US3115133A - Needleless prefilled disposable hypodermic injector - Google Patents

Needleless prefilled disposable hypodermic injector Download PDF

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US3115133A
US3115133A US194893A US19489362A US3115133A US 3115133 A US3115133 A US 3115133A US 194893 A US194893 A US 194893A US 19489362 A US19489362 A US 19489362A US 3115133 A US3115133 A US 3115133A
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casing
stopper
cartridge
medicament
chamber
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Morando Emilio Donald
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase

Definitions

  • This invention relates to a hypodermic injection device of the type wherein the injections of medicament are made without the piercing of the body tissues with a needle; and
  • the invention contemplates a hypodermic injection device of this character wherein the medicament is expelled from an ampule or cartridge t irough an orifice at high velocity under pressure of a gas.
  • An important object of the invention is to provide an hypodermic injection device of this character which shall embody novel and improved features of construction whereby the medicament is released from the ampule or cartridge automatically upon pressure of a part of the device bearing the orifice against the surface, for example, the skin of a human body, through which the injection is to be made.
  • Another object is to provide such an injection device which shall include a novel and improved combination of a casing, a glass cartridge or ampule and a chamber within said casing for gas under pressure wherein at all times the pressure inside and outside the cartridge shall be maintained substantially equal to reduce the possibility of breaking of the cartridge during handling and operation of the device.
  • Still another object of the invention is to provide a hypodermic injection device which includes a novel and improved construction and combination of a casing having a chamber therein for gas under pressure, a medicament containing cartridge or ampule having a puncturable end wall, and means associated with the casing for automatically puncturing said wall to permit the release of the medicament from the cartridge or ampule upon simple pressure of a portion of the casing against the surface through which an injection is to be made.
  • FIGURE 1 is a longitudinal sectional view through a hypodermic injection device embodying one form of the invention, showing the parts in normal position and condition ready for use;
  • FIGURE 2 is a similar View showing the operation of the parts during use of the device
  • FIGURE 3 is a horizontal sectional view on the plane of the line 3-5 of FIGURE 1;
  • FIGURE 4 is a view similar to FIGURE 1 showing a modification of the device
  • FIGURE 5 is a view similar to FIGURE 2 showing the modification of FIGURE 4 in use;
  • FIGURE 6 is a fragmentary view similar to FIGURE 5 but showing the operation of the device for releasing the gas pressure after an injection has been made;
  • FIGURE 7 is a horizontal sectional view on the plane of the line 77 of FIGURE 4.
  • the reference character A designates a cylindrical, tubular casing formed of suitable material in which is mounted a cylindrical, preferably glass, ampule or cartridge B which includes a tube 1, preferably of glass, which contains a liquid medicament C between a rubber stopper 2 that closes one end of the glass tube, and a rubber piston 3 which is slidable in the giass tube in liquid-tight contact with the walls thereof, said piston being actuatable by gas under pressure from a capsule D disposed within the casing, for ejecting the liquid medicament from the cartridge through a cannula 4 and a trigger-contactor E when the latter is pressed against a surface through which injection is to be made, such as the skin of a person that is indicated by the dotand-dash lines and designated F in FIGURE 2.
  • a cylindrical, preferably glass, ampule or cartridge B which includes a tube 1, preferably of glass, which contains a liquid medicament C between a rubber stopper 2 that closes one end of the glass tube, and a rubber piston
  • the stopper 2 tightly fits into the end of the glass tube 1 and has a perimetral flange 6 at one end thereof abutting the end of the glass tube and itself abutted by a rigid disc 7 over the edge of which the end portion of the casing A is inturned as indicated at 8 for holding the stopper and the cartridge firmly against displacement from the casing.
  • the trigger-contactor E is shown in the form of a cup having a bottom wall 9 and a cylindrical side wall l9 encircling and longitudinally slidably fitted on the end of the casing outwardly of said stopper 2 and having one end portion of the cannula d rigidly secured in the bottom wall thereof providing an orifice terminating in the outer surface of said wall and the other end portion extending into the cup and partially penetrating the rubber stopper 2 as shown in FIGURE 1 with the bottom wall 9 spaced a sufficient distance from the end 8 of the casing to permit the cannula to completely pass through the stopper upon contact of the trigger-contactor with the surface F and exertion of longitudinal pressure on the casing sufiicient to cause the casing to slide downwardly into the triggercontactor from the position shown in FIGURE 1 to the position shown in FIGURE 2.
  • the inner end of the cannula extends into the glass tube 1 so that tr e liquid in the tube can be ejected through the cannula under pressure and at sutficiently high velocity to cause the liquid to penetrate the skin of a person indicated at F in FIGURE 2.
  • the liquid medicament is ejected under the influence of gas under pressure in the capsule I) which may be generally of known construction and normally may be disposed with one end resting on the piston 3 as shown in FIGURE 1 with its other end closed by a plug lit which may be punctured or pushed into the capsule by a pin 12 which is mounted in the end wall of an internally screw-threaded cap 13 which in turn is screwed on an externally screw-threaded closure plug 14 for the end of the casing A opposite the stopper 2.
  • the closure plug has a perimetral end flange 15 over which the corresponding end of the casing A is inturned as indicated at 16 to firmly hold the plug from displacement from the casing.
  • the pin 12 is longitudinally loosely slidable in an axial opening 17 in the closure plug and preferably has its inner end pointed to penetrate a rubber safety seal disc 18 that is disposed at the inner end of the closure plug 14 and has a slit 19 in line with the pin E2.
  • the slit IR is such that the disc will normally seal the gas chamber within the casing under the normal gas pressure to be used in making an injection of the medicament, but will facilitate the penetration of the disc by the pin 12 for the purpose of puncturing or displacing the plug II of the capsule D when the cap 13 is rotated to move the pin longitudinally into the casing as shown in FIGURE 2.
  • the gas in the capsule quickly flows into the chamber within the casing A and against the piston 3 so as to eject the medicament through the cannula i, and the rubber disc with the pin seated in the slit will prevent the escape of gas.
  • the slit 19 will permit the gas under the excess pressure to escape and thus prevent damage to the injection device and injury to the persons in the vicinity of the device.
  • the glass tube l is spaced from the walls of the casing so that when the gas is released from the capsule, the glass tube is supported against cracking or damage by the equal pressures externally and internally of the tube.
  • the casing is grasped and the trigger-contactor is gently pressed into contact W the surface F through which the injection is to be made, with sufficient pressure applied to the casing to cause the cannula 4 to pass through the stopper 2, whereupon the gas under pressure will force the liquid medicament through the cannula at high velocity and through the surface F. It will be observed that none of the liquid medicament is released from the cartridge until the cannula has penetrated the stopper; thus no liquid enters the cannula until the moment of the injection.
  • the gas may be released from the casing after the injection by manipulation of the cap 13 to withdraw the pin 12 from the slit 19 so that the gas may escape through the slit and through the opening 17 of the closure plug in which the pin 12. is slidable.
  • FIGURES 4 through 7 A modification of the invention is shown in FIGURES 4 through 7 wherein instead of utilizing a gas filled capsule, the gas under pressure is injected directly into the chamber within the casing, and the trigger-contactor is so associated with the casing that the cannula may provide both a discharge orifice for a medicament in the cartridge and also as a vent for the gas pressure after the injection has been completed.
  • this form of the injection device includes a cylindrical tubular main casing G Within which is a medicament cartridge H that may be identical with the cartridge B including a cylindrical glass tube 2%) one end of which is closed by a rubber stopper 211 between which and the inturncd flange 22 of the casing is a rigid disc 23 having an axial opening 24- therein to permit the cannula to penetrate the stopper.
  • a piston 25 is slidable in the glass tube to eject the medicament I from the cartridge under gas pressure.
  • the rigid disc 26 is fixedly secured in the end of the casing and has an opening 27 to which may be connected a hose or conduit for supplying the gas under pressure to the chamber wit the casing. After the chamber in the casing has been charged to the desired pressure, the opening 27 is closed, for example, by a disc of fusable metal.
  • the trigger-contactor K is cup-shaped having a bottom wall 29 and a cylindrical side wall 39 that is slidably mounted on the casing in encircling relation thereto.
  • the trigger-contactor has a cannula ll s cured in an extending through the bottom wall 2? and projecting into the cup.
  • the bottom wall of the cup is normally spaced from the stopper 21 at such a distance that the inner end of the cannula clears the stopper 21 but so that the trigger-contactor can be pushed onto the casing to cause the cannula to puncture the stopper and release the medicament from the cartridge through the cannula as shown in FIGURE of the drawings.
  • the inner surface of the side wall of the trigger-contactor has an inwardly extending projection that is shown in the form 32 to initially abut the end of the and the movement of the cannula through the sto as shown in FIGURE 2 during the injection operation, but the rib and the side wall of the trigger-contactor are of such nature that upon further forcing of the trig s. contactor onto the casing, the rib will slip past the end or" the casing and permit the trigger-contactor to be pushed further onto the casing with the inner end or" the cannula projecting beyond the inner end of the stopper ill.
  • the side wall of the triggercontactor can be formed or resilient or slightly elastic material such as polyethylene so that it will slightly yield to permit the projection to slip past the end of the casing or the material of the trigger-contactor might be such as to permit the projection to be sheared off as the triggercontactor is forcibly pushed onto the casing.
  • both forms of the invention constitute hypodermic injectors that are prefilled with the medicament and gas under pressure, are ueedleiess so that the medicament can be ejected from an injection orifice at high velocity simply by pressiu the trigger-contractor into contact with the body to receive the injection, and can be economically manufactured so that they can be used once and then thrown away.
  • a hypodermic injector comprising the combination of a casing having therein a medicament cartridge including a tube and means associated therewith provided with a penetrable stopper closing one end of said casing and the corresponding end of said tube, and a triggercontactor axially slidably mounted on said casing at said end thereof and provided with a wall disposed outwardly of said stopper to move toward and away therefrom and having a cannula one end portion of which is rigidly secured on said wall providing an orifice terminating in the outer surface of said wall, the other end portion of the cannula projecting inwardly of said wall to penetrate said stopper and provide for discharge of said medicament from said cartridge upon relative movement of said casing and said trigger-contractor incident to pressing the latter against a body to receive an injection, and means to edect such discharge of the medicament at high velocity.
  • a hypodermic injector as defined in claim 1 Wherein said casing has a chamber in which said cartridge is disposed and said cartridge has its other end opening into said chamber and has a piston therein, and the lastnamed means comprises a normally sealed gas-containing capsule in said chamber, and means at the end of the casing opposite said trigger-contactor for opening said capsule to release gas under pressure into said chamber.
  • a hypodermic injector as defined in claim 1 wherein said casing has a chamber containing gas under a predetermined pressure, and with the addition of safety means operable upon occurrence of excessive pressure in said chamber to vent said gas from the chamber.
  • a hypodermic injector as defined in claim 1 wherein said cartridge is open at its other end and has a piston therein, and the last-named means includes a chamber containing gas under pressure which urges said piston toward said stopper to eject said liquid and with the addition of means for releasing gas from said chamber after completion of an injection.
  • a hypodermic injector as defined in claim 1 wherein said cartridge has its other end opening into said chamber and has a piston therein, the last-named means comprises a normally sealed capsule in said chamber containing gas at a predetermined pressure, the end of said chamber opposite said trigger-contactor having a safety sealing disc secured therein normally closing said chamber and formed with a slit and providing for sealing of the chamber against escape of gas under said predetermined normal pressure, said capsule having openable sealing means, and with the addition of means including a pin mounted at the second-mentioned end of the casing and movable longitudinally into the casing through said sealing means for opening said capsule to release gas pressure therefrom into said chamber and coacting with said sealing disc to retain said pressure in the chamber, said disc providing for release of gas under excessive pressure from the chamber through said slit in the sealing disc.
  • a hypodermic injector as defined in claim 1 wherein said cartridge is open at its other end and has a piston therein, and the last-named means includes a chamber containing gas under pressure which urges said piston toward said stopper to eject said liquid, and said tube of the cartridge is spaced throughout its length from the wall of the casing so that the gas pressure inside and outside said tube shall be approximately equal to reduce the possibility of breakage of said tube.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

Dec. 24, 1963 E. D. MORANDO NEEDLELESS PREFILLED DISPOSABLE HYPODERMIC INJECTOR Filed May 15, 1962 2 Sheets-Sheet l INVENTOR,
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ATTORNEY Dec. 24, 1963 I MORANDO 3,115,133
NEEDLELESS PREFILLED DISPOSABLE HYPODERMIC INJECTOR Filed May 15, 1962 2 Sheets-Sheet 2 F 15.4 E -E-- 22 K ll 29 K 3/ 30 K 23 24 22 INVENTOR.
lwiiz'a pamldjl amna United States Patent 3,115,133 NEEDLELESS PREELJIJED DISIUSAELE HYI QBERMIC INIEC'IUR Emilio Donald Moi-audio, Qedar Grove, NJ. (691 El Mirador Drive, Fullerton, Calif.) Filed May 15, 1962, Ser. No. 194,893 9 Claims. (El. 123173) This invention relates to a hypodermic injection device of the type wherein the injections of medicament are made without the piercing of the body tissues with a needle; and
sore particularly the invention contemplates a hypodermic injection device of this character wherein the medicament is expelled from an ampule or cartridge t irough an orifice at high velocity under pressure of a gas.
An important object of the invention is to provide an hypodermic injection device of this character which shall embody novel and improved features of construction whereby the medicament is released from the ampule or cartridge automatically upon pressure of a part of the device bearing the orifice against the surface, for example, the skin of a human body, through which the injection is to be made.
Another object is to provide such an injection device which shall include a novel and improved combination of a casing, a glass cartridge or ampule and a chamber within said casing for gas under pressure wherein at all times the pressure inside and outside the cartridge shall be maintained substantially equal to reduce the possibility of breaking of the cartridge during handling and operation of the device.
Still another object of the invention is to provide a hypodermic injection device which includes a novel and improved construction and combination of a casing having a chamber therein for gas under pressure, a medicament containing cartridge or ampule having a puncturable end wall, and means associated with the casing for automatically puncturing said wall to permit the release of the medicament from the cartridge or ampule upon simple pressure of a portion of the casing against the surface through which an injection is to be made.
It is another object of the invention to provide in a hypodermic injection device operable by gas under pressure, novel and improved means to prevent injury to the device or to the operator thereof from excessive pressure within the device, such as might be caused, for example, by excessive heating of the device after filling of the gascontaining chamber.
Other objects, advantages and results of the invention will be brought out by the following description in conjunction with the accompanying drawings in which FIGURE 1 is a longitudinal sectional view through a hypodermic injection device embodying one form of the invention, showing the parts in normal position and condition ready for use;
FIGURE 2 is a similar View showing the operation of the parts during use of the device;
FIGURE 3 is a horizontal sectional view on the plane of the line 3-5 of FIGURE 1;
FIGURE 4 is a view similar to FIGURE 1 showing a modification of the device;
FIGURE 5 is a view similar to FIGURE 2 showing the modification of FIGURE 4 in use;
FIGURE 6 is a fragmentary view similar to FIGURE 5 but showing the operation of the device for releasing the gas pressure after an injection has been made; and
FIGURE 7 is a horizontal sectional view on the plane of the line 77 of FIGURE 4.
Specifically describing the embodiment of the invention shown in FIGURES 1 through 3 the reference character A designates a cylindrical, tubular casing formed of suitable material in which is mounted a cylindrical, preferably glass, ampule or cartridge B which includes a tube 1, preferably of glass, which contains a liquid medicament C between a rubber stopper 2 that closes one end of the glass tube, and a rubber piston 3 which is slidable in the giass tube in liquid-tight contact with the walls thereof, said piston being actuatable by gas under pressure from a capsule D disposed within the casing, for ejecting the liquid medicament from the cartridge through a cannula 4 and a trigger-contactor E when the latter is pressed against a surface through which injection is to be made, such as the skin of a person that is indicated by the dotand-dash lines and designated F in FIGURE 2. Preferably, as shown, the stopper 2 tightly fits into the end of the glass tube 1 and has a perimetral flange 6 at one end thereof abutting the end of the glass tube and itself abutted by a rigid disc 7 over the edge of which the end portion of the casing A is inturned as indicated at 8 for holding the stopper and the cartridge firmly against displacement from the casing.
Normally the trigger-contactor E is shown in the form of a cup having a bottom wall 9 and a cylindrical side wall l9 encircling and longitudinally slidably fitted on the end of the casing outwardly of said stopper 2 and having one end portion of the cannula d rigidly secured in the bottom wall thereof providing an orifice terminating in the outer surface of said wall and the other end portion extending into the cup and partially penetrating the rubber stopper 2 as shown in FIGURE 1 with the bottom wall 9 spaced a sufficient distance from the end 8 of the casing to permit the cannula to completely pass through the stopper upon contact of the trigger-contactor with the surface F and exertion of longitudinal pressure on the casing sufiicient to cause the casing to slide downwardly into the triggercontactor from the position shown in FIGURE 1 to the position shown in FIGURE 2. In the latter position, the inner end of the cannula extends into the glass tube 1 so that tr e liquid in the tube can be ejected through the cannula under pressure and at sutficiently high velocity to cause the liquid to penetrate the skin of a person indicated at F in FIGURE 2.
As hereinbefore indicated, the liquid medicament is ejected under the influence of gas under pressure in the capsule I) which may be generally of known construction and normally may be disposed with one end resting on the piston 3 as shown in FIGURE 1 with its other end closed by a plug lit which may be punctured or pushed into the capsule by a pin 12 which is mounted in the end wall of an internally screw-threaded cap 13 which in turn is screwed on an externally screw-threaded closure plug 14 for the end of the casing A opposite the stopper 2. As shown, the closure plug has a perimetral end flange 15 over which the corresponding end of the casing A is inturned as indicated at 16 to firmly hold the plug from displacement from the casing. The pin 12 is longitudinally loosely slidable in an axial opening 17 in the closure plug and preferably has its inner end pointed to penetrate a rubber safety seal disc 18 that is disposed at the inner end of the closure plug 14 and has a slit 19 in line with the pin E2. The slit IR is such that the disc will normally seal the gas chamber within the casing under the normal gas pressure to be used in making an injection of the medicament, but will facilitate the penetration of the disc by the pin 12 for the purpose of puncturing or displacing the plug II of the capsule D when the cap 13 is rotated to move the pin longitudinally into the casing as shown in FIGURE 2. When the plug ll has been punctured or displaced, the gas in the capsule quickly flows into the chamber within the casing A and against the piston 3 so as to eject the medicament through the cannula i, and the rubber disc with the pin seated in the slit will prevent the escape of gas.
However, should the gas pressure in the casing become 3 excessive, for exa lple, by overheating of the casing, the slit 19 will permit the gas under the excess pressure to escape and thus prevent damage to the injection device and injury to the persons in the vicinity of the device.
It will also be observed the glass tube l is spaced from the walls of the casing so that when the gas is released from the capsule, the glass tube is supported against cracking or damage by the equal pressures externally and internally of the tube.
The use or the device will be clear from the foregoing, but may be summarized. Assuming the cartridge B charged with medicament in any known manner and the gas capsule D have been secured in the casing A the gas-releasing cap 13 and the trigger-contactor E have been arranged in their normal positions as shown in PBS RE 1, when it is decided to make the injection, the gas-releasing cap 13 is screwed onto the plug closure 1 to displace the plug Ill from the gas chamber and release the gas into the casing. Thereupon, the casing is grasped and the trigger-contactor is gently pressed into contact W the surface F through which the injection is to be made, with sufficient pressure applied to the casing to cause the cannula 4 to pass through the stopper 2, whereupon the gas under pressure will force the liquid medicament through the cannula at high velocity and through the surface F. It will be observed that none of the liquid medicament is released from the cartridge until the cannula has penetrated the stopper; thus no liquid enters the cannula until the moment of the injection. The gas may be released from the casing after the injection by manipulation of the cap 13 to withdraw the pin 12 from the slit 19 so that the gas may escape through the slit and through the opening 17 of the closure plug in which the pin 12. is slidable.
A modification of the invention is shown in FIGURES 4 through 7 wherein instead of utilizing a gas filled capsule, the gas under pressure is injected directly into the chamber within the casing, and the trigger-contactor is so associated with the casing that the cannula may provide both a discharge orifice for a medicament in the cartridge and also as a vent for the gas pressure after the injection has been completed.
More particularly, this form of the injection device includes a cylindrical tubular main casing G Within which is a medicament cartridge H that may be identical with the cartridge B including a cylindrical glass tube 2%) one end of which is closed by a rubber stopper 211 between which and the inturncd flange 22 of the casing is a rigid disc 23 having an axial opening 24- therein to permit the cannula to penetrate the stopper. A piston 25 is slidable in the glass tube to eject the medicament I from the cartridge under gas pressure.
Gas under pressure from a suitable source is injected into the end of the casing G opposite the stopper 21, and for this purpose, the rigid disc 26 is fixedly secured in the end of the casing and has an opening 27 to which may be connected a hose or conduit for supplying the gas under pressure to the chamber wit the casing. After the chamber in the casing has been charged to the desired pressure, the opening 27 is closed, for example, by a disc of fusable metal.
The trigger-contactor K is cup-shaped having a bottom wall 29 and a cylindrical side wall 39 that is slidably mounted on the casing in encircling relation thereto. The trigger-contactor has a cannula ll s cured in an extending through the bottom wall 2? and projecting into the cup. The bottom wall of the cup is normally spaced from the stopper 21 at such a distance that the inner end of the cannula clears the stopper 21 but so that the trigger-contactor can be pushed onto the casing to cause the cannula to puncture the stopper and release the medicament from the cartridge through the cannula as shown in FIGURE of the drawings. The inner surface of the side wall of the trigger-contactor has an inwardly extending projection that is shown in the form 32 to initially abut the end of the and the movement of the cannula through the sto as shown in FIGURE 2 during the injection operation, but the rib and the side wall of the trigger-contactor are of such nature that upon further forcing of the trig s. contactor onto the casing, the rib will slip past the end or" the casing and permit the trigger-contactor to be pushed further onto the casing with the inner end or" the cannula projecting beyond the inner end of the stopper ill. With this construction when the piston 25 reaches the limit of its movement during the liquid-ejecting operation, it will abut the end of the stopper and can be punctured by the cannula so that the cannula will serve as a vent for the gas pressure in the casing and in the cartridge, as best shown in FIGURE 6. It will be understood by those skilled in the art that the side wall of the triggercontactor can be formed or resilient or slightly elastic material such as polyethylene so that it will slightly yield to permit the projection to slip past the end of the casing or the material of the trigger-contactor might be such as to permit the projection to be sheared off as the triggercontactor is forcibly pushed onto the casing.
From the foregoing, it will be seen that both forms of the invention constitute hypodermic injectors that are prefilled with the medicament and gas under pressure, are ueedleiess so that the medicament can be ejected from an injection orifice at high velocity simply by pressiu the trigger-contractor into contact with the body to receive the injection, and can be economically manufactured so that they can be used once and then thrown away.
Modifications and changes in the construction of the injection device will occur to those skilled in the art as being within the spirit and scope of the invention.
Iclaim:
l. A hypodermic injector comprising the combination of a casing having therein a medicament cartridge including a tube and means associated therewith provided with a penetrable stopper closing one end of said casing and the corresponding end of said tube, and a triggercontactor axially slidably mounted on said casing at said end thereof and provided with a wall disposed outwardly of said stopper to move toward and away therefrom and having a cannula one end portion of which is rigidly secured on said wall providing an orifice terminating in the outer surface of said wall, the other end portion of the cannula projecting inwardly of said wall to penetrate said stopper and provide for discharge of said medicament from said cartridge upon relative movement of said casing and said trigger-contractor incident to pressing the latter against a body to receive an injection, and means to edect such discharge of the medicament at high velocity.
2. A hypodermic injector as defined in claim 1 wherein said cartridge is open at its other end and has a piston therein, and the last-named means includes a chamber containing gas under pressure which urges said piston toward said stopper to eject said liquid.
3. A hypodermic injector as defined in claim 1 Wherein said casing has a chamber in which said cartridge is disposed and said cartridge has its other end opening into said chamber and has a piston therein, and the lastnamed means comprises a normally sealed gas-containing capsule in said chamber, and means at the end of the casing opposite said trigger-contactor for opening said capsule to release gas under pressure into said chamber.
4. A hypodermic injector as defined in claim 1 wherein said casing has a chamber containing gas under a predetermined pressure, and with the addition of safety means operable upon occurrence of excessive pressure in said chamber to vent said gas from the chamber.
5. A hypodermic injector as defined in claim 1 wherein said cartridge is open at its other end and has a piston therein, and the last-named means includes a chamber containing gas under pressure which urges said piston toward said stopper to eject said liquid and with the addition of means for releasing gas from said chamber after completion of an injection.
6. A hypodermic injector as defined in claim 1 wherein said cartridge is open at its other end and has a piston therein, and the last-named means includes a chamber containing gas under pressure which urges said piston toward said stopper to eject said liquid and wherein said trigger-contactor is mounted for limited movement in one direction relative to the casing to puncture said stopper but is forcible farther in the same direction to enter said cartridge and puncture said piston after completion of an injection to release the gas from said chamber.
7. A hypodermic injector as defined in claim 1 wherein said cartridge has its other end opening into said chamber and has a piston therein, the last-named means comprises a normally sealed capsule in said chamber containing gas at a predetermined pressure, the end of said chamber opposite said trigger-contactor having a safety sealing disc secured therein normally closing said chamber and formed with a slit and providing for sealing of the chamber against escape of gas under said predetermined normal pressure, said capsule having openable sealing means, and with the addition of means including a pin mounted at the second-mentioned end of the casing and movable longitudinally into the casing through said sealing means for opening said capsule to release gas pressure therefrom into said chamber and coacting with said sealing disc to retain said pressure in the chamber, said disc providing for release of gas under excessive pressure from the chamber through said slit in the sealing disc.
8. A hypodermic injector as defined in claim 1 wherein said cartridge has its other end opening into said chamber and has a piston therein, the end of said chamber opposite said trigger-contactor having a safety sealing device comprising a rigid disc having an opening therein and a disc of material having a low melting point underlying said rigid disc and normally closing said opening, said disc of low melting point being fusable under excessive ambient temperature to release the gas under consequent excessive pressure from said chamber.
9. A hypodermic injector as defined in claim 1 wherein said cartridge is open at its other end and has a piston therein, and the last-named means includes a chamber containing gas under pressure which urges said piston toward said stopper to eject said liquid, and said tube of the cartridge is spaced throughout its length from the wall of the casing so that the gas pressure inside and outside said tube shall be approximately equal to reduce the possibility of breakage of said tube.
References Cited in the file of this patent UNITED STATES PATENTS 2,001,686 Moore et a1. May 14, 1935 2,545,017 Billingsley Mar. 13, 1951 2,605,763 Smoot Aug. 5, 1952 2,617,359 Van Horn et a1. Nov. 11, 1952 2,699,167 Raiche Ian. 11, 1955 2,754,818 Scherer July 17, 1956 2,854,925 Crockford et al Oct. 7, 1958 2,876,771 Dunmire Mar. 10, 1959 2,896,661 Becker et a1. July 28, 1959 2,940,446 Hein June 14, 1960

Claims (1)

1. A HYPODERMIC INJECTOR COMPRISING THE COMBINATION OF A CASING HAVING THEREIN A MEDICAMENT CARTRIDGE INCLUDING A TUBE AND MEANS ASSOCIATED THEREWITH PROVIDED WITH A PENETRABLE STOPPER CLOSING ONE END OF SAID CASING AND THE CORRESPONDING END OF SAID TUBE, AND A TRIGGERCONTACTOR AXIALLY SLIDABLY MOUNTED ON SAID CASING AT SAID END THEREOF AND PROVIDED WITH A WALL DISPOSED OUTWARDLY OF SAID STOPPER TO MOVE TOWARD AND AWAY THEREFROM AND HAVING A CANNULA ONE END PORTION OF WHICH IS RIGIDLY SECURED ON SAID WALL PROVIDING AN ORIFICE TERMINATING IN THE OUTER SURFACE OF SAID WALL, THE OTHER END PORTION OF THE CANNULA PROJECTING INWARDLY OF SAID WALL TO PENETRATE SAID STOPPER AND PROVIDE FOR DISCHARGE OF SAID MEDICAMENT FROM SAID CARTRIDGE UPON RELATIVE MOVEMENT OF SAID CASING AND SAID TRIGGER-CONTACTOR INCIDENT TO PRESSING THE LATTER AGAINST A BODY TO RECEIVE AN INJECTION, AND MEANS TO EFFECT SUCH DISCHARGE OF THE MEDICAMENT AT HIGH VELOCITY.
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Cited By (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433224A (en) * 1965-11-24 1969-03-18 Robert B Black Gas actuated hypodermic syringe
US3977401A (en) * 1975-03-25 1976-08-31 William Floyd Pike Injection apparatus
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
EP0197625A1 (en) * 1985-03-25 1986-10-15 Bioject, Inc. Hypodermic injection apparatus
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US4926859A (en) * 1985-12-04 1990-05-22 Field John E A medical treatment device for treating an undesired formation in a living body
US5009637A (en) * 1987-11-16 1991-04-23 Sy-Quest International Limited Apparatus for hypodermic injection of liquids
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5649912A (en) * 1994-03-07 1997-07-22 Bioject, Inc. Ampule filling device
WO1997031665A1 (en) * 1996-02-29 1997-09-04 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
WO1997036783A1 (en) 1996-04-01 1997-10-09 Medi-Ject Corporation Nozzle and adapter for loading an injector
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5704921A (en) * 1995-05-17 1998-01-06 Carilli; Brian D. Prefilled hypodermic syringe system
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5891086A (en) * 1993-07-31 1999-04-06 Weston Medical Limited Needle-less injector
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
EP0934754A3 (en) * 1998-02-05 1999-08-18 The BOC Group plc Needleless medical device for delivering of therapeutic agent
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
EP1265663A1 (en) * 2000-03-23 2002-12-18 Antares Pharma, Inc. Single use disposable jet injector
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US6689095B1 (en) 1999-04-22 2004-02-10 Gilbert Garitano Needleless permanent makeup and tattoo device
US20040074076A1 (en) * 2002-10-16 2004-04-22 Bioject Inc. Drug cartridge assembly and method of manufacture
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
US20040199106A1 (en) * 2002-06-04 2004-10-07 Sergio Landau Needle-free injection system
US20050267403A1 (en) * 2004-05-28 2005-12-01 Sergio Landau Needle-free injection system
WO2006073394A1 (en) * 2005-01-04 2006-07-13 Bioject Inc. Needle-free injection system
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US20070118094A1 (en) * 2005-05-03 2007-05-24 John Bingham Needle-less injector and method of fluid delivery
US20070191762A1 (en) * 2002-05-30 2007-08-16 Kerry Quinn Needleless injector and ampule system
US20080086079A1 (en) * 2006-10-06 2008-04-10 Bioject, Inc. Triggering mechanism for needle-free injector
US7416540B2 (en) 2004-11-22 2008-08-26 Intelliject, Llc Devices systems and methods for medicament delivery
US20080281261A1 (en) * 2005-05-03 2008-11-13 Genesis Medical Technologies, Inc. Needle-less injector
US7544188B2 (en) 2001-07-19 2009-06-09 Intelliject, Inc. Medical injector
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7744563B2 (en) 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
US7749194B2 (en) 2005-02-01 2010-07-06 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8221347B2 (en) 2004-12-01 2012-07-17 Acushot, Inc. Needle-free injector
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
EP2671605A1 (en) * 2011-02-04 2013-12-11 Daicel Corporation Needleless syringe
US8622973B2 (en) 2008-07-28 2014-01-07 Intelliject, Inc. Simulated medicament delivery device configured to produce an audible output
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8932252B2 (en) 2005-02-01 2015-01-13 Kaleo, Inc. Medical injector simulation device
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
US9433735B2 (en) 2011-12-13 2016-09-06 Pharmajet Inc. Needle-free intradermal injection device
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9542826B2 (en) 2012-12-27 2017-01-10 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
CN107580489A (en) * 2015-03-26 2018-01-12 因内博注射剂公司 The medicament transfer of gas-pressurized driving and settling flux apparatus and method
US10080848B2 (en) 2013-11-12 2018-09-25 Novo Nordisk A/S Drug delivery device with movable needle mount
US10332623B2 (en) 2017-01-17 2019-06-25 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
WO2020012178A1 (en) * 2018-07-10 2020-01-16 Pacifi Limited Method and apparatus
US10576206B2 (en) 2015-06-30 2020-03-03 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
US10688244B2 (en) 2016-12-23 2020-06-23 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10695495B2 (en) 2015-03-24 2020-06-30 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US11167087B2 (en) 2019-08-09 2021-11-09 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
WO2021225565A1 (en) * 2020-05-04 2021-11-11 Zhytariuk Ihor Tarasovych Single-use medical syringe
US11305056B2 (en) 2017-07-14 2022-04-19 Amgen Inc. Needle insertion-retraction system having dual torsion spring system
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2001686A (en) * 1932-04-23 1935-05-14 J W Moore Valve Corp Fusible safety device
US2545017A (en) * 1947-06-02 1951-03-13 Gordon D Billingsley Hypodermic syringe
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2617359A (en) * 1951-11-16 1952-11-11 George E Van Horn Hypodermic projectile
US2699167A (en) * 1952-04-25 1955-01-11 Paul A Raiche Hypodermic injector
US2754818A (en) * 1950-06-24 1956-07-17 Scherer Corp R P Hypo jet injector
US2854925A (en) * 1957-07-23 1958-10-07 Palmer Chemical & Equipment Co Projectile for delivery of drugs to animals
US2876771A (en) * 1951-09-28 1959-03-10 Dunmire Russell Paul Hypodermic syringes
US2896661A (en) * 1955-01-03 1959-07-28 Mine Safety Appliances Co Pressure relief valve
US2940446A (en) * 1958-02-26 1960-06-14 Becton Dickinson Co Hypodermic assembly

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2001686A (en) * 1932-04-23 1935-05-14 J W Moore Valve Corp Fusible safety device
US2545017A (en) * 1947-06-02 1951-03-13 Gordon D Billingsley Hypodermic syringe
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2754818A (en) * 1950-06-24 1956-07-17 Scherer Corp R P Hypo jet injector
US2876771A (en) * 1951-09-28 1959-03-10 Dunmire Russell Paul Hypodermic syringes
US2617359A (en) * 1951-11-16 1952-11-11 George E Van Horn Hypodermic projectile
US2699167A (en) * 1952-04-25 1955-01-11 Paul A Raiche Hypodermic injector
US2896661A (en) * 1955-01-03 1959-07-28 Mine Safety Appliances Co Pressure relief valve
US2854925A (en) * 1957-07-23 1958-10-07 Palmer Chemical & Equipment Co Projectile for delivery of drugs to animals
US2940446A (en) * 1958-02-26 1960-06-14 Becton Dickinson Co Hypodermic assembly

Cited By (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433224A (en) * 1965-11-24 1969-03-18 Robert B Black Gas actuated hypodermic syringe
US3977401A (en) * 1975-03-25 1976-08-31 William Floyd Pike Injection apparatus
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
EP0197625A1 (en) * 1985-03-25 1986-10-15 Bioject, Inc. Hypodermic injection apparatus
US4926859A (en) * 1985-12-04 1990-05-22 Field John E A medical treatment device for treating an undesired formation in a living body
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
US5009637A (en) * 1987-11-16 1991-04-23 Sy-Quest International Limited Apparatus for hypodermic injection of liquids
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
US5891086A (en) * 1993-07-31 1999-04-06 Weston Medical Limited Needle-less injector
US5649912A (en) * 1994-03-07 1997-07-22 Bioject, Inc. Ampule filling device
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5919159A (en) * 1995-01-09 1999-07-06 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5891085A (en) * 1995-01-09 1999-04-06 Medi-Ject Corporation Nozzle assembly with lost motion connection for medical injector assembly
US5704921A (en) * 1995-05-17 1998-01-06 Carilli; Brian D. Prefilled hypodermic syringe system
US6083197A (en) * 1995-12-19 2000-07-04 Umbaugh; Jerald C. Spring-actuated needleless injector
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
WO1997031665A1 (en) * 1996-02-29 1997-09-04 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5769138A (en) * 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
WO1997036783A1 (en) 1996-04-01 1997-10-09 Medi-Ject Corporation Nozzle and adapter for loading an injector
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
EP0934754A3 (en) * 1998-02-05 1999-08-18 The BOC Group plc Needleless medical device for delivering of therapeutic agent
AU754907B2 (en) * 1998-02-05 2002-11-28 Powderject Research Limited Needleless medical device
CZ297194B6 (en) * 1998-02-05 2006-09-13 Powderject Research Limited Apparatus for draining the therapeutic agent against the patient's skin
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
US6689095B1 (en) 1999-04-22 2004-02-10 Gilbert Garitano Needleless permanent makeup and tattoo device
US20040158196A1 (en) * 1999-04-22 2004-08-12 Gilbert Garitano Needleless permanent makeup and tatoo device
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6682504B2 (en) * 2000-03-23 2004-01-27 Antares Pharma, Inc. Single use disposable jet injector
EP1265663A1 (en) * 2000-03-23 2002-12-18 Antares Pharma, Inc. Single use disposable jet injector
EP1265663A4 (en) * 2000-03-23 2004-11-10 Antares Pharma Inc Single use disposable jet injector
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US6641554B2 (en) * 2001-03-05 2003-11-04 Bioject Medical Technologies, Inc. Disposable needle-free injection apparatus and method
US7544188B2 (en) 2001-07-19 2009-06-09 Intelliject, Inc. Medical injector
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US20070191762A1 (en) * 2002-05-30 2007-08-16 Kerry Quinn Needleless injector and ampule system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US20040199106A1 (en) * 2002-06-04 2004-10-07 Sergio Landau Needle-free injection system
US7238167B2 (en) 2002-06-04 2007-07-03 Bioject Inc. Needle-free injection system
US6883222B2 (en) 2002-10-16 2005-04-26 Bioject Inc. Drug cartridge assembly and method of manufacture
US20040074076A1 (en) * 2002-10-16 2004-04-22 Bioject Inc. Drug cartridge assembly and method of manufacture
US20050267403A1 (en) * 2004-05-28 2005-12-01 Sergio Landau Needle-free injection system
US7854720B2 (en) 2004-05-28 2010-12-21 Bioject, Inc. Needle-free injection system
US7717874B2 (en) 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
US20100069831A1 (en) * 2004-05-28 2010-03-18 Bioject Inc. Needle-free injection system
US9056170B2 (en) 2004-11-22 2015-06-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7416540B2 (en) 2004-11-22 2008-08-26 Intelliject, Llc Devices systems and methods for medicament delivery
US10071203B2 (en) 2004-11-22 2018-09-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9833573B2 (en) 2004-11-22 2017-12-05 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US10335549B2 (en) 2004-11-22 2019-07-02 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9737669B2 (en) 2004-11-22 2017-08-22 Kaleo, Inc. Devices, systems and methods for medicament delivery
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9352091B2 (en) 2004-11-22 2016-05-31 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7731690B2 (en) 2004-11-22 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9149579B2 (en) 2004-11-22 2015-10-06 Kaleo, Inc. Devices, systems and methods for medicament delivery
US10314977B2 (en) 2004-11-22 2019-06-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8361029B2 (en) 2004-11-22 2013-01-29 Intelliject, Llc Devices, systems and methods for medicament delivery
US7918823B2 (en) 2004-11-22 2011-04-05 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8016788B2 (en) 2004-11-22 2011-09-13 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8105281B2 (en) 2004-11-22 2012-01-31 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8920377B2 (en) 2004-11-22 2014-12-30 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8313466B2 (en) 2004-11-22 2012-11-20 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8608698B2 (en) 2004-11-22 2013-12-17 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8425462B2 (en) 2004-11-22 2013-04-23 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US8221347B2 (en) 2004-12-01 2012-07-17 Acushot, Inc. Needle-free injector
WO2006073394A1 (en) * 2005-01-04 2006-07-13 Bioject Inc. Needle-free injection system
US8899987B2 (en) 2005-02-01 2014-12-02 Kaleo, Inc. Simulated medicament delivery device having an electronic circuit system
US9278182B2 (en) 2005-02-01 2016-03-08 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9805620B2 (en) 2005-02-01 2017-10-31 Kaleo, Inc. Medical injector simulation device
US8544645B2 (en) 2005-02-01 2013-10-01 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9867938B2 (en) 2005-02-01 2018-01-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US10960155B2 (en) 2005-02-01 2021-03-30 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8172082B2 (en) 2005-02-01 2012-05-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US10918791B2 (en) 2005-02-01 2021-02-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US10835673B2 (en) 2005-02-01 2020-11-17 Kaleo, Inc. Devices, systems, and methods for medicament delivery
US8690827B2 (en) 2005-02-01 2014-04-08 Kaleo, Inc. Devices, systems, and methods for medicament delivery
US10796604B2 (en) 2005-02-01 2020-10-06 Kaleo, Inc. Medical injector simulation device and containers for storing delivery devices
US8123719B2 (en) 2005-02-01 2012-02-28 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8920367B2 (en) 2005-02-01 2014-12-30 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8926594B2 (en) 2005-02-01 2015-01-06 Kaleo, Inc. Devices, systems and methods for medicament delivery
US8932252B2 (en) 2005-02-01 2015-01-13 Kaleo, Inc. Medical injector simulation device
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US10105489B2 (en) 2005-02-01 2018-10-23 Kaleo, Inc. Medical injector with compliance tracking and monitoring
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US7749194B2 (en) 2005-02-01 2010-07-06 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US10099023B2 (en) 2005-02-01 2018-10-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9327077B2 (en) 2005-02-01 2016-05-03 Kaleo, Inc. Medical injector with compliance tracking and monitoring
US10076611B2 (en) 2005-02-01 2018-09-18 Kaleo, Inc. Medicament delivery device having an electronic circuit system
US9238108B2 (en) 2005-02-01 2016-01-19 Kaleo, Inc. Medicament delivery device having an electronic circuit system
US9259539B2 (en) 2005-02-01 2016-02-16 Kaleo, Inc. Devices, systems and methods for medicament delivery
US9724471B2 (en) 2005-02-01 2017-08-08 Kaleo, Inc. Devices, systems, and methods for medicament delivery
US9278177B2 (en) 2005-02-01 2016-03-08 Kaleo, Inc. Medical injector with compliance tracking and monitoring
US10099011B2 (en) 2005-05-03 2018-10-16 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US9333300B2 (en) 2005-05-03 2016-05-10 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20080281261A1 (en) * 2005-05-03 2008-11-13 Genesis Medical Technologies, Inc. Needle-less injector
US20070118094A1 (en) * 2005-05-03 2007-05-24 John Bingham Needle-less injector and method of fluid delivery
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US8529500B2 (en) 2005-05-03 2013-09-10 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US7699802B2 (en) 2005-05-03 2010-04-20 Pharmajet, Inc. Needle-less injector
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
US8105272B2 (en) 2006-10-06 2012-01-31 Bioject, Inc. Triggering mechanism for a needle-free injector
US20080086079A1 (en) * 2006-10-06 2008-04-10 Bioject, Inc. Triggering mechanism for needle-free injector
US11878147B2 (en) 2006-11-13 2024-01-23 Pharmajet Inc. Needle-less injector and method of fluid delivery
US9555191B2 (en) 2007-01-22 2017-01-31 Kaleo, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US10258735B2 (en) 2007-02-05 2019-04-16 Kaleo, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US7744563B2 (en) 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
USD1043972S1 (en) 2008-05-12 2024-09-24 Kaleo, Inc. Medicament delivery device cover
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US11263921B2 (en) 2008-07-28 2022-03-01 Kaleo, Inc. Medicament delivery device configured to produce wireless and audible outputs
US8622973B2 (en) 2008-07-28 2014-01-07 Intelliject, Inc. Simulated medicament delivery device configured to produce an audible output
US10192464B2 (en) 2008-07-28 2019-01-29 Kaleo, Inc. Medicament delivery device configured to produce wireless and audible outputs
US10342924B2 (en) 2011-01-26 2019-07-09 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US10238806B2 (en) 2011-01-26 2019-03-26 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US11426520B2 (en) 2011-01-26 2022-08-30 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
USD994110S1 (en) 2011-01-26 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
USD1011520S1 (en) 2011-01-26 2024-01-16 Kaleo, Inc. Medicament delivery device and cover assembly
US9814838B2 (en) 2011-01-26 2017-11-14 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US10322239B2 (en) 2011-01-26 2019-06-18 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US10183116B2 (en) 2011-01-26 2019-01-22 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
EP2671605A1 (en) * 2011-02-04 2013-12-11 Daicel Corporation Needleless syringe
CN106975127A (en) * 2011-02-04 2017-07-25 株式会社大赛璐 Needleless injector
CN103442755A (en) * 2011-02-04 2013-12-11 株式会社大赛璐 Needleless syringe
CN103442755B (en) * 2011-02-04 2016-10-26 株式会社大赛璐 Needleless injector
US9474860B2 (en) 2011-02-04 2016-10-25 Daicel Corporation Needleless syringe
EP2671605A4 (en) * 2011-02-04 2014-07-16 Daicel Corp Needleless syringe
US10307540B2 (en) 2011-02-04 2019-06-04 Daicel Corporation Needleless syringe
US10143792B2 (en) 2011-02-28 2018-12-04 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9022022B2 (en) 2011-02-28 2015-05-05 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9474869B2 (en) 2011-02-28 2016-10-25 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US11471603B2 (en) 2011-08-02 2022-10-18 Pharmajet, Inc. Needle-free injector
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
US10463795B2 (en) 2011-08-02 2019-11-05 Pharmajet Inc. Needle-free injection methods
US10322238B2 (en) 2011-12-13 2019-06-18 Pharmajet, Inc. Needle-free intradermal injection device
US9700675B2 (en) 2011-12-13 2017-07-11 Pharmajet Inc. Needle-free intradermal injection device
US9433735B2 (en) 2011-12-13 2016-09-06 Pharmajet Inc. Needle-free intradermal injection device
US11154659B2 (en) 2011-12-13 2021-10-26 Pharmajet Inc. Needle-free intradermal injection device
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US10226583B2 (en) 2012-05-22 2019-03-12 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US10726701B2 (en) 2012-12-27 2020-07-28 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US9542826B2 (en) 2012-12-27 2017-01-10 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US10839669B2 (en) 2012-12-27 2020-11-17 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US9836948B2 (en) 2012-12-27 2017-12-05 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US10229578B2 (en) 2012-12-27 2019-03-12 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US9911308B2 (en) 2012-12-27 2018-03-06 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US10080848B2 (en) 2013-11-12 2018-09-25 Novo Nordisk A/S Drug delivery device with movable needle mount
US10220158B2 (en) 2014-07-18 2019-03-05 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10695495B2 (en) 2015-03-24 2020-06-30 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
US12005236B2 (en) 2015-03-24 2024-06-11 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
CN107580489A (en) * 2015-03-26 2018-01-12 因内博注射剂公司 The medicament transfer of gas-pressurized driving and settling flux apparatus and method
US10507285B2 (en) * 2015-03-26 2019-12-17 Enable Injections, Inc. Pressurized gas powered medicament transfer and re-suspension apparatus and method
US10576206B2 (en) 2015-06-30 2020-03-03 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
US11517674B2 (en) 2015-06-30 2022-12-06 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
US11771830B2 (en) 2016-12-23 2023-10-03 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10842938B2 (en) 2016-12-23 2020-11-24 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10688244B2 (en) 2016-12-23 2020-06-23 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10937537B2 (en) 2017-01-17 2021-03-02 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
US10332623B2 (en) 2017-01-17 2019-06-25 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
US11305056B2 (en) 2017-07-14 2022-04-19 Amgen Inc. Needle insertion-retraction system having dual torsion spring system
WO2020012178A1 (en) * 2018-07-10 2020-01-16 Pacifi Limited Method and apparatus
US20210252224A1 (en) * 2018-07-10 2021-08-19 Pacifi Limited Method and apparatus
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
US11167087B2 (en) 2019-08-09 2021-11-09 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
US12017047B2 (en) 2019-08-09 2024-06-25 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
WO2021225565A1 (en) * 2020-05-04 2021-11-11 Zhytariuk Ihor Tarasovych Single-use medical syringe

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