JPH0459312B2 - - Google Patents

Info

Publication number
JPH0459312B2
JPH0459312B2 JP57137832A JP13783282A JPH0459312B2 JP H0459312 B2 JPH0459312 B2 JP H0459312B2 JP 57137832 A JP57137832 A JP 57137832A JP 13783282 A JP13783282 A JP 13783282A JP H0459312 B2 JPH0459312 B2 JP H0459312B2
Authority
JP
Japan
Prior art keywords
hydrogen atom
carbon atoms
group
general formula
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57137832A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5877867A (ja
Inventor
Kan Jannhooru
Bijeeru Katoran
Joruju Berumyuuto Kamyu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JPS5877867A publication Critical patent/JPS5877867A/ja
Publication of JPH0459312B2 publication Critical patent/JPH0459312B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP57137832A 1981-08-07 1982-08-06 ピリダジンのアミノ誘導体、その製造法およびそれを有効成分とする中枢神経系賦活剤 Granted JPS5877867A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8115380 1981-08-07
FR8115380A FR2510998B1 (fr) 1981-08-07 1981-08-07 Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent

Publications (2)

Publication Number Publication Date
JPS5877867A JPS5877867A (ja) 1983-05-11
JPH0459312B2 true JPH0459312B2 (OSRAM) 1992-09-21

Family

ID=9261294

Family Applications (2)

Application Number Title Priority Date Filing Date
JP57137833A Pending JPS5877868A (ja) 1981-08-07 1982-08-06 ピリダジン誘導体、その製造法およびそれを有効成分とする中枢神経系賦活剤
JP57137832A Granted JPS5877867A (ja) 1981-08-07 1982-08-06 ピリダジンのアミノ誘導体、その製造法およびそれを有効成分とする中枢神経系賦活剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP57137833A Pending JPS5877868A (ja) 1981-08-07 1982-08-06 ピリダジン誘導体、その製造法およびそれを有効成分とする中枢神経系賦活剤

Country Status (30)

Country Link
US (1) US4508720A (OSRAM)
EP (2) EP0074863B1 (OSRAM)
JP (2) JPS5877868A (OSRAM)
KR (2) KR880001624B1 (OSRAM)
AR (2) AR231637A1 (OSRAM)
AT (2) ATE18216T1 (OSRAM)
AU (2) AU548931B2 (OSRAM)
CA (2) CA1174240A (OSRAM)
CS (2) CS229940B2 (OSRAM)
DD (2) DD202549A5 (OSRAM)
DE (2) DE3262671D1 (OSRAM)
DK (2) DK148537C (OSRAM)
EG (2) EG15788A (OSRAM)
ES (2) ES8305737A1 (OSRAM)
FI (2) FI72969C (OSRAM)
FR (1) FR2510998B1 (OSRAM)
GR (2) GR76430B (OSRAM)
HU (2) HU190028B (OSRAM)
IE (2) IE53388B1 (OSRAM)
IL (2) IL66408A (OSRAM)
MA (2) MA19562A1 (OSRAM)
NO (2) NO157861C (OSRAM)
NZ (2) NZ201518A (OSRAM)
OA (2) OA07175A (OSRAM)
PH (1) PH18545A (OSRAM)
PL (2) PL130647B1 (OSRAM)
PT (2) PT75351B (OSRAM)
SU (2) SU1140685A3 (OSRAM)
YU (2) YU172082A (OSRAM)
ZA (2) ZA825513B (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
CA1218655A (en) * 1983-01-28 1987-03-03 Kathleen Biziere Process for the preparation of pyridazine derivatives having a psychotropic action
US4628088A (en) * 1984-07-17 1986-12-09 Eli Lilly And Company Preparation of substituted pyridazines
DE3664772D1 (en) * 1985-01-14 1989-09-07 Boehringer Ingelheim Kg 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use
US5461053A (en) * 1989-02-07 1995-10-24 Sanofi Pyridazine derivatives
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2654727B1 (fr) * 1989-11-17 1992-03-27 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2642754B1 (fr) * 1989-02-07 1991-05-24 Sanofi Sa Nouveaux derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant
US5656631A (en) * 1989-02-07 1997-08-12 Sanofi Pyridazine derivatives
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
US20030176437A1 (en) * 2001-08-31 2003-09-18 D.M. Watterson Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
US20060235021A1 (en) * 2002-08-13 2006-10-19 Wesley Blackaby Phenylpyridazine derivatives as ligands for gaba receptors
CA2589106C (en) 2004-11-02 2015-07-21 Northwestern University Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases
WO2006050359A2 (en) * 2004-11-02 2006-05-11 Northwestern University Pyridazine compounds and methods
WO2007127448A2 (en) * 2006-04-28 2007-11-08 Northwestern University Salts of pyridazine compounds
AU2007243280A1 (en) 2006-04-28 2007-11-08 Northwestern University Formulations containing pyridazine compounds for treating neuroinflammatory diseases
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
RU2555969C1 (ru) * 2014-07-09 2015-07-10 Юлия Алексеевна Щепочкина Керамическая масса для изготовления облицовочной плитки

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345880A (en) * 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives

Also Published As

Publication number Publication date
AR231637A1 (es) 1985-01-31
NZ201520A (en) 1985-04-30
AR231441A1 (es) 1984-11-30
FI822747L (fi) 1983-02-08
IE53387B1 (en) 1988-10-26
ZA825512B (en) 1983-06-29
US4508720A (en) 1985-04-02
NO157861B (no) 1988-02-22
AU8655382A (en) 1983-02-10
FI822748L (fi) 1983-02-08
NO822510L (no) 1983-02-08
EP0072726A1 (fr) 1983-02-23
AU8655482A (en) 1983-02-10
JPS5877868A (ja) 1983-05-11
ES514794A0 (es) 1983-04-16
IE53388B1 (en) 1988-10-26
FI72968B (fi) 1987-04-30
CS229940B2 (en) 1984-07-16
IL66409A0 (en) 1982-11-30
ES514795A0 (es) 1983-04-16
PL237808A1 (en) 1983-02-28
KR880001624B1 (ko) 1988-09-02
CA1174240A (en) 1984-09-11
PL237809A1 (en) 1983-02-28
JPS5877867A (ja) 1983-05-11
GR76430B (OSRAM) 1984-08-10
NZ201518A (en) 1985-04-30
FR2510998B1 (fr) 1986-01-10
PL130647B1 (en) 1984-08-31
HU190028B (en) 1986-08-28
EG15747A (en) 1986-06-30
DK148537C (da) 1986-01-13
FR2510998A1 (fr) 1983-02-11
DE3269383D1 (en) 1986-04-03
EG15788A (en) 1986-09-30
HU189166B (en) 1986-06-30
ZA825513B (en) 1983-06-29
PH18545A (en) 1985-08-09
FI822747A0 (fi) 1982-08-06
EP0074863B1 (fr) 1986-02-26
PT75350A (fr) 1982-08-01
PT75350B (fr) 1984-08-01
DK354382A (da) 1983-02-08
FI72969B (fi) 1987-04-30
IL66408A (en) 1985-12-31
DK148537B (da) 1985-07-29
SU1140685A3 (ru) 1985-02-15
IE821779L (en) 1983-02-07
AU548930B2 (en) 1986-01-09
FI822748A0 (fi) 1982-08-06
NO157102B (no) 1987-10-12
DD202549A5 (de) 1983-09-21
IE821778L (en) 1983-02-07
OA07175A (fr) 1984-04-30
IL66409A (en) 1985-09-29
KR840001145A (ko) 1984-03-28
DK354482A (da) 1983-02-08
AU548931B2 (en) 1986-01-09
KR890001569B1 (ko) 1989-05-08
PT75351A (fr) 1982-08-01
EP0074863A1 (fr) 1983-03-23
PT75351B (fr) 1984-08-01
SU1138024A3 (ru) 1985-01-30
DK148795B (da) 1985-09-30
FI72968C (fi) 1987-08-10
DD202715A5 (de) 1983-09-28
IL66408A0 (en) 1982-11-30
FI72969C (fi) 1987-08-10
ATE12227T1 (de) 1985-04-15
DK148795C (da) 1986-03-10
EP0072726B1 (fr) 1985-03-20
MA19562A1 (fr) 1983-04-01
MA19560A1 (fr) 1983-04-01
CA1179346A (en) 1984-12-11
DE3262671D1 (en) 1985-04-25
ES8305737A1 (es) 1983-04-16
ATE18216T1 (de) 1986-03-15
CS229941B2 (en) 1984-07-16
NO822509L (no) 1983-02-08
PL137199B1 (en) 1986-05-31
KR840001159A (ko) 1984-03-28
YU172082A (en) 1985-03-20
NO157861C (no) 1988-06-01
GR76429B (OSRAM) 1984-08-10
ES8305738A1 (es) 1983-04-16
NO157102C (no) 1988-01-20
YU171882A (en) 1985-03-20
OA07176A (fr) 1984-04-30

Similar Documents

Publication Publication Date Title
JPH0459312B2 (OSRAM)
US3686206A (en) Pyrazole and pyrazolone aminoketones
FI89355C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 1-aminobut-3-en-foereningar
SI20473A (sl) Tienilazolilalkoksietanamini, njihova priprava in njihova uporaba kot zdravila
NL8204126A (nl) Werkwijze voor het bereiden van een farmaceutisch preparaat met locaal-anesthetische werking dat een dialylamino-2',6'acetoxylidide en/of een farmaceutisch aanvaardbaar zout daarvan bevat, alsmede de onder toepassing van deze werkwijze verkregen gevormde farmaceutische preparaten en werkwijze voor het bereiden van dialkylamino-2',6'acetoxylididen en de farmaceutisch aanvaardbare zouten daarvan.
CS208660B2 (en) Method of making the n-/2-phenyl-2-hydroxyethyl/-1,1-dimethyl-3-phenylpropylamin derivatives
CS274405B2 (en) Method of 4-cyanopyridazines preparation
RU2222532C2 (ru) Соединения ряда бензофуроксана, способ их получения (варианты), фармацевтическая композиция, способ получения парентерального состава и способ лечения коронарных сердечных заболеваний
US3959292A (en) 2-Amino-4,5-dihydropyridine derivatives
HU191586B (en) Process for preparing new derivatives of pyridazine and pyrimidine
KR900003301B1 (ko) 2-피페라지닐-4-페닐 퀴나졸린 유도체 및 그의 산염의 제조 방법
JPS60158190A (ja) ヒダントイン誘導体およびその製法ならびにそれを含有する医薬
US4638009A (en) Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof
JPH0558633B2 (OSRAM)
KR100226328B1 (ko) 4-(4-또는6-(트리플루오로메틸-2-피리디닐))-1-피페라지닐알킬치환된락탐
US4094871A (en) 1,3,4-Benzotriazepine-2-thiones
US3818008A (en) 1-phenylhexahydro-pyridazines
US3222365A (en) 4-halophenyl-2-alkyl-1(2)-phthalazinones
PT98184A (pt) Processo de preparacao de derivados de 5-isotiazolamina e de composicoes farmaceuticas que os contem
KR840002432B1 (ko) 아미노프로판올 유도체의 제조방법
US3379726A (en) Tetrahydropyidazines
JPS59141565A (ja) 向精神性活性を有するピリダジン誘導体，その製造方法および該誘導体を含有する薬剤
US4168310A (en) Psychoactive 1,3,4-benzotriazepine-2-thiones and a method for treating central nervous system depression and anxiety
FR2539414A1 (fr) Derives de la pyrimidine, leur procede de preparation et les medicaments ayant une activite sur le systeme nerveux central qui en contiennent
IE48883B1 (en) Antithrombotic therapeutic composition