DE69130113D1 - Proteine mit geänderten epitopen und verfahren zur deren herstellung - Google Patents
Proteine mit geänderten epitopen und verfahren zur deren herstellungInfo
- Publication number
- DE69130113D1 DE69130113D1 DE69130113T DE69130113T DE69130113D1 DE 69130113 D1 DE69130113 D1 DE 69130113D1 DE 69130113 T DE69130113 T DE 69130113T DE 69130113 T DE69130113 T DE 69130113T DE 69130113 D1 DE69130113 D1 DE 69130113D1
- Authority
- DE
- Germany
- Prior art keywords
- epitopes
- proteins
- changed
- production
- variants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38654—Preparations containing enzymes, e.g. protease or amylase containing oxidase or reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90610072 | 1990-12-05 | ||
PCT/DK1991/000382 WO1992010755A1 (en) | 1990-12-05 | 1991-12-05 | Proteins with changed epitopes and methods for the production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69130113D1 true DE69130113D1 (de) | 1998-10-08 |
DE69130113T2 DE69130113T2 (de) | 1999-05-12 |
Family
ID=8205875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69130113T Revoked DE69130113T2 (de) | 1990-12-05 | 1991-12-05 | Proteine mit geänderten epitopen und verfahren zur deren herstellung |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0561907B1 (de) |
JP (3) | JP3355186B2 (de) |
KR (1) | KR100237968B1 (de) |
AT (1) | ATE170630T1 (de) |
AU (1) | AU9052891A (de) |
BR (1) | BR9107206A (de) |
CA (2) | CA2331936C (de) |
DE (1) | DE69130113T2 (de) |
DK (1) | DK0561907T3 (de) |
FI (1) | FI932561A0 (de) |
WO (1) | WO1992010755A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2139928C (en) * | 1992-07-17 | 2005-09-06 | Leonardus Johannes Sofie Marie Mulleners | High alkaline serine proteases |
WO1996012186A1 (en) * | 1994-10-14 | 1996-04-25 | Chiron Mimotopes Pty. Ltd. | Method and apparatus for efficient mimotope discovery |
WO1998035026A1 (en) * | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
US6284246B1 (en) | 1997-07-30 | 2001-09-04 | The Procter & Gamble Co. | Modified polypeptides with high activity and reduced allergenicity |
AU2742499A (en) * | 1998-03-26 | 1999-10-18 | Procter & Gamble Company, The | Serine protease variants having amino acid substitutions |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
US6495136B1 (en) * | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
CA2324422A1 (en) * | 1998-03-26 | 1999-09-30 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
US6838269B1 (en) * | 1998-04-15 | 2005-01-04 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
US6642011B2 (en) * | 1998-04-15 | 2003-11-04 | Genencor International, Inc. | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
US6936249B1 (en) | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
US6461849B1 (en) * | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
ES2220114T3 (es) * | 1998-10-30 | 2004-12-01 | Novozymes A/S | Variantes de proteinas poco alergenicas. |
US6686164B1 (en) | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
CN1202128C (zh) * | 1998-12-08 | 2005-05-18 | 拜奥威神有限公司 | 修饰蛋白的免疫原性 |
KR20020021397A (ko) * | 1999-07-22 | 2002-03-20 | 데이비드 엠 모이어 | 규정된 에피토프 영역에 아미노산 결실 및 치환을 갖는서브틸리신 프로테아제 변이체 |
WO2001007578A2 (en) * | 1999-07-22 | 2001-02-01 | The Procter & Gamble Company | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
EP1196548A2 (de) | 1999-07-22 | 2002-04-17 | The Procter & Gamble Company | Proteasekonjugaten mit sterisch geschützten hydrolysierbaren stellen |
CN1369008A (zh) * | 1999-07-22 | 2002-09-11 | 宝洁公司 | 免疫原性降低的分子内交联的枯草杆菌蛋白酶 |
AU777550B2 (en) * | 1999-07-22 | 2004-10-21 | Procter & Gamble Company, The | Protease conjugates having sterically protected epitope regions |
EP2236611A1 (de) * | 2000-04-28 | 2010-10-06 | Novozymes A/S | Variante eines lipolytischen Enzyms |
MXPA03000793A (es) | 2000-07-28 | 2003-06-04 | Henkel Kgaa | Enzima amilolitica novedosa, extraida de bacilo sp a 7-7 (dsm 12368) y agentes de lavado y limpiadores que contienen esta enzima amilolitica novedosa. |
DE60144399D1 (de) * | 2000-10-02 | 2011-05-19 | Danisco Us Inc | Methode zur bestimmung der immunogenität von proteinen, die eine veränderte immunantwort hervorrufen |
US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
CA2441595C (en) | 2001-03-23 | 2012-07-03 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
WO2003020761A1 (en) * | 2001-09-04 | 2003-03-13 | Merck Patent Gmbh | Modified human growth hormone |
CA2471972A1 (en) * | 2001-12-31 | 2003-07-17 | Genencor International, Inc. | Proteases producing an altered immunological response and methods of making and using the same |
JP2005535284A (ja) * | 2001-12-31 | 2005-11-24 | ジェネンコー・インターナショナル・インク | 免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法 |
EP1474508B1 (de) | 2002-02-08 | 2011-11-16 | Novozymes A/S | Phytasenvarianten |
PL212139B1 (pl) * | 2002-05-16 | 2012-08-31 | Alk Abello As | Zrekombinowany alergen, zastosowanie zrekombinowanego alergenu, kompozycja zawierająca dwa lub więcej wariantów zrekombinowanych zmutowanych alergenów, zastosowanie takiej kompozycji, kompozycja farmaceutyczna zawierająca zrekombinowany alergen lub wymienioną kompozycję, zastosowanie zrekombinowanego alergenu, kompozycji lub kompozycji farmaceutycznej, sposób przygotowania kompozycji farmaceutycznej, sposób przygotowania zrekombinowanego alergenu, sposób przygotowania biblioteki zrekombinowanego alergenu, sekwencja DNA kodująca zrekombinowany alergen, wektor ekspresyjny obejmujący wymienione DNA, komórka gospodarza zawierająca taki wektor ekspresyjny, sposób produkcji zrekombinowanego mutanta alergenu, oraz oznaczenie diagnostyczne do oceny odpowiedniości, bezpieczeństwa lub wyniku terapii |
CA2493361A1 (en) | 2002-07-30 | 2004-02-05 | Genencor International, Inc. | Reduced aerosol generating formulations |
WO2004014938A2 (en) * | 2002-08-09 | 2004-02-19 | Xencor | Thrombopoiesis-stimulating proteins having reduced immunogenicity |
WO2004031378A2 (en) | 2002-10-01 | 2004-04-15 | Novozymes A/S | Family gh 61 polypeptides |
EP2500423B1 (de) | 2003-02-26 | 2015-06-17 | Danisco US Inc. | Amylasen, die eine veränderte immunogene Reaktion bewirken, und Verfahren zu ihrer Herstellung und Verwendung |
AU2003213273A1 (en) | 2003-02-26 | 2004-09-28 | Genencor International, Inc. | Amylases producing an altered immunogenic response and methods of making and using the same |
WO2004111224A1 (en) | 2003-06-19 | 2004-12-23 | Novozymes A/S | Improved proteases and methods for producing them |
CN102505007B (zh) | 2003-06-19 | 2016-04-20 | 诺维信公司 | 蛋白酶 |
ES2358092T3 (es) | 2003-10-10 | 2011-05-05 | Novozymes A/S | Variantes de proteasa. |
CN100453556C (zh) | 2003-10-16 | 2009-01-21 | 麦克罗梅特股份公司 | 多特异性的去免疫化cd3结合物 |
WO2005066339A2 (en) | 2004-01-06 | 2005-07-21 | Novozymes A/S | Polypeptides of alicyclobacillus sp. |
ES2330860T3 (es) | 2004-01-22 | 2009-12-16 | Merck Patent Gmbh | Anticuerpos anticancerosos con fijacion del complemento reducida. |
ATE491025T1 (de) | 2004-04-02 | 2010-12-15 | Novozymes As | Subtilasevarianten mit veränderter immunogenität |
ATE541034T1 (de) | 2004-06-21 | 2012-01-15 | Novozymes As | Nocardiopsis-proteasen |
MX285771B (es) | 2004-10-04 | 2011-04-07 | Novozymes As | Polipeptidos que tienen avtividad de fitasa y polinucleotidos queridos mama y papa: codifican los mismos. |
AR050895A1 (es) | 2004-10-04 | 2006-11-29 | Novozymes As | Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican |
EP1920052A2 (de) | 2005-08-16 | 2008-05-14 | Novozymes A/S | Polypeptide des stamms bacillus sp. p203 |
ES2856451T3 (es) | 2005-10-11 | 2021-09-27 | Amgen Res Munich Gmbh | Composiciones que comprenden anticuerpos específicos para diferentes especies, y usos de las mismas |
EP1960517A2 (de) | 2005-12-06 | 2008-08-27 | Genencor International, Inc. | Perhydrolase-epitope |
RU2426743C2 (ru) | 2005-12-21 | 2011-08-20 | Микромет Аг | Фармацевтические композиции с устойчивостью к растворимому сеа |
PT1966238E (pt) | 2005-12-30 | 2012-07-31 | Merck Patent Gmbh | Uso de hsp70 como um regulador de atividade enzimática |
KR101397290B1 (ko) | 2005-12-30 | 2014-05-21 | 메르크 파텐트 게엠베하 | 감소한 면역원성을 가지는 항-cd19 항체 |
WO2007107573A1 (en) | 2006-03-22 | 2007-09-27 | Novozymes A/S | Use of polypeptides having antimicrobial activity |
JP5221516B2 (ja) | 2006-04-04 | 2013-06-26 | ノボザイムス アクティーゼルスカブ | フィターゼ変異体 |
CA2670643C (en) | 2006-12-21 | 2017-04-25 | Novozymes A/S | Lipase variants for pharmaceutical use |
US8221743B2 (en) | 2006-12-22 | 2012-07-17 | Novozymes A/S | Use of polypeptides against diseases caused by protozoans |
CA2681392C (en) | 2007-03-26 | 2017-08-01 | Novozymes A/S | Hafnia phytase |
EP2933329B1 (de) | 2008-09-26 | 2017-05-17 | Novozymes A/S | Hafnia-phytasevarianten |
EA201171259A1 (ru) | 2009-04-22 | 2012-05-30 | Мерк Патент Гмбх | Антительные гибридные белки с модифицированными сайтами связывания fcrn |
US8932588B2 (en) | 2009-11-05 | 2015-01-13 | Teva Pharmaceuticals Australia Pty. Ltd. | Treatment of cancer involving mutated KRAS or BRAF genes |
WO2012119989A2 (en) | 2011-03-04 | 2012-09-13 | Oryzon Genomics, S.A. | Methods and antibodies for the diagnosis and treatment of cancer |
WO2016087514A1 (en) | 2014-12-02 | 2016-06-09 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
PE20231568A1 (es) | 2020-08-13 | 2023-10-04 | Novozymes As | Variantes de fitasa y polinucleotidos que codifican las mismas |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903068A (en) * | 1972-12-26 | 1975-09-02 | Us Health Education & Welfare | Facile synthesis of human insulin by modification of porcine insulin |
DK6488D0 (da) * | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
DK316989D0 (da) * | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
-
1991
- 1991-12-05 KR KR1019930701690A patent/KR100237968B1/ko not_active IP Right Cessation
- 1991-12-05 JP JP50164192A patent/JP3355186B2/ja not_active Expired - Lifetime
- 1991-12-05 CA CA002331936A patent/CA2331936C/en not_active Expired - Lifetime
- 1991-12-05 AU AU90528/91A patent/AU9052891A/en not_active Abandoned
- 1991-12-05 AT AT92900779T patent/ATE170630T1/de not_active IP Right Cessation
- 1991-12-05 BR BR919107206A patent/BR9107206A/pt not_active IP Right Cessation
- 1991-12-05 WO PCT/DK1991/000382 patent/WO1992010755A1/en active IP Right Grant
- 1991-12-05 CA CA002095852A patent/CA2095852C/en not_active Expired - Lifetime
- 1991-12-05 DE DE69130113T patent/DE69130113T2/de not_active Revoked
- 1991-12-05 DK DK92900779T patent/DK0561907T3/da active
- 1991-12-05 EP EP92900779A patent/EP0561907B1/de not_active Revoked
-
1993
- 1993-06-04 FI FI932561A patent/FI932561A0/fi not_active Application Discontinuation
-
2001
- 2001-07-16 JP JP2001215943A patent/JP3450840B2/ja not_active Expired - Lifetime
-
2002
- 2002-12-04 JP JP2002352804A patent/JP2003174871A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH06502994A (ja) | 1994-04-07 |
CA2331936A1 (en) | 1992-06-06 |
WO1992010755A1 (en) | 1992-06-25 |
EP0561907A1 (de) | 1993-09-29 |
FI932561A (fi) | 1993-06-04 |
DE69130113T2 (de) | 1999-05-12 |
CA2095852A1 (en) | 1992-06-06 |
ATE170630T1 (de) | 1998-09-15 |
DK0561907T3 (da) | 1999-05-31 |
EP0561907B1 (de) | 1998-09-02 |
JP2003174871A (ja) | 2003-06-24 |
JP2002101880A (ja) | 2002-04-09 |
AU9052891A (en) | 1992-07-08 |
BR9107206A (pt) | 1993-11-03 |
JP3450840B2 (ja) | 2003-09-29 |
KR930703610A (ko) | 1993-11-30 |
KR100237968B1 (ko) | 2000-01-15 |
JP3355186B2 (ja) | 2002-12-09 |
CA2095852C (en) | 2001-05-08 |
CA2331936C (en) | 2007-07-31 |
FI932561A0 (fi) | 1993-06-04 |
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