BG60348B2 - Nаnв диагностика: полинуклеотиди, приложими за скрининг на вируса на хепатит с - Google Patents
Nаnв диагностика: полинуклеотиди, приложими за скрининг на вируса на хепатит с Download PDFInfo
- Publication number
- BG60348B2 BG60348B2 BG095495A BG9549591A BG60348B2 BG 60348 B2 BG60348 B2 BG 60348B2 BG 095495 A BG095495 A BG 095495A BG 9549591 A BG9549591 A BG 9549591A BG 60348 B2 BG60348 B2 BG 60348B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- sequence
- hcv
- oligomer
- sequences
- polynucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35596189A | 1989-05-18 | 1989-05-18 | |
| US45663789A | 1989-12-21 | 1989-12-21 | |
| US50543590A | 1990-04-04 | 1990-04-04 | |
| PCT/US1990/002853 WO1990014436A1 (en) | 1989-05-18 | 1990-05-18 | Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60348B2 true BG60348B2 (bg) | 1994-09-30 |
Family
ID=27408242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG095495A BG60348B2 (bg) | 1989-05-18 | 1991-11-18 | Nаnв диагностика: полинуклеотиди, приложими за скрининг на вируса на хепатит с |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0398748B1 (de) |
| JP (3) | JP2656996B2 (de) |
| AT (1) | ATE211772T1 (de) |
| AU (1) | AU638719B2 (de) |
| BG (1) | BG60348B2 (de) |
| CA (1) | CA2017157C (de) |
| DE (1) | DE69033891T2 (de) |
| DK (1) | DK0398748T3 (de) |
| ES (1) | ES2166749T3 (de) |
| FI (1) | FI105279B (de) |
| GE (1) | GEP20002164B (de) |
| HU (1) | HUT59964A (de) |
| LV (1) | LV10729B (de) |
| MC (1) | MC2188A1 (de) |
| NO (1) | NO303503B1 (de) |
| RO (1) | RO113059B1 (de) |
| WO (1) | WO1990014436A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6489246A (en) * | 1987-09-30 | 1989-04-03 | Sony Corp | Fixing method for color sorting mechanism of color cathode-ray tube |
| US5698390A (en) * | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
| US5712088A (en) * | 1987-11-18 | 1998-01-27 | Chiron Corporation | Methods for detecting Hepatitis C virus using polynucleotides specific for same |
| US6171782B1 (en) | 1987-11-18 | 2001-01-09 | Chiron Corporation | Antibody compositions to HCV and uses thereof |
| US6861212B1 (en) | 1987-11-18 | 2005-03-01 | Chiron Corporation | NANBV diagnostics and vaccines |
| US5714596A (en) * | 1987-11-18 | 1998-02-03 | Chiron Corporation | NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus |
| US6027729A (en) * | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
| US7166287B1 (en) | 1989-12-18 | 2007-01-23 | Glaxo Wellcome Inc. | Viral agent |
| BR9006422A (pt) * | 1989-12-18 | 1991-09-24 | Wellcome Found | Processo para preparar um polipeptidio viral pt-nanbh e processo para detectar o mesmo |
| CA2044296A1 (en) * | 1990-06-12 | 1991-12-13 | Hiroaki Okamoto | Oligonucleotide primers, and their application for high-fidelity detection of non-a, non-b hepatitis virus |
| JP3268502B2 (ja) | 1990-06-12 | 2002-03-25 | 徹雄 中村 | 非a非b型肝炎ウイルス関連ポリヌクレオチド、ポリペプ タイド |
| US5747339A (en) * | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
| DE69106141T2 (de) * | 1990-06-30 | 1995-05-24 | Akzo Nobel Nv | Non-a non-b sequenzen. |
| EP0469348B1 (de) * | 1990-07-11 | 1997-03-12 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | cDNS-Sequenz und Detektion des Hepatitis C-Virus |
| WO1992001714A1 (fr) * | 1990-07-24 | 1992-02-06 | Yamanouchi Pharmaceutical Co., Ltd. | Antigene du virus de l'hepatite non a, non b |
| WO1992002642A1 (en) * | 1990-08-10 | 1992-02-20 | Chiron Corporation | Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus |
| KR920703640A (ko) * | 1990-11-29 | 1992-12-18 | 테루카츄 아리마 | 비a비b형 간염 바이러스 항원 단백질 |
| AU1459792A (en) * | 1991-01-14 | 1992-08-27 | James N. Gamble Institute Of Medical Research | Basic structural immunogenic polypeptides having epitopes for hcv, antibodies, polynucleotide sequences, vaccines and methods |
| IE65424B1 (en) * | 1991-03-01 | 1995-10-18 | Akzo Nv | Peptides immunochemically reactive with antibodies directed against hepatitis non-A non-B virus |
| US5574132A (en) * | 1991-04-05 | 1996-11-12 | Biochem Immunosystems Inc. | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) |
| EP0510952A1 (de) * | 1991-04-26 | 1992-10-28 | Immuno Japan Inc. | Oligonukleotid-Primer und ihre Anwendung zum Nachweis von Non-A, Non-B-Hepatitis mit höchster Genauigkeit |
| FR2677372B1 (fr) * | 1991-06-06 | 1994-11-10 | Pasteur Institut | Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques. |
| IT1249684B (it) * | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
| ATE241704T1 (de) * | 1991-08-27 | 2003-06-15 | Hoffmann La Roche | Primers und sondern zum nachweis von hepatitis c |
| WO1993005181A1 (en) * | 1991-09-12 | 1993-03-18 | Cedars-Sinai Medical Center | Direct detection of hepatitis c virus rna |
| HU227510B1 (en) * | 1991-09-13 | 2011-07-28 | Novartis Vaccines & Diagnostic | Immunoreactive hepatitis c virus polypeptide compositions |
| CA2099883A1 (en) * | 1991-11-07 | 1993-05-08 | John A. Kink | Epitope mapping of the c33c region of hcv |
| ES2065863T3 (es) * | 1991-11-21 | 2003-09-01 | Common Services Agency | Analisis para la deteccion de virus de la hepatitis c. |
| GB9204274D0 (en) * | 1992-02-28 | 1992-04-08 | Wellcome Found | Novel peptides |
| US5866139A (en) * | 1992-06-04 | 1999-02-02 | Institut Pasteur | Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications |
| US5922857A (en) * | 1992-09-28 | 1999-07-13 | Chiron Corporation | Methods and compositions for controlling translation of HCV proteins |
| JPH06153961A (ja) * | 1992-11-27 | 1994-06-03 | Imuno Japan:Kk | C型肝炎ウイルス部分遺伝子、ならびにc型肝炎ウイルス遺 伝子の高感度検出法 |
| JPH08510240A (ja) | 1993-05-12 | 1996-10-29 | カイロン コーポレイション | C型肝炎ウイルスe2/ns1領域の保存モチーフ |
| AU3241095A (en) * | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| EP1510580B1 (de) | 1994-07-29 | 2008-12-10 | Novartis Vaccines and Diagnostics, Inc. | Hepatitis C E2 verkuerzte Polypeptid sowie Verfahen zu seiner Herstellung |
| US5837442A (en) | 1995-11-29 | 1998-11-17 | Roche Molecular Systems, Inc. | Oligonucleotide primers for amplifying HCV nucleic acid |
| ATE437951T1 (de) | 1997-05-06 | 2009-08-15 | Novartis Vaccines & Diagnostic | Intrazelluläre herstellung von verkürztem hepatitis c-polypeptid e2 |
| DE19832050C2 (de) * | 1998-07-16 | 2002-10-10 | Biotest Pharma Gmbh | Verfahren zum Nachweis von Hepatitis B- bzw. Hepatitis C-Virusgenomen in Plasmaproben und spezifische Primer |
| CA2366688A1 (en) | 1999-02-26 | 2000-08-31 | Chiron Corporation | Use of bioadhesives and adjuvants for the mucosal delivery of antigens |
| EP1156781B1 (de) | 1999-02-26 | 2005-06-08 | Chiron Corporation | Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln |
| US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
| US6630298B2 (en) * | 2000-06-15 | 2003-10-07 | Chiron Corporation | HCV antigen/antibody combination assay |
| RU2286172C2 (ru) | 2000-08-17 | 2006-10-27 | Трипеп Аб | Вакцины, содержащие рибавирин, и способы их использования |
| DE60130998T2 (de) | 2000-08-17 | 2008-07-17 | Tripep Ab | Ribavirin-enthaltende vakzine |
| US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
| ES2624854T3 (es) | 2001-05-31 | 2017-07-17 | Glaxosmithkline Biologicals Sa | Partículas de replicón de alfavirus quimérico |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| EP1531796B1 (de) | 2002-02-20 | 2016-09-28 | GlaxoSmithKline Biologicals SA | Mikropartikel mit adsorbierten polypeptidhaltigen molekülen |
| US7598421B2 (en) | 2002-05-08 | 2009-10-06 | Ucl Biomedica Plc | Materials for the delivery of biologically-active material to cells |
| CA2511512C (en) | 2002-12-27 | 2013-10-29 | Chiron Corporation | Immunogenic compositions containing phospholipid |
| WO2004084936A2 (en) | 2003-02-06 | 2004-10-07 | Cerus Corporation | Modified free-living microbes, vaccine compositions and methods of use thereof |
| US7695725B2 (en) | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| MXPA05008342A (es) | 2003-02-06 | 2006-02-28 | Cerus Corp | Listeria atenuada para la entrada a las celulas no fagociticas, vacunas que comprenden la listeria, y metodos de uso de las mismas. |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| WO2006078318A2 (en) | 2004-07-29 | 2006-07-27 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| ATE527545T1 (de) | 2004-08-27 | 2011-10-15 | Novartis Vaccines & Diagnostic | Hcv-antigene zur mehrfachen epitopfusion mit modifizierten proteolytischen spaltungsorten und verwendungen davon |
| CA2618429A1 (en) | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
| WO2008046923A2 (en) * | 2006-10-20 | 2008-04-24 | Innogenetics N.V. | Methodology for analysis of sequence variations within the hcv ns3/4a genomic region |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| EP3067048B1 (de) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Zusammensetzungen zur induzierung von immunreaktionen |
| WO2009130588A2 (en) | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
| KR20110027695A (ko) | 2008-05-19 | 2011-03-16 | 아두로 바이오테크 | Prfa* 돌연변이 리스테리아를 포함하는 조성물 및 그것의 사용방법 |
| US20120100171A1 (en) | 2009-03-09 | 2012-04-26 | William Henry | Hapten-carrier conjugates with bacterial toxins having a signal peptide as carrier and their use in immunogenic compositions |
| FI122954B (fi) | 2011-01-31 | 2012-09-14 | Teknoware Oy | LED-putkilamppu ja valaisinjärjestely |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| CN1074422C (zh) * | 1987-11-18 | 2001-11-07 | 希龙股份有限公司 | 制备含有hcv表位的分离多肽的方法 |
| US5191064A (en) * | 1988-09-30 | 1993-03-02 | The Research Foundation For Microbial Diseases (Osaka University) | Non-a, non-b hepatitis virus antigen peptide |
| JP2656995B2 (ja) * | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | Nanbvの診断用薬 |
| AU638304B2 (en) * | 1989-12-22 | 1993-06-24 | Abbott Laboratories | Hepatitis c assay |
| CA2079677A1 (en) * | 1990-04-03 | 1991-10-04 | Kenneth H. Burk | Purified hcv and hcv proteins and peptides |
-
1990
- 1990-05-18 EP EP90305421A patent/EP0398748B1/de not_active Expired - Lifetime
- 1990-05-18 WO PCT/US1990/002853 patent/WO1990014436A1/en not_active Ceased
- 1990-05-18 RO RO149205A patent/RO113059B1/ro unknown
- 1990-05-18 CA CA002017157A patent/CA2017157C/en not_active Expired - Lifetime
- 1990-05-18 DE DE69033891T patent/DE69033891T2/de not_active Expired - Lifetime
- 1990-05-18 GE GE1876A patent/GEP20002164B/en unknown
- 1990-05-18 DK DK90305421T patent/DK0398748T3/da active
- 1990-05-18 JP JP2508534A patent/JP2656996B2/ja not_active Expired - Lifetime
- 1990-05-18 AT AT90305421T patent/ATE211772T1/de not_active IP Right Cessation
- 1990-05-18 MC MC@@@@@@@@@@@@D patent/MC2188A1/xx unknown
- 1990-05-18 HU HU904754A patent/HUT59964A/hu unknown
- 1990-05-18 AU AU58123/90A patent/AU638719B2/en not_active Expired
- 1990-05-18 ES ES90305421T patent/ES2166749T3/es not_active Expired - Lifetime
-
1991
- 1991-11-18 FI FI915443A patent/FI105279B/fi active
- 1991-11-18 NO NO914517A patent/NO303503B1/no not_active IP Right Cessation
- 1991-11-18 BG BG095495A patent/BG60348B2/bg unknown
-
1993
- 1993-06-01 LV LVP-93-456A patent/LV10729B/en unknown
-
1996
- 1996-10-30 JP JP30570796A patent/JP3701754B2/ja not_active Expired - Lifetime
-
1997
- 1997-05-19 JP JP14598597A patent/JP3698520B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH1089A (ja) | 1998-01-06 |
| EP0398748A3 (de) | 1991-10-23 |
| CA2017157C (en) | 2003-07-29 |
| JP3698520B2 (ja) | 2005-09-21 |
| RO113059B1 (ro) | 1998-03-30 |
| JPH10113176A (ja) | 1998-05-06 |
| EP0398748B1 (de) | 2002-01-09 |
| HUT59964A (en) | 1992-07-28 |
| NO914517D0 (no) | 1991-11-18 |
| DK0398748T3 (da) | 2002-03-18 |
| FI915443A0 (fi) | 1991-11-18 |
| JP2656996B2 (ja) | 1997-09-24 |
| DE69033891D1 (de) | 2002-02-21 |
| FI105279B (fi) | 2000-07-14 |
| CA2017157A1 (en) | 1990-11-18 |
| ES2166749T3 (es) | 2002-05-01 |
| MC2188A1 (fr) | 1992-09-16 |
| NO303503B1 (no) | 1998-07-20 |
| AU5812390A (en) | 1990-12-18 |
| NO914517L (no) | 1992-01-16 |
| EP0398748A2 (de) | 1990-11-22 |
| LV10729A (lv) | 1995-06-20 |
| JP3701754B2 (ja) | 2005-10-05 |
| WO1990014436A1 (en) | 1990-11-29 |
| AU638719B2 (en) | 1993-07-08 |
| DE69033891T2 (de) | 2002-08-29 |
| HU904754D0 (en) | 1992-01-28 |
| GEP20002164B (en) | 2000-07-10 |
| ATE211772T1 (de) | 2002-01-15 |
| JPH05500155A (ja) | 1993-01-21 |
| LV10729B (en) | 1995-12-20 |
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