ZA985277B - Novel ß-amino and ß-azido carboxylic and acid derivatives, their preparation and use as endothelin receptor antagonists. - Google Patents
Novel ß-amino and ß-azido carboxylic and acid derivatives, their preparation and use as endothelin receptor antagonists.Info
- Publication number
- ZA985277B ZA985277B ZA9805277A ZA985277A ZA985277B ZA 985277 B ZA985277 B ZA 985277B ZA 9805277 A ZA9805277 A ZA 9805277A ZA 985277 A ZA985277 A ZA 985277A ZA 985277 B ZA985277 B ZA 985277B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino
- novel
- preparation
- acid derivatives
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19726146A DE19726146A1 (en) | 1997-06-19 | 1997-06-19 | New ß-amino and ß-azidopcarboxylic acid derivatives, their preparation and use as endothelin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA985277B true ZA985277B (en) | 1999-12-20 |
Family
ID=7833081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9805277A ZA985277B (en) | 1997-06-19 | 1998-06-18 | Novel ß-amino and ß-azido carboxylic and acid derivatives, their preparation and use as endothelin receptor antagonists. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0994861A1 (en) |
JP (1) | JP2002504130A (en) |
KR (1) | KR20010013981A (en) |
CN (1) | CN1261352A (en) |
AR (1) | AR015893A1 (en) |
AU (1) | AU8213398A (en) |
BG (1) | BG104022A (en) |
BR (1) | BR9810182A (en) |
CA (1) | CA2294050A1 (en) |
CO (1) | CO4950605A1 (en) |
DE (1) | DE19726146A1 (en) |
HR (1) | HRP980331A2 (en) |
HU (1) | HUP0002714A3 (en) |
ID (1) | ID24346A (en) |
IL (1) | IL133104A0 (en) |
NO (1) | NO996268L (en) |
NZ (1) | NZ502319A (en) |
PL (1) | PL337507A1 (en) |
SK (1) | SK176299A3 (en) |
TR (1) | TR199903159T2 (en) |
WO (1) | WO1998058916A1 (en) |
ZA (1) | ZA985277B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19806438A1 (en) * | 1998-02-17 | 1999-08-19 | Basf Ag | New pyrimidinyloxy-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiac insufficiency, restenosis, hypertension, kidney failure, asthma and prostate cancer |
DE19858779A1 (en) * | 1998-12-18 | 2000-06-21 | Basf Ag | New 3-acylamino-propionic acid and 3-sulfonylamino-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiovascular and renal disorders, migraine and cancer |
DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
WO2002064573A1 (en) * | 2001-02-14 | 2002-08-22 | Abbott Gmbh & Co. Kg | Novel carboxylic acid derivatives containing alkyl substituted triazines, production of the same and use thereof as endothelin receptor antagonists |
EP1632821B1 (en) | 2004-09-01 | 2012-05-30 | Océ-Technologies B.V. | Intermediate transfer member with a cleaning member |
US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US8217155B2 (en) | 2007-07-31 | 2012-07-10 | Gilead Colorado, Inc. | Metabolites and derivatives of ambrisentan |
CN109422664B (en) * | 2017-08-23 | 2022-02-18 | 中国科学院福建物质结构研究所 | Interferon regulator and its prepn and use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
DE4411225A1 (en) * | 1994-03-31 | 1995-10-05 | Basf Ag | Use of carboxylic acid derivatives as a drug |
DE19614533A1 (en) * | 1996-04-12 | 1997-10-16 | Basf Ag | New alpha-hydroxy acid derivatives, their production and use |
-
1997
- 1997-06-19 DE DE19726146A patent/DE19726146A1/en not_active Withdrawn
-
1998
- 1998-06-05 CN CN98806397A patent/CN1261352A/en active Pending
- 1998-06-05 NZ NZ502319A patent/NZ502319A/en unknown
- 1998-06-05 WO PCT/EP1998/003366 patent/WO1998058916A1/en not_active Application Discontinuation
- 1998-06-05 HU HU0002714A patent/HUP0002714A3/en unknown
- 1998-06-05 PL PL98337507A patent/PL337507A1/en unknown
- 1998-06-05 AU AU82133/98A patent/AU8213398A/en not_active Abandoned
- 1998-06-05 SK SK1762-99A patent/SK176299A3/en unknown
- 1998-06-05 ID IDW991614A patent/ID24346A/en unknown
- 1998-06-05 IL IL13310498A patent/IL133104A0/en unknown
- 1998-06-05 EP EP98932123A patent/EP0994861A1/en not_active Withdrawn
- 1998-06-05 BR BR9810182-0A patent/BR9810182A/en not_active IP Right Cessation
- 1998-06-05 CA CA002294050A patent/CA2294050A1/en not_active Abandoned
- 1998-06-05 TR TR1999/03159T patent/TR199903159T2/en unknown
- 1998-06-05 KR KR19997012007A patent/KR20010013981A/en not_active Application Discontinuation
- 1998-06-05 JP JP50366799A patent/JP2002504130A/en active Pending
- 1998-06-17 AR ARP980102873A patent/AR015893A1/en unknown
- 1998-06-17 HR HR19726146.9A patent/HRP980331A2/en not_active Application Discontinuation
- 1998-06-18 ZA ZA9805277A patent/ZA985277B/en unknown
- 1998-06-18 CO CO98034781A patent/CO4950605A1/en unknown
-
1999
- 1999-12-16 BG BG104022A patent/BG104022A/en unknown
- 1999-12-17 NO NO996268A patent/NO996268L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO996268D0 (en) | 1999-12-17 |
DE19726146A1 (en) | 1998-12-24 |
NZ502319A (en) | 2002-03-01 |
CN1261352A (en) | 2000-07-26 |
JP2002504130A (en) | 2002-02-05 |
ID24346A (en) | 2000-07-13 |
EP0994861A1 (en) | 2000-04-26 |
TR199903159T2 (en) | 2000-07-21 |
NO996268L (en) | 1999-12-17 |
BG104022A (en) | 2001-04-30 |
HRP980331A2 (en) | 1999-02-28 |
AU8213398A (en) | 1999-01-04 |
SK176299A3 (en) | 2000-06-12 |
WO1998058916A1 (en) | 1998-12-30 |
AR015893A1 (en) | 2001-05-30 |
CO4950605A1 (en) | 2000-09-01 |
HUP0002714A2 (en) | 2001-05-28 |
BR9810182A (en) | 2000-08-08 |
CA2294050A1 (en) | 1998-12-30 |
KR20010013981A (en) | 2001-02-26 |
PL337507A1 (en) | 2000-08-28 |
IL133104A0 (en) | 2001-03-19 |
HUP0002714A3 (en) | 2001-07-30 |
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