ES8305737A1 - Procedimiento para la preparacion de compuestos aminados de la piridazina. - Google Patents

Procedimiento para la preparacion de compuestos aminados de la piridazina.

Info

Publication number
ES8305737A1
ES8305737A1 ES514794A ES514794A ES8305737A1 ES 8305737 A1 ES8305737 A1 ES 8305737A1 ES 514794 A ES514794 A ES 514794A ES 514794 A ES514794 A ES 514794A ES 8305737 A1 ES8305737 A1 ES 8305737A1
Authority
ES
Spain
Prior art keywords
central nerve
nerve system
pyridazine derivative
formula
derivative active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514794A
Other languages
English (en)
Other versions
ES514794A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8305737A1 publication Critical patent/ES8305737A1/es
Publication of ES514794A0 publication Critical patent/ES514794A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS AMINADOS DE LA PIRIDAZINA DE FORMULA GENERAL (I), DONDE R , R Y R REPRESENTAN UN GRUPO FENILO O HIDROXIFENILO, HIDROGENO O UN GRUPO ALQUILO CON 1 A 4 ATOMOS DE CARBONO. SE HACE REACCIONAR UN CLORO-3 PIRIDAZINA CONVENIENTEMENTE SUSTITUIDA CON UNA AMINA DE FORMULA (II), EN DONDE A REPRESENTA UN GRUPO ALQUILENO RECTO O RAMIFICADO QUE TENGA DE 2 A 5 ATOMOS DE CARBONO Y X REPRESENTA HIDROGENO O UN GRUPO ALQUILO CON 1 A 4 ATOMOS DE CARBONO, EFECTUANDOSE LA CITADA REACCION EN EL SENO DE UN DISOLVENTE TAL COMO UN ALCOHOL A TEMPERATURA PROXIMA A LA TEMPERATURA DE EBULLICION DEL DISOLVENTE Y EN PRESENCIA DE UN ACEPTOR DE HIDRACIDO. SE UTILIZAN COMO COMPUESTOS ACTIVOS SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES514794A 1981-08-07 1982-08-06 Procedimiento para la preparacion de compuestos aminados de la piridazina. Granted ES514794A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8115380A FR2510998B1 (fr) 1981-08-07 1981-08-07 Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent

Publications (2)

Publication Number Publication Date
ES8305737A1 true ES8305737A1 (es) 1983-04-16
ES514794A0 ES514794A0 (es) 1983-04-16

Family

ID=9261294

Family Applications (2)

Application Number Title Priority Date Filing Date
ES514795A Expired ES8305738A1 (es) 1981-08-07 1982-08-06 Procedimiento para la preparacion de derivados substituidos de la piridazina.
ES514794A Granted ES514794A0 (es) 1981-08-07 1982-08-06 Procedimiento para la preparacion de compuestos aminados de la piridazina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES514795A Expired ES8305738A1 (es) 1981-08-07 1982-08-06 Procedimiento para la preparacion de derivados substituidos de la piridazina.

Country Status (30)

Country Link
US (1) US4508720A (es)
EP (2) EP0072726B1 (es)
JP (2) JPS5877868A (es)
KR (2) KR880001624B1 (es)
AR (2) AR231441A1 (es)
AT (2) ATE18216T1 (es)
AU (2) AU548930B2 (es)
CA (2) CA1174240A (es)
CS (2) CS229941B2 (es)
DD (2) DD202549A5 (es)
DE (2) DE3262671D1 (es)
DK (2) DK148537C (es)
EG (2) EG15747A (es)
ES (2) ES8305738A1 (es)
FI (2) FI72969C (es)
FR (1) FR2510998B1 (es)
GR (2) GR76429B (es)
HU (2) HU189166B (es)
IE (2) IE53388B1 (es)
IL (2) IL66408A (es)
MA (2) MA19560A1 (es)
NO (2) NO157861C (es)
NZ (2) NZ201518A (es)
OA (2) OA07176A (es)
PH (1) PH18545A (es)
PL (2) PL137199B1 (es)
PT (2) PT75350B (es)
SU (2) SU1138024A3 (es)
YU (2) YU172082A (es)
ZA (2) ZA825513B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
US4565814A (en) * 1983-01-28 1986-01-21 Sanofi Pyridazine derivatives having a psychotropic action and compositions
US4628088A (en) * 1984-07-17 1986-12-09 Eli Lilly And Company Preparation of substituted pyridazines
DE3664772D1 (en) * 1985-01-14 1989-09-07 Boehringer Ingelheim Kg 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2654727B1 (fr) * 1989-11-17 1992-03-27 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2642754B1 (fr) * 1989-02-07 1991-05-24 Sanofi Sa Nouveaux derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant
US5461053A (en) * 1989-02-07 1995-10-24 Sanofi Pyridazine derivatives
US5631255A (en) * 1989-02-07 1997-05-20 Sanofi Pyridazine derivatives
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
EP1430033A4 (en) * 2001-08-31 2004-12-15 Univ Northwestern PROTEIN KINASE ANTI-INFLAMMATORY AND INHIBITOR COMPOSITION AND METHOD OF USE
AU2003246979B8 (en) * 2002-08-13 2009-08-06 Merck Sharp & Dohme Limited Phenylpyridazine derivatives as ligands for GABA receptors
WO2006050359A2 (en) * 2004-11-02 2006-05-11 Northwestern University Pyridazine compounds and methods
ES2543813T3 (es) 2004-11-02 2015-08-24 Northwestern University Compuestos de piridazina para el tratamiento de enfermedades inflamatorias
EP2015751A2 (en) * 2006-04-28 2009-01-21 Northwestern University Salts of pyridazine compounds
WO2007127375A2 (en) 2006-04-28 2007-11-08 Northwestern University Formulations containing pyridazine compounds for treating neuroinflammatory diseases
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
RU2555969C1 (ru) * 2014-07-09 2015-07-10 Юлия Алексеевна Щепочкина Керамическая масса для изготовления облицовочной плитки

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345880A (en) * 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives

Also Published As

Publication number Publication date
CA1179346A (en) 1984-12-11
AR231441A1 (es) 1984-11-30
CS229941B2 (en) 1984-07-16
PT75351B (fr) 1984-08-01
FR2510998A1 (fr) 1983-02-11
MA19560A1 (fr) 1983-04-01
IE53387B1 (en) 1988-10-26
IL66408A0 (en) 1982-11-30
US4508720A (en) 1985-04-02
ES514795A0 (es) 1983-04-16
PT75351A (fr) 1982-08-01
IL66408A (en) 1985-12-31
PT75350A (fr) 1982-08-01
FI822748L (fi) 1983-02-08
ZA825512B (en) 1983-06-29
KR840001145A (ko) 1984-03-28
IE53388B1 (en) 1988-10-26
EP0074863A1 (fr) 1983-03-23
EP0074863B1 (fr) 1986-02-26
FI72968B (fi) 1987-04-30
PL137199B1 (en) 1986-05-31
FI822747A0 (fi) 1982-08-06
NO157102B (no) 1987-10-12
NO157102C (no) 1988-01-20
JPS5877868A (ja) 1983-05-11
YU172082A (en) 1985-03-20
KR890001569B1 (ko) 1989-05-08
IE821778L (en) 1983-02-07
FI72969B (fi) 1987-04-30
GR76429B (es) 1984-08-10
SU1140685A3 (ru) 1985-02-15
IE821779L (en) 1983-02-07
AR231637A1 (es) 1985-01-31
HU190028B (en) 1986-08-28
ES514794A0 (es) 1983-04-16
DK148795C (da) 1986-03-10
NO157861B (no) 1988-02-22
ATE18216T1 (de) 1986-03-15
FI72968C (fi) 1987-08-10
NZ201518A (en) 1985-04-30
DK354382A (da) 1983-02-08
IL66409A (en) 1985-09-29
DK148795B (da) 1985-09-30
AU8655382A (en) 1983-02-10
DK148537C (da) 1986-01-13
PL237809A1 (en) 1983-02-28
OA07175A (fr) 1984-04-30
PL237808A1 (en) 1983-02-28
ES8305738A1 (es) 1983-04-16
SU1138024A3 (ru) 1985-01-30
PT75350B (fr) 1984-08-01
EP0072726A1 (fr) 1983-02-23
YU171882A (en) 1985-03-20
DE3262671D1 (en) 1985-04-25
FI822748A0 (fi) 1982-08-06
NO157861C (no) 1988-06-01
EG15747A (en) 1986-06-30
AU548930B2 (en) 1986-01-09
GR76430B (es) 1984-08-10
DK354482A (da) 1983-02-08
DK148537B (da) 1985-07-29
KR840001159A (ko) 1984-03-28
JPH0459312B2 (es) 1992-09-21
FI72969C (fi) 1987-08-10
NZ201520A (en) 1985-04-30
ATE12227T1 (de) 1985-04-15
DD202549A5 (de) 1983-09-21
MA19562A1 (fr) 1983-04-01
NO822509L (no) 1983-02-08
FI822747L (fi) 1983-02-08
EP0072726B1 (fr) 1985-03-20
ZA825513B (en) 1983-06-29
AU548931B2 (en) 1986-01-09
HU189166B (en) 1986-06-30
KR880001624B1 (ko) 1988-09-02
DD202715A5 (de) 1983-09-28
AU8655482A (en) 1983-02-10
NO822510L (no) 1983-02-08
DE3269383D1 (en) 1986-04-03
EG15788A (en) 1986-09-30
FR2510998B1 (fr) 1986-01-10
PL130647B1 (en) 1984-08-31
CA1174240A (en) 1984-09-11
JPS5877867A (ja) 1983-05-11
PH18545A (en) 1985-08-09
CS229940B2 (en) 1984-07-16
IL66409A0 (en) 1982-11-30
OA07176A (fr) 1984-04-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401