US3557784A - Syringe - Google Patents

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Publication number
US3557784A
US3557784A US3557784DA US3557784A US 3557784 A US3557784 A US 3557784A US 3557784D A US3557784D A US 3557784DA US 3557784 A US3557784 A US 3557784A
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United States
Prior art keywords
barrel
plunger
cartridge
syringe
latches
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
Walter A Shields
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WALTER A SHIELDS
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WALTER A SHIELDS
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Publication date
Application filed by WALTER A SHIELDS filed Critical WALTER A SHIELDS
Priority to US78661068A priority Critical
Application granted granted Critical
Publication of US3557784A publication Critical patent/US3557784A/en
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Application status is Expired - Lifetime legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/30Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A syringe comprising a barrel carrying a cartridge containing a liquid medicament and closed at one end by a penetrable closure and the opposite end provided with a plunger slidable in the cartridge. A piercing member is slidable mounted on the barrel to pierce the penetrable closure and permit the discharge of the liquid medicament upon pushing the plunger into the cartridge. The plunger of the cartridge is pushed into the cartridge by spring actuated mechanism mounted in the barrel contiguous to the cartridge plunger and retained in compressed condition by latch members of resilient material and actuated into and out of engagement with the spring actuated mechanism by a pair of manipulating members slidable over the latch members and removable from the latch members and the barrel for the removal of the spring actuated mechanism and the replacement of a spent cartridge.

Description

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[56] References Cited UNITED STATES PATENTS 2,650,591 9/1953 Love 2,667,874 2/1954 Dickinson,

PATENTED JAN 2 6 I97! SHEET [1F 4 ATTORNEY SYRINGE The spring actuated mechanism comprises a piston, a plunger and a spring between the piston and the plunger with the piston contiguous to the cartridge plunger and the spring actuated plunger having an end portion extended from the end of the barrel opposite the end provided with the piercing member and said extended end of the spring actuated plunger provided with a manipulating knob arranged to be engaged by the latch members to maintain the spring in compressed condition. The resiliency of the latch members moves said latch members into and out of engagement with the piston and the manipulating knob of the spring actuated plunger under the control of the sliding movements of the annular members.

In the drawings:

FIG. 1 is a perspective view of the syringe completely assembled and ready for use;

FIG. 2 is a perspective view of a cartridge in condition to be placed in the barrel;

FIG. 3 is a top plan view of the syringe;

FIG. 4 is a sectional view showing the positions of the spring actuated plunger and piston after a cartridge has been positioned in the barrel with the latch members retaining the piston contiguous to the cartridge plunger;

FIG. 5 is a sectional view taken on the line 5-5 of FIG. 3 looking in the direction of the arrows and showing the penetrable closure of the cartridge being pierced by the penetrating member and the spring of the spring actuated mechanism in fully compressed condition;

FIG. 6 is a sectional view showing the spring actuated piston in released condition with the cartridge plunger abutting the penetrable closure of the cartridge indicating that said cartridge is fully spent;

FIG. 7 is a cross-sectional view taken on the line 7-7 of FIG. 5 looking in the direction of the arrows to show latch members retaining the spring actuated piston .in spring compressing position;

FIG. 8 is a cross-sectional view taken on' the line 8-8 of FIG. 5 looking in the direction of the arrows to show the latch members retaining the spring actuated plunger in spring compressing position;

FIG. 9 is an exploded perspective view of the parts of the syringe in their order of assembly; and

FIG. 10 is an exploded perspective view of the cartridge.

The syringe comprises a barrel 11 having a fully open end 12 and a center opening 13 at the opposite end. Intermediate the ends of the barrel, there is provided diametrically opposed openings 14 for a purpose to be hereinafter described.

A cartridge 15 having a penetrable closure in the discharge end comprising a body 16 having friction grooves 17 and a tapering flow passage 18 closed by a thin penetrable wall 19 at the extremity of a protuberance 20 adapted to project through the barrel opening 13, as shown in FIGS. 4, 5 and 6. The opposite end of the cartridge 15 is closed by a plunger 21 having friction grooves 22. Either-the closure 16-20 or the plunger 21, 22 is first inserted in the cartridge and then the cartridge is filled with a liquid medicament 23 and then the cartridge is fully sealed by either the closure 16-20 or the plunger 21, 22.

The fully filled cartridge 15 is inserted into the barrel 11 through the open end 12 and positioned in said barrel with the protuberance 20 projecting from the opening 13 of the barrel.

A piston 24 of a spring actuated mechanism is inserted in the barrel 11 against the plunger 21 and said piston 24 is provided with a center recess 25 for the reception of an end of a spring 26 having the other end engaged in a recess 27 in one end of a plunger 28 having a manipulating knob 29 secured to the opposite end of the plunger 28. The knob 29 is arranged with an annular ridge 30 for a purpose to be hereinafter described. The diameter of the piston isslightly less than the inner diameter of the cartridge 15 so that said piston can slide in said cartridge.

The movement of the piston 24 and the plunger 28 under the influence of the spring 26 is controlled by latch members comprising a pair of latches 31 of resilient material pivoted at one end on a pin 32 supported by ears 33 extended from diametrically opposite portions of the barrel 11 between the openings 14 and the open end 12. The opposite ends of the latches 31 are provided with lateral end portions or projections 34 having a beveled edge 35 adapted to project into the barrel 11 through the openings 14 to engage a beveled edge 36 on the piston 24, the beveled edges 35 being normally positioned out of the bore of the barrel under the influence of the resiliency of the latches, as shown in FIG. 6. A pair of latches 37 of resilient material are pivoted on the pins 31 between forked end portions 38 of the latches 31, as shown in FIGS. 1 and 3, with the free end portions of the latches 37 arranged with outwardly extending projections or lateral end portions 39 to engage the ridge 30 of the manipulating knob 29. The resilience of the latches 37 will normally position the projections 38 into engagement with the ridge 30. To facilitate said engagement, the projections are beveled as at 40 to slide over a beveled face 41 of the ridge 30.

In assembling the syringe, the cartridge 15 is first inserted into the barrel 11 with the protuberance 20 positioned in the opening 13 of the barrel. After the cartridge 15 is inserted into the barrel 11, the piston 24, the spring 26 and the plunger 28 are sequentially inserted into the barrel. To permit the insertion of the piston 24, the spring 26 and the plunger 28 into the barrel 1 1 through the open end 12, the projections 34 have to be positioned out of-the bore of the barrel 11 and the projections 39 have to be out of the path of movement of the ridge 30. This is accomplished by providing two annular members 42 and 43 arranged with manipulating annular flanges 44 and 45, respectively, and slidingly engaged on the latches 31 and 37, respectively. To permit engagement of the annular members 42 and 43 onto the latches 31 and 37, respectively, the member 42 is provided with diametrically opposed notches 46 and the member 43 is provided with diametrically opposed notches 47, as shown in FIGS. 1, 7 and 9. The notches 46 and 47 are of sufficient depth to permit passage of the projections 34 and 39, respectively, through said notches when the notches are aligned with said projections.

After the piston 24, the spring 26 and the plunger 28 are assembled in the barrel 11, the annular member 42 is actuated toward the projections 34 to position the beveled edges 35 into engagement with the beveled edge 36 and retain the piston 24 in spaced relation to the plunger 21 of the cartridge 15. The annular member 43 is moved toward the pins 32 to permit the projections 39 to engage the ridge 30 of the manipulating knob 29 under the influence of the resiliency of the latches 37, as shown in FIG. 5.

In this position of the piston 24 and the plunger 28, the spring 26 is compressed and the syringe is in condition to expel the liquid medicament 23 into a patient. Before this is possible, the thin penetrable wall 19 is punctured by a penetrating member comprising a cap member 48 slidably engaged on the end portion of the barrel 11 arranged with the opening 13 and said cap member is provided with nipples 49 to engage an annular groove 50 in the barrel 11 and position a piercing spike 51 in spaced relation to the thin penetrable wall 19, as shown in FIG. 4. The piercing spike 51 is carried by a base 52 inserted in the cap member 48. The cap member 48 is in the position shown in FIG. 4 when the syringe is in condition for storage and shipping. when it is desired to place the syringe in condition for expelling or injecting the liquid medicament 23, the nipples 49 are forcedly disengaged from the annular groove 50 by pushing the cap member 48 onto the barrel 11 which will force the piercing spike 51 through the thin penetrable wall 19.

When it is desired to inject the liquid medicament 23 into a patient, the cap member 48 is removed from its forward position on the barrel 11, the protuberance 20 is placed on the patient's skin at the desired point of injection, and the annular member 42 is moved toward the annular member 43 by the person applying the injection engaging the manipulating knob 29 in the palm of his hand'and the two forward fingers engaging the annular flange 44. Said movement of the annular member 42 will permit the latches 31 under the influence of their resiliency to move the beveled edges 35 out of the bore of the barrel 11 and the spring 26 to forcedly move the piston 24 against the plunger 21 and expel the liquid medicament into the patient, as shown in H0. 6.

After an injection, the annular member 43 is actuated by engaging the annular flange 45 toward the manipulating knob 29 to position the projections 39 out of engagement with the annular ridge 30 which will permit the removal of the plunger 28, the spring 26 and the piston 24 from the barrel H. The removal of the spring actuated mechanism will permit the removal of the spent or exhausted cartridge from the barrel 11 and the replacement of a fresh cartridge shown in FIG. 2. The spring actuated mechanism is assembled in the barrel 11 in the manner hereinbefore described.

lclaim:

l. A syringe comprising a barrel, a cartridge containing a liquid medicament and provided with a penetrable closure in one end projecting from one end of the barrel and a plunger in the other end of the cartridge, spring actuated mechanism removably mounted in the barrel contiguous to the plunger of the cartridge, latch members mountedon an intermediate portion of the barrel and arranged to retain the spring actuated mechanism in the barrel and adapted to be actuated to release the spring actuated mechanism to move'the plunger of the cartridge toward the penetrable closure, and a penetrating member slidably mounted on the end portion of the barrel arranged with the penetrable closure and actuated to pierce said penetrable closure prior to the actuation of the latch members.

2. A syringe as claimed in claim ll, wherein the barrel is provided with an open end to assemble the cartridge andthe spring actuated mechanism in said barrel with the opposite end having a center opening smaller than the inner diameter of the barrel for projecting the penetrable closure of the cartridge.

3. A syringe as claimed in claim 1, wherein the spring actuated mechanism comprises a piston slidable in the barrel, a plunger slidable in the barrel with a portion extended from the barrel, and a spring compressed between the piston and the plunger.

4. A syringe as claimed in claim 3, wherein the latch members comprise two pairs of latches of resilient material supported on the barrel, the first pair oflatches having lateral end portions extended into the barrel to engage and space the piston from the plunger of the cartridge.

5. A syringe as claimed in claim 4, wherein the second pair of latches is provided with lateral portionspositioned beyond the open end of the barrel to engage the extended portion of the plunger of the spring actuated mechanism and retain the plunger in a predetermined position in the barrel.

6. A syringe as claimed in claim 5, wherein the lateral end portions of the first pair of latches extend toward each other and the lateral end portions of the second pair of latches extend away from each other.

7. A syringe as claimed in claim 5, wherein the extended portion of the plunger of the spring actuated mechanism is provided with a manipulating knob having an annular ridge to be engaged by the second pair of latches.

8. A syringe as claimed in claim 3, wherein the latch members comprises two pairs of latches of resilient material mounted on a pair of opposed pivots on the barrel, each pivot supporting a latch of each pair, a pair of annular members, each member slidable on a different pair of latches to actuate the free ends of the latches into and out of latching engagement with the piston and the plunger of the spring actuated mechanism.

9. A syringe as claimed in claim 8, wherein each annular member is provided with an annular flange to form a manipulating portion.

10. A syringe as claimed in claim 8, wherein each annular member is arranged with diametrically opposed notches for sliding said annular members on and off the latches.

11. A syringe as claimed in claim 1, wherein the penetrating member comprises a cap member releasably mounted on the barrel and a piercing spike secured in the bottom of the cap member to pierce the penetrable closure of the cartridge upon moving the cap member onto the barrel.

Claims (11)

1. A syringe comprising a barrel, a cartridge containing a liquid medicament and provided with a penetrable closure in one end projecting from one end of the barrel and a plunger in the other end of the cartridge, spring actuated mechanism removably mounted in the barrel contiguous to the plunger of the cartridge, latch members mounted on an intermediate portion of the barrel and arranged to retain the spring actuated mechanism in the barrel and adapted to be actuated to release the spring actuated mechanism to move the plunger of the cartridge toward the penetrable closure, and a penetrating member slidably mounted on the end portion of the barrel arranged with the penetrable closure and actuated to pierce said penetrable closure prior to the actuation of the latch members.
2. A syringe as claimed in claim 1, wherein the barrel is provided with an open end to assemble the cartridge and the spring actuated mechanism in said barrel with the opposite end having a center opening smaller than the inner diameter of the barrel for projecting the penetrable closure of the cartridge.
3. A syringe as claimed in claim 1, wherein the spring actuated mechanism comprises a piston slidable in the barrel, a plunger slidable in the barrel with a portion extended from the barrel, and a spring compressed between the piston and the plunger.
4. A syringe as claimed in claim 3, wherein the latch members comprise two pairs of latches of resilient material supported on the barrel, the first pair of lAtches having lateral end portions extended into the barrel to engage and space the piston from the plunger of the cartridge.
5. A syringe as claimed in claim 4, wherein the second pair of latches is provided with lateral portions positioned beyond the open end of the barrel to engage the extended portion of the plunger of the spring actuated mechanism and retain the plunger in a predetermined position in the barrel.
6. A syringe as claimed in claim 5, wherein the lateral end portions of the first pair of latches extend toward each other and the lateral end portions of the second pair of latches extend away from each other.
7. A syringe as claimed in claim 5, wherein the extended portion of the plunger of the spring actuated mechanism is provided with a manipulating knob having an annular ridge to be engaged by the second pair of latches.
8. A syringe as claimed in claim 3, wherein the latch members comprises two pairs of latches of resilient material mounted on a pair of opposed pivots on the barrel, each pivot supporting a latch of each pair, a pair of annular members, each member slidable on a different pair of latches to actuate the free ends of the latches into and out of latching engagement with the piston and the plunger of the spring actuated mechanism.
9. A syringe as claimed in claim 8, wherein each annular member is provided with an annular flange to form a manipulating portion.
10. A syringe as claimed in claim 8, wherein each annular member is arranged with diametrically opposed notches for sliding said annular members on and off the latches.
11. A syringe as claimed in claim 1, wherein the penetrating member comprises a cap member releasably mounted on the barrel and a piercing spike secured in the bottom of the cap member to pierce the penetrable closure of the cartridge upon moving the cap member onto the barrel.
US3557784D 1968-12-24 1968-12-24 Syringe Expired - Lifetime US3557784A (en)

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Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742948A (en) * 1969-08-25 1973-07-03 Philips Corp Hypodermic syringe with radially movable blocking elements
US3789844A (en) * 1971-04-16 1974-02-05 A Burges Foil sealed syringe
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
WO1988009677A1 (en) * 1987-06-08 1988-12-15 Antonio Nicholas F D Hypodermic fluid dispenser
US4850967A (en) * 1986-06-17 1989-07-25 Sicim Spa Portable endermic injector
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US5256142A (en) * 1991-08-06 1993-10-26 Sicim Spa Injector administering subcutaneous injections without a needle and with a one-shot cap
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
WO2001030425A1 (en) * 1999-10-22 2001-05-03 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
WO2002083211A1 (en) * 2001-04-13 2002-10-24 Penjet Corporation Modular gas-pressured needled-less injector
US6613011B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Gas-pressured engine with valve
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
US20050020984A1 (en) * 2002-02-15 2005-01-27 Lesch Paul R. Injector with bypass channel
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US20050228396A1 (en) * 2002-06-03 2005-10-13 Soren Jonsson Feeding device for a monomer
US20050267411A1 (en) * 2004-05-28 2005-12-01 Huang-Chuan Chen Breakable syringe with a safety sleeve
US7018356B2 (en) 2002-10-31 2006-03-28 Wise Roger R Method and apparatus for adjusting the contents of a needle-less injector
US20060106333A1 (en) * 1999-10-11 2006-05-18 Leon Nanthaniel J Universal protector cap with auto-disable features for needle-free injectors
WO2009006987A1 (en) * 2007-07-10 2009-01-15 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one drawer hook which can be forcibly decoupled
WO2009006984A1 (en) * 2007-07-10 2009-01-15 Lts Lohmann Therapie-Systeme Ag Disposable injector with at least one tension hook
WO2009012855A1 (en) * 2007-07-24 2009-01-29 Lts Lohmann Therapie-Systeme Ag Disposable injector with manually actuated piston
WO2010069469A1 (en) * 2008-12-18 2010-06-24 Lts Lohmann Therapie-Systeme Ag Single-use injector having a flexurally elastic housing
WO2010069468A1 (en) * 2008-12-18 2010-06-24 Lts Lohmann Therapie-Systeme Ag Single-use injector having a flexurally elastic metal housing
WO2010069470A1 (en) * 2008-12-18 2010-06-24 Lts Lohmann Therapie-Systeme Ag Single-use injector capable of pumping and having a flexurally elastic housing
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
EP3291858B1 (en) * 2015-05-04 2019-03-13 LTS Lohmann Therapie-Systeme AG Onewayinjector having a trigger assembly unit for ease of assembly
US10279131B2 (en) 2011-07-15 2019-05-07 Antares Pharma, Inc. Injection device with cammed RAM assembly
US10357609B2 (en) 2016-05-16 2019-07-23 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force

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US2667874A (en) * 1951-07-09 1954-02-02 Becton Dickinson Co Medicament cartridge assembly

Patent Citations (2)

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US2650591A (en) * 1951-03-10 1953-09-01 Ideal Roller And Mfg Company Device for making injections
US2667874A (en) * 1951-07-09 1954-02-02 Becton Dickinson Co Medicament cartridge assembly

Cited By (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742948A (en) * 1969-08-25 1973-07-03 Philips Corp Hypodermic syringe with radially movable blocking elements
US3789844A (en) * 1971-04-16 1974-02-05 A Burges Foil sealed syringe
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US4850967A (en) * 1986-06-17 1989-07-25 Sicim Spa Portable endermic injector
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
WO1988009677A1 (en) * 1987-06-08 1988-12-15 Antonio Nicholas F D Hypodermic fluid dispenser
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US5318522A (en) * 1987-06-08 1994-06-07 Antonio Nicholas F D Hypodermic fluid dispenser
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5503627A (en) * 1989-11-09 1996-04-02 Bioject, Inc. Ampule for needleless injection
US5256142A (en) * 1991-08-06 1993-10-26 Sicim Spa Injector administering subcutaneous injections without a needle and with a one-shot cap
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5919159A (en) * 1995-01-09 1999-07-06 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5891085A (en) * 1995-01-09 1999-04-06 Medi-Ject Corporation Nozzle assembly with lost motion connection for medical injector assembly
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US20060106333A1 (en) * 1999-10-11 2006-05-18 Leon Nanthaniel J Universal protector cap with auto-disable features for needle-free injectors
US7341575B2 (en) 1999-10-22 2008-03-11 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
AU784838B2 (en) * 1999-10-22 2006-07-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
WO2001030425A1 (en) * 1999-10-22 2001-05-03 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US20040134563A1 (en) * 1999-10-22 2004-07-15 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
WO2002083211A1 (en) * 2001-04-13 2002-10-24 Penjet Corporation Modular gas-pressured needled-less injector
US6613011B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Gas-pressured engine with valve
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
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