DE69232859T2 - Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden - Google Patents
Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptidenInfo
- Publication number
- DE69232859T2 DE69232859T2 DE69232859T DE69232859T DE69232859T2 DE 69232859 T2 DE69232859 T2 DE 69232859T2 DE 69232859 T DE69232859 T DE 69232859T DE 69232859 T DE69232859 T DE 69232859T DE 69232859 T2 DE69232859 T2 DE 69232859T2
- Authority
- DE
- Germany
- Prior art keywords
- composition
- virus polypeptides
- several immune
- immune reactive
- reactive hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75957591A | 1991-09-13 | 1991-09-13 | |
PCT/US1992/007683 WO1993006126A1 (en) | 1991-09-13 | 1992-09-11 | Immunoreactive hepatitis c virus polypeptide compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232859D1 DE69232859D1 (de) | 2003-01-16 |
DE69232859T2 true DE69232859T2 (de) | 2003-04-10 |
Family
ID=25056174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232859T Expired - Lifetime DE69232859T2 (de) | 1991-09-13 | 1992-09-11 | Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden |
Country Status (16)
Country | Link |
---|---|
US (6) | US5756312A (de) |
EP (1) | EP0608261B1 (de) |
JP (5) | JPH06511149A (de) |
AT (1) | ATE228564T1 (de) |
AU (1) | AU679429B2 (de) |
BG (1) | BG62973B1 (de) |
CA (1) | CA2116764C (de) |
DE (1) | DE69232859T2 (de) |
DK (1) | DK0608261T3 (de) |
ES (1) | ES2182822T3 (de) |
FI (1) | FI112438B (de) |
HU (1) | HU227510B1 (de) |
PL (2) | PL171489B1 (de) |
RO (1) | RO116199B1 (de) |
RU (2) | RU2136311C1 (de) |
WO (1) | WO1993006126A1 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6596476B1 (en) * | 1989-12-22 | 2003-07-22 | Abbott Laboratories | Hepatitis C assay |
PL171489B1 (pl) * | 1991-09-13 | 1997-05-30 | Chiron Corp | Sposób wytwarzania kompozycji immunogenicznej reagujacej immunologicznie krzyzowo z wieloma izolatami HCV PL |
US6297048B1 (en) * | 1992-02-04 | 2001-10-02 | Chiron Corporation | Hepatitis therapeutics |
US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
EP0671926B1 (de) * | 1992-08-11 | 2002-11-13 | President And Fellows Of Harvard College | Immunmodulierende peptide |
US6762024B2 (en) | 1993-04-27 | 2004-07-13 | Innogenetics, S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
US7255997B1 (en) | 1993-04-27 | 2007-08-14 | N.V. Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
EP1421951A3 (de) | 1993-05-12 | 2005-10-05 | Chiron Corporation | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
US5514539A (en) | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
JPH09504534A (ja) | 1993-11-04 | 1997-05-06 | インノジェネティクス・エヌ・ブイ | C型肝炎ウイルスの免疫優性ヒトt細胞エピトープ |
JP3556228B2 (ja) | 1994-07-25 | 2004-08-18 | ロシュ ダイアグノスティックス ゲーエムベーハー | 複数の抗原を使用した特異的免疫グロブリンの測定 |
CA2172273A1 (en) | 1994-07-29 | 1996-02-15 | Geert Maertens | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
ES2176342T5 (es) | 1994-10-21 | 2010-02-09 | Innogenetics N.V. | Secuencias del genotipo 7 del virus de la hepatitis c y su utilizacion como agentes profilacticos, terapeuticos y de diagnosticos. |
US6110465A (en) * | 1995-06-07 | 2000-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines |
US7235394B1 (en) | 1995-08-29 | 2007-06-26 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
US6127116A (en) | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
US7045363B2 (en) * | 1996-05-01 | 2006-05-16 | Fujirebio Inc. | Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide |
US6001613A (en) * | 1996-05-24 | 1999-12-14 | Board Of Regents Of University Of Nebraska | Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid |
JP4021493B2 (ja) | 1996-11-08 | 2007-12-12 | ザ ガヴァメント オブ ザ ユナイテッド ステイツ オブ アメリカ、レプリゼンテッド バイ ザ セクレタリー、 デパートメント オブ ヘルス アンド ヒューマン サーヴィスィズ | C型肝炎ウイルス様粒子の合成および精製 |
US6322965B1 (en) * | 1997-02-10 | 2001-11-27 | Advanced Life Science Institute, Inc. | Chimera antigen peptide |
US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
US7049428B1 (en) * | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
DE69841919D1 (de) * | 1997-11-06 | 2010-11-11 | Innogenetics Nv | Multimere peptide, die auf dem hepatitis c virus hüllprotein basieren, für diagnostische verwendung und für impfzwecke |
US6815431B2 (en) | 1998-04-15 | 2004-11-09 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US6451306B1 (en) | 1998-04-15 | 2002-09-17 | The Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US7157435B2 (en) | 1998-04-15 | 2007-01-02 | The Regents Of The University Of California | Methods for modulation of the effects of aging on the primate brain |
US6683058B1 (en) | 1998-04-15 | 2004-01-27 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US7052830B1 (en) * | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
US7108855B2 (en) * | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
US6548634B1 (en) * | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
US20030180284A1 (en) * | 1998-11-05 | 2003-09-25 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
DK1141315T3 (da) * | 1998-12-31 | 2008-05-19 | Novartis Vaccines & Diagnostic | Modificerede HIV Env-polypeptider |
CA2358385C (en) * | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
CA2360347C (en) | 1998-12-31 | 2013-05-07 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
EP1535628B1 (de) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-ähnliche teilchen |
US6740323B1 (en) | 1999-11-24 | 2004-05-25 | Chiron Corporation | HBV/HCV virus-like particle |
AU6175801A (en) * | 2000-07-19 | 2002-02-05 | Univ California | Methods for therapy of neurodegenerative disease of the brain |
KR20070114209A (ko) | 2000-08-17 | 2007-11-29 | 트리펩 아베 | 리바비린 함유 백신 및 이것의 사용 방법 |
US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
EP1326625A4 (de) | 2000-09-13 | 2005-05-04 | Hawaii Biotech Inc | Immunogene zusammensetzung von hepatitis c und methoden für ihre verwendung |
WO2003004620A2 (en) | 2001-07-05 | 2003-01-16 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
JP4302513B2 (ja) * | 2001-07-05 | 2009-07-29 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 抗原性b型hivポリペプチドおよび/または抗原性c型hivポリペプチドをコードするポリヌクレオチド、それらのポリペプチドおよびそれらの使用 |
CA2458995C (en) * | 2001-08-31 | 2013-04-30 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
US20070073048A1 (en) | 2003-05-15 | 2007-03-29 | Ying Lian | Hiv polynucleotides and polypeptides derived from botswana mj4 |
WO2005010035A2 (en) * | 2003-07-22 | 2005-02-03 | Branch Andrea D | Alternate reading frame polypeptides derived from hepatitis c and methods of their use |
WO2005017125A2 (en) * | 2003-08-14 | 2005-02-24 | California Institute Of Molecular Medicine | Method for isolation and replication of infectious human hepatitis-c virus |
US8124747B2 (en) | 2003-08-29 | 2012-02-28 | Innogenetics | HCV clade and prototype sequences thereof |
WO2006050394A2 (en) | 2004-11-01 | 2006-05-11 | Novartis Vaccines And Diagnostics Inc. | Combination approaches for generating immune responses |
US7968697B2 (en) * | 2005-05-25 | 2011-06-28 | Chrontech Pharma Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
AU2007207544A1 (en) | 2006-01-17 | 2007-07-26 | Health Research, Inc. | Heteroduplex tracking assay |
EP2185195A2 (de) * | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen-plattform |
US20100286070A1 (en) * | 2007-09-14 | 2010-11-11 | Gert Verheyden | Affinity tag |
KR102271404B1 (ko) | 2007-09-28 | 2021-07-02 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Xa 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
EP3604510A1 (de) | 2009-03-30 | 2020-02-05 | Portola Pharmaceuticals, Inc. | Gegenmittel für faktor-xa-inhibitoren und verfahren zur verwendung davon |
WO2010148117A1 (en) | 2009-06-17 | 2010-12-23 | Scantibodies Laboratory, Inc. | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
CN102625712B (zh) | 2009-07-15 | 2017-07-25 | 博尔托拉制药公司 | 用于因子xa抑制剂的解毒剂的单位剂量制剂及其使用方法 |
EP3456316A1 (de) | 2011-07-06 | 2019-03-20 | GlaxoSmithKline Biologicals S.A. | Kationische öl-in-wasser-emulsionen |
WO2013006834A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Oil-in-water emulsions that contain nucleic acids |
WO2013016449A2 (en) | 2011-07-26 | 2013-01-31 | Indicator Systems International, Inc. | Assays for the detection of microbes |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
KR102143887B1 (ko) | 2012-03-16 | 2020-08-12 | 유니버시티 헬스 네트워크 | Toso 활성을 조절하기 위한 방법 및 조성물 |
RU2520710C1 (ru) * | 2012-12-10 | 2014-06-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Челябинская государственная медицинская академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ЧелГМА Минздравсоцразвития России) | Способ прогнозирования персистенции онкогенных типов вируса папилломы человека в цервикальном эпителии |
US20150250853A1 (en) | 2014-03-07 | 2015-09-10 | University Health Network | Methods and compositions for modifying the immune response |
RU2675108C2 (ru) * | 2015-06-15 | 2018-12-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) | Композиция на основе синтетических пептидов и липидов для вакцины против гепатита с |
US10287338B2 (en) | 2015-07-10 | 2019-05-14 | Miran NERSISSIAN | Factor VIII protein compositions and methods of treating of hemophilia A |
EP3365027B1 (de) | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu-spezifische antikörper und deren verwendeng zur hemmung von biofilm |
JP2020513838A (ja) | 2017-01-04 | 2020-05-21 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | Dnabiiワクチンおよび強化された活性を有する抗体 |
EP3565834A1 (de) | 2017-01-04 | 2019-11-13 | The Research Institute at Nationwide Children's Hospital | Antikörperfragmente zur behandlung von biofilmbedingten erkrankungen |
US11746136B2 (en) | 2017-03-15 | 2023-09-05 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
CA3145385A1 (en) | 2019-07-08 | 2021-01-14 | Steven D. Goodman | Antibody compositions for disrupting biofilms |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3400079A1 (de) * | 1984-01-03 | 1985-07-11 | Röhm GmbH, 6100 Darmstadt | Wasserspreitendes kunststoffmaterial, verfahren zu seiner herstellung u. verwendung als verglasungs- und bedachungsmaterial |
NZ219516A (en) * | 1987-02-10 | 1991-02-26 | Wellcome Found | Fusion proteins of hbcag (hepatitis b virus core antigen) |
BR8807310A (pt) * | 1987-11-18 | 1990-03-13 | Chiron Corp | Polinucleotidio,polinucleotidio recombinante,vetor recombinante,celula hospedeira,sistema de expressao recombinante,celula transformada,polipeptidio,hcv,preparacao de polipeptidio,polipeptidio de hcv,polipeptidio purificado,polipeptidio recombinante,polipeptidio de fusao,anticorpo monoclonal,preparacao purificada de anticorpos policlonais,particula,sonda de polinucleotidio,kit anticorpo para epetopo de hcv,metodo para producao de polipeptidio,metodo para deteccao de acidos nucleicos de hcv,imunoensaio para detectar antigeno de hcv,imunoensaio para detectar anticorpos dirigidos contra antigeno de hcv,vacina para tratamento de infeccao de hcv,celula,celula infectada com hcv,metodo para producao de anticorpos para hcv e metodo para isolar cdna derivado do genoma de um agente infeccioso nao identificado |
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
UA50829C2 (uk) * | 1989-03-17 | 2002-11-15 | Чірон Корпорейшн | Очищений поліпептид, що містить антиген вірусу гепатиту с, полінуклеотид, вектор, клітини, система експресії, моноклональне антитіло, препарат поліклональних антитіл, нуклеотидна проба, аналітичні набори, спосіб виявлення нуклеїнових кислот, способи імуноаналізу, вакцина, спосіб одержання антитіл |
DK0398748T3 (da) * | 1989-05-18 | 2002-03-18 | Chiron Corp | NANBV-diagnostika: polynukleotider anvendelige til screening for hepatitis C virus |
US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
WO1991004262A1 (en) * | 1989-09-15 | 1991-04-04 | National Institute Of Health Of Japan | New hcv isolates |
ATE318309T1 (de) * | 1990-11-03 | 2006-03-15 | Dade Behring Marburg Gmbh | Hcv-spezifische peptide, mittel dazu und ihre verwendung |
PL171489B1 (pl) * | 1991-09-13 | 1997-05-30 | Chiron Corp | Sposób wytwarzania kompozycji immunogenicznej reagujacej immunologicznie krzyzowo z wieloma izolatami HCV PL |
-
1992
- 1992-09-11 PL PL92302729A patent/PL171489B1/pl unknown
- 1992-09-11 JP JP5506119A patent/JPH06511149A/ja not_active Withdrawn
- 1992-09-11 DE DE69232859T patent/DE69232859T2/de not_active Expired - Lifetime
- 1992-09-11 DK DK92919917T patent/DK0608261T3/da active
- 1992-09-11 CA CA002116764A patent/CA2116764C/en not_active Expired - Lifetime
- 1992-09-11 RU RU94024561A patent/RU2136311C1/ru active
- 1992-09-11 WO PCT/US1992/007683 patent/WO1993006126A1/en active IP Right Grant
- 1992-09-11 EP EP92919917A patent/EP0608261B1/de not_active Expired - Lifetime
- 1992-09-11 AT AT92919917T patent/ATE228564T1/de active
- 1992-09-11 RO RO94-00391A patent/RO116199B1/ro unknown
- 1992-09-11 PL PL92313797A patent/PL171972B1/pl unknown
- 1992-09-11 HU HU9400741A patent/HU227510B1/hu unknown
- 1992-09-11 ES ES92919917T patent/ES2182822T3/es not_active Expired - Lifetime
- 1992-09-11 RU RU98117084/14A patent/RU2212899C2/ru active
- 1992-09-11 AU AU26436/92A patent/AU679429B2/en not_active Expired
-
1994
- 1994-03-11 BG BG98653A patent/BG62973B1/bg unknown
- 1994-03-14 FI FI941199A patent/FI112438B/fi not_active IP Right Cessation
- 1994-04-19 US US08/231,368 patent/US5756312A/en not_active Expired - Lifetime
-
1995
- 1995-05-12 US US08/440,542 patent/US5670153A/en not_active Expired - Lifetime
- 1995-05-12 US US08/440,103 patent/US5670152A/en not_active Expired - Lifetime
- 1995-05-12 US US08/440,210 patent/US5766845A/en not_active Expired - Lifetime
- 1995-06-06 US US08/471,498 patent/US5728520A/en not_active Expired - Lifetime
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1998
- 1998-03-24 US US09/046,604 patent/US6303292B1/en not_active Expired - Fee Related
-
2001
- 2001-07-11 JP JP2001211447A patent/JP2002167336A/ja not_active Withdrawn
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2003
- 2003-09-18 JP JP2003326811A patent/JP2004073207A/ja not_active Withdrawn
-
2005
- 2005-01-27 JP JP2005020454A patent/JP4353905B2/ja not_active Expired - Lifetime
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2008
- 2008-02-20 JP JP2008038799A patent/JP2008133301A/ja not_active Withdrawn
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