MC2188A1 - Diagnostic du nanbv:polynucleotides permettant de depister le virus de l'hepatite c - Google Patents

Diagnostic du nanbv:polynucleotides permettant de depister le virus de l'hepatite c

Info

Publication number
MC2188A1
MC2188A1 MC@@@@@@@@@@@@D MC2188D MC2188A1 MC 2188 A1 MC2188 A1 MC 2188A1 MC 2188 D MC2188 D MC 2188D MC 2188 A1 MC2188 A1 MC 2188A1
Authority
MC
Monaco
Prior art keywords
virus
hepatitis
polynucleotides
nanbv
diagnosis
Prior art date
Application number
MC@@@@@@@@@@@@D
Other languages
English (en)
Inventor
Michael Houghton
Qui-Lim Choo
George Kuo
Jang Han
Michael Urdea
Amy Weiner
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of MC2188A1 publication Critical patent/MC2188A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
MC@@@@@@@@@@@@D 1989-05-18 1990-05-18 Diagnostic du nanbv:polynucleotides permettant de depister le virus de l'hepatite c MC2188A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35596189A 1989-05-18 1989-05-18
US45663789A 1989-12-21 1989-12-21
US50543590A 1990-04-04 1990-04-04
PCT/US1990/002853 WO1990014436A1 (fr) 1989-05-18 1990-05-18 Diagnostic du nanbv (virus de l'hepatite non-a et non-b): polynucleotides utiles pour depister le virus de l'hepatite c

Publications (1)

Publication Number Publication Date
MC2188A1 true MC2188A1 (fr) 1992-09-16

Family

ID=27408242

Family Applications (1)

Application Number Title Priority Date Filing Date
MC@@@@@@@@@@@@D MC2188A1 (fr) 1989-05-18 1990-05-18 Diagnostic du nanbv:polynucleotides permettant de depister le virus de l'hepatite c

Country Status (17)

Country Link
EP (1) EP0398748B1 (fr)
JP (3) JP2656996B2 (fr)
AT (1) ATE211772T1 (fr)
AU (1) AU638719B2 (fr)
BG (1) BG60348B2 (fr)
CA (1) CA2017157C (fr)
DE (1) DE69033891T2 (fr)
DK (1) DK0398748T3 (fr)
ES (1) ES2166749T3 (fr)
FI (1) FI105279B (fr)
GE (1) GEP20002164B (fr)
HU (1) HUT59964A (fr)
LV (1) LV10729B (fr)
MC (1) MC2188A1 (fr)
NO (1) NO303503B1 (fr)
RO (1) RO113059B1 (fr)
WO (1) WO1990014436A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6489246A (en) * 1987-09-30 1989-04-03 Sony Corp Fixing method for color sorting mechanism of color cathode-ray tube
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
ES2029171A6 (es) * 1989-12-18 1992-07-16 Wellcome Found Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh)
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
EP0461863A1 (fr) * 1990-06-12 1991-12-18 Immuno Japan Inc. Amorces oligonucléotidiques et leur utilisation pour la détection de non-A, non-B virus d'hépatite à haute fidélité
US5747339A (en) * 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
JPH05508318A (ja) * 1990-06-30 1993-11-25 アクゾ・エヌ・ヴエー 非―ａ非―ｂ配列
ATE150086T1 (de) * 1990-07-11 1997-03-15 Shionogi & Co Cdns-sequenz und detektion des hepatitis c-virus
WO1992001714A1 (fr) * 1990-07-24 1992-02-06 Yamanouchi Pharmaceutical Co., Ltd. Antigene du virus de l'hepatite non a, non b
CZ282573B6 (cs) * 1990-08-10 1997-08-13 Chiron Corporation Způsob detekce HCV sekvence, souprava a reakční činidlo pro detekci HCV
WO1992009634A1 (fr) * 1990-11-29 1992-06-11 Toray Industries, Incorporated Proteine anti-genique du virus de l'hepatite non a et non b
WO1992012992A2 (fr) * 1991-01-14 1992-08-06 James N. Gamble Institute Of Medical Research Polypeptides immunogeniques structuraux de base ayant des epitopes pour vhc, anticorps, sequences de polynucleotides, vaccins et methodes
ATE112782T1 (de) * 1991-03-01 1994-10-15 Akzo Nobel Nv Mit antikörper gegen hepatitis non-a, non-b-virus immunochemische reaktive peptide.
US5574132A (en) * 1991-04-05 1996-11-12 Biochem Immunosystems Inc. Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)
EP0510952A1 (fr) * 1991-04-26 1992-10-28 Immuno Japan Inc. Primaires d'oligonucleotides et leur application de détection à haut détail de non-A, non-B hepatitis
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
IT1249684B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
ES2198514T3 (es) * 1991-08-27 2004-02-01 F. Hoffmann-La Roche Ag Cebadores y sondas para la deteccion de la hepatitis c.
JPH06502770A (ja) * 1991-09-12 1994-03-31 シーダーズ−サイナイ・メディカル・センター Ｃ型肝炎ウイルスｒｎａの直接検出法
JPH06511149A (ja) * 1991-09-13 1994-12-15 カイロン　コーポレイション 免疫反応性ｃ型肝炎ウイルスのポリペプチド組成物
CA2099883A1 (fr) * 1991-11-07 1993-05-08 John A. Kink Cartographie de l'epitope de la region c33c du vhc
JP3688290B2 (ja) * 1991-11-21 2005-08-24 コモン サーヴィシス エージェンシー Ｃ型肝炎ウイルス検査
GB9204274D0 (en) * 1992-02-28 1992-04-08 Wellcome Found Novel peptides
US5866139A (en) * 1992-06-04 1999-02-02 Institut Pasteur Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications
US5922857A (en) * 1992-09-28 1999-07-13 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
JPH06153961A (ja) * 1992-11-27 1994-06-03 Imuno Japan:Kk Ｃ型肝炎ウイルス部分遺伝子、ならびにｃ型肝炎ウイルス遺 伝子の高感度検出法
EP0697888B1 (fr) 1993-05-12 2003-09-17 Chiron Corporation Motif conserve de la region e2/ns1 du virus de l'hepatite c
CA2195312A1 (fr) 1994-07-29 1996-02-15 Mark Selby Nouveaux polypeptides a troncature e1 et e2 de l'hepatite c et procede d'obtention de ces derniers
WO1996004301A2 (fr) * 1994-07-29 1996-02-15 Chiron Corporation Nouveaux polypeptides a troncature e1 et e2 de l'hepatite c et procede d'obtention de ces derniers
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
EP0980434B1 (fr) 1997-05-06 2009-07-29 Novartis Vaccines and Diagnostics, Inc. Production intracellulaire d'un polypeptide e2 tronque dirige contre l'hepatite c
DE19832050C2 (de) * 1998-07-16 2002-10-10 Biotest Pharma Gmbh Verfahren zum Nachweis von Hepatitis B- bzw. Hepatitis C-Virusgenomen in Plasmaproben und spezifische Primer
JP2002537355A (ja) 1999-02-26 2002-11-05 カイロン コーポレイション 抗原の粘膜送達のための生体接着剤およびアジュバントの使用
CA2689696C (fr) 1999-02-26 2013-08-06 Novartis Vaccines And Diagnostics, Inc. Microemulsions a macromolecules et microparticules adsorbees
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
SI1354204T2 (sl) * 2000-06-15 2010-09-30 Novartis Vaccines & Diagnostic Hcv antigen antitelo kombinacijska analiza
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
CA2419418A1 (fr) 2000-08-17 2002-02-21 Tripep Ab Vaccins contenant de la ribavirine et procedes d'utilisation associes
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
CA2448066A1 (fr) 2001-05-31 2002-12-12 Chiron Corporation Particules de replicon d'alphavirus chimerique
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
CA2476626A1 (fr) 2002-02-20 2003-08-28 Chiron Corporation Microparticules comprenant des molecules adsorbees qui contiennent polypeptides
US7598421B2 (en) 2002-05-08 2009-10-06 Ucl Biomedica Plc Materials for the delivery of biologically-active material to cells
WO2004060396A2 (fr) 2002-12-27 2004-07-22 Chiron Corporation Immunogenes contenant des compositions de phospholipide
WO2004084936A2 (fr) 2003-02-06 2004-10-07 Cerus Corporation Microbes modifies vivant en milieu naturel, compositions de vaccins, et procedes d'utilisation correspondants
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
ES2382332T3 (es) 2003-02-06 2012-06-07 Aduro Biotech Listeria atenuada para entrar en células no fagocíticas, vacunas que comprenden esta listeria y métodos de uso de las mismas
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
EP1784211A4 (fr) 2004-07-29 2010-06-30 Novartis Vaccines & Diagnostic Compositions immunogenes pour bacteries a gram positif telles que streptococcus agalactiae
ES2377978T3 (es) 2004-08-27 2012-04-03 Novartis Vaccines And Diagnostics, Inc. Mutantes de proteínas no estructurales de VHC y usos de los mismos
WO2007031867A2 (fr) 2005-05-25 2007-03-22 Tripep Ab Gene de fusion ns3/4a non structurel de l'hepatite c
EP2121991A2 (fr) * 2006-10-20 2009-11-25 Innogenetics N.V. Méthode d'analyse des mutations
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
WO2009076158A1 (fr) 2007-12-07 2009-06-18 Novartis Ag Compositions utilisées pour induire des réponses immunitaires
WO2009130588A2 (fr) 2008-04-22 2009-10-29 Tripep Ab Plateforme immunogène
CN102076843A (zh) 2008-05-19 2011-05-25 艾杜罗生物科技公司 包含prfa*突变体李斯特菌的组合物及其使用方法
WO2010103017A2 (fr) 2009-03-09 2010-09-16 William Henry Conjugués haptène-support liés à des toxines bactériennes et ayant un peptide signal comme support, et leur utilisation dans des compositions immunogènes
FI122954B (fi) 2011-01-31 2012-09-14 Teknoware Oy LED-putkilamppu ja valaisinjärjestely

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
CN1074422C (zh) * 1987-11-18 2001-11-07 希龙股份有限公司 制备含有hcv表位的分离多肽的方法
US5191064A (en) * 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
HU225068B1 (en) * 1989-03-17 2006-05-29 Chiron Corp Process for producing diagnostics and vaccine of nanbh
AU638304B2 (en) * 1989-12-22 1993-06-24 Abbott Laboratories Hepatitis c assay
AU7672991A (en) * 1990-04-03 1991-10-30 Southwest Foundation For Biomedical Research Purified hcv and hcv proteins and peptides

Also Published As

Publication number Publication date
ES2166749T3 (es) 2002-05-01
BG60348B2 (bg) 1994-06-30
LV10729B (en) 1995-12-20
FI915443A0 (fi) 1991-11-18
ATE211772T1 (de) 2002-01-15
NO914517L (no) 1992-01-16
CA2017157C (fr) 2003-07-29
AU5812390A (en) 1990-12-18
JP3701754B2 (ja) 2005-10-05
NO303503B1 (no) 1998-07-20
HU904754D0 (en) 1992-01-28
JP2656996B2 (ja) 1997-09-24
FI105279B (fi) 2000-07-14
WO1990014436A1 (fr) 1990-11-29
JPH05500155A (ja) 1993-01-21
AU638719B2 (en) 1993-07-08
EP0398748B1 (fr) 2002-01-09
DK0398748T3 (da) 2002-03-18
JPH1089A (ja) 1998-01-06
HUT59964A (en) 1992-07-28
RO113059B1 (ro) 1998-03-30
DE69033891D1 (de) 2002-02-21
DE69033891T2 (de) 2002-08-29
LV10729A (lv) 1995-06-20
JPH10113176A (ja) 1998-05-06
EP0398748A3 (fr) 1991-10-23
CA2017157A1 (fr) 1990-11-18
EP0398748A2 (fr) 1990-11-22
JP3698520B2 (ja) 2005-09-21
NO914517D0 (no) 1991-11-18
GEP20002164B (en) 2000-07-10

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