BR9810182A - Derived from ß-amino acid and ß-azido carboxylic acid, use of it, formulation of medication for oral, parenteral or intraparenteral administration, compound, use of it, and structural fragment - Google Patents
Derived from ß-amino acid and ß-azido carboxylic acid, use of it, formulation of medication for oral, parenteral or intraparenteral administration, compound, use of it, and structural fragmentInfo
- Publication number
- BR9810182A BR9810182A BR9810182-0A BR9810182A BR9810182A BR 9810182 A BR9810182 A BR 9810182A BR 9810182 A BR9810182 A BR 9810182A BR 9810182 A BR9810182 A BR 9810182A
- Authority
- BR
- Brazil
- Prior art keywords
- carboxylic acid
- oral
- formulation
- derived
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
"DERIVADO DE áCIDO <225>-AMINO E <225>-AZIDO CARBOXìLICO, USO DO MESMO, FORMULAçãO DE MEDICAMENTO PARA ADMINISTRAçãO ORAL, PARENTERAL OU INTRAPARENTERAL, COMPOSTO, USO DO MESMO, E, FRAGMENTO ESTRUTURAL". A invenção diz respeito a derivados de ácido carboxílico de fórmula (I) em que os constituintes têm os significados dados na descrição. A invenção também diz respeito à produção de ditos derivados, e a seu uso como antagonistas receptores de endotelina."DERIVED FROM <225> -AMINO AND <225> -CARBOXYLIC ACID, USE OF THE SAME, FORMULATION OF MEDICINE FOR ORAL, PARENTAL OR INTRAPARENTERAL ADMINISTRATION, COMPOUND, USE OF THE SAME, AND, STRUCTURAL FRAGMENT". The invention relates to carboxylic acid derivatives of formula (I) in which the constituents have the meanings given in the description. The invention also concerns the production of said derivatives, and their use as endothelin receptor antagonists.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19726146A DE19726146A1 (en) | 1997-06-19 | 1997-06-19 | New ß-amino and ß-azidopcarboxylic acid derivatives, their preparation and use as endothelin receptor antagonists |
PCT/EP1998/003366 WO1998058916A1 (en) | 1997-06-19 | 1998-06-05 | NEW β-AMINO AND β-AZIDOCARBOXYLIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810182A true BR9810182A (en) | 2000-08-08 |
Family
ID=7833081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810182-0A BR9810182A (en) | 1997-06-19 | 1998-06-05 | Derived from ß-amino acid and ß-azido carboxylic acid, use of it, formulation of medication for oral, parenteral or intraparenteral administration, compound, use of it, and structural fragment |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0994861A1 (en) |
JP (1) | JP2002504130A (en) |
KR (1) | KR20010013981A (en) |
CN (1) | CN1261352A (en) |
AR (1) | AR015893A1 (en) |
AU (1) | AU8213398A (en) |
BG (1) | BG104022A (en) |
BR (1) | BR9810182A (en) |
CA (1) | CA2294050A1 (en) |
CO (1) | CO4950605A1 (en) |
DE (1) | DE19726146A1 (en) |
HR (1) | HRP980331A2 (en) |
HU (1) | HUP0002714A3 (en) |
ID (1) | ID24346A (en) |
IL (1) | IL133104A0 (en) |
NO (1) | NO996268D0 (en) |
NZ (1) | NZ502319A (en) |
PL (1) | PL337507A1 (en) |
SK (1) | SK176299A3 (en) |
TR (1) | TR199903159T2 (en) |
WO (1) | WO1998058916A1 (en) |
ZA (1) | ZA985277B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19806438A1 (en) * | 1998-02-17 | 1999-08-19 | Basf Ag | New pyrimidinyloxy-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiac insufficiency, restenosis, hypertension, kidney failure, asthma and prostate cancer |
DE19858779A1 (en) * | 1998-12-18 | 2000-06-21 | Basf Ag | New 3-acylamino-propionic acid and 3-sulfonylamino-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiovascular and renal disorders, migraine and cancer |
DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
WO2002064573A1 (en) * | 2001-02-14 | 2002-08-22 | Abbott Gmbh & Co. Kg | Novel carboxylic acid derivatives containing alkyl substituted triazines, production of the same and use thereof as endothelin receptor antagonists |
EP1632821B1 (en) | 2004-09-01 | 2012-05-30 | Océ-Technologies B.V. | Intermediate transfer member with a cleaning member |
US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US8217155B2 (en) | 2007-07-31 | 2012-07-10 | Gilead Colorado, Inc. | Metabolites and derivatives of ambrisentan |
CN109422664B (en) * | 2017-08-23 | 2022-02-18 | 中国科学院福建物质结构研究所 | Interferon regulator and its prepn and use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
DE4411225A1 (en) * | 1994-03-31 | 1995-10-05 | Basf Ag | Use of carboxylic acid derivatives as a drug |
DE19614533A1 (en) * | 1996-04-12 | 1997-10-16 | Basf Ag | New alpha-hydroxy acid derivatives, their production and use |
-
1997
- 1997-06-19 DE DE19726146A patent/DE19726146A1/en not_active Withdrawn
-
1998
- 1998-06-05 CA CA002294050A patent/CA2294050A1/en not_active Abandoned
- 1998-06-05 EP EP98932123A patent/EP0994861A1/en not_active Withdrawn
- 1998-06-05 CN CN98806397A patent/CN1261352A/en active Pending
- 1998-06-05 TR TR1999/03159T patent/TR199903159T2/en unknown
- 1998-06-05 KR KR19997012007A patent/KR20010013981A/en not_active Application Discontinuation
- 1998-06-05 HU HU0002714A patent/HUP0002714A3/en unknown
- 1998-06-05 BR BR9810182-0A patent/BR9810182A/en not_active IP Right Cessation
- 1998-06-05 AU AU82133/98A patent/AU8213398A/en not_active Abandoned
- 1998-06-05 SK SK1762-99A patent/SK176299A3/en unknown
- 1998-06-05 PL PL98337507A patent/PL337507A1/en unknown
- 1998-06-05 NZ NZ502319A patent/NZ502319A/en unknown
- 1998-06-05 ID IDW991614A patent/ID24346A/en unknown
- 1998-06-05 WO PCT/EP1998/003366 patent/WO1998058916A1/en not_active Application Discontinuation
- 1998-06-05 IL IL13310498A patent/IL133104A0/en unknown
- 1998-06-05 JP JP50366799A patent/JP2002504130A/en active Pending
- 1998-06-17 AR ARP980102873A patent/AR015893A1/en unknown
- 1998-06-17 HR HR19726146.9A patent/HRP980331A2/en not_active Application Discontinuation
- 1998-06-18 ZA ZA9805277A patent/ZA985277B/en unknown
- 1998-06-18 CO CO98034781A patent/CO4950605A1/en unknown
-
1999
- 1999-12-16 BG BG104022A patent/BG104022A/en unknown
- 1999-12-17 NO NO996268A patent/NO996268D0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0002714A3 (en) | 2001-07-30 |
CO4950605A1 (en) | 2000-09-01 |
NO996268L (en) | 1999-12-17 |
WO1998058916A1 (en) | 1998-12-30 |
HRP980331A2 (en) | 1999-02-28 |
ZA985277B (en) | 1999-12-20 |
SK176299A3 (en) | 2000-06-12 |
IL133104A0 (en) | 2001-03-19 |
ID24346A (en) | 2000-07-13 |
DE19726146A1 (en) | 1998-12-24 |
AR015893A1 (en) | 2001-05-30 |
JP2002504130A (en) | 2002-02-05 |
TR199903159T2 (en) | 2000-07-21 |
NO996268D0 (en) | 1999-12-17 |
EP0994861A1 (en) | 2000-04-26 |
BG104022A (en) | 2001-04-30 |
HUP0002714A2 (en) | 2001-05-28 |
PL337507A1 (en) | 2000-08-28 |
CN1261352A (en) | 2000-07-26 |
NZ502319A (en) | 2002-03-01 |
KR20010013981A (en) | 2001-02-26 |
CA2294050A1 (en) | 1998-12-30 |
AU8213398A (en) | 1999-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0411155A (en) | compound that binds to and activates the erythropoietin receptor, pharmaceutical composition and its use | |
BR9909565A (en) | Bicyclic derivatives of hydroxamic acid | |
BR9811093A (en) | Pyridines replaced with 2-amino-6- (2-substituted 4-phenoxy) | |
AR023401A1 (en) | DERIVATIVES OF 1,4-BENZOTIAZEPINA-1,1-DIOXIDE REPLACED WITH SUGAR REMAINS, PROCEDURES FOR THEIR PREPARATION, MEDICATIONS CONTAINING THESE COMPOUNDS, AND THEIR EMPLOYMENT TO PREPARE A MEDICINAL PRODUCT | |
BR9813028A (en) | Prostaglandin agonists and their use to treat bone disorders | |
BR9910144A (en) | Chemokine receptor antagonists and their use | |
BR9915553A (en) | Anthranilic acid amides and their use as a medicine | |
BR9812944A (en) | Bicyclic kinase inhibitors | |
BR9807843A (en) | Bicyclic heterocycles dissubstituted, their preparation and their use as medicines | |
SE0001899D0 (en) | New compounds | |
BR0210711A (en) | Use of a compound, pharmaceutical composition, compound, and process for preparing a compound | |
BRPI0410741A (en) | immunosuppressive compound and compositions | |
BR9911771A (en) | Substituted cyclic compounds, a process for their preparation and pharmaceutical compositions containing the same | |
BRPI9605663B8 (en) | Bis(resorcinyl) triazines. | |
BRPI0519398A2 (en) | Pyridine Compounds for the Treatment of Prostaglandin-Mediated Diseases | |
BR9915403A (en) | 4-aroyl-piperidin-ccr-3 iii receptor antagonists | |
BR9915735A (en) | Piperidine ccr-3 receptor antagonists | |
BR0214243A (en) | Sulfonamide derivative Process for the preparation of a sulfonamide derivative and its physiologically acceptable salts, pharmaceutical composition and use of a sulfonamide derivative | |
BR9713338A (en) | Benzonaphyridines as bronchial therapeutics. | |
BR9706386A (en) | Vitronectin receptor antagonists, their preparation and their use | |
BR9811028A (en) | Compound, pharmaceutical composition, and, processes for treating a platelet aggregating disease and for the preparation of a compound | |
BR0008011A (en) | Fluorescent whitening agent, its preparation and use | |
BR0015322A (en) | Derivatives of indene-, naphtha- and benzocyclohepta-dihydrothiazole, their preparation and their use as anoretic drugs | |
BR0016133A (en) | Compound, pharmaceutical formulation, and, use of a compound | |
BR9810182A (en) | Derived from ß-amino acid and ß-azido carboxylic acid, use of it, formulation of medication for oral, parenteral or intraparenteral administration, compound, use of it, and structural fragment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Free format text: ABBOTT GMBH & CO. KG (DE) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A,8A E 9AANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |