ES8500209A1 - Procedimiento para la preparacion de derivados de carbaciclina - Google Patents
Procedimiento para la preparacion de derivados de carbaciclinaInfo
- Publication number
- ES8500209A1 ES8500209A1 ES529636A ES529636A ES8500209A1 ES 8500209 A1 ES8500209 A1 ES 8500209A1 ES 529636 A ES529636 A ES 529636A ES 529636 A ES529636 A ES 529636A ES 8500209 A1 ES8500209 A1 ES 8500209A1
- Authority
- ES
- Spain
- Prior art keywords
- carbacyclins
- manufacture
- pharmaceutical compounds
- carbon atoms
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
- Basic Packing Technique (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Lubricants (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBACICLINA Y DE SUS SALES CON BASES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1-4 SON HIDROGENO O ALCOHILO C1-5; Y R5 ES ALCOHILO C1-5.CONSISTE EN LA REACCION DE ETERIFICACION DE UN COMPUESTO DE FORMULA (II), CON UN DERIVADO DE ACIDO HALOGENOACETICO, DE FORMULA (III), EN LAS QUE THP ES RADICAL TETRAHIDROPIRANILO, HAL ES CLORO, BROMO O YODO, R6 PUEDE SER VARIOS RADICALES, Y R1-R5 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN MULTIPLES APLICACIONES FARMACEUTICAS, ENTRE ELLAS PARA LA DISMINUCION DE LA PRESION SANGUINEA, TRATAMIENTO DE APOPLEJIA Y DE ENFERMEDADES CARDIACAS CORONARIAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833306123 DE3306123A1 (de) | 1983-02-18 | 1983-02-18 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8500209A1 true ES8500209A1 (es) | 1984-11-01 |
ES529636A0 ES529636A0 (es) | 1984-11-01 |
Family
ID=6191513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529636A Granted ES529636A0 (es) | 1983-02-18 | 1984-02-10 | Procedimiento para la preparacion de derivados de carbaciclina |
Country Status (22)
Country | Link |
---|---|
US (1) | US5013758A (es) |
EP (1) | EP0119949B1 (es) |
JP (1) | JPH0611726B2 (es) |
AT (1) | ATE38831T1 (es) |
AU (1) | AU580728B2 (es) |
CA (1) | CA1251200A (es) |
CS (1) | CS270552B2 (es) |
DD (1) | DD216448A5 (es) |
DE (2) | DE3306123A1 (es) |
DK (1) | DK155828C (es) |
ES (1) | ES529636A0 (es) |
FI (1) | FI78065C (es) |
GR (1) | GR81961B (es) |
HU (1) | HU191994B (es) |
IE (1) | IE56703B1 (es) |
IL (1) | IL70905A (es) |
NO (1) | NO157060C (es) |
NZ (1) | NZ207061A (es) |
PH (1) | PH21468A (es) |
SU (1) | SU1384196A3 (es) |
YU (1) | YU45173B (es) |
ZA (1) | ZA841198B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3608088C2 (de) * | 1986-03-07 | 1995-11-16 | Schering Ag | Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten |
DE3610556A1 (de) * | 1986-03-26 | 1987-10-01 | Schering Ag | 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung |
DE3727065A1 (de) * | 1987-08-11 | 1989-02-23 | Schering Ag | Verfahren zur herstellung von e/z-gemischen von 2-(bicyclo-(3.3.0)-octan-3-yliden) -essigsaeurederivaten mit ueberwiegendem e- oder z-anteil |
US5169960A (en) * | 1987-08-11 | 1992-12-08 | Schering Aktiengesellschaft | Process for the production of E/Z mixtures of 2-(bicyclo[3.3.0]octan-3-ylidene)-acetic acid derivatives with predominant E or Z portion |
US5371284A (en) * | 1987-09-03 | 1994-12-06 | Schering Corporation | Phenyl acetylenic acetals |
DE3835162A1 (de) * | 1988-10-13 | 1990-04-19 | Schering Ag | (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung |
DE3909329A1 (de) * | 1989-03-17 | 1990-09-20 | Schering Ag | 20-alkyl-13,14,18,18,19,19-hexadehydro-3- oxa-isocarbacyclin-derivate und ihre pharmazeutische verwendung |
DE3933523A1 (de) * | 1989-10-05 | 1991-04-11 | Schering Ag | Antimetastatisch wirkende mittel |
GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
DE4028864A1 (de) * | 1990-09-07 | 1992-03-12 | Schering Ag | Verfahren zur herstellung von e/z-mischungen von 2-(6-alkyl-bicyclo-(3.3.0)-octan-3-yliden) -essigsaeure-derivaten mit ueberwiegendem anteil des e-isomeren |
US6201015B1 (en) * | 1996-09-17 | 2001-03-13 | Toray Industries, Inc. | Therapeutic method for thrombocytopathy treatment |
RU2007106714A (ru) * | 2004-07-26 | 2008-09-10 | Байер Шеринг Фарма Аг (De) | Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц |
EP2269611B1 (en) | 2006-11-16 | 2016-03-23 | Gemmus Pharma Inc. | EP2 and EP4 agonists as agents for the treatment of influenza A viral infection |
EP2488168A1 (en) | 2009-10-14 | 2012-08-22 | Gemmus Pharma Inc. | Combination therapy treatment for viral infections |
US9492422B2 (en) | 2009-11-13 | 2016-11-15 | Toray Industries, Inc. | Therapeutic or prophylactic agent for diabetes |
AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3121155A1 (de) * | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1983
- 1983-02-18 DE DE19833306123 patent/DE3306123A1/de not_active Withdrawn
-
1984
- 1984-02-01 IE IE236/84A patent/IE56703B1/en not_active IP Right Cessation
- 1984-02-02 AU AU24015/84A patent/AU580728B2/en not_active Ceased
- 1984-02-07 NZ NZ207061A patent/NZ207061A/en unknown
- 1984-02-08 DK DK055584A patent/DK155828C/da not_active IP Right Cessation
- 1984-02-09 IL IL70905A patent/IL70905A/xx not_active IP Right Cessation
- 1984-02-09 EP EP84730009A patent/EP0119949B1/de not_active Expired
- 1984-02-09 DE DE8484730009T patent/DE3475302D1/de not_active Expired
- 1984-02-09 AT AT84730009T patent/ATE38831T1/de not_active IP Right Cessation
- 1984-02-10 ES ES529636A patent/ES529636A0/es active Granted
- 1984-02-10 SU SU843700051A patent/SU1384196A3/ru active
- 1984-02-10 YU YU244/84A patent/YU45173B/xx unknown
- 1984-02-14 JP JP59024556A patent/JPH0611726B2/ja not_active Expired - Lifetime
- 1984-02-14 CS CS841036A patent/CS270552B2/cs unknown
- 1984-02-16 DD DD84260135A patent/DD216448A5/de not_active IP Right Cessation
- 1984-02-16 FI FI840635A patent/FI78065C/fi not_active IP Right Cessation
- 1984-02-17 ZA ZA841198A patent/ZA841198B/xx unknown
- 1984-02-17 GR GR73840A patent/GR81961B/el unknown
- 1984-02-17 NO NO840595A patent/NO157060C/no unknown
- 1984-02-17 CA CA000447678A patent/CA1251200A/en not_active Expired
- 1984-02-17 HU HU84632A patent/HU191994B/hu not_active IP Right Cessation
- 1984-02-17 PH PH30264A patent/PH21468A/en unknown
-
1989
- 1989-11-13 US US07/434,561 patent/US5013758A/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040601 |