ATE229543T1 - Polypeptide des hepatitis c-virus (hiv) - Google Patents

Polypeptide des hepatitis c-virus (hiv)

Info

Publication number
ATE229543T1
ATE229543T1 AT92914835T AT92914835T ATE229543T1 AT E229543 T1 ATE229543 T1 AT E229543T1 AT 92914835 T AT92914835 T AT 92914835T AT 92914835 T AT92914835 T AT 92914835T AT E229543 T1 ATE229543 T1 AT E229543T1
Authority
AT
Austria
Prior art keywords
hepatitis
hiv
polypeptides
virus
epitopes
Prior art date
Application number
AT92914835T
Other languages
English (en)
Inventor
David Y Chien
William Rutter
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE229543T1 publication Critical patent/ATE229543T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT92914835T 1991-06-24 1992-06-24 Polypeptide des hepatitis c-virus (hiv) ATE229543T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72248991A 1991-06-24 1991-06-24
PCT/US1992/005388 WO1993000365A2 (en) 1991-06-24 1992-06-24 Hepatitis c virus (hcv) polypeptides

Publications (1)

Publication Number Publication Date
ATE229543T1 true ATE229543T1 (de) 2002-12-15

Family

ID=24902063

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92914835T ATE229543T1 (de) 1991-06-24 1992-06-24 Polypeptide des hepatitis c-virus (hiv)

Country Status (16)

Country Link
US (2) US6346375B1 (de)
EP (1) EP0591431B1 (de)
JP (9) JP3516681B2 (de)
KR (1) KR0185426B1 (de)
AT (1) ATE229543T1 (de)
BG (1) BG61843B1 (de)
CA (1) CA2110058C (de)
DE (1) DE69232871T2 (de)
ES (1) ES2188583T3 (de)
FI (2) FI110099B (de)
HU (1) HU227547B1 (de)
NO (1) NO309528B1 (de)
RO (1) RO117329B1 (de)
RU (1) RU2148587C1 (de)
UA (1) UA40572C2 (de)
WO (1) WO1993000365A2 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698390A (en) 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5582968A (en) * 1990-02-16 1996-12-10 United Biomedical, Inc. Branched hybrid and cluster peptides effective in diagnosing and detecting non-A, non-B hepatitis
US5639594A (en) * 1990-02-16 1997-06-17 United Biomedical, Inc. Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
GB9204274D0 (en) * 1992-02-28 1992-04-08 Wellcome Found Novel peptides
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
DE4240980A1 (de) * 1992-08-07 1994-02-10 Boehringer Mannheim Gmbh HCV Peptidantigene und Verfahren zur Bestimmung von HCV
CA2139100C (en) 1993-04-27 2009-06-23 Geert Maertens New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
DK0698216T4 (da) * 1993-05-10 2009-06-15 Novartis Vaccines & Diagnostic Fremgangsmåder til typebestemmelse af hepatitis-C-virus og anvendte reagenser heri
JPH08510240A (ja) 1993-05-12 1996-10-29 カイロン コーポレイション C型肝炎ウイルスe2/ns1領域の保存モチーフ
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5639856A (en) * 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5885771A (en) * 1993-10-29 1999-03-23 Srl, Inc. Antigenic peptide compound and immunoassay
CA2175692A1 (en) * 1993-11-04 1995-05-11 Geert Leroux-Roels Immunodominant human t-cell epitopes of hepatitis c virus
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
ES2176342T5 (es) 1994-10-21 2010-02-09 Innogenetics N.V. Secuencias del genotipo 7 del virus de la hepatitis c y su utilizacion como agentes profilacticos, terapeuticos y de diagnosticos.
GB2294690B (en) * 1994-11-01 1998-10-28 United Biomedical Inc Peptides effective for diagnosis and detection of hepatitis C infection
US6034064A (en) * 1995-04-07 2000-03-07 Hoechst Pharmaceuticals & Chemicals K.K. Peptides and therapeutic agent for autoimmune diseases containing the same
JPH08333390A (ja) * 1995-04-07 1996-12-17 Hoechst Japan Ltd ペプチド及びそれからなる自己免疫疾患治療剤
WO1996034013A1 (en) * 1995-04-28 1996-10-31 Srl, Inc. Antigen peptide compound and immunoassay method
GB9513261D0 (en) * 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
US6127116A (en) 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
JP3945822B2 (ja) * 1996-05-24 2007-07-18 カイロン コーポレイション 複数エピトープ融合タンパク質
US6514731B1 (en) 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US7049428B1 (en) 1998-03-04 2006-05-23 Washington University HCV variants
US6696545B1 (en) * 1997-04-11 2004-02-24 Sangstat Medical Corporation Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation
WO1999015901A1 (en) 1997-09-22 1999-04-01 Chiron Corporation Buffers for stabilizing antigens
EP1071955B2 (de) 1998-04-17 2009-02-18 N.V. Innogenetics S.A. Verbessertes immundiagnostische tests durch verwendung von reduzierende agenzien
US7052830B1 (en) 1998-06-09 2006-05-30 Branch Andrea D Hepatitis C virus peptides and uses thereof
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
US6191256B1 (en) * 1998-11-20 2001-02-20 Bayer Corporation Recombinant factor VIII binding peptides
CA2377525A1 (en) * 1999-07-19 2001-03-29 Epimmune Inc. Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions
DE60125240T3 (de) 2000-06-15 2010-10-28 Novartis Vaccines and Diagnostics, Inc., Emeryville Hcv-antigen/antikörper-kombinations-assay
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
KR100801123B1 (ko) 2000-08-17 2008-02-05 트리펩 아베 리바비린 함유 백신 및 이것의 사용 방법
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
EP1195381A1 (de) * 2000-09-28 2002-04-10 Immusystems GmbH CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope
OA13092A (en) 2001-04-24 2006-11-10 Innogenetics Nv Constructs and methods for expression of recombinant HCV envelope proteins.
US20030152942A1 (en) * 2001-05-09 2003-08-14 Lance Fors Nucleic acid detection in pooled samples
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US20030100467A1 (en) * 2001-09-12 2003-05-29 Wolfgang Aehle Binding phenol oxidizing enzyme-peptide complexes
AR045702A1 (es) * 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
US7332269B2 (en) * 2001-11-11 2008-02-19 Ortho-Clinical Diagnostics, Inc. HCV core protein sequences
US20050221381A1 (en) * 2002-02-28 2005-10-06 Christof Klade Method for isolating ligands
PT1490383E (pt) * 2002-03-11 2009-05-25 Lab 21 Ltd Métodos e composições para identificar e caracterizar a hepatite c
AU2003301865A1 (en) * 2002-05-16 2004-06-07 The General Hospital Corporation Epitopes of hepatitis c virus
FR2839722A1 (fr) * 2002-05-17 2003-11-21 Bio Merieux Nouvelles compositions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c
WO2004011650A2 (en) * 2002-07-24 2004-02-05 Intercell Ag Antigens encoded by alternative reading frame from pathogenic viruses
CA2498228C (en) 2002-09-09 2011-03-22 Chiron Corporation Hcv assay
WO2004024182A2 (en) * 2002-09-13 2004-03-25 Intercell Ag Method for isolating hepatitis c virus peptides
EP2287314A1 (de) 2003-03-04 2011-02-23 Intercell AG Streptococcus-pyogenes-Antigene
US7704514B2 (en) 2003-03-24 2010-04-27 Intercell Ag Vaccines
CN101214375B (zh) * 2003-03-24 2011-04-06 英特塞尔股份公司 改进的疫苗
JP2007525157A (ja) 2003-04-15 2007-09-06 インターツェル・アクチェンゲゼルシャフト 肺炎連鎖球菌抗原
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
ATE489967T1 (de) 2003-07-11 2010-12-15 Intercell Ag Hcv-vakzin
WO2005010035A2 (en) * 2003-07-22 2005-02-03 Branch Andrea D Alternate reading frame polypeptides derived from hepatitis c and methods of their use
ES2596753T3 (es) 2003-08-29 2017-01-11 Fujirebio Europe N.V. Nuevo clado del virus de la hepatitis C y secuencias prototipo del mismo
FR2859909B1 (fr) 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
RU2365624C2 (ru) * 2003-10-27 2009-08-27 Вертекс Фармасьютикалз Инкорпорейтед Резистентные мутанты протеазы ns3-ns4a hcv
AU2005250333A1 (en) * 2004-04-16 2005-12-15 Genentech, Inc. Omi PDZ modulators
US7871625B2 (en) * 2004-08-27 2011-01-18 Novartis Vaccines And Diagnostics, Inc. HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
EP1871785B1 (de) * 2005-04-20 2010-05-05 Viromed Co., Ltd Zusammensetzungen und verfahren zur trennung von fusionsproteinen
WO2007031867A2 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-stru tural ns3/4a fusion gene
JP5474547B2 (ja) 2006-08-25 2014-04-16 ノバルティス アーゲー Hcv融合ポリペプチド
JP4975600B2 (ja) * 2007-03-16 2012-07-11 シスメックス株式会社 Hcv抗体測定用試薬キット及びhcv抗体測定方法
US20090214593A1 (en) * 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
EP2244695A1 (de) 2007-12-07 2010-11-03 Novartis AG Zusammensetzungen zur induktion von immunantworten
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
EP3456316A1 (de) 2011-07-06 2019-03-20 GlaxoSmithKline Biologicals S.A. Kationische öl-in-wasser-emulsionen
CN103781470A (zh) 2011-07-06 2014-05-07 诺华股份有限公司 包含核酸的水包油乳液
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
WO2013150450A1 (en) * 2012-04-02 2013-10-10 Universidade Do Porto Hcv homolog fragments, cell-lines and applications thereof
BR112015023239A8 (pt) 2013-03-14 2018-04-17 Abbott Lab ensaio de combinação de anticorpo-antígeno de hcv e métodos e composições para uso do mesmo
MX376492B (es) 2013-03-14 2025-03-07 Abbott Lab Anticuerpos monoclonares que se unen al dominio de unión a lípidos de la proteína de la cápside del virus de la hepatitis c (vhc)
MX2015012824A (es) 2013-03-14 2016-06-24 Abbott Lab Antigenos recombinantes ns3 del vhc y mutantes de los mismos para la deteccion mejorada de anticuerpos.
BR112017020539B8 (pt) 2015-03-27 2024-01-09 Grifols Worldwide Operations Ltd Reagente para imunoensaio compreendendo um polipeptídeo, métodos de detecção de anticorpos e/ou antígenos para o vírus da hepatite c em uma amostra biológica, de seleção de amostras biológicas de um suprimento de amostras biológicas humanas, bem como polipeptídeo isolado e kit para teste imunodiagnóstico
CN111153963B (zh) * 2020-01-19 2021-08-10 华南理工大学 抗炎五肽及其提取分离方法和在改善记忆中的应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861588A (en) * 1985-02-05 1989-08-29 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
YU48038B (sh) 1987-11-18 1996-10-18 Chiron Corp. Postupak za dijagnostiku ne-a, ne-v hepatitisa
EP0318216B2 (de) * 1987-11-18 2001-08-29 Chiron Corporation NANBV-Diagnostika
US5312737A (en) 1988-03-11 1994-05-17 Abbott Laboratories CKS method of HCV protein synthesis
KR0185373B1 (ko) * 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
EP0416725A3 (en) 1989-07-14 1991-03-20 Chugai Seiyaku Kabushiki Kaisha Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production
JP2818761B2 (ja) 1989-09-14 1998-10-30 財団法人化学及血清療法研究所 非a非b型肝炎ウイルス抗原をコードする核酸断片およびその利用法
JP3156200B2 (ja) * 1989-09-15 2001-04-16 国立予防衛生研究所長 新規のhcv分離株
US5372928A (en) 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
CA2032381C (en) * 1989-12-18 2006-02-21 Peter E. Highfield Viral agent
JPH03190898A (ja) 1989-12-21 1991-08-20 Shima Kenkyusho:Kk 合成ポリペプチド及びそれを用いたhcv抗体測定試薬
CA2032907C (en) * 1989-12-22 2002-05-14 Richard R. Lesniewski Hepatitis c assay
EP0435229A1 (de) 1989-12-27 1991-07-03 Sanwa Kagaku Kenkyusho Co., Ltd. DNS-Gen von einem Non-A Non-B Hepatitis-Virus, seine Klonierung und Verwendung
KR940000755B1 (ko) * 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
DK0527788T3 (da) 1990-04-04 2004-09-06 Chiron Corp Hepatitis C virus protease
ATE194844T1 (de) * 1990-04-06 2000-08-15 Genelabs Tech Inc Hepatitis c-virus-epitope
JPH044880A (ja) 1990-04-20 1992-01-09 Terumasa Arima 非a非b型肝炎抗原をコードするdna及びポリペプチド
JP3268502B2 (ja) 1990-06-12 2002-03-25 徹雄 中村 非a非b型肝炎ウイルス関連ポリヌクレオチド、ポリペプ タイド
JPH0446196A (ja) 1990-06-13 1992-02-17 Kuraray Co Ltd 抗原蛋白質およびそれをコードしているdna断片
NZ238681A (en) 1990-06-25 1992-03-26 Univ Osaka Res Found Non-a, non-b hepatitis virus particles and their production
EP0464287A1 (de) 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, Non-B Hepatitis Virus genomisches DNS und Antigenpolypeptide
KR0181517B1 (ko) 1990-07-09 1999-04-01 나까하라 노부유끼 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도
JPH04126086A (ja) 1990-07-12 1992-04-27 Yamanouchi Pharmaceut Co Ltd 非a非b型肝炎ウイルス抗原ポリペプチド、該抗原ポリペプチドをコードするポリヌクレオチド、及びそれらを用いた非a非b型肝炎の診断法
CA2047792C (en) 1990-07-26 2002-07-02 Chang Y. Wang Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines
JP2714255B2 (ja) 1990-08-10 1998-02-16 カイロン コーポレイション Nanbv診断法:c型肝炎ウイルスのスクリーニングに有用なポリヌクレオチド
CA2049679C (en) 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
KR920004577A (ko) 1990-08-24 1992-03-27 원본미기재 단백질 합성의 cks 방법
CA2090335A1 (en) 1990-08-25 1992-02-26 Suzanne Zebedee Non-a, non-b hepatitis virus antigen, diagnostic methods and vaccines
JP3055793B2 (ja) 1990-09-07 2000-06-26 財団法人化学及血清療法研究所 非a非b型肝炎ウイルス融合ペプチドおよびその製法
JPH04144686A (ja) 1990-10-04 1992-05-19 Kunitada Shimotoono 構造蛋白質遺伝子、組換えベクター、それにより形質転換された大腸菌、ポリペプチドおよびポリペプチドの製造方法
JPH04159298A (ja) 1990-10-19 1992-06-02 Olympus Optical Co Ltd Hcvペプチド
DK0484787T3 (da) 1990-11-03 2002-02-04 Dade Behring Marburg Gmbh HCV-specifikke peptider, fremgangsmåde til opnåelse deraf og anvendelse deraf
EP0485209A1 (de) 1990-11-08 1992-05-13 Immuno Japan Inc. Mit Non-A Non-B Hepatitis Virus verwandtes Antigen, Aufspürsysteme für Antikörper, Polynukleotide und Polypeptide
JPH04179482A (ja) 1990-11-11 1992-06-26 Kunitada Shimotoono C型肝炎ウイルス由来の遺伝子
JPH04187090A (ja) 1990-11-22 1992-07-03 Toshio Shikata 非a非b型肝炎抗原をコードするdna及びポリペプチド
EP0516859A1 (de) 1990-11-29 1992-12-09 Toray Industries, Inc. Non-a non-b hepatitisvirus-antigenprotein
ATE185350T1 (de) * 1990-12-14 1999-10-15 Innogenetics Nv Synthetische antigene zum nachweis von antikörpern gegen hepatitis c virus
DK0569537T3 (da) 1991-01-31 1999-04-06 Abbott Lab Monoklonale antistoffer mod formodede HCV-kapperegioner og fremgangsmåder til anvendelse deraf
JP3244284B2 (ja) 1991-02-14 2002-01-07 武田薬品工業株式会社 C型肝炎ウイルス関連抗体および抗原の測定法
US5574132A (en) 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
JPH0568562A (ja) 1991-05-30 1993-03-23 Sanwa Kagaku Kenkyusho Co Ltd ヒトC型肝炎ウイルスのcDNA、そのクローン及びこれらの利用法
JP3055964B2 (ja) 1991-05-31 2000-06-26 株式会社トクヤマ Hcv 抗原活性ポリペプチド、ポリペプチドの製造方法、形質転換された大腸菌、および抗hcv 抗体の検出方法
FR2677372B1 (fr) 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
BR9206131A (pt) 1991-06-10 1995-05-02 Lucky Ltd Hepatite C: diagnóstico e vacinas
CA2070952A1 (en) 1991-06-11 1992-12-12 Makoto Seki Gene of hepatitis c virus or fragment thereof, polypeptide encoded by the same
AU648912B2 (en) 1991-06-13 1994-05-05 Dade International Inc. Immunoassay for non-A non-B hepatitis
JP3103180B2 (ja) 1992-01-30 2000-10-23 昭和電工株式会社 軟質性合成樹脂製シート
JP3190898B2 (ja) 1998-11-09 2001-07-23 米沢日本電気株式会社 ノート型パーソナルコンピュータ

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HU227547B1 (en) 2011-08-29
US6150087A (en) 2000-11-21
JP2003277396A (ja) 2003-10-02
NO934542D0 (no) 1993-12-10
JPH06508837A (ja) 1994-10-06
WO1993000365A3 (en) 1993-04-29
HU9303703D0 (en) 1994-04-28
BG98332A (bg) 1995-02-28
EP0591431A1 (de) 1994-04-13
HUT73098A (en) 1996-06-28
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JP2009084285A (ja) 2009-04-23
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RO117329B1 (ro) 2002-01-30
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NO934542L (no) 1994-02-10
JP2007077168A (ja) 2007-03-29
JP4456596B2 (ja) 2010-04-28
JP2004115533A (ja) 2004-04-15
FI20021626L (fi) 2002-09-11
KR0185426B1 (ko) 1999-04-01
JP3926817B2 (ja) 2007-06-06
RU2148587C1 (ru) 2000-05-10
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WO1993000365A2 (en) 1993-01-07
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JP3516681B2 (ja) 2004-04-05
CA2110058A1 (en) 1993-01-07
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JP2008001716A (ja) 2008-01-10
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AU2305392A (en) 1993-01-25
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