ES2038660T3 - Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica. - Google Patents

Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica.

Info

Publication number
ES2038660T3
ES2038660T3 ES198787303967T ES87303967T ES2038660T3 ES 2038660 T3 ES2038660 T3 ES 2038660T3 ES 198787303967 T ES198787303967 T ES 198787303967T ES 87303967 T ES87303967 T ES 87303967T ES 2038660 T3 ES2038660 T3 ES 2038660T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
optionally replaced
group
alcoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787303967T
Other languages
English (en)
Inventor
John Morris Cno Beecham Pharmaceuticals Evans
Geoffrey Cno Beecham Pharmaceuticals Stemp
Frederick Cno Beecham Pharmaceuticals Cassidy
Gordon Cno Beecham Pharmaceuticals Burrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868610911A external-priority patent/GB8610911D0/en
Priority claimed from GB868623768A external-priority patent/GB8623768D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2038660T3 publication Critical patent/ES2038660T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS: EN DONDE: Y ES N O (CUANDO R3 ES HIDROXI, ALCOXI C1-6 O ACILOXI C1-7) CH; UNO DE R1 Y R2 ES HIDROGENO O ALQUILO C1-4 Y EL OTRO ES ALQUILO C1-4 O R1 Y R2 JUNTOS SON POLIMETILENO C2-5; R3 ES HIDROGENO, HIDROXI, ALCOXI C1-6 O ACILOXI C1-7; R4 ES UN GRUPO CICLOALQUILO C3-8 O UN GRUPO ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO POR UN GRUPO R7 QUE ES HIDROXI, ALCOXI C1-6, AMINO OPCIONALMENTE SUSTITUIDO POR UNO O MAS GRUPOS ALQUILO C1-6; ALCANOILAMINO C1-7, CICLOALQUILOXI C3-8, CICLOALQUILAMINO C3-8 O 1,3-DIOXO-2-ISOINDOLINA; CUANDO Y ES N, R5 ES HIDROGENO, ALQUILO C1-6 OPCIONALMENTE SUSTITUIDO POR HALOGENO, HIDROXI, ALCOXI C1-6, ALCOXICARBONILO C1-6, CARBOXI O AMINO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS ALQUILO C1-6 INDEPENDIENTES O ALQUENILO C2-6, AMINO OPCIONALMENTE SUSTITUIDO POR UN GRUPO ALQUILO C1-6, CICLOALQUILO C3-8 O ALQUENILO C1-6 O POR UN GRUPO ALCANOILO C1-6 OPCIONALMENTE SUSTITUIDO POR HASTA TRES ATOMOS DE HALO, POR UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO POR ALQUILO C1-6, ALCOXI C1-6 O HALOGENO O ARILO O HETEROARILO, SIENDO BIEN OPCIONALMENTE SUSTITUIDO POR UNO O MAS GRUPOS O ATOMOS SELECCIONADOS DE LA CLASE DE ALQUILO C1-6, ALCOXI C1-6, HIDROXI, HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, ACILO CARBOXILICO C1-12 O AMINO O AMINOCARBONILO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS ALQUILO C1-6 Y R6 ES HIDROGENO O ALQUILO C1-6 O R5 Y R6 JUNTOS SON -CH2-(CH2)N-Z(CH2)MNDE M Y N SON DE 0 A 2 DE TAL MODO QUE M + N ES 1 O 2 Y Z ES CH2, O, S O NR EN DONDE R ES HIDROGENO, ALQUILO C1-9, ALCANOILO C2-7, FENILALQUILO C1-4, NAFTILCARBONILO, FENILCARBONILO O BENCILCARBONILO OPCIONALMENTE SUSTITUIDO EN EL ANILLO FENILO O NAFTILO POR UNO O DOS DE ALQUILO C1-6, ALCOXI C16 O HALOGENO; HETEROARILCARBONILO MONO 8R9 EN DONDE R8 Y R9 SON, INDEPENDIENTEMENTE, ALQUILO C1-6, R8 ES HIDROGENO Y R9 ES ALQUILO C1-6 O R8 Y R9 JUNTOS SON POLIMETILENO C4-5; O R6 Y R8 JUNTO SON -(CH2)P R9 ES HIDROGENO O ALQUILO C1-6; O R5 ES CH2R10 EN DONDE R10 ES HIDROGENO O ALQUILO C1-5; O R6 Y R10 SON -(CH2)Q 2 O 3; X ES OXIGENO O AZUFRE; O R5, R6, X E Y (CUANDO ES N) SON JUNTOS TETRAHIDROISOQUINOLINONA O TETRAHIDROISOQUINOLINTIONA, OPCIONALMENTE SUSTITUIDAS EN EL ANILLO DE FENILO TAL Y COMO SE HA DEFINIDO ANTES PARA R; EL GRUPO QUE CONTIENE NITROGENO SE ENCUENTRA EN LA POSICION 4 SIENDO TRANS AL GRUPO R3 CUANDO R3 ES HIDROXI, ALCOXI C1-6 O ACILOXI C1-7; TIENE UNA ACTIVIDAD ACTIVADORA DEL CANAL K +, PROCESOS PARA SU PREPARACION Y SU USO COMO PRODUCTOS FARMACEUTICOS.
ES198787303967T 1986-05-03 1987-05-01 Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica. Expired - Lifetime ES2038660T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868610911A GB8610911D0 (en) 1986-05-03 1986-05-03 Active compounds
GB868623768A GB8623768D0 (en) 1986-10-03 1986-10-03 Active compounds

Publications (1)

Publication Number Publication Date
ES2038660T3 true ES2038660T3 (es) 1993-08-01

Family

ID=26290724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787303967T Expired - Lifetime ES2038660T3 (es) 1986-05-03 1987-05-01 Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica.

Country Status (10)

Country Link
US (2) US4943582A (es)
EP (1) EP0250077B1 (es)
AU (1) AU599975B2 (es)
CA (1) CA1308105C (es)
DE (1) DE3775628D1 (es)
DK (1) DK224687A (es)
ES (1) ES2038660T3 (es)
GR (1) GR3003504T3 (es)
NZ (1) NZ220171A (es)
PT (1) PT84806B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
US5364878A (en) * 1988-07-19 1994-11-15 Hoechst Aktiengesellschaft Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs
ES2071668T3 (es) * 1988-12-13 1995-07-01 Beecham Group Plc Benzopirano y compuestos relacionados.
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
DE3926001A1 (de) * 1989-08-05 1991-02-07 Merck Patent Gmbh Chromanderivate
GB8918298D0 (en) * 1989-08-10 1989-09-20 Beecham Group Plc Novel compounds
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
GB9002458D0 (en) * 1990-02-03 1990-04-04 Beecham Group Plc Pharmaceuticals
FR2661676A1 (fr) * 1990-05-02 1991-11-08 Lipha Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant.
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
FR2670780B1 (fr) * 1990-12-20 1993-07-09 Synthelabo Derives de 4-(acylamino)benzopyranes, leur preparation et leur application en therapeutique.
EP0508425A1 (en) 1991-04-12 1992-10-14 Schering Corporation Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
US5240943A (en) * 1991-12-19 1993-08-31 G. D. Searle & Co. Benzopyran class iii antiarrhythmic agents
US5416118A (en) * 1992-04-09 1995-05-16 Schering Corporation Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
GR1002276B (el) * 1992-10-08 1996-05-02 Smithkline Beecham P.L.C. Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς.
AP360A (en) * 1992-12-04 1994-09-07 Smithkline Beecham Plc Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity.
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
US5574049A (en) * 1994-07-22 1996-11-12 Sandoz Ltd. 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062870A (en) * 1974-05-31 1977-12-13 Beecham Group Limited Chroman derivatives
US4016226A (en) * 1975-02-10 1977-04-05 The Babcock & Wilcox Company Method of making porous nuclear fuel
NZ183551A (en) * 1976-04-02 1978-09-20 Beecham Group Ltd Aminochromanols and pharmaceutical compositions containingthem
DE3064285D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0028064B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
ATE23718T1 (de) * 1981-09-25 1986-12-15 Beecham Group Plc Benzopyran-verbindungen mit pharmazeutischer wirkung.
NZ213469A (en) * 1981-09-25 1986-04-11 Beecham Group Plc Benzopyran compounds as intermediates
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
DE3368057D1 (en) * 1982-05-21 1987-01-15 Beecham Group Plc Pharmaceutically active aminobenzopyrans
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
GB8313679D0 (en) * 1983-05-18 1983-06-22 Beecham Group Plc Active compounds
DE3479726D1 (de) * 1983-05-18 1989-10-19 Beecham Group Plc Benzopyran derivatives.
EP0139992B1 (en) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
EP0218373B1 (en) * 1985-09-11 1990-03-07 Beecham Group Plc Chroman derivatives and analogues having antihypertensive activity
US4853410A (en) * 1986-01-17 1989-08-01 Pfizer Inc. Hydroxyacetic acid derivatives for the treatment of diabetic complications

Also Published As

Publication number Publication date
US5075460A (en) 1991-12-24
DK224687D0 (da) 1987-05-01
CA1308105C (en) 1992-09-29
AU7242987A (en) 1987-11-05
EP0250077B1 (en) 1992-01-02
AU599975B2 (en) 1990-08-02
PT84806B (pt) 1989-12-29
DE3775628D1 (de) 1992-02-13
NZ220171A (en) 1990-05-28
US4943582A (en) 1990-07-24
GR3003504T3 (es) 1993-03-16
EP0250077A3 (en) 1988-01-07
PT84806A (en) 1987-05-01
EP0250077A2 (en) 1987-12-23
DK224687A (da) 1987-11-04

Similar Documents

Publication Publication Date Title
ES2038660T3 (es) Un procedimiento para la preparacion de nuevos benzopiranos con actividad farmacologica.
AR022848A1 (es) Compuestos de imidazol sustituido con un anillo heterociclico de seis o siete miembros que contiene dos atomos de nitrogeno
AR035617A1 (es) Compuestos derivados de fenetanolamina, combinaciones y formulaciones farmaceuticas de los mismos, proceso para su preparacion, su uso en la preparacion de medicamentos para el tratamiento o profilaxis de una condicion clinica para la cual se indica un agonista beta2 adreno-receptor e intermediarios
AR014102A1 (es) 4-haloalquil-3-heterociclilpiridinas y 4-haloalquil-5- heterociclilpirimidinas, procedimiento para su preparacion, productos que lascontienen, uso de las mismas para preparar un medicamento veterinario, procedimiento para proteger plantas cultivadas y su empleo para combatir
AR016762A1 (es) Compuestos del acido 4-bromo o 4-yodo fenilamino benzohidroxamico, formulaciones farmaceuticas y uso del mismo
ES2075036T3 (es) 3-piperidinil-1,2-benzoisoxazoles.
CO4810298A1 (es) Nuevas amidas aromaticas y su procedimiento de preparacion .
ECSP034730A (es) Quinazolinas como inhibidores de mmp-13
ES2110003T3 (es) Nuevas composiciones a base de derivados de la clase de los taxanos.
ES2059557T3 (es) Nuevas bis-(3,5-dicarbamoil-2,4,6-triyodo-anilidas) de acidos dicarboxilicos, procedimiento para su preparacion asi como agentes de contraste de rayos x que contienen a estos.
ES2123039T3 (es) Nuevas 3-(hidroxi-bencilidenil)-indolin-2-onas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ES2159922T3 (es) Nuevos derivados de bencimidazol, de benzoxazol y de benzotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
AR036176A1 (es) Un derivado de fenil-acetamido-tiazol, un procedimiento para su preparacion, una composicion farmaceutica que lo comprende, un producto o kit que los comprende, y un metodo que utiliza dicho derivado
ES2070002T3 (es) Composiciones terapeuticas a base de derivados de 1,2-ditiol-3-tiona.
AR040140A1 (es) Derivados de esteres de camptotecina en la posicion 20
ES2095848T3 (es) Nuevos derivados de fosfolipidos y su utilizacion para la preparacion de medicamentos antiviricos.
ES2054811T3 (es) Derivados de tetrahidroisoquinolin-2-ilo como antagonistas de tromboxano a2.
AR017460A2 (es) Compuestos intermediarios para preparar arilsulfonamidas y procedimientos para su preparacion
AR040139A1 (es) Camptotecinas con un anillo lactona modificado
MX9306394A (es) Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene
ES2179548T3 (es) Nuevos derivados de la acronicina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2174582T3 (es) Nuevos derivados de 1,2-ditiolano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
HUP0002714A2 (hu) Béta-amino és béta-azido-karbonsavszármazékok, és a vegyületeket tartalmazó endotelin-receptor antagonista hatású gyógyszerkészítmények

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 250077

Country of ref document: ES