FI932561A0 - Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning - Google Patents

Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning

Info

Publication number
FI932561A0
FI932561A0 FI932561A FI932561A FI932561A0 FI 932561 A0 FI932561 A0 FI 932561A0 FI 932561 A FI932561 A FI 932561A FI 932561 A FI932561 A FI 932561A FI 932561 A0 FI932561 A0 FI 932561A0
Authority
FI
Finland
Prior art keywords
protein
pharyngeal
intact epithelium
variants
epithelium
Prior art date
Application number
FI932561A
Other languages
English (en)
Other versions
FI932561A (fi
Inventor
Uffe Loevborg
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8205875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI932561(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI932561A publication Critical patent/FI932561A/fi
Publication of FI932561A0 publication Critical patent/FI932561A0/fi

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38654—Preparations containing enzymes, e.g. protease or amylase containing oxidase or reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
FI932561A 1990-12-05 1993-06-04 Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning FI932561A0 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90610072 1990-12-05

Publications (2)

Publication Number Publication Date
FI932561A FI932561A (fi) 1993-06-04
FI932561A0 true FI932561A0 (fi) 1993-06-04

Family

ID=8205875

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932561A FI932561A0 (fi) 1990-12-05 1993-06-04 Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning

Country Status (11)

Country Link
EP (1) EP0561907B1 (fi)
JP (3) JP3355186B2 (fi)
KR (1) KR100237968B1 (fi)
AT (1) ATE170630T1 (fi)
AU (1) AU9052891A (fi)
BR (1) BR9107206A (fi)
CA (2) CA2331936C (fi)
DE (1) DE69130113T2 (fi)
DK (1) DK0561907T3 (fi)
FI (1) FI932561A0 (fi)
WO (1) WO1992010755A1 (fi)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU682314B2 (en) * 1992-07-17 1997-10-02 Genencor International, Inc. High alkaline serine proteases
WO1996012186A1 (en) * 1994-10-14 1996-04-25 Chiron Mimotopes Pty. Ltd. Method and apparatus for efficient mimotope discovery
JP2001511162A (ja) 1997-02-06 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体
US6284246B1 (en) 1997-07-30 2001-09-04 The Procter & Gamble Co. Modified polypeptides with high activity and reduced allergenicity
AU2003203147B2 (en) 1998-03-23 2008-05-29 Novozymes A/S Phytase variants
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
KR20010052223A (ko) * 1998-03-26 2001-06-25 데이비드 엠 모이어 아미노산 결실 및 치환을 갖는 세린 프로테아제 변이체
JP2002507426A (ja) 1998-03-26 2002-03-12 ザ、プロクター、エンド、ギャンブル、カンパニー アミノ酸置換を有するセリンプロテアーゼ変異体
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
US6838269B1 (en) 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6936249B1 (en) 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6461849B1 (en) * 1998-10-13 2002-10-08 Novozymes, A/S Modified polypeptide
NZ511291A (en) 1998-10-30 2003-08-29 Novozymes As A method for selecting a protein variant that has reduced immunogenicity as compared with the parent or wild-type protein
US6686164B1 (en) 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
EP1051432B1 (en) * 1998-12-08 2007-01-24 Biovation Limited Method for reducing immunogenicity of proteins
KR20020021396A (ko) * 1999-07-22 2002-03-20 데이비드 엠 모이어 입체적으로 보호된 에피토프 영역을 갖는 프로테아제콘쥬게이트
AU5928100A (en) 1999-07-22 2001-02-13 Procter & Gamble Company, The Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
MXPA02000840A (es) 1999-07-22 2002-07-30 Procter & Gamble Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas.
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
CZ2002171A3 (cs) 1999-07-22 2002-06-12 The Procter & Gamble Company Proteinázový konjugát, čistící prostředek a prostředek osobní péče
BR0012570A (pt) * 1999-07-22 2002-06-04 Procter & Gamble Proteases subtilisina intramolecularmente reticuladas com imunogenicidade reduzida
AU2001254622A1 (en) * 2000-04-28 2001-11-12 Novozymes A/S Laccase mutants
KR20030037267A (ko) 2000-07-28 2003-05-12 헨켈 코만디트게젤샤프트 아우프 악티엔 바실러스속 ａ ７－７ (ｄｓｍ １２３６８) 에서 추출한신규한 아밀분해 효소 및 상기 신규한 아밀분해 효소를함유하는 세척 및 세정제
DE60144399D1 (de) * 2000-10-02 2011-05-19 Danisco Us Inc Methode zur bestimmung der immunogenität von proteinen, die eine veränderte immunantwort hervorrufen
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
CN100489094C (zh) 2001-03-23 2009-05-20 金克克国际有限公司 具有改变的免疫原性反应的蛋白质及制备和使用该蛋白质的方法
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
WO2003020761A1 (en) * 2001-09-04 2003-03-13 Merck Patent Gmbh Modified human growth hormone
AU2002353178C1 (en) * 2001-12-31 2011-02-03 Genencor International, Inc. Proteases producing an altered immunological response and methods of making and using the same
BR0215383A (pt) 2001-12-31 2006-11-28 Genencor Int proteases que produzem resposta imunogênica alterada e métodos de fabricação e uso das mesmas
WO2003096869A2 (en) * 2002-05-16 2003-11-27 Alk Abelló A/S Recombinant bet. v. 1. allergen mutants, methods and process thereof
KR101211445B1 (ko) 2002-07-30 2012-12-12 다니스코 유에스 인크. 에어로졸 발생을 감소시킨 제형물
WO2004014938A2 (en) * 2002-08-09 2004-02-19 Xencor Thrombopoiesis-stimulating proteins having reduced immunogenicity
WO2004031378A2 (en) 2002-10-01 2004-04-15 Novozymes A/S Family gh 61 polypeptides
EP2500423B1 (en) 2003-02-26 2015-06-17 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
JP2006513709A (ja) 2003-02-26 2006-04-27 ジェネンコー・インターナショナル・インク 修飾されたアミラーゼ免疫反応を示すアミラーゼ変異体、及び、これらの製造方法並びに用途
EP1639107B1 (en) 2003-06-19 2013-08-14 Novozymes A/S Improved proteases and methods for producing them
DE602004027376D1 (de) 2003-06-19 2010-07-08 Novozymes As Proteasen
DE602004030595D1 (de) 2003-10-10 2011-01-27 Novozymes As Proteasevarianten
BRPI0415457A (pt) 2003-10-16 2006-12-05 Micromet Ag constructo de ligação especìfico de cd3 citotoxicamente ativo, seu processo de produção, composição compreendendo o mesmo, seqüência de ácido nucléico, vetor, hospedeiro, seus usos na preparação de uma composição farmacêutica e kit compreendendo os mesmo
EP1709165B1 (en) 2004-01-06 2014-04-23 Novozymes A/S Polypeptides of alicyclobacillus
WO2005070967A2 (en) 2004-01-22 2005-08-04 Merck Patent Gmbh Anti-cancer antibodies with reduced complement fixation
EP1735433B1 (en) 2004-04-02 2010-12-08 Novozymes A/S Subtilase variants having altered immunogenicity
WO2005123911A2 (en) 2004-06-21 2005-12-29 Novozymes A/S Proteases
EP1809747B1 (en) 2004-10-04 2016-12-14 Novozymes A/S Polypeptides having phytase activity and polynucleotides encoding same
AR050895A1 (es) 2004-10-04 2006-11-29 Novozymes As Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
EP1920052A2 (en) 2005-08-16 2008-05-14 Novozymes A/S Polypeptides of strain bacillus sp. p203
US8236308B2 (en) 2005-10-11 2012-08-07 Micromet Ag Composition comprising cross-species-specific antibodies and uses thereof
EP1960517A2 (en) 2005-12-06 2008-08-27 Genencor International, Inc. Perhydrolase epitopes
PL1976880T3 (pl) 2005-12-21 2017-01-31 Amgen Research (Munich) Gmbh Kompozycje farmaceutyczne odporne na rozpuszczalny cea
CN101351477B (zh) 2005-12-30 2011-11-16 默克专利有限公司 具有降低的免疫原性的抗cd19抗体
PL1966238T3 (pl) 2005-12-30 2012-09-28 Merck Patent Gmbh Warianty interleukiny-12p40 o polepszonej stabilności
WO2007107573A1 (en) 2006-03-22 2007-09-27 Novozymes A/S Use of polypeptides having antimicrobial activity
EP2001999B1 (en) 2006-04-04 2012-05-16 Novozymes A/S Phytase variants
CN105112386A (zh) 2006-12-21 2015-12-02 诺维信公司 用于药物用途的脂肪酶变体
US8221743B2 (en) 2006-12-22 2012-07-17 Novozymes A/S Use of polypeptides against diseases caused by protozoans
MX289945B (es) 2007-03-26 2011-09-05 Novozymes As Fitasa de hafnia.
BRPI0919314A2 (pt) 2008-09-26 2015-08-11 Novozymes As Fitase, métodos para produzir um variante de fitase e um produto de fermentacao, para melhorar o valor nutricional de uma ração animal, e para o tratamento de proteínas vegetais, sequência isolada de ácidos nucleicos, construto de acido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, microorganismo transgênico, ou produtos, ou elementos destes, composição, processo para reduzir níveis de fitato em extrume de animal, e, uso da fitase.
MX2011011044A (es) 2009-04-22 2011-11-04 Merck Patent Gmbh Proteinas de fusion de anticuerpos con sitios de enlace de receptor fc neonatal (fcrn) modificados.
MX2012005164A (es) 2009-11-05 2012-10-03 Cephalon Australia Pty Ltd Tratamiento de cancer que involucra genes kras o braf mutados.
WO2012119989A2 (en) 2011-03-04 2012-09-13 Oryzon Genomics, S.A. Methods and antibodies for the diagnosis and treatment of cancer
EP3227341A1 (en) 2014-12-02 2017-10-11 CeMM - Forschungszentrum für Molekulare Medizin GmbH Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies
KR20230050402A (ko) 2020-08-13 2023-04-14 노보자임스 에이/에스 피타제 변이체 및 이를 암호화하는 폴리뉴클레오티드

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
DK6488D0 (da) * 1988-01-07 1988-01-07 Novo Industri As Enzymer
DK316989D0 (da) * 1989-06-26 1989-06-26 Novo Nordisk As Enzymer

Also Published As

Publication number Publication date
EP0561907A1 (en) 1993-09-29
ATE170630T1 (de) 1998-09-15
JP3355186B2 (ja) 2002-12-09
WO1992010755A1 (en) 1992-06-25
JP2002101880A (ja) 2002-04-09
DE69130113T2 (de) 1999-05-12
DE69130113D1 (de) 1998-10-08
CA2331936C (en) 2007-07-31
KR930703610A (ko) 1993-11-30
JPH06502994A (ja) 1994-04-07
DK0561907T3 (da) 1999-05-31
CA2331936A1 (en) 1992-06-06
EP0561907B1 (en) 1998-09-02
BR9107206A (pt) 1993-11-03
KR100237968B1 (ko) 2000-01-15
AU9052891A (en) 1992-07-08
JP3450840B2 (ja) 2003-09-29
CA2095852C (en) 2001-05-08
JP2003174871A (ja) 2003-06-24
CA2095852A1 (en) 1992-06-06
FI932561A (fi) 1993-06-04

Similar Documents

Publication Publication Date Title
FI932561A0 (fi) Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning
FI941199A0 (fi) Immunoreaktiiviset hepatiitti-C-viruksen polypeptidikoostumukset
DE69021002D1 (de) Schimärische Hepadnavirus-Kernantigenproteine.
FI972945A (fi) Antigeenien antamiseen soveltuvia koostumuksia
BR9500732B8 (pt) Kit diagnóstico para a detecção de anticorpos contra vírus que causam imunodeficiência.
PT97159A (pt) Processo para a preparacao de uma proteina do antigenio de superficie da hepatite b ou de um seu fragmento e processo para a preparacao de uma vacina
ATE68826T1 (de) Verfahren zur herstellung von reifem, menschlichem serum-albumin.
ES2013328A6 (es) Un metodo para detectar anticuerpos contra antigenos hiv-1.
DE69231663T2 (de) Polysaccharid-protein-konjugate
FI931393A0 (fi) Peptider foer anvaendning vid vaccinering och induktion av neutraliserande motkroppar mot humant immunbristvirus
BG97123A (bg) Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
CA2178635A1 (en) Immunofluorescence assay for the detection of antibodies using recombinant antigens in insoluble form
FR2692282B1 (fr) Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications.
FI892222A0 (fi) Peptidalkoholer med antikoagulantverkan.
NO900758L (no) Fremgangsmaate for fremstilling av hybridprotein.
DK0471718T3 (da) Paracetamolholdigt farmaceutisk præparat
FR2624854B1 (fr) Nouveaux sulfonamides du benzylidene camphre derivant d'aminoacides et leur application en cosmetique, notamment en tant que filtres solaires
DK13087D0 (da) Gensekvens til fremstilling af human serumalbumin i bacillus
NO881942D0 (no) Fremgangsmaate for fremstilling av fremmede proteiner i streptomyceten.
DE68922896D1 (de) RHOPTRY-MEMBRAN-ANTIGEN VON -i(PLASMODIUM FALCIPARUM).
ATE175357T1 (de) Empfängnisverhütender impfstoff
ITFI920071A1 (it) Antigeni ricombinanti proteici ad aumentata immunogenicita' contenenti il peptide rappresentato dalla sequenza vqgeesndk
FR2363603A1 (fr) Compositions de polyterephtalate d'alkylene et d'ester sulfonique, cristallisant rapidement
IT8620596V0 (it) Lenti sovrapponibili per variare l'intensita' dell'assorbimento di luce degli occhiali.
IT8821726A0 (it) Stampo per l'esecuzione di prodotti con porzioni ad elevata resistenza lumgo direzioni preferenziali,in particolare per lenti intraoculari

Legal Events

Date Code Title Description
FC Application refused
FCK Appeal rejected

Free format text: APPLICATION REJECTED