DE3582284D1 - Hepatitis-b-impfstoff. - Google Patents
Hepatitis-b-impfstoff.Info
- Publication number
- DE3582284D1 DE3582284D1 DE8585305457T DE3582284T DE3582284D1 DE 3582284 D1 DE3582284 D1 DE 3582284D1 DE 8585305457 T DE8585305457 T DE 8585305457T DE 3582284 T DE3582284 T DE 3582284T DE 3582284 D1 DE3582284 D1 DE 3582284D1
- Authority
- DE
- Germany
- Prior art keywords
- gly
- ser
- hepatitis
- phe
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 title 1
- 229940124736 hepatitis-B vaccine Drugs 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/22—Viral peptide or viral protein
- Y10S930/223—Hepatitis related
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15912484A JPS6137738A (ja) | 1984-07-31 | 1984-07-31 | Ｂ型肝炎ワクチン |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3582284D1 true DE3582284D1 (de) | 1991-05-02 |
Family
ID=15686755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585305457T Expired - Fee Related DE3582284D1 (de) | 1984-07-31 | 1985-07-31 | Hepatitis-b-impfstoff. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5019386A (de) |
| EP (1) | EP0171260B1 (de) |
| JP (1) | JPS6137738A (de) |
| AT (1) | ATE61938T1 (de) |
| DE (1) | DE3582284D1 (de) |
| DK (1) | DK345685A (de) |
| IE (1) | IE58647B1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861588A (en) * | 1985-02-05 | 1989-08-29 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US4847080A (en) * | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
| US5204096A (en) * | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US5158769A (en) * | 1984-03-07 | 1992-10-27 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| FR2637184A1 (fr) * | 1988-10-05 | 1990-04-06 | Inst Nat Sante Rech Med | Anticorps monoclonal reconnaissant une region pre-s1 de la grande proteine d'enveloppe du virus de l'hepatite b et ses applications, notamment pour le diagnostic in vitro et le traitement de l'hepatite b |
| US5274081A (en) * | 1989-09-20 | 1993-12-28 | Immuno A.G. | Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen |
| AT392417B (de) * | 1989-09-20 | 1991-03-25 | Immuno Ag | Komplex geeignet zur durchfuehrung eines verfahrens zur reinigung von pre-s-hepatitis-b- virus-oberflaechenantigen |
| US5576175A (en) * | 1989-09-20 | 1996-11-19 | Immuno Aktiengesellschaft | Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen |
| DE69131709T2 (de) * | 1990-06-29 | 2000-05-25 | Chiron Corp | Liposomen enthaltende impfstoffzusammensetzungen |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| US6607727B1 (en) | 1991-08-26 | 2003-08-19 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus |
| US6322789B1 (en) | 1991-08-26 | 2001-11-27 | Epimmune, Inc. | HLA-restricted hepatitis B virus CTL epitopes |
| US6419931B1 (en) | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| US5780036A (en) * | 1991-08-26 | 1998-07-14 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus |
| US5736378A (en) * | 1991-09-12 | 1998-04-07 | The Scripps Research Institute | Molecular cloning and characterization of the feline immunodeficiency virus isolate PPR |
| US6689363B1 (en) | 1992-01-29 | 2004-02-10 | Epimmune Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
| US20110097352A9 (en) * | 1992-01-29 | 2011-04-28 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
| US7611713B2 (en) * | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
| US6235288B1 (en) | 1992-08-26 | 2001-05-22 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus |
| FR2711670B1 (fr) * | 1993-10-22 | 1996-01-12 | Pasteur Institut | Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite. |
| US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| KR0158430B1 (ko) * | 1994-10-07 | 1998-12-01 | 허영섭 | p53 단백질을 이용한 B형 간염 바이러스의 복제 억제방법 |
| CN102294024B (zh) * | 2011-01-17 | 2013-03-13 | 广东现代农业集团研究院有限公司 | 一种多肽疫苗及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4415491A (en) * | 1980-01-14 | 1983-11-15 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
| US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| JPH0625069B2 (ja) * | 1981-01-29 | 1994-04-06 | ブリティッシュ・テクノロジー・グループ・リミテッド | Ｂ型肝炎ワクチン製造方法 |
| AU8746582A (en) * | 1981-09-02 | 1983-03-10 | Biogen N.V. | Hepatitis b virus e type antigen |
| US4596792A (en) * | 1981-09-04 | 1986-06-24 | The Regents Of The University Of California | Safe vaccine for hepatitis containing polymerized serum albumin |
| JPS58194897A (ja) * | 1982-05-07 | 1983-11-12 | Takeda Chem Ind Ltd | 新規ｄｎａ，その製造方法およびそれで形質転換させた宿主 |
| FR2550203B1 (fr) * | 1983-08-01 | 1985-11-22 | Anvar | Peptides synthetiques immunogenes porteurs d'un epitope caracteristique de l'antigene de surface du virus de l'hepatite b et compositions les contenant |
| US4847080A (en) * | 1984-03-07 | 1989-07-11 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers |
| US4599231A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4599230A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| EP0174444B1 (de) * | 1984-06-18 | 1992-03-11 | Chiron Corporation | Hepatitisoberflächenantigenpartikelvakzin |
| EP0401941A3 (de) * | 1984-07-11 | 1991-04-17 | Takeda Chemical Industries, Ltd. | Hepatitis B-Virus-Oberflächen-Antigen und seine Herstellung |
| US4683136A (en) * | 1985-03-06 | 1987-07-28 | Scripps Clinic And Research Foundation | Proteinaceous antigens with conformation-independent and conformation-dependent determinants |
| US4816564A (en) * | 1986-01-31 | 1989-03-28 | Merck & Co., Inc. | Method for producing hepatitis B virus proteins in yeast |
| US4818527A (en) * | 1986-12-09 | 1989-04-04 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4778784A (en) * | 1987-01-07 | 1988-10-18 | Baylor College Of Medicine | Cyclic peptide and method of use for inducing an immunological response to hepatitis B virus |
-
1984
- 1984-07-31 JP JP15912484A patent/JPS6137738A/ja active Granted
-
1985
- 1985-07-30 DK DK345685A patent/DK345685A/da not_active Application Discontinuation
- 1985-07-31 EP EP85305457A patent/EP0171260B1/de not_active Expired - Lifetime
- 1985-07-31 AT AT85305457T patent/ATE61938T1/de not_active IP Right Cessation
- 1985-07-31 DE DE8585305457T patent/DE3582284D1/de not_active Expired - Fee Related
- 1985-07-31 IE IE191285A patent/IE58647B1/en not_active IP Right Cessation
-
1988
- 1988-08-29 US US07/239,028 patent/US5019386A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK345685D0 (da) | 1985-07-30 |
| IE58647B1 (en) | 1993-11-03 |
| IE851912L (en) | 1986-01-31 |
| JPS6137738A (ja) | 1986-02-22 |
| JPH045653B2 (de) | 1992-02-03 |
| DK345685A (da) | 1986-02-01 |
| US5019386A (en) | 1991-05-28 |
| EP0171260A3 (en) | 1987-08-12 |
| ATE61938T1 (de) | 1991-04-15 |
| EP0171260B1 (de) | 1991-03-27 |
| EP0171260A2 (de) | 1986-02-12 |
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| DK0623169T3 (da) | Hepatitis E virus og fremgangsmåde | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |