A (en) * | 1967-11-13 | 1970-01-20 | Scherer Corp R P | Hypodermic jet injector nozzle |
US3518990A (en) * | 1968-05-02 | 1970-07-07 | Oscar H Banker | Gun type inoculator |
US3507276A (en) * | 1968-08-28 | 1970-04-21 | Murray B Burgess | Jet injector |
US3561443A (en) * | 1968-09-06 | 1971-02-09 | Oscar H Banker | Inoculator gun with delayed action |
US3557784A (en) * | 1968-12-24 | 1971-01-26 | Walter A Shields | Syringe |
US3625208A (en) * | 1969-05-19 | 1971-12-07 | Mediquip Corp | Apparatus for pressure-administering medicaments |
US3688765A (en) * | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
US3659587A (en) * | 1970-06-30 | 1972-05-02 | Affiliated Hospital Prod | Valved connector arrangement |
US3838689A (en) * | 1970-11-04 | 1974-10-01 | M Cohen | Disposable syringe with slit valve |
US3714943A (en) * | 1970-12-01 | 1973-02-06 | H Yanof | Medicament injectors |
US3805783A (en) * | 1971-02-12 | 1974-04-23 | A Ismach | Hand powered hypodermic jet injector gun |
US3783895A (en) * | 1971-05-04 | 1974-01-08 | Sherwood Medical Ind Inc | Universal parenteral fluid administration connector |
US3768472A (en) * | 1972-02-07 | 1973-10-30 | M Hodosh | Fluid dispensing gun |
US3779371A (en) * | 1972-03-13 | 1973-12-18 | W Rovinski | Package of separated materials to be mixed |
DE2254153A1 (de) | 1972-11-04 | 1974-05-09 | Werner Dipl Ing Kullmann | Selbsttaetiges, universelles injektionsgeraet |
US3782380A (en) * | 1973-01-04 | 1974-01-01 | Gaast H V D | Medicament injecting device |
US3827601A (en) * | 1973-03-23 | 1974-08-06 | J Magrath | Hand powered liquid dispenser of the metering type |
US3908651A (en) * | 1974-05-17 | 1975-09-30 | Daystrol Scient Inc | Medicament injection device |
US3938520A (en) * | 1974-06-10 | 1976-02-17 | Abbott Laboratories | Transfer unit having a dual channel transfer member |
US3945383A (en) * | 1974-08-08 | 1976-03-23 | Smithkline Corporation | Unit dose ampul for jet injector |
US3945379A (en) * | 1974-08-08 | 1976-03-23 | Smithkline Corporation | Injection device |
JPS51130094A (en) * | 1975-05-08 | 1976-11-12 | Asahi Chemical Ind | Twoostage pressure injector |
US4141675A (en) * | 1975-12-22 | 1979-02-27 | Physics International Company | Gas-actuated fuel pump wherein the pump piston is driven by a spring |
US4089334A (en) * | 1976-10-07 | 1978-05-16 | Schwebel Paul R | Pyrotechnically powered needleless injector |
DE2817102C2 (de) * | 1978-04-19 | 1985-01-24 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Anschlußstück für Kunststoffkanülen oder Venenkatheter |
US4328802A (en) * | 1980-05-14 | 1982-05-11 | Survival Technology, Inc. | Wet dry syringe package |
GB2084704B (en) | 1980-10-01 | 1983-06-29 | Theobald David Reginald | Air rifle |
US4373559A (en) * | 1980-12-04 | 1983-02-15 | Abbott Laboratories | Apparatus for pressurizing an additive transfer device |
JPS57103947A (en) * | 1980-12-18 | 1982-06-28 | Kuroda Precision Ind Ltd | Pneumatic shock absorber |
US4421508A (en) * | 1981-02-24 | 1983-12-20 | Cohen Edgar C | Vacuum-compression injector |
US4436519A (en) | 1981-05-28 | 1984-03-13 | Argon Medical Corp. | Removable hemostasis valve |
US4447225A (en) * | 1982-03-22 | 1984-05-08 | Taff Barry E | Multidose jet injector |
CA1178503A (en) | 1982-05-27 | 1984-11-27 | Health-Mor Personal Care Corporation | Needleless hypodermic injector |
US4507113A (en) * | 1982-11-22 | 1985-03-26 | Derata Corporation | Hypodermic jet injector |
US4505709A (en) * | 1983-02-22 | 1985-03-19 | Froning Edward C | Liquid transfer device |
US4518385A (en) * | 1983-06-13 | 1985-05-21 | Preci-Tech Ltd. | Disposable syringe for needleless injector |
HU186718B (en) | 1983-06-29 | 1985-09-30 | Radelkis Electrokemiai | Automatic needleless syringe operable by cardox cylinder suitable for personal giving injection e.g. insulin |
US4561856A (en) | 1983-08-18 | 1985-12-31 | Cochran Ulrich D | Infusion pump |
DE3444817A1 (de) | 1984-01-20 | 1985-07-25 | Rasmussen Gmbh, 6457 Maintal | Steckkupplung |
US4619651A (en) | 1984-04-16 | 1986-10-28 | Kopfer Rudolph J | Anti-aerosoling drug reconstitution device |
US4588403A (en) | 1984-06-01 | 1986-05-13 | American Hospital Supply Corporation | Vented syringe adapter assembly |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
GB2173287B (en) | 1985-04-01 | 1988-08-10 | Utec Bv | Air weapon air compression system |
US4675020A (en) | 1985-10-09 | 1987-06-23 | Kendall Mcgaw Laboratories, Inc. | Connector |
US4662878A (en) | 1985-11-13 | 1987-05-05 | Patents Unlimited Ltd. | Medicine vial adaptor for needleless injector |
US4680027A (en) | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
US4744786A (en) | 1986-06-17 | 1988-05-17 | Cordis Corporation | Infusion pump |
EP0250022A3 (en) | 1986-06-17 | 1988-06-22 | SICIM SpA | Portable endermic injector |
US4753316A (en) | 1986-06-26 | 1988-06-28 | Hydroacoustics Inc. | Seismic source |
US4722728A (en) | 1987-01-23 | 1988-02-02 | Patents Unlimited, Ltd. | Needleless hypodermic injector |
IT1217047B (it) | 1987-03-19 | 1990-03-14 | Cocchi Pietro | Siringa per iniezioni,in specie endovenose,realizzata per poteressere usata una sola volta,senza possibilita' di riaspirazione. |
USD304616S (en) | 1987-04-30 | 1989-11-14 | Derata Corporation | Medicament injector |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4768568A (en) | 1987-07-07 | 1988-09-06 | Survival Technology, Inc. | Hazardous material vial apparatus providing expansible sealed and filter vented chambers |
US4874367A (en) | 1988-02-05 | 1989-10-17 | Marpam International, Inc. | Hypodermic jet injector and cartridge therefor |
US5073165A (en) | 1988-02-05 | 1991-12-17 | Marpam International, Inc. | Hypodermic jet injector and cartridge therefor |
EP0333967B1 (en) | 1988-03-25 | 1992-11-25 | DEMATEX DEVELOPMENT & TRADING INC. c/o QUIJANO AND ASSOCIATES | Tube, stopper and compression ring for blood sampling systems |
DE8806642U1 (ja) | 1988-05-20 | 1988-09-08 | Stabilus Gmbh, 5400 Koblenz, De | |
DE3818811A1 (de) | 1988-06-03 | 1989-12-14 | Stabilus Gmbh | Gasfeder mit mehreren hintereinander angeordneten druckraeumen |
US5024656A (en) * | 1988-08-30 | 1991-06-18 | Injet Medical Products, Inc. | Gas-pressure-regulated needleless injection system |
US4950240A (en) | 1988-10-04 | 1990-08-21 | Greenwood Eugene C | Hypodermic syringe for single use |
JPH02212768A (ja) | 1989-02-13 | 1990-08-23 | Terumo Corp | 採液管 |
US5188599A (en) | 1989-07-11 | 1993-02-23 | Med-Design, Inc. | Retractable needle system |
DE3923513A1 (de) | 1989-07-15 | 1991-01-24 | Stabilus Gmbh | Verfahren und vorrichtung zum einbringen von druckgas in das behaelterrohr einer pneumatischen feder oder dergleichen |
CA1325149C (en) | 1989-08-31 | 1993-12-14 | Gavin Mcgregor | Variable intensity remote controlled needleless injector |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
AU6550990A (en) | 1989-11-09 | 1991-05-16 | Bioject, Inc. | Needleless hypodermic injection device |
US5031266A (en) | 1989-12-21 | 1991-07-16 | Whirlpool Corporation | Vacuum cleaner wand seal |
US4989905A (en) | 1990-02-05 | 1991-02-05 | Lamson & Sessions Co. | Fitting for corrugated tubing |
US5062830A (en) | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
GB9012829D0 (en) | 1990-06-08 | 1990-08-01 | Bernard D J C | Reduced diameter dummy piston |
GB9017007D0 (en) | 1990-08-02 | 1990-09-19 | Bernard Derek J C | Improvements to pre-charged pneumatic airguns |
GB9020749D0 (en) | 1990-09-24 | 1990-11-07 | Bates William T D | Improved single-use syringe |
DE4038010A1 (de) | 1990-11-29 | 1992-06-04 | Stabilus Gmbh | Hydraulisch verstellbare lenksaeule |
CA2032830C (en) | 1990-12-20 | 1994-07-26 | Robert Graham Straghan | Coupling |
GB9103291D0 (en) | 1991-02-15 | 1991-04-03 | Waverley Pharma Ltd | Transfer adaptor |
US5085332B1 (en) | 1991-04-11 | 1994-04-05 | Gettig Technologies Inc | Closure assembly |
IL98036A0 (en) | 1991-05-02 | 1992-06-21 | Yoav Cohen | Plastic stand pipe support for load-bearing adjustable piston |
GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
DE4129271C1 (ja) | 1991-09-03 | 1992-09-17 | Fresenius Ag, 6380 Bad Homburg, De | |
US5356380A (en) | 1991-10-23 | 1994-10-18 | Baxter International Inc. | Drug delivery system |
US5181912A (en) | 1991-12-05 | 1993-01-26 | Roy Hammett | Non-reusable syringe |
US5209362A (en) | 1992-01-24 | 1993-05-11 | Lutzker Robert S | Can resealer |
US5165560A (en) | 1992-03-26 | 1992-11-24 | Genesis Industries, Inc. | Nonrotating hermetically sealed closure for bottle containing liquid |
US5312577A (en) | 1992-05-08 | 1994-05-17 | Bioject Inc. | Method for manufacturing an ampule |
JP2931715B2 (ja) | 1992-05-12 | 1999-08-09 | 三菱電機株式会社 | 樹脂封止方法、樹脂封止装置、及びガススプリング |
JPH05317383A (ja) | 1992-05-19 | 1993-12-03 | Nissho Corp | 薬剤容器との連通手段を備えた溶解液容器 |
US5279576A (en) * | 1992-05-26 | 1994-01-18 | George Loo | Medication vial adapter |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
USD349958S (en) | 1992-07-24 | 1994-08-23 | Bioject Inc. | Needleless injector |
US5304128A (en) | 1992-09-22 | 1994-04-19 | Habley Medical Technology Corporation | Gas powered self contained syringe |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
AU5293393A (en) | 1992-09-28 | 1994-04-26 | Equidyne Systems, Incorporated | Hypodermic jet injector |
US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
US5292308A (en) | 1993-05-04 | 1994-03-08 | Ryan Dana W | Three piece intravenous line connector |
US5344125A (en) | 1993-09-17 | 1994-09-06 | Diebolt International, Inc. | Gas spring with filler valve |
US5352203A (en) | 1994-03-31 | 1994-10-04 | Vallelunga Anthony J | Aspirating non-reuseable syringe |
US5509912A (en) | 1994-10-24 | 1996-04-23 | Vlv Associates | Connector |
-
1995
- 1995-01-09 US US08/369,812 patent/US5599302A/en not_active Expired - Lifetime
-
1996
- 1996-01-11 AU AU46935/96A patent/AU4693596A/en not_active Abandoned
- 1996-01-11 DE DE69627474T patent/DE69627474D1/de not_active Expired - Lifetime
- 1996-01-11 WO PCT/US1996/000086 patent/WO1996021482A2/en active IP Right Grant
- 1996-01-11 EP EP96902588A patent/EP0802809B1/en not_active Expired - Lifetime
- 1996-01-11 JP JP52172796A patent/JPH10512165A/ja not_active Ceased
- 1996-01-11 AT AT96902588T patent/ATE237380T1/de not_active IP Right Cessation
- 1996-01-25 TW TW85100851A patent/TW387814B/zh active
-
1997
- 1997-01-09 US US08/780,920 patent/US5919159A/en not_active Expired - Fee Related
- 1997-01-09 US US08/780,918 patent/US5846233A/en not_active Expired - Lifetime
- 1997-01-09 US US08/780,917 patent/US5891085A/en not_active Expired - Fee Related
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003529417A (ja) * | 2000-03-23 | 2003-10-07 | アンタレス・ファーマ・インコーポレーテッド | 1回限り使用の使い捨て型ジェット注射器 |
JP2012183337A (ja) * | 2000-03-23 | 2012-09-27 | Antares Pharma Inc | 1回限り使用の使い捨て型ジェット注射器 |
JP2003033434A (ja) * | 2001-07-23 | 2003-02-04 | Shimadzu Corp | 針無注射器 |
JP2006297100A (ja) * | 2004-05-25 | 2006-11-02 | Tecpharma Licensing Ag | 保護されたプライミング装置を備える投与装置 |
JP2012035099A (ja) * | 2004-12-01 | 2012-02-23 | Acushot Inc | 無針注射装置 |
JP2009539436A (ja) * | 2006-06-07 | 2009-11-19 | アキュショット インク | 無針注射器用の充薬機構 |
KR101386532B1 (ko) * | 2006-06-07 | 2014-04-17 | 아큐샷 인크. | 무바늘 주사기를 위한 충전 기구 |
JP2010527639A (ja) * | 2007-02-14 | 2010-08-19 | デピュー ミテック インコーポレイテッド | 損傷した骨組織を修復するために骨プラグを採取および移植するための外科用工具として特に有用な、工具を方向付けるための器具 |
US8764753B2 (en) | 2007-02-14 | 2014-07-01 | Depuy Mitek Inc. | Implement for orientating a tool, particularly useful in surgical tools for harvesting and implanting bone plugs to repair damaged bone tissue |
JP2016221342A (ja) * | 2011-01-10 | 2016-12-28 | ゾゲニクス インコーポレーティッド | 改善された無針注射器 |
WO2016163348A1 (ja) * | 2015-04-10 | 2016-10-13 | 株式会社ダイセル | 注射器 |
JP2016198328A (ja) * | 2015-04-10 | 2016-12-01 | 株式会社ダイセル | 注射器 |
US10894130B2 (en) | 2015-04-10 | 2021-01-19 | Daicel Corporation | Syringe |
WO2020138476A1 (ja) * | 2018-12-27 | 2020-07-02 | 株式会社ダイセル | 無針注射器 |
JPWO2020138476A1 (ja) * | 2018-12-27 | 2021-09-27 | 株式会社ダイセル | 無針注射器 |
Also Published As
Publication number | Publication date |
---|---|
US5599302A (en) | 1997-02-04 |
EP0802809B1 (en) | 2003-04-16 |
US5919159A (en) | 1999-07-06 |
EP0802809A2 (en) | 1997-10-29 |
US5846233A (en) | 1998-12-08 |
AU4693596A (en) | 1996-07-31 |
WO1996021482A2 (en) | 1996-07-18 |
WO1996021482A3 (en) | 1996-09-12 |
DE69627474D1 (de) | 2003-05-22 |
TW387814B (en) | 2000-04-21 |
US5891085A (en) | 1999-04-06 |
ATE237380T1 (de) | 2003-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH10512165A (ja) | 気体スプリングを有する医療用注入システム | |
US11878147B2 (en) | Needle-less injector and method of fluid delivery | |
JP2781719B2 (ja) | 使い捨て無針注射器 | |
US6673034B2 (en) | Gas power sources for a needle-less injector and needle-less injectors incorporating the same | |
US5643211A (en) | Nozzle assembly having a frangible plunger | |
EP0973567B1 (en) | Jet injector | |
RU2179864C2 (ru) | Безыгольный инъектор | |
EP2023981B1 (en) | Charging mechanism for a needle-free injector | |
US5697917A (en) | Nozzle assembly with adjustable plunger travel gap | |
US7862543B2 (en) | Drug delivery system | |
US20050192530A1 (en) | Method and apparatus for needle-less injection with a degassed fluid | |
JP2001505069A (ja) | 調整可能なプランジャ移動ギャップを備えたノズル組立体 | |
US20070021716A1 (en) | Nozzle device with skin stretching means | |
WO1995031235A1 (en) | Modular automatic or manual emergency medicine injection system | |
CN101072604A (zh) | 用于输送肾上腺素的方法和器械 | |
MX2007006251A (es) | Metodo y aparato para entregar la epinefrina. | |
WO1997031664A1 (en) | Frangible plunger for nozzle assembly | |
WO1995016481A1 (en) | Medical jet injector for administering injections without a needle | |
CA1258019A (en) | Actuator for needleless disposable syringe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A72 | Notification of change in name of applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A721 Effective date: 20040804 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050517 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050817 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20051003 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20060105 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20060425 |