ES8307239A1 - Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos. - Google Patents
Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos.Info
- Publication number
- ES8307239A1 ES8307239A1 ES510599A ES510599A ES8307239A1 ES 8307239 A1 ES8307239 A1 ES 8307239A1 ES 510599 A ES510599 A ES 510599A ES 510599 A ES510599 A ES 510599A ES 8307239 A1 ES8307239 A1 ES 8307239A1
- Authority
- ES
- Spain
- Prior art keywords
- esters
- salts
- acids
- tetrahydrothienylcarbamoyl
- alkylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ACIDOS (2-OXO-3-TETRAHIDROTIENILCARBAMOIL)-ALQUILTIO) ACETICOS. SE HACE REACCIONAR UN 3-HALOACIL AMINO-2-OXO-TETRAHIDROTIOFENO DE FORMULA (II) CON UN ACIDO TIOGLICOLICO HS-CH -COOR , EN PRESENCIA DE UN ACEPTADOR DE PROTONES A UNA TEMPERATURA DE 15 A 120 C. CUANDO R ES HIDROGENO EL PRODUCTO OBTENIDO (I) SE TRANSFORMA EN SUS SALES ALCALINAS Y EN SUS ESTERES CORRESPONDIENTES; N ES 0 O 1 MIENTRAS UNO DE LOS SUSTITUYENTES R Y R SON UN ATOMO DE HIDROGENO O UN GRUPO METILO Y EL OTRO ES UN GRUPO -S-CH -COOR .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8105496A FR2502153A1 (fr) | 1981-03-19 | 1981-03-19 | Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8307239A1 true ES8307239A1 (es) | 1983-06-16 |
ES510599A0 ES510599A0 (es) | 1983-06-16 |
Family
ID=9256420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510599A Granted ES510599A0 (es) | 1981-03-19 | 1982-03-18 | Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4411909A (es) |
EP (1) | EP0061386B1 (es) |
JP (1) | JPS57167982A (es) |
AT (1) | ATE8047T1 (es) |
DE (2) | DE3260262D1 (es) |
ES (1) | ES510599A0 (es) |
FR (1) | FR2502153A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
NZ199061A (en) * | 1980-12-09 | 1984-10-19 | Beecham Group Ltd | 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions |
US4562182A (en) * | 1980-12-23 | 1985-12-31 | Beecham Group P.L.C. | Compounds containing beta-lactams |
US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
IT1173441B (it) * | 1984-03-14 | 1987-06-24 | Edmond Pharma Srl | Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
IT1215238B (it) * | 1985-02-22 | 1990-01-31 | Chiesi Farma Spa | Derivati di omocisteina tiolattone,loro procedimento di preparazione e formulazioni farmaceutiche |
IT1254530B (it) * | 1992-03-18 | 1995-09-25 | Derivati mercapto acetamidici | |
US5274122A (en) * | 1992-10-15 | 1993-12-28 | Merck & Co., Inc. | Acidic derivatives of homocysteine thiolactone |
WO1995001175A1 (en) * | 1993-07-02 | 1995-01-12 | The University Of Nottingham | Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone |
ATE527248T1 (de) * | 2007-11-16 | 2011-10-15 | Edmond Pharma Srl | Polymorphe von enantioreinem erdostein |
RO125302B1 (ro) | 2008-09-08 | 2013-03-29 | Rafifarm S.R.L. | Utilizarea erdosteinei ca antidot în tratamentul intoxicaţiilor, în special intoxicaţiile cu metale grele cum ar fi plumb şi mercur |
CN101941963A (zh) * | 2010-04-22 | 2011-01-12 | 浙江康乐药业股份有限公司 | 一种厄多司坦的合成方法 |
CN106187991B (zh) * | 2016-07-19 | 2019-04-30 | 山东罗欣药业集团股份有限公司 | 一种治疗呼吸系统疾病的化合物及其制备方法 |
CN106176642B (zh) * | 2016-07-19 | 2019-08-13 | 山东罗欣药业集团股份有限公司 | 一种治疗呼吸系统疾病的分散片剂及其制备方法 |
CN108640900A (zh) * | 2018-06-07 | 2018-10-12 | 扬子江药业集团江苏海慈生物药业有限公司 | 一种厄多司坦的纯化方法 |
KR102701892B1 (ko) * | 2020-05-15 | 2024-09-02 | 제이투에이치바이오텍 (주) | 에르도스테인 유도체 및 이를 함유하는 약학 조성물 |
IT202000016816A1 (it) | 2020-07-10 | 2022-01-10 | Edmond Pharma Srl | Composizioni comprendenti composti antiossidanti come coadiuvanti nel trattamento di infezioni virali |
IT202000018286A1 (it) | 2020-07-28 | 2022-01-28 | Edmond Pharma Srl | Preparazione di erdosteina o di uno dei suoi derivati in processo di flusso continuo |
KR102583743B1 (ko) | 2021-03-23 | 2023-10-05 | 대봉엘에스 주식회사 | L,d-엘도스테인의 개별적 합성방법 |
EP4316481A1 (en) | 2022-08-01 | 2024-02-07 | Edmond Pharma S.R.L. | Erdosteine, salts, enantiomers or metabolites thereof for use in the treatment of acute and chronic pain states |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE610270A (es) * | 1960-11-14 | |||
FR1451177A (fr) * | 1962-03-06 | 1966-01-07 | Degussa | Procédé de préparation d'une n-acylhomocystéine thiolactone |
FR2129877B1 (es) * | 1971-03-18 | 1974-08-02 | Fuveau Sa | |
FR2147468A5 (en) * | 1971-07-28 | 1973-03-09 | Fuveau Sa | N-acetyl homocysteine thiolactone - by demethylating methionine with hydriodic acid and acetic anhydride, then acetylating |
FR2265355B1 (es) * | 1974-03-28 | 1977-11-04 | Blum Jean | |
US4241078A (en) * | 1975-02-10 | 1980-12-23 | Chevron Research Company | Fungicidal 3-(N-acyl-N-arylamino)-gamma-butyrolactones and gamma-butyrothiolactones |
GB1548398A (en) * | 1975-06-05 | 1979-07-11 | Lilly Industries Ltd | Acylamino pyrroles furans and thiophenes |
-
1981
- 1981-03-19 FR FR8105496A patent/FR2502153A1/fr active Granted
-
1982
- 1982-03-11 AT AT82400433T patent/ATE8047T1/de not_active IP Right Cessation
- 1982-03-11 DE DE8282400433T patent/DE3260262D1/de not_active Expired
- 1982-03-11 DE DE1999175059 patent/DE19975059I2/de active Active
- 1982-03-11 EP EP82400433A patent/EP0061386B1/fr not_active Expired
- 1982-03-15 US US06/358,370 patent/US4411909A/en not_active Expired - Lifetime
- 1982-03-18 ES ES510599A patent/ES510599A0/es active Granted
- 1982-03-19 JP JP57045502A patent/JPS57167982A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DE19975059I2 (de) | 2004-07-01 |
FR2502153B1 (es) | 1984-01-27 |
FR2502153A1 (fr) | 1982-09-24 |
EP0061386B1 (fr) | 1984-06-20 |
ATE8047T1 (de) | 1984-07-15 |
US4411909A (en) | 1983-10-25 |
JPS57167982A (en) | 1982-10-16 |
DE3260262D1 (en) | 1984-07-26 |
EP0061386A1 (fr) | 1982-09-29 |
ES510599A0 (es) | 1983-06-16 |
JPH0239507B2 (es) | 1990-09-05 |
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