ES2106325T3 - Derivados de mercapto-acetamida. - Google Patents
Derivados de mercapto-acetamida.Info
- Publication number
- ES2106325T3 ES2106325T3 ES93905278T ES93905278T ES2106325T3 ES 2106325 T3 ES2106325 T3 ES 2106325T3 ES 93905278 T ES93905278 T ES 93905278T ES 93905278 T ES93905278 T ES 93905278T ES 2106325 T3 ES2106325 T3 ES 2106325T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- derivatives
- acute
- compounds
- damage caused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001154 acute effect Effects 0.000 abstract 2
- 206010006451 bronchitis Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000729 antidote Substances 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 101150111293 cor-1 gene Proteins 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000010408 sweeping Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBEN UNOS NUEVOS DERIVADOS FARMACOLOGICAMENTE ACTIVOS DE HOMOCISTEINA N-(2-MERCAPTO TIOLACTONICA CICLADA O EN FORMA DE CADENA ABIERTA, TALES DERIVADOS TIENE LA FORMULA (I) DONDE R ES UN ATOMO DE HIDROGENO, ALQUILO C1-3, ARALQUILO C7-9 O UN GRUPO COR1 DONE R1 ES ALQUILO C1-3 O ARALQUILO C7-9, LOS GRUPOS ARALQUILOS SE SUSTITUYEN O NO EN EL ANILLO FENILO POR UNO O MAS HALOGENOS, ALQUILO C1-3 O ALCOXI C1-3; L ES H, Q ES HIDROXILO, O L Y Q JUNTOS FORMAN UN ENLACE. SE DESCRIBE EL PROCESO DE PREPARACION DE LOS COMPUESTOS Y LAS COMPOSICIONES QUE LOS CONTIENEN. LOS COMPUESTOS SON POTENTES AGENTES DE BARRIDO DE RADICAL LIBRE, PUEDEN PREVENIR EL DAÑO CELULAR PROVOCADO POR RADICALES LIBRES Y TIENEN ACTIVIDADES LOCALES MUCOCINETICAS, MUCOLITICAS Y ANTIINFLAMATORIAS, Y PUEDEN SER UTILES EN EL TRATAMIENTO DE BRONQUITIS AGUDA Y CRONICA, ENFISEMA Y PATOLOGIAS ORL AGUDAS Y CRONICAS, COMO ANTIDOTOS CONTRA LA MERMA PROVOCADA POR DROGAS DE GLUTACION ENDROGENA Y EN CASO DE ALTERACION DEL BALANCE OXIDANTE-ANTOXIDANTE BIOLOGICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920631A IT1254530B (it) | 1992-03-18 | 1992-03-18 | Derivati mercapto acetamidici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2106325T3 true ES2106325T3 (es) | 1997-11-01 |
Family
ID=11362490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93905278T Expired - Lifetime ES2106325T3 (es) | 1992-03-18 | 1993-02-26 | Derivados de mercapto-acetamida. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0593697B1 (es) |
| JP (1) | JPH06507919A (es) |
| AT (1) | ATE156487T1 (es) |
| DE (1) | DE69312849T2 (es) |
| ES (1) | ES2106325T3 (es) |
| IT (1) | IT1254530B (es) |
| WO (1) | WO1993019024A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0935227A (ja) * | 1995-07-21 | 1997-02-07 | Sony Corp | 磁気ヘッド装置 |
| US7875268B2 (en) | 2004-04-06 | 2011-01-25 | L'oreal S.A. | Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith |
| FR2868420B1 (fr) * | 2004-04-06 | 2006-06-16 | Oreal | Utilisation de dimercaptoamides pour la deformation permanente des fibres keratiniques |
| UA95139C2 (ru) * | 2009-11-11 | 2011-07-11 | Владислав Лазаревич Розенфельд | Профилактическое средство-антиоксидант, для защиты тканей организма от последствий табакокурения |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2502153A1 (fr) * | 1981-03-19 | 1982-09-24 | Rech Pharmaceutiq Medicale | Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant |
| IT1140394B (it) * | 1981-12-23 | 1986-09-24 | Maggioni Farma | Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice |
| IT1173441B (it) * | 1984-03-14 | 1987-06-24 | Edmond Pharma Srl | Sali di eritromicina con derivati dell'acido acetico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| IT1215238B (it) * | 1985-02-22 | 1990-01-31 | Chiesi Farma Spa | Derivati di omocisteina tiolattone,loro procedimento di preparazione e formulazioni farmaceutiche |
-
1992
- 1992-03-18 IT ITMI920631A patent/IT1254530B/it active
-
1993
- 1993-02-26 AT AT93905278T patent/ATE156487T1/de active
- 1993-02-26 JP JP5516198A patent/JPH06507919A/ja active Pending
- 1993-02-26 WO PCT/EP1993/000449 patent/WO1993019024A2/en active IP Right Grant
- 1993-02-26 EP EP93905278A patent/EP0593697B1/en not_active Expired - Lifetime
- 1993-02-26 DE DE69312849T patent/DE69312849T2/de not_active Expired - Fee Related
- 1993-02-26 ES ES93905278T patent/ES2106325T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69312849D1 (de) | 1997-09-11 |
| ITMI920631A0 (it) | 1992-03-18 |
| WO1993019024A2 (en) | 1993-09-30 |
| DE69312849T2 (de) | 1998-01-08 |
| ATE156487T1 (de) | 1997-08-15 |
| WO1993019024A3 (en) | 1993-10-28 |
| IT1254530B (it) | 1995-09-25 |
| EP0593697B1 (en) | 1997-08-06 |
| EP0593697A1 (en) | 1994-04-27 |
| JPH06507919A (ja) | 1994-09-08 |
| ITMI920631A1 (it) | 1993-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR016762A1 (es) | Compuestos del acido 4-bromo o 4-yodo fenilamino benzohidroxamico, formulaciones farmaceuticas y uso del mismo | |
| ES2037752T3 (es) | Utilizacion de un derivado de benzoxazol y su procedimiento de preparacion. | |
| EA200200708A1 (ru) | Производные бензазола и их применение в качестве модуляторов jnk | |
| PE20040071A1 (es) | Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion | |
| AR065937A2 (es) | Compuesto derivado indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de proteina quinasa | |
| AR014110A1 (es) | Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicion | |
| DK322783D0 (da) | Amidderivater | |
| TR200000671T2 (tr) | FP agonistleri olarak yararlı aromatik C16-C20-ikameli tetrahidro prostaglandinler. | |
| CO5580771A2 (es) | Antagonistas ccr5 como agentes terapeuticos | |
| ES2126099T3 (es) | Compuestos heterociclicos y su preparacion y uso. | |
| ES2174989T3 (es) | Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion. | |
| TR200000670T2 (tr) | FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler. | |
| ES2038660T3 (es) | Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica. | |
| AR011913A1 (es) | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. | |
| EA200100983A1 (ru) | Производные 13-метилэритромицина | |
| EA202092923A1 (ru) | Полициклическое производное пиридона | |
| DK0409435T3 (da) | Heteroarylpiperaziner som antipsykotiske midler | |
| AR009145A1 (es) | Compuetos heterociclicos de guanidinilo utiles como agonistas de alfa-2 adrenoreceptores y composiciones farmaceuticas que los comprenden | |
| ES2174298T3 (es) | Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| PE29798A1 (es) | Acetidinas | |
| ES2045044T3 (es) | Derivados de sulfonamidolfenilo y agentes terapeuticos y preventivos de la arritmia que contienen los mismos. | |
| ES2045126T3 (es) | Agentes terapeuticos. | |
| ES2106325T3 (es) | Derivados de mercapto-acetamida. | |
| ES2062202T3 (es) | Derivado del indol. | |
| RU94038042A (ru) | Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 593697 Country of ref document: ES |