EA201691603A1 - Производные сахаров, содержащие серосодержащие фрагменты, способы их получения и способы их применения для лечения mps iiic - Google Patents
Производные сахаров, содержащие серосодержащие фрагменты, способы их получения и способы их применения для лечения mps iiicInfo
- Publication number
- EA201691603A1 EA201691603A1 EA201691603A EA201691603A EA201691603A1 EA 201691603 A1 EA201691603 A1 EA 201691603A1 EA 201691603 A EA201691603 A EA 201691603A EA 201691603 A EA201691603 A EA 201691603A EA 201691603 A1 EA201691603 A1 EA 201691603A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- treatment
- receiving
- application
- sero
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
В настоящем документе описаны модифицированные соединения сахаров, иминосахаров и азасахаров и способы их получения. Одно или несколько этих модифицированных соединений содержат сульфаты, сульфиты, сульфаматы и/или сульфонамиды. Также описаны фармацевтические композиции/составы, содержащие эти соединения, а также способы, в которых применяют эти модифицированные соединения сахаров для лечения MPS IIIC (также известного как синдром Санфилиппо типа С).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461938924P | 2014-02-12 | 2014-02-12 | |
US14/620,283 US9598438B2 (en) | 2014-02-12 | 2015-02-12 | Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of MPS IIIC |
PCT/US2015/015557 WO2015123385A1 (en) | 2014-02-12 | 2015-02-12 | Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of mps iiic |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201691603A1 true EA201691603A1 (ru) | 2016-11-30 |
Family
ID=53774364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691603A EA201691603A1 (ru) | 2014-02-12 | 2015-02-12 | Производные сахаров, содержащие серосодержащие фрагменты, способы их получения и способы их применения для лечения mps iiic |
Country Status (13)
Country | Link |
---|---|
US (2) | US9598438B2 (ru) |
EP (1) | EP3105235B1 (ru) |
JP (1) | JP2017505350A (ru) |
KR (1) | KR20160113720A (ru) |
CN (1) | CN105992758B (ru) |
AU (2) | AU2015217172B2 (ru) |
CA (1) | CA2939380A1 (ru) |
EA (1) | EA201691603A1 (ru) |
ES (1) | ES2771849T3 (ru) |
IL (1) | IL247141A0 (ru) |
MX (1) | MX2016010365A (ru) |
TW (1) | TW201613861A (ru) |
WO (1) | WO2015123385A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
WO2020046132A1 (en) | 2018-08-31 | 2020-03-05 | Leiden University | Pharmacological chaperones for enzyme treatment therapy |
NL2021840B1 (en) * | 2018-10-19 | 2020-05-13 | Univ Leiden | Pharmacological Chaperones For Enzyme Treatment Therapy |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4407957A (en) | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
DE3722788A1 (de) * | 1987-07-10 | 1989-01-19 | Bayer Ag | Chirale 6-hydroxymethylenverzweigte 3-amino-4,5-dihydroxypiperidine, zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung |
EP0585368B1 (en) | 1991-04-25 | 1997-08-06 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
DE69332105T2 (de) | 1992-09-29 | 2003-03-06 | Inhale Therapeutic Systems San | Pulmonale abgabe von aktiven fragmenten des parathormons |
FR2718357B1 (fr) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Perfectionnements apportés à un dispositif d'injection par jet sans aiguille. |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5780014A (en) | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
US6545021B1 (en) * | 1999-02-12 | 2003-04-08 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
US6774140B1 (en) * | 1999-05-11 | 2004-08-10 | The Scripps Research Institute | Iminocyclitol inhibitors of hexoaminidase and glycosidase |
WO2000068194A1 (en) * | 1999-05-11 | 2000-11-16 | The Scripps Research Institute | Iminocyclitol inhibitors of hexoaminidase and glycosidase |
AU2007291870B2 (en) * | 2006-08-31 | 2012-12-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
WO2010015816A2 (en) * | 2008-08-06 | 2010-02-11 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
CN102625661B (zh) * | 2009-04-09 | 2015-05-27 | 阿米库斯治疗学公司 | 用于预防和/或治疗溶酶体贮积失调的方法 |
RU2016103139A (ru) * | 2009-10-19 | 2018-11-22 | Амикус Терапьютикс, Инк. | Новые композиции для предупреждения и/или лечения лизосомных болезней накопления |
JP2014520876A (ja) * | 2011-07-20 | 2014-08-25 | ウニヴェルシテ ピエール エ マリー キュリー(パリ 6) | イミノ糖c−グリコシド、その製造および使用 |
MX354127B (es) * | 2012-03-27 | 2018-02-14 | Amicus Therapeutics Inc | Compuestos novedosos para prevenir y/o tratar tesaurismosis lisosomicas y/o trastornos degenerativos del sistema nervioso central. |
-
2015
- 2015-02-12 WO PCT/US2015/015557 patent/WO2015123385A1/en active Application Filing
- 2015-02-12 EP EP15707462.6A patent/EP3105235B1/en active Active
- 2015-02-12 JP JP2016568493A patent/JP2017505350A/ja active Pending
- 2015-02-12 TW TW104104841A patent/TW201613861A/zh unknown
- 2015-02-12 ES ES15707462T patent/ES2771849T3/es active Active
- 2015-02-12 US US14/620,283 patent/US9598438B2/en active Active
- 2015-02-12 MX MX2016010365A patent/MX2016010365A/es unknown
- 2015-02-12 CN CN201580008450.8A patent/CN105992758B/zh active Active
- 2015-02-12 KR KR1020167024156A patent/KR20160113720A/ko not_active Application Discontinuation
- 2015-02-12 CA CA2939380A patent/CA2939380A1/en not_active Abandoned
- 2015-02-12 AU AU2015217172A patent/AU2015217172B2/en not_active Ceased
- 2015-02-12 EA EA201691603A patent/EA201691603A1/ru unknown
-
2016
- 2016-08-07 IL IL247141A patent/IL247141A0/en unknown
-
2017
- 2017-03-17 US US15/461,577 patent/US20170190665A1/en not_active Abandoned
-
2019
- 2019-08-28 AU AU2019222876A patent/AU2019222876A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN105992758B (zh) | 2021-08-31 |
AU2019222876A1 (en) | 2019-09-26 |
TW201613861A (en) | 2016-04-16 |
AU2015217172A1 (en) | 2016-08-25 |
IL247141A0 (en) | 2016-09-29 |
WO2015123385A1 (en) | 2015-08-20 |
EP3105235B1 (en) | 2019-11-06 |
CN105992758A (zh) | 2016-10-05 |
JP2017505350A (ja) | 2017-02-16 |
CA2939380A1 (en) | 2015-08-20 |
MX2016010365A (es) | 2016-11-30 |
US20150225420A1 (en) | 2015-08-13 |
EP3105235A1 (en) | 2016-12-21 |
US20170190665A1 (en) | 2017-07-06 |
US9598438B2 (en) | 2017-03-21 |
KR20160113720A (ko) | 2016-09-30 |
AU2015217172B2 (en) | 2019-09-19 |
ES2771849T3 (es) | 2020-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201890725A1 (ru) | Агонисты фарнезоидного х-рецептора и их применение | |
EA201890817A1 (ru) | Кристаллические формы бета-никотинамида мононуклеотида | |
EA201890857A1 (ru) | Соединения, применимые в качестве иммуномодуляторов | |
EA201890493A1 (ru) | РЕПРЕССОРЫ Htt И ИХ ПРИМЕНЕНИЕ | |
EA201792047A1 (ru) | Новые соединения | |
EA201692177A1 (ru) | Соединения и композиции в качестве агонистов toll-подобного рецептора 7 | |
EA201692422A1 (ru) | Состав, содержащий пролекарство гемцитабина | |
EA201691590A1 (ru) | Бензимидазол-2-амины в качестве ингибиторов midhi | |
EA201692007A1 (ru) | Соединения изоиндолинона в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных с ними нарушений | |
EA201791733A1 (ru) | Производные 9h-пирролодипиридина | |
EA201692049A1 (ru) | Гетероарилзамещенные гетероциклилсульфоны | |
EA201891399A1 (ru) | Бипиразолильные производные, пригодные для лечения аутоиммунных заболеваний | |
CY1125150T1 (el) | Ενωσεις φαινυλο-2-υδροξυ-ακετυλαμινο-2-μεθυλο-φαινυλιου | |
EA201790787A1 (ru) | Снижение вязкости фармацевтических составов | |
EA201791896A1 (ru) | Дезацетокситубулизин н и его аналоги | |
EA201892225A1 (ru) | АНТИТЕЛА К ФАКТОРУ Bb КОМПЛЕМЕНТА И ИХ ПРИМЕНЕНИЕ | |
EA201991798A1 (ru) | Стабильные при хранении составы | |
EA201792561A1 (ru) | Антитела, нацеленные на морфогенетический белок кости 9 (bmp9), и способы их применения | |
EA201790773A1 (ru) | Композиции и способы для ингибирования биологической активности растворимых биомолекул | |
EA201890434A1 (ru) | Антитела к cd154 и способы их применения | |
EA201700019A1 (ru) | Высокочистый оритаванцин и способ его получения | |
MX2019005821A (es) | Proteínas de unión a antígenos anti-gitr y métodos de uso de las mismas. | |
EA201991951A1 (ru) | Низковязкие высококонцентрированные составы на основе эволокумаба и способы их получения | |
EA201890177A1 (ru) | Мультиспецифические связывающие белки | |
EA201691603A1 (ru) | Производные сахаров, содержащие серосодержащие фрагменты, способы их получения и способы их применения для лечения mps iiic |