BR112017020539B8 - Reagente para imunoensaio compreendendo um polipeptídeo, métodos de detecção de anticorpos e/ou antígenos para o vírus da hepatite c em uma amostra biológica, de seleção de amostras biológicas de um suprimento de amostras biológicas humanas, bem como polipeptídeo isolado e kit para teste imunodiagnóstico - Google Patents
Reagente para imunoensaio compreendendo um polipeptídeo, métodos de detecção de anticorpos e/ou antígenos para o vírus da hepatite c em uma amostra biológica, de seleção de amostras biológicas de um suprimento de amostras biológicas humanas, bem como polipeptídeo isolado e kit para teste imunodiagnósticoInfo
- Publication number
- BR112017020539B8 BR112017020539B8 BR112017020539A BR112017020539A BR112017020539B8 BR 112017020539 B8 BR112017020539 B8 BR 112017020539B8 BR 112017020539 A BR112017020539 A BR 112017020539A BR 112017020539 A BR112017020539 A BR 112017020539A BR 112017020539 B8 BR112017020539 B8 BR 112017020539B8
- Authority
- BR
- Brazil
- Prior art keywords
- biological samples
- polypeptide
- hepatitis
- virus
- immunoassay
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 241000711549 Hepacivirus C Species 0.000 title abstract 2
- 238000003018 immunoassay Methods 0.000 title abstract 2
- 239000012472 biological sample Substances 0.000 title 3
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 101001124041 Human coronavirus 229E Non-structural protein 4a Proteins 0.000 abstract 2
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
- G01N2333/186—Hepatitis C; Hepatitis NANB
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
polipeptídeos ns3 modificados/ns4a de hcv e usos dos mesmos. são descritos polipeptídeos modificados do vírus da hepatite c. os polipeptídeos incluem o domínio ns4a do hcv e o domínio ns3 modificado de hcv. os polipeptídeos retêm os epítopos conformacionais. também são descritos imunoensaios para hcv que incluem os polipeptídeos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562139183P | 2015-03-27 | 2015-03-27 | |
US62/139,183 | 2015-03-27 | ||
PCT/US2015/036941 WO2016160046A1 (en) | 2015-03-27 | 2015-06-22 | Hcv ns4a/modified ns3 polypeptides and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112017020539A2 BR112017020539A2 (pt) | 2018-07-10 |
BR112017020539B1 BR112017020539B1 (pt) | 2023-12-12 |
BR112017020539B8 true BR112017020539B8 (pt) | 2024-01-09 |
Family
ID=57004859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017020539A BR112017020539B8 (pt) | 2015-03-27 | 2015-06-22 | Reagente para imunoensaio compreendendo um polipeptídeo, métodos de detecção de anticorpos e/ou antígenos para o vírus da hepatite c em uma amostra biológica, de seleção de amostras biológicas de um suprimento de amostras biológicas humanas, bem como polipeptídeo isolado e kit para teste imunodiagnóstico |
Country Status (10)
Country | Link |
---|---|
US (2) | US10267803B2 (pt) |
EP (1) | EP3274478B1 (pt) |
JP (2) | JP6859314B2 (pt) |
CN (1) | CN107735499B (pt) |
BR (1) | BR112017020539B8 (pt) |
CA (1) | CA2980718C (pt) |
DK (1) | DK3274478T3 (pt) |
ES (1) | ES2832335T3 (pt) |
RU (1) | RU2017133463A (pt) |
WO (1) | WO2016160046A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3274478T3 (da) * | 2015-03-27 | 2020-11-23 | Ortho Clinical Diagnostics K K | Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf |
WO2020205510A1 (en) * | 2019-03-29 | 2020-10-08 | Trustees Of Boston University | Chimeric antigen receptor (car) modulation |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3886363T3 (de) | 1987-11-18 | 2004-09-09 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | NANBV-Diagnostika |
US5256532A (en) | 1988-05-02 | 1993-10-26 | Zynaxis Technologies, Inc. | Methods, reagents and test kits for determination of subpopulations of biological entities |
KR0185373B1 (ko) | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
DE69232871T2 (de) | 1991-06-24 | 2003-05-08 | Chiron Corp | Polypeptide des hepatitis c-virus (hiv) |
UA39944C2 (uk) | 1992-07-07 | 2001-07-16 | Чірон Корпорейшн | Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі |
ATE551423T1 (de) * | 1993-04-27 | 2012-04-15 | Innogenetics Nv | Sequenzen von hepatitis c virus-genotypen sowie ihre verwendungen als therapeutika und diagnostika |
JP3217600B2 (ja) | 1994-07-12 | 2001-10-09 | 株式会社先端生命科学研究所 | 非a非b型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ |
CA2250723C (en) | 1996-05-24 | 2012-07-17 | Chiron Corporation | Multiple epitope fusion protein |
WO1999028482A2 (en) * | 1997-11-28 | 1999-06-10 | Schering Corporation | Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide |
JP2002534084A (ja) * | 1999-01-08 | 2002-10-15 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎ウイルスns3プロテアーゼの修飾形 |
BRPI0111682B8 (pt) | 2000-06-15 | 2021-07-27 | Chiron Corp | suporte sólido de imunoensaio, kit de teste de imunodiagnóstico, métodos de produção de um suporte sólido de imunoensaio, e de detecção de infecção pelo vírus da hepatite c (hcv) em uma amostra biológica, e, uso de um suporte sólido de imunoensaio |
US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
EP1539809A4 (en) * | 2002-07-02 | 2006-03-08 | Chiron Corp | HCV fusion proteins with modified NS3 domains |
EP1802778B1 (en) * | 2004-08-27 | 2011-10-05 | Novartis Vaccines and Diagnostics, Inc. | Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof |
ES2387321T3 (es) * | 2006-03-09 | 2012-09-20 | Transgene Sa | Proteína de fusión no estructural del virus de la hepatitis C |
US20100297607A1 (en) * | 2009-05-20 | 2010-11-25 | Jian Zheng | Reagents For HCV Antigen-Antibody Combination Assays |
WO2014093602A1 (en) * | 2012-12-14 | 2014-06-19 | Profectus Biosciences, Inc. | Compositions and methods for treating and preventing hepatitis c virus infection |
DK3274478T3 (da) * | 2015-03-27 | 2020-11-23 | Ortho Clinical Diagnostics K K | Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf |
-
2015
- 2015-06-22 DK DK15888046.8T patent/DK3274478T3/da active
- 2015-06-22 JP JP2018501133A patent/JP6859314B2/ja active Active
- 2015-06-22 CN CN201580078268.XA patent/CN107735499B/zh active Active
- 2015-06-22 RU RU2017133463A patent/RU2017133463A/ru not_active Application Discontinuation
- 2015-06-22 US US15/025,301 patent/US10267803B2/en active Active
- 2015-06-22 ES ES15888046T patent/ES2832335T3/es active Active
- 2015-06-22 CA CA2980718A patent/CA2980718C/en active Active
- 2015-06-22 WO PCT/US2015/036941 patent/WO2016160046A1/en active Application Filing
- 2015-06-22 EP EP15888046.8A patent/EP3274478B1/en active Active
- 2015-06-22 BR BR112017020539A patent/BR112017020539B8/pt active IP Right Grant
-
2019
- 2019-03-08 US US16/297,311 patent/US10753939B2/en active Active
-
2020
- 2020-05-11 JP JP2020083351A patent/JP2020129001A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2020129001A (ja) | 2020-08-27 |
RU2017133463A3 (pt) | 2019-04-29 |
JP2018513390A (ja) | 2018-05-24 |
US10753939B2 (en) | 2020-08-25 |
DK3274478T3 (da) | 2020-11-23 |
CA2980718A1 (en) | 2016-10-06 |
ES2832335T3 (es) | 2021-06-10 |
US20180011096A1 (en) | 2018-01-11 |
US10267803B2 (en) | 2019-04-23 |
ES2832335T8 (es) | 2021-06-23 |
CN107735499B (zh) | 2022-05-03 |
BR112017020539B1 (pt) | 2023-12-12 |
CA2980718C (en) | 2021-06-01 |
JP6859314B2 (ja) | 2021-04-14 |
BR112017020539A2 (pt) | 2018-07-10 |
US20190271700A1 (en) | 2019-09-05 |
EP3274478A1 (en) | 2018-01-31 |
EP3274478B1 (en) | 2020-09-23 |
CN107735499A (zh) | 2018-02-23 |
RU2017133463A (ru) | 2019-04-29 |
EP3274478A4 (en) | 2018-08-08 |
WO2016160046A1 (en) | 2016-10-06 |
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