IT1254530B - Derivati mercapto acetamidici - Google Patents

Derivati mercapto acetamidici

Info

Publication number
IT1254530B
IT1254530B ITMI920631A ITMI920631A IT1254530B IT 1254530 B IT1254530 B IT 1254530B IT MI920631 A ITMI920631 A IT MI920631A IT MI920631 A ITMI920631 A IT MI920631A IT 1254530 B IT1254530 B IT 1254530B
Authority
IT
Italy
Prior art keywords
alkyl
aralkyl
acute
formula
groups
Prior art date
Application number
ITMI920631A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ITMI920631A priority Critical patent/IT1254530B/it
Publication of ITMI920631A0 publication Critical patent/ITMI920631A0/it
Priority to ES93905278T priority patent/ES2106325T3/es
Priority to AT93905278T priority patent/ATE156487T1/de
Priority to JP5516198A priority patent/JPH06507919A/ja
Priority to EP93905278A priority patent/EP0593697B1/en
Priority to DE69312849T priority patent/DE69312849T2/de
Priority to PCT/EP1993/000449 priority patent/WO1993019024A2/en
Publication of ITMI920631A1 publication Critical patent/ITMI920631A1/it
Application granted granted Critical
Publication of IT1254530B publication Critical patent/IT1254530B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Abstract

L'invenzione concerne nuovi derivati farmacologicamente attivi dell'N- (2-mercaptoacetil) omocisteina sia in forma -tiolattonica ciclizzata in forma di catena aperta, aventi formula: (FORMULA I) dove R rappresenta un atomo di idrogeno, un alchile C1-3, un aralchile C 7-9 o gruppi COR1, nei quali R1 è un alchile C1-3, eventualmente sostituito con un gruppo metossi, o un aralchile C7-9, i gruppi aralchilici possono essere non sostituiti o sostituiti sull'anello fenilico da uno o più alogeni, alchile C1-3 o alcossile C1-3; L è idrogeno, Q è ossidrile oppure L e Q insieme formano un legame.Viene inoltre descritto il processo per la preparazione dei suddetti composti. Tali composti risultano utili nel trattamento di bronchiti acute e croniche, enfisema, patologie acute e croniche ORL, quali antidoti contro deplezione di glutatione endogeno indotti da farmaci, da radiazioni e in caso di alterazione della bilancia biologica ossido-riduttiva.
ITMI920631A 1992-03-18 1992-03-18 Derivati mercapto acetamidici IT1254530B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI920631A IT1254530B (it) 1992-03-18 1992-03-18 Derivati mercapto acetamidici
ES93905278T ES2106325T3 (es) 1992-03-18 1993-02-26 Derivados de mercapto-acetamida.
AT93905278T ATE156487T1 (de) 1992-03-18 1993-02-26 Mercapto-acetamid-derivate
JP5516198A JPH06507919A (ja) 1992-03-18 1993-02-26 メルカプトアセトアミド誘導体
EP93905278A EP0593697B1 (en) 1992-03-18 1993-02-26 Mercapto-acetamide derivatives
DE69312849T DE69312849T2 (de) 1992-03-18 1993-02-26 Mercapto-acetamid-derivate
PCT/EP1993/000449 WO1993019024A2 (en) 1992-03-18 1993-02-26 Mercapto-acetamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920631A IT1254530B (it) 1992-03-18 1992-03-18 Derivati mercapto acetamidici

Publications (3)

Publication Number Publication Date
ITMI920631A0 ITMI920631A0 (it) 1992-03-18
ITMI920631A1 ITMI920631A1 (it) 1993-09-18
IT1254530B true IT1254530B (it) 1995-09-25

Family

ID=11362490

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920631A IT1254530B (it) 1992-03-18 1992-03-18 Derivati mercapto acetamidici

Country Status (7)

Country Link
EP (1) EP0593697B1 (it)
JP (1) JPH06507919A (it)
AT (1) ATE156487T1 (it)
DE (1) DE69312849T2 (it)
ES (1) ES2106325T3 (it)
IT (1) IT1254530B (it)
WO (1) WO1993019024A2 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0935227A (ja) * 1995-07-21 1997-02-07 Sony Corp 磁気ヘッド装置
US7875268B2 (en) 2004-04-06 2011-01-25 L'oreal S.A. Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
FR2868420B1 (fr) * 2004-04-06 2006-06-16 Oreal Utilisation de dimercaptoamides pour la deformation permanente des fibres keratiniques
UA95139C2 (ru) * 2009-11-11 2011-07-11 Владислав Лазаревич Розенфельд Профилактическое средство-антиоксидант, для защиты тканей организма от последствий табакокурения

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2502153A1 (fr) * 1981-03-19 1982-09-24 Rech Pharmaceutiq Medicale Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant
IT1140394B (it) * 1981-12-23 1986-09-24 Maggioni Farma Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice
IT1173441B (it) * 1984-03-14 1987-06-24 Edmond Pharma Srl Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1215238B (it) * 1985-02-22 1990-01-31 Chiesi Farma Spa Derivati di omocisteina tiolattone,loro procedimento di preparazione e formulazioni farmaceutiche

Also Published As

Publication number Publication date
DE69312849D1 (de) 1997-09-11
ES2106325T3 (es) 1997-11-01
JPH06507919A (ja) 1994-09-08
WO1993019024A3 (en) 1993-10-28
ITMI920631A1 (it) 1993-09-18
EP0593697B1 (en) 1997-08-06
DE69312849T2 (de) 1998-01-08
ATE156487T1 (de) 1997-08-15
EP0593697A1 (en) 1994-04-27
WO1993019024A2 (en) 1993-09-30
ITMI920631A0 (it) 1992-03-18

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