BR9509421A - Novas sequências de genotipos de vírus de hepatite C e uso como agentes profiláticos terapêuticos e diagnósticos - Google Patents
Novas sequências de genotipos de vírus de hepatite C e uso como agentes profiláticos terapêuticos e diagnósticosInfo
- Publication number
- BR9509421A BR9509421A BR9509421A BR9509421A BR9509421A BR 9509421 A BR9509421 A BR 9509421A BR 9509421 A BR9509421 A BR 9509421A BR 9509421 A BR9509421 A BR 9509421A BR 9509421 A BR9509421 A BR 9509421A
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic
- diagnostic
- sequences
- prophylactic agents
- virus genotype
- Prior art date
Links
- 230000000069 prophylactic effect Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94870166 | 1994-10-21 | ||
EP95870076 | 1995-06-28 | ||
PCT/EP1995/004155 WO1996013590A2 (en) | 1994-10-21 | 1995-10-23 | New sequences of hepatitis c virus genotypes and their use as prophylactic, therapeutic and diagnostic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9509421A true BR9509421A (pt) | 1997-09-30 |
Family
ID=26137782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9509421A BR9509421A (pt) | 1994-10-21 | 1995-10-23 | Novas sequências de genotipos de vírus de hepatite C e uso como agentes profiláticos terapêuticos e diagnósticos |
Country Status (12)
Country | Link |
---|---|
US (2) | US7129337B1 (pt) |
EP (2) | EP1076092A3 (pt) |
JP (2) | JPH10507643A (pt) |
AT (1) | ATE218617T1 (pt) |
AU (1) | AU702436B2 (pt) |
BR (1) | BR9509421A (pt) |
CA (1) | CA2201703A1 (pt) |
DE (1) | DE69526973T3 (pt) |
DK (1) | DK0804584T3 (pt) |
ES (1) | ES2176342T5 (pt) |
PT (1) | PT804584E (pt) |
WO (1) | WO1996013590A2 (pt) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9620075D0 (en) * | 1996-09-26 | 1996-11-13 | Dynal As | Method |
US7078500B1 (en) * | 1998-01-30 | 2006-07-18 | The General Hospital Corporation | Genetic immunization with nonstructural proteins of hepatitis C virus |
TR200202213T2 (tr) | 1998-04-17 | 2002-11-21 | Innogenetics N.V. | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller |
WO1999055385A2 (de) * | 1998-04-28 | 1999-11-04 | Wolfgang Bergter | Radioimmunpharmaka zur therapie der hepatitis c |
DE69922958T3 (de) * | 1998-06-24 | 2008-06-26 | Innogenetics N.V. | Hcv hüllproteine partikel : verwendung für therapeutische impfung |
RU2286172C2 (ru) * | 2000-08-17 | 2006-10-27 | Трипеп Аб | Вакцины, содержащие рибавирин, и способы их использования |
WO2002014362A2 (en) * | 2000-08-17 | 2002-02-21 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
US8124747B2 (en) * | 2003-08-29 | 2012-02-28 | Innogenetics | HCV clade and prototype sequences thereof |
JP5138230B2 (ja) * | 2004-01-07 | 2013-02-06 | サード・ウェーブ・テクノロジーズ・インク | C型肝炎ウイルスの遺伝子型の決定方法 |
RU2267496C2 (ru) * | 2004-01-15 | 2006-01-10 | Сергей Иванович Черныш | Противоопухолевые и антивирусные пептиды |
WO2007031867A2 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-stru tural ns3/4a fusion gene |
US7465561B2 (en) | 2005-06-30 | 2008-12-16 | Roche Molecular Systems, Inc. | Probes and methods for hepatitis C virus typing using single probe analysis |
CA2632822C (en) | 2005-12-12 | 2018-08-28 | Ruth Greferath | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
CN101516911B (zh) | 2006-07-14 | 2016-11-16 | Ac免疫有限公司 | 针对淀粉状蛋白β的人源化抗体 |
AR062065A1 (es) | 2006-07-14 | 2008-10-15 | Ac Immune Sa | Anticuerpo humanizado |
KR101500017B1 (ko) * | 2006-08-25 | 2015-03-09 | 더 맥파레인 버넷 인스티튜트 포 메디칼 리서치 앤드 퍼블릭 헬스 리미티드 | 재조합 hcv e2 당단백질 |
EP2527474A1 (en) | 2006-10-20 | 2012-11-28 | Innogenetics N.V. | Methodology for analysis of sequence variations within the HCV NS3/4A genomic region |
US20090325145A1 (en) | 2006-10-20 | 2009-12-31 | Erwin Sablon | Methodology for analysis of sequence variations within the hcv ns5b genomic region |
KR101450356B1 (ko) | 2006-11-24 | 2014-10-15 | 에이씨 이뮨 에스.에이. | 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 n-(메틸)-1h-피라졸-3-아민, n-(메틸)-피리딘-2-아민 및 n-(메틸)-티아졸-2-아민 유도체 |
PT2170389E (pt) | 2007-06-12 | 2015-02-10 | Genentech Inc | Anticorpos humanizados contra amilóide beta |
BRPI0812484A2 (pt) | 2007-06-12 | 2018-06-05 | Ac Immune Sa | anticorpo monoclonal, regiões variáveis de cadeia leve e de cadeia pesada, cdr isolada, polinucleotídeo, composição terapêutica, métodos para tratar doenças e distúrbios, para produzir um anticorpo, para tratar ou aliviar os efeitos de doenças e distúrbios, para reduzir a carga de placas no cérebro de um indivíduo, para reduzir a quantidade de placas no cérebro de um indivíduo, para diminuir a quantidade total de abeta solúvel no cérebro de um indivíduo, para reter ou aumentar a capacidade de memória cognitiva em um indivíduo, de diagnose de ou para diagnosticar uma predisposição para uma doença associada com amilóide ou condição em um paciente, para determinar a extensão de carga de placa amiloidogênica em um tecido de um indivíduo, para monitorar doença residual mínima em um indivíduo e para prever responsividade de um indivíduo, linhagem de células, kit de teste, epítopo abeta |
WO2009022939A1 (fr) * | 2007-08-09 | 2009-02-19 | Uchrezhdenie Rossiiskoi Akademii Nauk Institut Molekulyarnoi Biologii Im. V.A. Engelgardta Ran (Imb Ran) | Procédé d'identification du génotype et du sous-type du virus de l'hépatite c sur une biopuce |
EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
BRPI0818623A2 (pt) | 2007-10-05 | 2017-05-23 | Ac Immune Sa | composição farmacêutica, e, métodos para reduzir a carga da placa na camada de célula de gânglio retinal de um animal, para reduzir a quantidade de placas na camada de célula de gânglio retinal de um animal, para diminuir a quantidade total de amilóide-beta solúvel na camada de célula de gânglio retinal de um animal, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular associada com anormalidades patológicas/mudanças no tecido do sistema visual, para monitorar doença ocular residual mínima associada com anormalidades patológicas/mudanças nos tecidos do sistema visual, para predizer responsividade de um paciente, e para reter ou diminuir a pressão ocular nos olhos de um animal |
WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
EP2311823A1 (en) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
EP2377860A1 (en) | 2010-04-16 | 2011-10-19 | AC Immune S.A. | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
AU2011239966B2 (en) | 2010-04-16 | 2014-05-08 | Ac Immune S.A. | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
US8962241B2 (en) * | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
CA2806909C (en) | 2010-07-30 | 2019-12-17 | Ac Immune S.A. | Safe and functional humanized antibodies |
WO2012045882A2 (en) | 2010-10-07 | 2012-04-12 | Ac Immune S.A. | Pharmaceutical composition |
CN103189050B (zh) | 2010-10-26 | 2017-09-29 | Ac免疫有限公司 | 包含通过疏水部分修饰的肽的基于脂质体的构建体 |
EP2764022B9 (en) | 2011-10-07 | 2017-02-22 | AC Immune S.A. | Phosphospecific antibodies recognising tau |
KR102132041B1 (ko) | 2012-04-05 | 2020-07-09 | 에이씨 이뮨 에스.에이. | 인간화된 타우 항체 |
AU2013270684B2 (en) | 2012-06-08 | 2018-04-19 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
EP2863955B1 (en) | 2012-06-26 | 2016-11-23 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
CN102766701B (zh) * | 2012-07-04 | 2016-05-04 | 福州泰普生物科学有限公司 | 丙型肝炎病毒基因分型的试剂盒及方法 |
JP6826367B2 (ja) | 2012-08-31 | 2021-02-03 | ストロ バイオファーマ インコーポレーテッド | アジド基を含む修飾アミノ酸 |
EP2970452A2 (en) | 2013-03-15 | 2016-01-20 | AC Immune S.A. | Anti-tau antibodies and methods of use |
US9891225B2 (en) * | 2013-05-10 | 2018-02-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for simultaneous detection of HCV antigen/antibody |
EP3019522B1 (en) | 2013-07-10 | 2017-12-13 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
AU2014317035B2 (en) | 2013-09-05 | 2020-02-27 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) in inflammatory diseases |
US9840493B2 (en) | 2013-10-11 | 2017-12-12 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
CN107660150B (zh) | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
WO2017218698A1 (en) | 2016-06-15 | 2017-12-21 | Sutro Biopharma, Inc. | Antibodies with engineered ch2 domains, compositions thereof and methods of using the same |
GB201807367D0 (en) | 2018-05-04 | 2018-06-20 | Univ Newcastle | Biomarker |
WO2021178597A1 (en) | 2020-03-03 | 2021-09-10 | Sutro Biopharma, Inc. | Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use |
US20230173021A1 (en) | 2020-05-06 | 2023-06-08 | Ab2 Bio Sa | IL-18 Binding Protein (IL-18BP) In Respiratory Diseases |
EP3943097A1 (en) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
WO2023166206A1 (en) | 2022-03-04 | 2023-09-07 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in the treatment of vexas |
WO2024006563A1 (en) | 2022-07-01 | 2024-01-04 | Sutro Biopharma, Inc. | Il-12 mutants with reduced toxicity, compositions thereof and methods of using the same |
WO2024044780A1 (en) | 2022-08-26 | 2024-02-29 | Sutro Biopharma, Inc. | Interleukin-18 variants and uses thereof |
WO2024098023A2 (en) | 2022-11-04 | 2024-05-10 | Sutro Biopharma, Inc. | Interferon alpha polypeptides and conjugates |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2656995B2 (ja) † | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
JP3156200B2 (ja) | 1989-09-15 | 2001-04-16 | 国立予防衛生研究所長 | 新規のhcv分離株 |
US5372928A (en) | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
BR9006422A (pt) | 1989-12-18 | 1991-09-24 | Wellcome Found | Processo para preparar um polipeptidio viral pt-nanbh e processo para detectar o mesmo |
FI913068A (fi) | 1990-06-25 | 1991-12-26 | Univ Osaka Res Found | Non-a-, non-b-hepatitisviruspartiklar. |
CZ288720B6 (cs) | 1991-05-08 | 2001-08-15 | Chiron Corporation | Nukleová kyselina, kompozice s jejím obsahem, způsob tvorby hybridizačního produktu a způsob detekce genotypů HCV |
JP3516681B2 (ja) * | 1991-06-24 | 2004-04-05 | カイロン コーポレイション | C型肝炎ウイルス(hcv)ポリペプチド |
EP0532167A3 (en) | 1991-08-09 | 1993-03-31 | Immuno Japan Inc. | Non-a, non-b hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
DK0608261T3 (da) * | 1991-09-13 | 2003-03-17 | Chiron Corp | Sammensætninger med immunreaktivt hepatitis C virus polypeptid |
DE610436T1 (de) | 1991-11-21 | 1995-08-03 | Common Services Agency | Detektion des Hepatis-C Virus. |
SG50563A1 (en) * | 1993-04-27 | 1998-07-20 | Innogenetics Nv | New sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents |
JPH06319563A (ja) * | 1993-05-13 | 1994-11-22 | Imuno Japan:Kk | C型肝炎ウイルス遺伝子、オリゴヌクレオチド、並びにc型 肝炎ウイルス遺伝子型判定方法 |
US5514539A (en) | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
-
1995
- 1995-10-23 US US08/836,075 patent/US7129337B1/en not_active Expired - Fee Related
- 1995-10-23 EP EP00118731A patent/EP1076092A3/en not_active Withdrawn
- 1995-10-23 EP EP95936537A patent/EP0804584B2/en not_active Expired - Lifetime
- 1995-10-23 DE DE69526973T patent/DE69526973T3/de not_active Expired - Lifetime
- 1995-10-23 PT PT95936537T patent/PT804584E/pt unknown
- 1995-10-23 DK DK95936537T patent/DK0804584T3/da active
- 1995-10-23 AT AT95936537T patent/ATE218617T1/de not_active IP Right Cessation
- 1995-10-23 AU AU38440/95A patent/AU702436B2/en not_active Ceased
- 1995-10-23 JP JP8514299A patent/JPH10507643A/ja active Pending
- 1995-10-23 WO PCT/EP1995/004155 patent/WO1996013590A2/en active IP Right Grant
- 1995-10-23 CA CA002201703A patent/CA2201703A1/en not_active Abandoned
- 1995-10-23 BR BR9509421A patent/BR9509421A/pt not_active Application Discontinuation
- 1995-10-23 ES ES95936537T patent/ES2176342T5/es not_active Expired - Lifetime
-
2001
- 2001-05-09 US US09/851,138 patent/US6974864B2/en not_active Expired - Fee Related
-
2004
- 2004-10-20 JP JP2004305574A patent/JP2005118044A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU702436B2 (en) | 1999-02-18 |
DE69526973T3 (de) | 2010-01-07 |
WO1996013590A2 (en) | 1996-05-09 |
ATE218617T1 (de) | 2002-06-15 |
AU3844095A (en) | 1996-05-23 |
JP2005118044A (ja) | 2005-05-12 |
CA2201703A1 (en) | 1996-05-09 |
WO1996013590A3 (en) | 1996-08-15 |
DK0804584T3 (da) | 2002-09-23 |
ES2176342T5 (es) | 2010-02-09 |
US7129337B1 (en) | 2006-10-31 |
US20020183508A1 (en) | 2002-12-05 |
DE69526973T2 (de) | 2003-01-02 |
PT804584E (pt) | 2002-11-29 |
EP0804584B1 (en) | 2002-06-05 |
DE69526973D1 (de) | 2002-07-11 |
JPH10507643A (ja) | 1998-07-28 |
EP0804584B2 (en) | 2008-07-09 |
EP1076092A3 (en) | 2001-03-28 |
EP0804584A1 (en) | 1997-11-05 |
US6974864B2 (en) | 2005-12-13 |
EP1076092A2 (en) | 2001-02-14 |
ES2176342T3 (es) | 2002-12-01 |
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