ES2188583T3 - Polipeptidos para el virus de la hepatitis c (hcv). - Google Patents
Polipeptidos para el virus de la hepatitis c (hcv).Info
- Publication number
- ES2188583T3 ES2188583T3 ES92914835T ES92914835T ES2188583T3 ES 2188583 T3 ES2188583 T3 ES 2188583T3 ES 92914835 T ES92914835 T ES 92914835T ES 92914835 T ES92914835 T ES 92914835T ES 2188583 T3 ES2188583 T3 ES 2188583T3
- Authority
- ES
- Spain
- Prior art keywords
- hcv
- hepatitis
- polypeptides
- virus
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
SE PRESENTAN EPITOPES UTILES COMO REACTIVOS INMUNOGENICOS Y LOS ANTICUERPOS Y METODOS DE USO CORRESPONDIENTES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72248991A | 1991-06-24 | 1991-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2188583T3 true ES2188583T3 (es) | 2003-07-01 |
Family
ID=24902063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92914835T Expired - Lifetime ES2188583T3 (es) | 1991-06-24 | 1992-06-24 | Polipeptidos para el virus de la hepatitis c (hcv). |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6346375B1 (es) |
| EP (1) | EP0591431B1 (es) |
| JP (9) | JP3516681B2 (es) |
| KR (1) | KR0185426B1 (es) |
| AT (1) | ATE229543T1 (es) |
| BG (1) | BG61843B1 (es) |
| CA (1) | CA2110058C (es) |
| DE (1) | DE69232871T2 (es) |
| ES (1) | ES2188583T3 (es) |
| FI (2) | FI110099B (es) |
| HU (1) | HU227547B1 (es) |
| NO (1) | NO309528B1 (es) |
| RO (1) | RO117329B1 (es) |
| RU (1) | RU2148587C1 (es) |
| UA (1) | UA40572C2 (es) |
| WO (1) | WO1993000365A2 (es) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171782B1 (en) | 1987-11-18 | 2001-01-09 | Chiron Corporation | Antibody compositions to HCV and uses thereof |
| US5714596A (en) * | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
| US5698390A (en) * | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
| US5712088A (en) * | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
| US6861212B1 (en) | 1987-11-18 | 2005-03-01 | Chiron Corporation | NANBV diagnostics and vaccines |
| US6027729A (en) * | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
| US5582968A (en) * | 1990-02-16 | 1996-12-10 | United Biomedical, Inc. | Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| GB9204274D0 (en) * | 1992-02-28 | 1992-04-08 | Wellcome Found | Novel peptides |
| US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
| US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
| DE4240980A1 (de) * | 1992-08-07 | 1994-02-10 | Boehringer Mannheim Gmbh | HCV Peptidantigene und Verfahren zur Bestimmung von HCV |
| US7157226B1 (en) | 1993-04-27 | 2007-01-02 | Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
| US7255997B1 (en) | 1993-04-27 | 2007-08-14 | N.V. Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
| RO115471B1 (ro) * | 1993-05-10 | 2000-02-28 | Chiron Corp Emeryville | Metoda pentru stabilirea unuia sau a mai multor tipuri de virus al hepatitei c |
| JPH08510240A (ja) | 1993-05-12 | 1996-10-29 | カイロン コーポレイション | C型肝炎ウイルスe2/ns1領域の保存モチーフ |
| US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
| WO1995011918A1 (en) * | 1993-10-29 | 1995-05-04 | Srl, Inc. | Antigen peptide compound and immunoassay method |
| US6555114B1 (en) | 1993-11-04 | 2003-04-29 | Innogenetics N.V. | Immunodominant human T-cell epitopes of hepatitis C virus |
| US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| AU702436B2 (en) * | 1994-10-21 | 1999-02-18 | Innogenetics N.V. | New sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents |
| GB2294690B (en) * | 1994-11-01 | 1998-10-28 | United Biomedical Inc | Peptides effective for diagnosis and detection of hepatitis C infection |
| US6034064A (en) * | 1995-04-07 | 2000-03-07 | Hoechst Pharmaceuticals & Chemicals K.K. | Peptides and therapeutic agent for autoimmune diseases containing the same |
| JPH08333390A (ja) * | 1995-04-07 | 1996-12-17 | Hoechst Japan Ltd | ペプチド及びそれからなる自己免疫疾患治療剤 |
| AU2352995A (en) * | 1995-04-28 | 1996-11-18 | Srl Inc. | Antigen peptide compound and immunoassay method |
| GB9513261D0 (en) * | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| US6127116A (en) | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| WO1997044469A2 (en) * | 1996-05-24 | 1997-11-27 | Chiron Corporation | Multiple epitope fusion protein |
| US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
| US7049428B1 (en) | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
| US6696545B1 (en) * | 1997-04-11 | 2004-02-24 | Sangstat Medical Corporation | Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation |
| WO1999015901A1 (en) | 1997-09-22 | 1999-04-01 | Chiron Corporation | Buffers for stabilizing antigens |
| JP2002512370A (ja) * | 1998-04-17 | 2002-04-23 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 還元剤を用いる改良された免疫診断アッセイ |
| US7052830B1 (en) * | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
| US7052696B2 (en) * | 1998-07-10 | 2006-05-30 | The United States Of America As Represented By The Department Of Health And Human Services | Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins |
| US6191256B1 (en) * | 1998-11-20 | 2001-02-20 | Bayer Corporation | Recombinant factor VIII binding peptides |
| AU6226100A (en) * | 1999-07-19 | 2001-04-24 | Epimmune, Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
| US6630298B2 (en) | 2000-06-15 | 2003-10-07 | Chiron Corporation | HCV antigen/antibody combination assay |
| US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| RU2286172C2 (ru) | 2000-08-17 | 2006-10-27 | Трипеп Аб | Вакцины, содержащие рибавирин, и способы их использования |
| DE60130998T2 (de) | 2000-08-17 | 2008-07-17 | Tripep Ab | Ribavirin-enthaltende vakzine |
| US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| EP1195381A1 (de) * | 2000-09-28 | 2002-04-10 | Immusystems GmbH | CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope |
| AU2002252856A1 (en) | 2001-04-24 | 2002-11-05 | Innogenetics N.V. | Expression of core-glycosylated hcv envelope proteins in yeast |
| AU2002311897A1 (en) * | 2001-05-09 | 2002-11-18 | Third Wave Technologies, Inc. | Nucleic acid detection in pooled samples |
| US7196183B2 (en) | 2001-08-31 | 2007-03-27 | Innogenetics N.V. | Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent |
| US20030100467A1 (en) * | 2001-09-12 | 2003-05-29 | Wolfgang Aehle | Binding phenol oxidizing enzyme-peptide complexes |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| US7332269B2 (en) * | 2001-11-11 | 2008-02-19 | Ortho-Clinical Diagnostics, Inc. | HCV core protein sequences |
| WO2003073097A2 (en) * | 2002-02-28 | 2003-09-04 | Intercell Ag | Methods for isolating ligands e.g. t cell epitopes |
| EP1490383B1 (en) * | 2002-03-11 | 2009-02-25 | Lab 21 Limited | Methods and compositions for identifying and characterizing hepatitis c |
| WO2004041842A2 (en) * | 2002-05-16 | 2004-05-21 | The General Hospital Corporation | Epitopes of hepatitis c virus |
| FR2839722A1 (fr) | 2002-05-17 | 2003-11-21 | Bio Merieux | Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c |
| CN1650012A (zh) | 2002-07-24 | 2005-08-03 | 英特塞尔股份公司 | 来自致病病毒的备选阅读框所编码的抗原 |
| JP4585314B2 (ja) | 2002-09-09 | 2010-11-24 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Hcvアッセイ |
| JP2006504687A (ja) * | 2002-09-13 | 2006-02-09 | インターツェル・アクチェンゲゼルシャフト | C型肝炎ウイルスペプチドの単離方法 |
| EP2287315A1 (en) | 2003-03-04 | 2011-02-23 | Intercell AG | Streptococcus pyogenes antigens |
| EP1608401A1 (en) * | 2003-03-24 | 2005-12-28 | Intercell AG | Use of alum and a th1 immune response inducing adjuvant for enhancing immune respones |
| WO2004084938A1 (en) | 2003-03-24 | 2004-10-07 | Intercell Ag | Improved vaccines |
| EP2336357A1 (en) | 2003-04-15 | 2011-06-22 | Intercell AG | S. pneumoniae antigens |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| AU2004255456B2 (en) | 2003-07-11 | 2010-06-24 | Intercell Ag | HCV vaccines |
| US20050202036A1 (en) * | 2003-07-22 | 2005-09-15 | Branch Andrea D. | Alternate reading frame polypeptides drived from hepatitis C and methods of their use |
| ES2596753T3 (es) | 2003-08-29 | 2017-01-11 | Fujirebio Europe N.V. | Nuevo clado del virus de la hepatitis C y secuencias prototipo del mismo |
| FR2859909B1 (fr) | 2003-09-22 | 2007-09-07 | Biomerieux Sa | Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation |
| RU2365624C2 (ru) * | 2003-10-27 | 2009-08-27 | Вертекс Фармасьютикалз Инкорпорейтед | Резистентные мутанты протеазы ns3-ns4a hcv |
| US20060003348A1 (en) * | 2004-04-16 | 2006-01-05 | Genentech. Inc. | Omi PDZ modulators |
| ATE527545T1 (de) * | 2004-08-27 | 2011-10-15 | Novartis Vaccines & Diagnostic | Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon |
| CN101287748B (zh) * | 2005-04-20 | 2013-03-27 | 百疗医株式会社 | 一种融合蛋白的组成及其分离方法 |
| CA2618429A1 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
| EP2061888A2 (en) | 2006-08-25 | 2009-05-27 | Novartis AG | Hcv fusion polypeptides |
| JP4975600B2 (ja) * | 2007-03-16 | 2012-07-11 | シスメックス株式会社 | Hcv抗体測定用試薬キット及びhcv抗体測定方法 |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| ES2702318T3 (es) | 2011-07-06 | 2019-02-28 | Glaxosmithkline Biologicals Sa | Emulsiones catiónicas de aceite en agua |
| CN103781470A (zh) | 2011-07-06 | 2014-05-07 | 诺华股份有限公司 | 包含核酸的水包油乳液 |
| FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
| WO2013150450A1 (en) * | 2012-04-02 | 2013-10-10 | Universidade Do Porto | Hcv homolog fragments, cell-lines and applications thereof |
| EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
| US9194873B2 (en) | 2013-03-14 | 2015-11-24 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
| EP2970947A4 (en) | 2013-03-14 | 2016-10-12 | Abbott Lab | RECOMBINANT HCV NS3 ANTIGENS AND THEIR MUTANTS FOR ENHANCED ANTIBODY DETECTION |
| WO2016160046A1 (en) | 2015-03-27 | 2016-10-06 | Ortho-Clinical Diagnostics, Inc. | Hcv ns4a/modified ns3 polypeptides and uses thereof |
| CN111153963B (zh) * | 2020-01-19 | 2021-08-10 | 华南理工大学 | 抗炎五肽及其提取分离方法和在改善记忆中的应用 |
Family Cites Families (51)
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|---|---|---|---|---|
| US4861588A (en) * | 1985-02-05 | 1989-08-29 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
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| GB2212511B (en) | 1987-11-18 | 1992-01-22 | Chiron Corp | Hepatitis c virus |
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| AU650038B2 (en) | 1988-03-11 | 1994-06-09 | Abbott Laboratories | CKS method of protein synthesis |
| US5312737A (en) | 1988-03-11 | 1994-05-17 | Abbott Laboratories | CKS method of HCV protein synthesis |
| JP2656995B2 (ja) * | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
| EP0416725A3 (en) | 1989-07-14 | 1991-03-20 | Chugai Seiyaku Kabushiki Kaisha | Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production |
| JP2818761B2 (ja) | 1989-09-14 | 1998-10-30 | 財団法人化学及血清療法研究所 | 非a非b型肝炎ウイルス抗原をコードする核酸断片およびその利用法 |
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| JP3156200B2 (ja) * | 1989-09-15 | 2001-04-16 | 国立予防衛生研究所長 | 新規のhcv分離株 |
| BR9006422A (pt) * | 1989-12-18 | 1991-09-24 | Wellcome Found | Processo para preparar um polipeptidio viral pt-nanbh e processo para detectar o mesmo |
| JPH03190898A (ja) | 1989-12-21 | 1991-08-20 | Shima Kenkyusho:Kk | 合成ポリペプチド及びそれを用いたhcv抗体測定試薬 |
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| JP3320411B2 (ja) | 1990-04-04 | 2002-09-03 | カイロン コーポレイション | C型肝炎ウイルスプロテアーゼ |
| JPH05506230A (ja) * | 1990-04-06 | 1993-09-16 | ジーンラブス テクノロジイズ インコーポレイテッド | C型肝炎ウイルスエピトープ |
| JPH044880A (ja) | 1990-04-20 | 1992-01-09 | Terumasa Arima | 非a非b型肝炎抗原をコードするdna及びポリペプチド |
| JP3268502B2 (ja) | 1990-06-12 | 2002-03-25 | 徹雄 中村 | 非a非b型肝炎ウイルス関連ポリヌクレオチド、ポリペプ タイド |
| JPH0446196A (ja) | 1990-06-13 | 1992-02-17 | Kuraray Co Ltd | 抗原蛋白質およびそれをコードしているdna断片 |
| EP0464287A1 (en) | 1990-06-25 | 1992-01-08 | The Research Foundation for Microbial Diseases of Osaka University | Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptide |
| CA2045326A1 (en) | 1990-06-25 | 1991-12-26 | Hiroto Okayama | Non-a, non-b, hepatitis virus particles |
| KR0181517B1 (ko) | 1990-07-09 | 1999-04-01 | 나까하라 노부유끼 | 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도 |
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| CA2047792C (en) | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
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-
1992
- 1992-06-24 CA CA002110058A patent/CA2110058C/en not_active Expired - Lifetime
- 1992-06-24 HU HU9303703A patent/HU227547B1/hu unknown
- 1992-06-24 UA UA93004481A patent/UA40572C2/uk unknown
- 1992-06-24 JP JP50167193A patent/JP3516681B2/ja not_active Expired - Lifetime
- 1992-06-24 KR KR1019930704022A patent/KR0185426B1/ko not_active Expired - Lifetime
- 1992-06-24 ES ES92914835T patent/ES2188583T3/es not_active Expired - Lifetime
- 1992-06-24 AT AT92914835T patent/ATE229543T1/de active
- 1992-06-24 RU RU93058563A patent/RU2148587C1/ru active
- 1992-06-24 RO RO93-01778A patent/RO117329B1/ro unknown
- 1992-06-24 WO PCT/US1992/005388 patent/WO1993000365A2/en not_active Ceased
- 1992-06-24 DE DE69232871T patent/DE69232871T2/de not_active Expired - Lifetime
- 1992-06-24 EP EP92914835A patent/EP0591431B1/en not_active Expired - Lifetime
-
1993
- 1993-12-10 NO NO934542A patent/NO309528B1/no not_active IP Right Cessation
- 1993-12-22 FI FI935808A patent/FI110099B/fi not_active IP Right Cessation
- 1993-12-23 BG BG98332A patent/BG61843B1/bg unknown
-
1995
- 1995-03-14 US US08/403,590 patent/US6346375B1/en not_active Expired - Lifetime
- 1995-05-18 US US08/444,818 patent/US6150087A/en not_active Expired - Lifetime
-
1999
- 1999-11-25 JP JP33516799A patent/JP3514680B2/ja not_active Expired - Lifetime
-
2002
- 2002-09-11 FI FI20021626A patent/FI111645B/fi not_active IP Right Cessation
-
2003
- 2003-02-28 JP JP2003054819A patent/JP3514751B2/ja not_active Expired - Lifetime
- 2003-11-14 JP JP2003385979A patent/JP3619827B2/ja not_active Expired - Lifetime
-
2004
- 2004-09-27 JP JP2004280446A patent/JP3926817B2/ja not_active Expired - Lifetime
-
2006
- 2006-11-21 JP JP2006314881A patent/JP4456596B2/ja not_active Expired - Lifetime
- 2006-11-21 JP JP2006314880A patent/JP4456595B2/ja not_active Expired - Lifetime
-
2007
- 2007-08-21 JP JP2007215324A patent/JP2008001716A/ja not_active Withdrawn
-
2008
- 2008-10-20 JP JP2008270386A patent/JP2009084285A/ja not_active Withdrawn
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