HUP0002714A2 - Béta-amino és béta-azido-karbonsavszármazékok, és a vegyületeket tartalmazó endotelin-receptor antagonista hatású gyógyszerkészítmények - Google Patents
Béta-amino és béta-azido-karbonsavszármazékok, és a vegyületeket tartalmazó endotelin-receptor antagonista hatású gyógyszerkészítményekInfo
- Publication number
- HUP0002714A2 HUP0002714A2 HU0002714A HUP0002714A HUP0002714A2 HU P0002714 A2 HUP0002714 A2 HU P0002714A2 HU 0002714 A HU0002714 A HU 0002714A HU P0002714 A HUP0002714 A HU P0002714A HU P0002714 A2 HUP0002714 A2 HU P0002714A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- betha
- general formula
- formula
- amino
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002308 endothelin receptor antagonist Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgyát az általános képletű új b-amino- és b-azido-karbonsavszármazékok - ahol R1 azidocsoport vagy -CO-R általánosképletű csoport; A -NR7R8 általános képletű csoport vagy azidocsoport;W és Z N vagy metincsoport; bizonyos megszorítással; X N vagy CR9általános képletű csoport; Y N vagy CR10 általános képletű csoport; Q N vagy CR11 általános képletű csoport; bizonyos megszorítással; R2és R3 adott esetben szubsztituált fenil- vagy naftilcsoport; vagyolyan fenil- vagy naftilcsoportok, amelyeket o-helyzetben egy kémiaikötés, egy metilén-, etilén- vagy viniléncsoport, egy oxigén- vagykénatom vagy egy -SO2-, -NH- vagy -N(alkil)- képletű csoport kötegymással össze; adott esetben szubsztituált cikloalkilcsoport -előállításuk és endotelin-receptor antagonistákként való alkalmazásukképezi. A vegyületek többek között a magas vérnyomás, az agyi isémia,a jóindulatú prosztata megnagyobbodás és prosztatarák kezelésérealkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19726146A DE19726146A1 (de) | 1997-06-19 | 1997-06-19 | Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| PCT/EP1998/003366 WO1998058916A1 (de) | 1997-06-19 | 1998-06-05 | NEUE β-AMINO UND β-AZIDOCARBONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ENDOTHELINREZEPTORANTAGONISTEN |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002714A2 true HUP0002714A2 (hu) | 2001-05-28 |
| HUP0002714A3 HUP0002714A3 (en) | 2001-07-30 |
Family
ID=7833081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002714A HUP0002714A3 (en) | 1997-06-19 | 1998-06-05 | Betha-amino and betha-azidocarboxylic acid derivatives, and pharmaceutical compositions containing them as endothelin receptor antagonists |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0994861A1 (hu) |
| JP (1) | JP2002504130A (hu) |
| KR (1) | KR20010013981A (hu) |
| CN (1) | CN1261352A (hu) |
| AR (1) | AR015893A1 (hu) |
| AU (1) | AU8213398A (hu) |
| BG (1) | BG104022A (hu) |
| BR (1) | BR9810182A (hu) |
| CA (1) | CA2294050A1 (hu) |
| CO (1) | CO4950605A1 (hu) |
| DE (1) | DE19726146A1 (hu) |
| HR (1) | HRP980331A2 (hu) |
| HU (1) | HUP0002714A3 (hu) |
| ID (1) | ID24346A (hu) |
| IL (1) | IL133104A0 (hu) |
| NO (1) | NO996268D0 (hu) |
| NZ (1) | NZ502319A (hu) |
| PL (1) | PL337507A1 (hu) |
| SK (1) | SK176299A3 (hu) |
| TR (1) | TR199903159T2 (hu) |
| WO (1) | WO1998058916A1 (hu) |
| ZA (1) | ZA985277B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19806438A1 (de) * | 1998-02-17 | 1999-08-19 | Basf Ag | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
| DE19858779A1 (de) * | 1998-12-18 | 2000-06-21 | Basf Ag | Neue ß-Amido und ß-Sulfonamidocarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| DE19924892A1 (de) * | 1999-06-01 | 2000-12-07 | Basf Ag | Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
| WO2002064573A1 (de) * | 2001-02-14 | 2002-08-22 | Abbott Gmbh & Co. Kg | Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten |
| EP1632821B1 (en) | 2004-09-01 | 2012-05-30 | Océ-Technologies B.V. | Intermediate transfer member with a cleaning member |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| JP2010535210A (ja) | 2007-07-31 | 2010-11-18 | ギリード・コロラド・インコーポレーテッド | アンブリセンタンの代謝産物および誘導体 |
| CN109422664B (zh) * | 2017-08-23 | 2022-02-18 | 中国科学院福建物质结构研究所 | 一类干扰素调节剂及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
| DE4411225A1 (de) * | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
| DE19614533A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung |
-
1997
- 1997-06-19 DE DE19726146A patent/DE19726146A1/de not_active Withdrawn
-
1998
- 1998-06-05 TR TR1999/03159T patent/TR199903159T2/xx unknown
- 1998-06-05 EP EP98932123A patent/EP0994861A1/de not_active Withdrawn
- 1998-06-05 AU AU82133/98A patent/AU8213398A/en not_active Abandoned
- 1998-06-05 NZ NZ502319A patent/NZ502319A/en unknown
- 1998-06-05 SK SK1762-99A patent/SK176299A3/sk unknown
- 1998-06-05 CA CA002294050A patent/CA2294050A1/en not_active Abandoned
- 1998-06-05 PL PL98337507A patent/PL337507A1/xx unknown
- 1998-06-05 CN CN98806397A patent/CN1261352A/zh active Pending
- 1998-06-05 WO PCT/EP1998/003366 patent/WO1998058916A1/de not_active Application Discontinuation
- 1998-06-05 HU HU0002714A patent/HUP0002714A3/hu unknown
- 1998-06-05 ID IDW991614A patent/ID24346A/id unknown
- 1998-06-05 BR BR9810182-0A patent/BR9810182A/pt not_active IP Right Cessation
- 1998-06-05 IL IL13310498A patent/IL133104A0/xx unknown
- 1998-06-05 KR KR19997012007A patent/KR20010013981A/ko not_active Application Discontinuation
- 1998-06-05 JP JP50366799A patent/JP2002504130A/ja active Pending
- 1998-06-17 AR ARP980102873A patent/AR015893A1/es unknown
- 1998-06-17 HR HR19726146.9A patent/HRP980331A2/hr not_active Application Discontinuation
- 1998-06-18 CO CO98034781A patent/CO4950605A1/es unknown
- 1998-06-18 ZA ZA9805277A patent/ZA985277B/xx unknown
-
1999
- 1999-12-16 BG BG104022A patent/BG104022A/xx unknown
- 1999-12-17 NO NO996268A patent/NO996268D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2294050A1 (en) | 1998-12-30 |
| AR015893A1 (es) | 2001-05-30 |
| DE19726146A1 (de) | 1998-12-24 |
| NZ502319A (en) | 2002-03-01 |
| NO996268L (no) | 1999-12-17 |
| BR9810182A (pt) | 2000-08-08 |
| HRP980331A2 (en) | 1999-02-28 |
| IL133104A0 (en) | 2001-03-19 |
| TR199903159T2 (xx) | 2000-07-21 |
| NO996268D0 (no) | 1999-12-17 |
| CO4950605A1 (es) | 2000-09-01 |
| HUP0002714A3 (en) | 2001-07-30 |
| BG104022A (en) | 2001-04-30 |
| ZA985277B (en) | 1999-12-20 |
| ID24346A (id) | 2000-07-13 |
| AU8213398A (en) | 1999-01-04 |
| WO1998058916A1 (de) | 1998-12-30 |
| EP0994861A1 (de) | 2000-04-26 |
| SK176299A3 (en) | 2000-06-12 |
| JP2002504130A (ja) | 2002-02-05 |
| CN1261352A (zh) | 2000-07-26 |
| KR20010013981A (ko) | 2001-02-26 |
| PL337507A1 (en) | 2000-08-28 |
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