JPS57167982A - Novel ((2-oxo-3-tetrahydrothienylcarbamoyl)- alkylthio)-acetic acids, manufacture and respiratory disease remedy - Google Patents

Novel ((2-oxo-3-tetrahydrothienylcarbamoyl)- alkylthio)-acetic acids, manufacture and respiratory disease remedy

Info

Publication number
JPS57167982A
JPS57167982A JP57045502A JP4550282A JPS57167982A JP S57167982 A JPS57167982 A JP S57167982A JP 57045502 A JP57045502 A JP 57045502A JP 4550282 A JP4550282 A JP 4550282A JP S57167982 A JPS57167982 A JP S57167982A
Authority
JP
Japan
Prior art keywords
tetrahydrothienylcarbamoyl
alkylthio
oxo
novel
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57045502A
Other languages
English (en)
Other versions
JPH0239507B2 (ja
Inventor
Gonerura Jiyakusu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REFUARUMEDO REHIERUKESU PHARM
REFUARUMEDO REHIERUKESU PHARM ETO MEDEIKARESU SA
Original Assignee
REFUARUMEDO REHIERUKESU PHARM
REFUARUMEDO REHIERUKESU PHARM ETO MEDEIKARESU SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REFUARUMEDO REHIERUKESU PHARM, REFUARUMEDO REHIERUKESU PHARM ETO MEDEIKARESU SA filed Critical REFUARUMEDO REHIERUKESU PHARM
Publication of JPS57167982A publication Critical patent/JPS57167982A/ja
Publication of JPH0239507B2 publication Critical patent/JPH0239507B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP57045502A 1981-03-19 1982-03-19 Novel ((2-oxo-3-tetrahydrothienylcarbamoyl)- alkylthio)-acetic acids, manufacture and respiratory disease remedy Granted JPS57167982A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8105496A FR2502153A1 (fr) 1981-03-19 1981-03-19 Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
JPS57167982A true JPS57167982A (en) 1982-10-16
JPH0239507B2 JPH0239507B2 (ja) 1990-09-05

Family

ID=9256420

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57045502A Granted JPS57167982A (en) 1981-03-19 1982-03-19 Novel ((2-oxo-3-tetrahydrothienylcarbamoyl)- alkylthio)-acetic acids, manufacture and respiratory disease remedy

Country Status (7)

Country Link
US (1) US4411909A (ja)
EP (1) EP0061386B1 (ja)
JP (1) JPS57167982A (ja)
AT (1) ATE8047T1 (ja)
DE (2) DE3260262D1 (ja)
ES (1) ES510599A0 (ja)
FR (1) FR2502153A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
EP0053893B1 (en) * 1980-12-09 1985-03-20 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
IT1173441B (it) * 1984-03-14 1987-06-24 Edmond Pharma Srl Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1215238B (it) * 1985-02-22 1990-01-31 Chiesi Farma Spa Derivati di omocisteina tiolattone,loro procedimento di preparazione e formulazioni farmaceutiche
IT1254530B (it) * 1992-03-18 1995-09-25 Derivati mercapto acetamidici
US5274122A (en) * 1992-10-15 1993-12-28 Merck & Co., Inc. Acidic derivatives of homocysteine thiolactone
ATE184194T1 (de) * 1993-07-02 1999-09-15 Univ Nottingham Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)- homoserinlacton
ATE527248T1 (de) 2007-11-16 2011-10-15 Edmond Pharma Srl Polymorphe von enantioreinem erdostein
RO125302B1 (ro) 2008-09-08 2013-03-29 Rafifarm S.R.L. Utilizarea erdosteinei ca antidot în tratamentul intoxicaţiilor, în special intoxicaţiile cu metale grele cum ar fi plumb şi mercur
CN101941963A (zh) * 2010-04-22 2011-01-12 浙江康乐药业股份有限公司 一种厄多司坦的合成方法
CN106187991B (zh) * 2016-07-19 2019-04-30 山东罗欣药业集团股份有限公司 一种治疗呼吸系统疾病的化合物及其制备方法
CN106176642B (zh) * 2016-07-19 2019-08-13 山东罗欣药业集团股份有限公司 一种治疗呼吸系统疾病的分散片剂及其制备方法
CN108640900A (zh) * 2018-06-07 2018-10-12 扬子江药业集团江苏海慈生物药业有限公司 一种厄多司坦的纯化方法
IT202000016816A1 (it) 2020-07-10 2022-01-10 Edmond Pharma Srl Composizioni comprendenti composti antiossidanti come coadiuvanti nel trattamento di infezioni virali
IT202000018286A1 (it) 2020-07-28 2022-01-28 Edmond Pharma Srl Preparazione di erdosteina o di uno dei suoi derivati in processo di flusso continuo
KR102583743B1 (ko) 2021-03-23 2023-10-05 대봉엘에스 주식회사 L,d-엘도스테인의 개별적 합성방법
EP4316481A1 (en) 2022-08-01 2024-02-07 Edmond Pharma S.R.L. Erdosteine, salts, enantiomers or metabolites thereof for use in the treatment of acute and chronic pain states

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE610270A (ja) * 1960-11-14
FR1451177A (fr) * 1962-03-06 1966-01-07 Degussa Procédé de préparation d'une n-acylhomocystéine thiolactone
FR2129877B1 (ja) * 1971-03-18 1974-08-02 Fuveau Sa
FR2147468A5 (en) * 1971-07-28 1973-03-09 Fuveau Sa N-acetyl homocysteine thiolactone - by demethylating methionine with hydriodic acid and acetic anhydride, then acetylating
FR2265355B1 (ja) * 1974-03-28 1977-11-04 Blum Jean
US4241078A (en) * 1975-02-10 1980-12-23 Chevron Research Company Fungicidal 3-(N-acyl-N-arylamino)-gamma-butyrolactones and gamma-butyrothiolactones
GB1548398A (en) * 1975-06-05 1979-07-11 Lilly Industries Ltd Acylamino pyrroles furans and thiophenes

Also Published As

Publication number Publication date
JPH0239507B2 (ja) 1990-09-05
DE19975059I2 (de) 2004-07-01
ATE8047T1 (de) 1984-07-15
EP0061386A1 (fr) 1982-09-29
US4411909A (en) 1983-10-25
DE3260262D1 (en) 1984-07-26
FR2502153B1 (ja) 1984-01-27
EP0061386B1 (fr) 1984-06-20
ES8307239A1 (es) 1983-06-16
FR2502153A1 (fr) 1982-09-24
ES510599A0 (es) 1983-06-16

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