JPH0581600B1 - - Google Patents

Info

Publication number
JPH0581600B1
JPH0581600B1 JP1500565A JP50056589A JPH0581600B1 JP H0581600 B1 JPH0581600 B1 JP H0581600B1 JP 1500565 A JP1500565 A JP 1500565A JP 50056589 A JP50056589 A JP 50056589A JP H0581600 B1 JPH0581600 B1 JP H0581600B1
Authority
JP
Japan
Prior art keywords
hcv
cdna
sequence
clone
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1500565A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02500880A (ja
Inventor
Michael Houghton
Qui-Lim Choo
George Kuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27557988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0581600(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of JPH02500880A publication Critical patent/JPH02500880A/ja
Publication of JPH0581600B1 publication Critical patent/JPH0581600B1/ja
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
JP89500565A 1987-11-18 1988-11-18 Ｎａｎｂｖの診断用薬およびワクチン Expired - Lifetime JPH02500880A (ja)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US12271487A 1987-11-18 1987-11-18
US122,714 1987-11-18
US13988687A 1987-12-30 1987-12-30
US16107288A 1988-02-26 1988-02-26
US161072 1988-02-26
US19126388A 1988-05-06 1988-05-06
US191263 1988-05-06
US26358488A 1988-10-26 1988-10-26
US27145088A 1988-11-14 1988-11-14
US263,584 1988-11-14
US271,450 1988-11-14
US139,886 1988-11-14

Related Child Applications (5)

Application Number Title Priority Date Filing Date
JP4361784A Division JP2809956B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬
JP4361786A Division JP2532805B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬およびワクチン
JP4361787A Division JP2662351B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬およびワクチン
JP4361785A Division JP2662350B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬
JP5178446A Division JP2662358B2 (ja) 1987-11-18 1993-06-11 Ｎａｎｂｖの診断用薬

Publications (2)

Publication Number Publication Date
JPH02500880A JPH02500880A (ja) 1990-03-29
JPH0581600B1 true JPH0581600B1 (https=) 1993-11-15

Family

ID=27557988

Family Applications (16)

Application Number Title Priority Date Filing Date
JP89500565A Expired - Lifetime JPH02500880A (ja) 1987-11-18 1988-11-18 Ｎａｎｂｖの診断用薬およびワクチン
JP4361786A Expired - Lifetime JP2532805B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬およびワクチン
JP4361784A Expired - Lifetime JP2809956B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬
JP4361787A Expired - Lifetime JP2662351B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬およびワクチン
JP4361785A Expired - Lifetime JP2662350B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬
JP5178446A Expired - Lifetime JP2662358B2 (ja) 1987-11-18 1993-06-11 Ｎａｎｂｖの診断用薬
JP8239921A Expired - Lifetime JP2810022B2 (ja) 1987-11-18 1996-08-21 Ｎａｎｂｖの診断用薬
JP24145196A Expired - Lifetime JP3171793B2 (ja) 1987-11-18 1996-08-22 Ｎａｎｂｖの診断用薬
JP9099651A Expired - Lifetime JP2810032B2 (ja) 1987-11-18 1997-04-01 Ｎａｎｂｖの診断用薬
JP10111631A Pending JPH10290696A (ja) 1987-11-18 1998-04-06 Ｎａｎｂｖの診断用薬およびワクチン
JP10111632A Pending JPH10290697A (ja) 1987-11-18 1998-04-06 Ｎａｎｂｖの培養法
JP11157193A Pending JP2000023683A (ja) 1987-11-18 1999-06-03 Ｎａｎｂｖの診断用薬
JP2005325483A Withdrawn JP2006104207A (ja) 1987-11-18 2005-11-09 Ｎａｎｂｖの診断用薬
JP2005325486A Withdrawn JP2006117681A (ja) 1987-11-18 2005-11-09 Ｎａｎｂｖの診断用薬およびワクチン
JP2007095590A Pending JP2007197456A (ja) 1987-11-18 2007-03-30 Ｎａｎｂｖの診断用薬
JP2007179093A Pending JP2008007508A (ja) 1987-11-18 2007-07-06 Ｎａｎｂｖの診断用薬およびワクチン

Family Applications After (15)

Application Number Title Priority Date Filing Date
JP4361786A Expired - Lifetime JP2532805B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬およびワクチン
JP4361784A Expired - Lifetime JP2809956B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬
JP4361787A Expired - Lifetime JP2662351B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬およびワクチン
JP4361785A Expired - Lifetime JP2662350B2 (ja) 1987-11-18 1992-12-16 Ｎａｎｂｖの診断用薬
JP5178446A Expired - Lifetime JP2662358B2 (ja) 1987-11-18 1993-06-11 Ｎａｎｂｖの診断用薬
JP8239921A Expired - Lifetime JP2810022B2 (ja) 1987-11-18 1996-08-21 Ｎａｎｂｖの診断用薬
JP24145196A Expired - Lifetime JP3171793B2 (ja) 1987-11-18 1996-08-22 Ｎａｎｂｖの診断用薬
JP9099651A Expired - Lifetime JP2810032B2 (ja) 1987-11-18 1997-04-01 Ｎａｎｂｖの診断用薬
JP10111631A Pending JPH10290696A (ja) 1987-11-18 1998-04-06 Ｎａｎｂｖの診断用薬およびワクチン
JP10111632A Pending JPH10290697A (ja) 1987-11-18 1998-04-06 Ｎａｎｂｖの培養法
JP11157193A Pending JP2000023683A (ja) 1987-11-18 1999-06-03 Ｎａｎｂｖの診断用薬
JP2005325483A Withdrawn JP2006104207A (ja) 1987-11-18 2005-11-09 Ｎａｎｂｖの診断用薬
JP2005325486A Withdrawn JP2006117681A (ja) 1987-11-18 2005-11-09 Ｎａｎｂｖの診断用薬およびワクチン
JP2007095590A Pending JP2007197456A (ja) 1987-11-18 2007-03-30 Ｎａｎｂｖの診断用薬
JP2007179093A Pending JP2008007508A (ja) 1987-11-18 2007-07-06 Ｎａｎｂｖの診断用薬およびワクチン

Country Status (18)

Country Link
EP (1) EP0318216B2 (https=)
JP (16) JPH02500880A (https=)
KR (2) KR0138776B1 (https=)
CN (5) CN1074422C (https=)
BR (1) BR8807310A (https=)
CA (1) CA1341629C (https=)
DE (2) DE318216T1 (https=)
ES (1) ES2012739T5 (https=)
FI (3) FI105652B (https=)
GR (1) GR900300069T1 (https=)
HK (1) HK38293A (https=)
HU (3) HU216017B (https=)
IE (1) IE62868B1 (https=)
LV (1) LV10726B (https=)
NO (1) NO304990B1 (https=)
NZ (1) NZ227011A (https=)
UA (1) UA42668C2 (https=)
WO (1) WO1989004669A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506018A (ja) * 2000-08-17 2004-02-26 トリペップ　アクチ　ボラゲット リバビリンを含むワクチンおよびその使用方法

Families Citing this family (259)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227011A (en) * 1987-11-18 1992-03-26 Chiron Corp Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
AU650038B2 (en) * 1988-03-11 1994-06-09 Abbott Laboratories CKS method of protein synthesis
JP2696116B2 (ja) * 1988-09-30 1998-01-14 財団法人阪大微生物病研究会 非ａ非ｂ肝炎患者の血清と抗原抗体反応するペプチド、及び該ペプチドをコードするｄｎａ
US5191064A (en) * 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
JPH02167081A (ja) * 1988-12-21 1990-06-27 Tetsuo Nakamura 非Ａ非Ｂ型肝炎ウイルスゲノムＲＮＡ、ｃＤＮＡおよびウイルス抗原蛋白質
KR0185373B1 (ko) * 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
DK0398748T3 (da) * 1989-05-18 2002-03-18 Chiron Corp NANBV-diagnostika: polynukleotider anvendelige til screening for hepatitis C virus
JPH0330676A (ja) * 1989-06-28 1991-02-08 Sanwa Kagaku Kenkyusho Co Ltd 非ａ非ｂ型肝炎ウイルスのｄｎａ、そのクローン及びこれらの調製法
EP0416725A3 (en) * 1989-07-14 1991-03-20 Chugai Seiyaku Kabushiki Kaisha Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production
EP0414475B1 (en) * 1989-08-25 1997-12-10 Chiron Corporation Methods for culturing HCV in B- or T-lymphocyte cell lines
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
WO1991004262A1 (en) 1989-09-15 1991-04-04 National Institute Of Health Of Japan New hcv isolates
FR2654113A1 (fr) * 1989-11-09 1991-05-10 Pasteur Institut Procede de diagnostic de virus appartenant a la famille des flaviviridae.
BE1005485A5 (fr) * 1989-12-18 1993-08-10 Wellcome Found Agent viral.
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
CA2032907C (en) * 1989-12-22 2002-05-14 Richard R. Lesniewski Hepatitis c assay
US5308750A (en) * 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
EP0435229A1 (en) * 1989-12-27 1991-07-03 Sanwa Kagaku Kenkyusho Co., Ltd. DNA of non-A, non-B hepatitis virus gene, its clone and use thereof
DK0441644T3 (https=) * 1990-02-09 1997-03-03 Japan Immuno Inc
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
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