ES2129123T3 - Nuevo derivado de bisoxadiazolidina. - Google Patents

Nuevo derivado de bisoxadiazolidina.

Info

Publication number
ES2129123T3
ES2129123T3 ES94913821T ES94913821T ES2129123T3 ES 2129123 T3 ES2129123 T3 ES 2129123T3 ES 94913821 T ES94913821 T ES 94913821T ES 94913821 T ES94913821 T ES 94913821T ES 2129123 T3 ES2129123 T3 ES 2129123T3
Authority
ES
Spain
Prior art keywords
group
formula
bisoxadiazolidine
lower alkyl
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913821T
Other languages
English (en)
Inventor
Kunihiro Niigata
Takumi Takahashi
Tatsuya Maruyama
Takayuki Suzuki
Kyoichi Maeno
Kenichi Onda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2129123T3 publication Critical patent/ES2129123T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN DERIVADO DE BISOXIDIAZOLIDINA DE FORMULA GENERAL (I) UTIL COMO UN MEJORADOR DE LA SENSIBILIDAD A LA INSULINA, UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, Y UNA COMPOSICION MEDICINAL DEL MISMO, EN DONDE (A) Y (B) PUEDEN SER IGUALES O DIFERENTES ENTRE SI Y CADA UNO REPRESENTA UN GRUPO FENILENO OPCIONALMENTE SUSTITUIDO, Y L REPRESENTA: (1) UN ATOMO DE OXIGENO, (2) UN GRUPO DE FORMULA (II) (R{SUP,1} SIENDO UN ATOMO DE HIDROGENO O UN GRUPO ALKILO BAJO), (3) UN GRUPO DE LA FORMULA: -S(O){SUB, N}- (SIENDO N 0, 1 O 2), (4) UN GRUPO DE LA FORMULA: CO-, (5) UN GRUPO DE LA FORMULA (III) O (IV) (R{SUP,2} SIENDO UN ATOMO DE HIDROGENO O UN GRUPO ALKILO BAJO), O (6) UN GRUPO ALQUILENO O ALQUENILENO QUE PUEDE SER SUSTITUIDO E INTERRUMPIDO POR UN ATOMO DE OXIGENO Y/O UN ATOMO DE AZUFRE, Y SIMILARES.
ES94913821T 1993-04-30 1994-04-26 Nuevo derivado de bisoxadiazolidina. Expired - Lifetime ES2129123T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12789893 1993-04-30
JP35020993 1993-12-29

Publications (1)

Publication Number Publication Date
ES2129123T3 true ES2129123T3 (es) 1999-06-01

Family

ID=26463731

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913821T Expired - Lifetime ES2129123T3 (es) 1993-04-30 1994-04-26 Nuevo derivado de bisoxadiazolidina.

Country Status (14)

Country Link
US (1) US5643931A (es)
EP (1) EP0696585B1 (es)
CN (1) CN1045005C (es)
AT (1) ATE174593T1 (es)
AU (1) AU680496B2 (es)
CA (1) CA2160989A1 (es)
DE (1) DE69415314T2 (es)
DK (1) DK0696585T3 (es)
ES (1) ES2129123T3 (es)
GR (1) GR3029428T3 (es)
HU (1) HUT73431A (es)
RU (1) RU2135487C1 (es)
TW (1) TW401418B (es)
WO (1) WO1994025448A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028257A1 (fr) * 1996-12-24 1998-07-02 Chugai Seiyaku Kabushiki Kaisha Derives d'amine aromatiques ayant une action inhibitrice a l'egard des nos
US6221914B1 (en) * 1997-11-10 2001-04-24 Array Biopharma Inc. Sulfonamide bridging compounds that inhibit tryptase activity
US6534037B1 (en) 1998-01-21 2003-03-18 Neorx Corporation Non-steroidal compounds for steroid receptors and uses relating thereto
EP1354602B1 (en) * 2000-12-26 2006-10-04 Sankyo Company, Limited Medicinal compositions containing diuretic and insulin resistance-improving agent
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
CA2541751A1 (en) * 2003-10-14 2005-04-28 Eli Lilly And Company Phenoxyether derivatives as ppar modulators
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
TW200932219A (en) * 2007-10-24 2009-08-01 Astellas Pharma Inc Oxadiazolidinedione compound
EP2332528A1 (de) * 2009-12-14 2011-06-15 Grünenthal GmbH Substituierte aromatische Dicarbonsäureamide als Arzneimittel
BR112014002363A2 (pt) * 2011-08-03 2017-06-13 National Taiwan University agonistas do domínio de homologia src 2 contendo proteína tirosina fosfatase - 1 e métodos de tratamento utilizando os mesmos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598153A (en) * 1984-12-19 1986-07-01 The United States Of America As Represented By The Department Of Health And Human Services Metaphit, a specific acylating agent for the [3 H] phencyclidine
KR930701420A (ko) * 1990-08-23 1993-06-11 알렌 제이. 스피겔 혈당저하제로서의 하이드록시우레아 유도체
ES2157204T3 (es) * 1991-04-17 2001-08-16 Upjohn Co Derivados de (s)-3-fenilpiperidina sustituidos, su preparacion y uso como antagonistas de autorreceptores de dopamina.
ES2128355T3 (es) * 1991-07-30 1999-05-16 Yamanouchi Pharma Co Ltd Nuevo derivado bisheterociclico o su sal y composicion hipoglicemica.
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
JPH09303021A (ja) * 1996-05-17 1997-11-25 Matsushita Electric Works Ltd 近接型ワイヤレス電気錠制御システム

Also Published As

Publication number Publication date
HU9503090D0 (en) 1995-12-28
EP0696585B1 (en) 1998-12-16
CN1122133A (zh) 1996-05-08
US5643931A (en) 1997-07-01
HUT73431A (en) 1996-07-29
GR3029428T3 (en) 1999-05-28
EP0696585A1 (en) 1996-02-14
DE69415314T2 (de) 1999-05-20
RU2135487C1 (ru) 1999-08-27
CA2160989A1 (en) 1994-11-10
AU680496B2 (en) 1997-07-31
DK0696585T3 (da) 1999-08-23
TW401418B (en) 2000-08-11
CN1045005C (zh) 1999-09-08
DE69415314D1 (de) 1999-01-28
WO1994025448A1 (en) 1994-11-10
ATE174593T1 (de) 1999-01-15
AU6582394A (en) 1994-11-21
EP0696585A4 (es) 1996-03-27

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