ATE211772T1 - Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus - Google Patents

Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus

Info

Publication number
ATE211772T1
ATE211772T1 AT90305421T AT90305421T ATE211772T1 AT E211772 T1 ATE211772 T1 AT E211772T1 AT 90305421 T AT90305421 T AT 90305421T AT 90305421 T AT90305421 T AT 90305421T AT E211772 T1 ATE211772 T1 AT E211772T1
Authority
AT
Austria
Prior art keywords
virus
hepatitis
polynucleotides suitable
hcv
serial examinations
Prior art date
Application number
AT90305421T
Other languages
English (en)
Inventor
Michael Houghton
Qui-Lim Choo
George Kuo
Jang Han
Michael S Urdea
Amy J Weiner
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE211772T1 publication Critical patent/ATE211772T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90305421T 1989-05-18 1990-05-18 Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus ATE211772T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35596189A 1989-05-18 1989-05-18
US45663789A 1989-12-21 1989-12-21
US50543590A 1990-04-04 1990-04-04

Publications (1)

Publication Number Publication Date
ATE211772T1 true ATE211772T1 (de) 2002-01-15

Family

ID=27408242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90305421T ATE211772T1 (de) 1989-05-18 1990-05-18 Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus

Country Status (17)

Country Link
EP (1) EP0398748B1 (de)
JP (3) JP2656996B2 (de)
AT (1) ATE211772T1 (de)
AU (1) AU638719B2 (de)
BG (1) BG60348B2 (de)
CA (1) CA2017157C (de)
DE (1) DE69033891T2 (de)
DK (1) DK0398748T3 (de)
ES (1) ES2166749T3 (de)
FI (1) FI105279B (de)
GE (1) GEP20002164B (de)
HU (1) HUT59964A (de)
LV (1) LV10729B (de)
MC (1) MC2188A1 (de)
NO (1) NO303503B1 (de)
RO (1) RO113059B1 (de)
WO (1) WO1990014436A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6489246A (en) * 1987-09-30 1989-04-03 Sony Corp Fixing method for color sorting mechanism of color cathode-ray tube
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
CA2032381C (en) * 1989-12-18 2006-02-21 Peter E. Highfield Viral agent
JP3268502B2 (ja) 1990-06-12 2002-03-25 徹雄 中村 非ａ非ｂ型肝炎ウイルス関連ポリヌクレオチド、ポリペプ タイド
EP0461863A1 (de) * 1990-06-12 1991-12-18 Immuno Japan Inc. Oligonukleotid-Primer und ihre Anwendung zum Nachweis von non-A, non-B-Hepatitisvirus mit grosser Genauigkeit
US5747339A (en) 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
ATE115964T1 (de) * 1990-06-30 1995-01-15 Akzo Nobel Nv Non-a non-b sequenzen.
EP0469348B1 (de) * 1990-07-11 1997-03-12 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. cDNS-Sequenz und Detektion des Hepatitis C-Virus
WO1992001714A1 (fr) * 1990-07-24 1992-02-06 Yamanouchi Pharmaceutical Co., Ltd. Antigene du virus de l'hepatite non a, non b
ATE154646T1 (de) * 1990-08-10 1997-07-15 Chiron Corp Nanbv diagnostik: für die untersuchung auf hepatitis c verwendbare polynukleotide
WO1992009634A1 (fr) * 1990-11-29 1992-06-11 Toray Industries, Incorporated Proteine anti-genique du virus de l'hepatite non a et non b
AU1459792A (en) * 1991-01-14 1992-08-27 James N. Gamble Institute Of Medical Research Basic structural immunogenic polypeptides having epitopes for hcv, antibodies, polynucleotide sequences, vaccines and methods
ATE112782T1 (de) * 1991-03-01 1994-10-15 Akzo Nobel Nv Mit antikörper gegen hepatitis non-a, non-b-virus immunochemische reaktive peptide.
US5574132A (en) * 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
EP0510952A1 (de) * 1991-04-26 1992-10-28 Immuno Japan Inc. Oligonukleotid-Primer und ihre Anwendung zum Nachweis von Non-A, Non-B-Hepatitis mit höchster Genauigkeit
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
IT1249684B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
DE69223562T2 (de) * 1991-08-27 1998-06-04 Hoffmann La Roche Verfahren und Reagenzien zum Nachweis von Hepatitis C
WO1993005181A1 (en) * 1991-09-12 1993-03-18 Cedars-Sinai Medical Center Direct detection of hepatitis c virus rna
DE69232859T2 (de) 1991-09-13 2003-04-10 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden
AU3063992A (en) * 1991-11-07 1993-06-07 Dade International Inc. Epitope mapping ot the c33c region of hcv
ES2065863T3 (es) 1991-11-21 2003-09-01 Common Services Agency Analisis para la deteccion de virus de la hepatitis c.
GB9204274D0 (en) * 1992-02-28 1992-04-08 Wellcome Found Novel peptides
US5866139A (en) * 1992-06-04 1999-02-02 Institut Pasteur Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications
US5922857A (en) * 1992-09-28 1999-07-13 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
JPH06153961A (ja) * 1992-11-27 1994-06-03 Imuno Japan:Kk Ｃ型肝炎ウイルス部分遺伝子、ならびにｃ型肝炎ウイルス遺 伝子の高感度検出法
DE69433160T2 (de) 1993-05-12 2004-07-08 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region
WO1996004301A2 (en) * 1994-07-29 1996-02-15 Chiron Corporation Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same
CA2195312A1 (en) 1994-07-29 1996-02-15 Mark Selby Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
JP4458556B2 (ja) 1997-05-06 2010-04-28 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｃ型肝炎のｅ２短縮型ポリペプチドの細胞内生成
DE19832050C2 (de) * 1998-07-16 2002-10-10 Biotest Pharma Gmbh Verfahren zum Nachweis von Hepatitis B- bzw. Hepatitis C-Virusgenomen in Plasmaproben und spezifische Primer
EP2286792A1 (de) 1999-02-26 2011-02-23 Novartis Vaccines and Diagnostics, Inc. Mikroemulsionen mit einer adsorbierenden Oberfläche, enthaltend eine Mikrotropfenemulsion
EP2275133A1 (de) 1999-02-26 2011-01-19 Novartis Vaccines and Diagnostics, Inc. Verwendung von Bioklebstoffen und Impfstoff-Adjuvantien für mucosale Verabreichung von antigenem Material
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
SK287694B6 (sk) * 2000-06-15 2011-06-06 Novartis Vaccines & Diagnostics, Inc. Pevný nosič imunoeseje a spôsob jeho prípravy, spôsob detekcie infekcie HIV a súprava na imunodiagnostickú skúšku
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
AU2001292151B2 (en) 2000-08-17 2006-05-04 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
AU2002303330B2 (en) 2001-05-31 2008-07-24 Novartis Vaccines And Diagnostics, Inc. Chimeric alphavirus replicon particles
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
US7501134B2 (en) 2002-02-20 2009-03-10 Novartis Vaccines And Diagnostics, Inc. Microparticles with adsorbed polypeptide-containing molecules
US7598421B2 (en) 2002-05-08 2009-10-06 Ucl Biomedica Plc Materials for the delivery of biologically-active material to cells
AU2003299994A1 (en) 2002-12-27 2004-07-29 Chiron Corporation Immunogenic compositions containing phospholpid
WO2004084936A2 (en) 2003-02-06 2004-10-07 Cerus Corporation Modified free-living microbes, vaccine compositions and methods of use thereof
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
DK1592441T3 (da) 2003-02-06 2012-05-14 Aduro Biotech Listeria, hvis indtrængen i ikke-phagocytiske celler er svækket, vacciner omfattende listeria og fremgangsmåder til anvendelse deraf
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
US20060165716A1 (en) 2004-07-29 2006-07-27 Telford John L Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
ATE542140T1 (de) 2004-08-27 2012-02-15 Novartis Vaccines & Diagnostic Nichtstrukturelle hcv-proteinmutanten und verwendungsmöglichkeiten dafür
WO2007031867A2 (en) 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-stru tural ns3/4a fusion gene
WO2008046923A2 (en) * 2006-10-20 2008-04-24 Innogenetics N.V. Methodology for analysis of sequence variations within the hcv ns3/4a genomic region
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
EP2244695A1 (de) 2007-12-07 2010-11-03 Novartis AG Zusammensetzungen zur induktion von immunantworten
WO2009130588A2 (en) 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
CN102076843A (zh) 2008-05-19 2011-05-25 艾杜罗生物科技公司 包含prfa*突变体李斯特菌的组合物及其使用方法
US20120100171A1 (en) 2009-03-09 2012-04-26 William Henry Hapten-carrier conjugates with bacterial toxins having a signal peptide as carrier and their use in immunogenic compositions
FI122954B (fi) 2011-01-31 2012-09-14 Teknoware Oy LED-putkilamppu ja valaisinjärjestely

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
BR8807310A (pt) * 1987-11-18 1990-03-13 Chiron Corp Polinucleotidio,polinucleotidio recombinante,vetor recombinante,celula hospedeira,sistema de expressao recombinante,celula transformada,polipeptidio,hcv,preparacao de polipeptidio,polipeptidio de hcv,polipeptidio purificado,polipeptidio recombinante,polipeptidio de fusao,anticorpo monoclonal,preparacao purificada de anticorpos policlonais,particula,sonda de polinucleotidio,kit anticorpo para epetopo de hcv,metodo para producao de polipeptidio,metodo para deteccao de acidos nucleicos de hcv,imunoensaio para detectar antigeno de hcv,imunoensaio para detectar anticorpos dirigidos contra antigeno de hcv,vacina para tratamento de infeccao de hcv,celula,celula infectada com hcv,metodo para producao de anticorpos para hcv e metodo para isolar cdna derivado do genoma de um agente infeccioso nao identificado
US5191064A (en) * 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
HU225068B1 (en) * 1989-03-17 2006-05-29 Chiron Corp Process for producing diagnostics and vaccine of nanbh
AU638304B2 (en) * 1989-12-22 1993-06-24 Abbott Laboratories Hepatitis c assay
AU7672991A (en) * 1990-04-03 1991-10-30 Southwest Foundation For Biomedical Research Purified hcv and hcv proteins and peptides

Also Published As

Publication number Publication date
AU5812390A (en) 1990-12-18
JP3701754B2 (ja) 2005-10-05
BG60348B2 (bg) 1994-09-30
JP2656996B2 (ja) 1997-09-24
HUT59964A (en) 1992-07-28
WO1990014436A1 (en) 1990-11-29
EP0398748B1 (de) 2002-01-09
EP0398748A2 (de) 1990-11-22
FI915443A0 (fi) 1991-11-18
LV10729B (en) 1995-12-20
AU638719B2 (en) 1993-07-08
MC2188A1 (fr) 1992-09-16
NO303503B1 (no) 1998-07-20
CA2017157A1 (en) 1990-11-18
RO113059B1 (ro) 1998-03-30
JPH1089A (ja) 1998-01-06
DE69033891D1 (de) 2002-02-21
FI105279B (fi) 2000-07-14
JP3698520B2 (ja) 2005-09-21
ES2166749T3 (es) 2002-05-01
EP0398748A3 (de) 1991-10-23
HU904754D0 (en) 1992-01-28
JPH10113176A (ja) 1998-05-06
DK0398748T3 (da) 2002-03-18
LV10729A (lv) 1995-06-20
NO914517D0 (no) 1991-11-18
CA2017157C (en) 2003-07-29
DE69033891T2 (de) 2002-08-29
GEP20002164B (en) 2000-07-10
NO914517L (no) 1992-01-16
JPH05500155A (ja) 1993-01-21

Similar Documents

Publication Publication Date Title
DE69033891D1 (de) NANBV-Diagnostika: Polynukleotide, geeignet für Reihenuntersuchungen auf Hepatitis C-Virus
ATE154646T1 (de) Nanbv diagnostik: für die untersuchung auf hepatitis c verwendbare polynukleotide
DE69334357D1 (de) Nachweis und Typisierung das Hepatitis C Virus (HCV) mittels 5'UTR und NS5 Nukleinsäuresequenzen
BR9509421A (pt) Novas sequências de genotipos de vírus de hepatite C e uso como agentes profiláticos terapêuticos e diagnósticos
DE69330372D1 (de) ZUSAMMENSETZUNGEN UND VERFAHREN FüR DIE BEHANDLUNG VON MIT HEPATITIS C VIREN ASSOZIIERTEN KRANKHEITEN
DE69829115D1 (de) Zusammensetzungen und verfahren zur behandlung von hepatitis c virus-bedingten erkrankungen
CA2139100A1 (en) New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
ATE252154T1 (de) Genomische hcv-sequenzen für diagnostik und therapie
ES2286212T3 (es) Secuencias suprimidas especificamente del genoma de mycobacterium tuberculosis, y su uso en el diagnostico y como vacunas.
ES8202566A1 (es) Un procedimiento de preparacion de un catalizador
ES8801902A1 (es) Un procedimiento para la preparacion de agentes inotropicos de quinolona
DE69009050D1 (de) Verfahren zur stabilisierung der hybridisierung von komplementären polynukleotidsequenzen.
ATE90073T1 (de) Verfahren zur herstellung von n-acyl-anilinen.
KR790000147B1 (en) Method of preparation for 2,6-diamino-dihydropyrimidwes
Fleer et al. Investigations Into the Plasma Thermal Cutting of Grade X 2 NiCoMo 18 8 5 High Strength Martensitic Age Hardenable Steel
IT1110168B (it) Composizione di un metallo di transizione e sua produzione
PT94081A (pt) Diagnosticos para o nambv: polinucleotidos uteis na deteccao do virus da hepatite c

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time