ES8702888A1 - Procedimiento para preparar derivados de n-(adamantil-1)-pirrolidon-5-carboxamida-2. - Google Patents

Procedimiento para preparar derivados de n-(adamantil-1)-pirrolidon-5-carboxamida-2.

Info

Publication number
ES8702888A1
ES8702888A1 ES548357A ES548357A ES8702888A1 ES 8702888 A1 ES8702888 A1 ES 8702888A1 ES 548357 A ES548357 A ES 548357A ES 548357 A ES548357 A ES 548357A ES 8702888 A1 ES8702888 A1 ES 8702888A1
Authority
ES
Spain
Prior art keywords
preparation
amine derivatives
medicines containing
derivatives
adamantan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548357A
Other languages
English (en)
Other versions
ES548357A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panmedica SA
Original Assignee
Panmedica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panmedica SA filed Critical Panmedica SA
Publication of ES8702888A1 publication Critical patent/ES8702888A1/es
Publication of ES548357A0 publication Critical patent/ES548357A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE N-(ADAMANTIL-1)-PIRROLIDON-5-CARBOXAMIDA-2. CONSISTE EN REACCIONAR SODIO METALICO DIVIDIDO O HIDRURO DE SODIO CON ESTER BENCILICO DEL ACIDO PIROGLUTAMICO, A TEMPERATURA ORDINARIA, Y DESPUES DE ALGUNAS HORAS, INTRODUCIR EL HALOGENURO DE ACILO O DE ALQUILO Y AGITAR ENTRE 40 Y 60JC HASTA QUE SE COMPLETA LA REACCION DETECTADA POR CROMATOGRAFIA EN CAPA DELGADA; PURIFICAR EL DERIVADO N-ALQUILICO O N-ACILICO DEL PIROGLUTAMATO DE BENCILO; CONVERTIR EL ACIDO N-ACIL P N-ALQUIL-PIROGLUTAMICO EN CLORURO DE ACIDO POR TRATAMIENTO CON UN EXCESO DE CLORURO DE TIONILO EN UN HALOALCANO DURANTE ALGUNAS HORAS Y A 50JC; TRATAR EL ACIDO SUSTITUIDO EN N CON LA CANTIDAD ESTEQUIOMETRICA DE ADAMANTAMINA EN SOLUCION EN CLOROFORMO Y EN PRESENCIA DE UN ACEPTOR DE HIDROGENO COMO PIRIDINA; Y DESPUES DE DIVERSOS LAVADOS ACUOSOS Y EVAPORACION DEL DISOLVENTE, EL DERIVADO N1-ACILICO O N-ALQUILICO DE LA N-(ADAMANTIL-1)PIROGLUTAMIDA SE PURIFICA POR TECNICAS HABITUALES. TIENE UTILIDADESFARMACOLOGICAS.
ES548357A 1984-10-31 1985-10-30 Procedimiento para preparar derivados de n-(adamantil-1)-pirrolidon-5-carboxamida-2. Expired ES8702888A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8416656A FR2572399B1 (fr) 1984-10-31 1984-10-31 Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant

Publications (2)

Publication Number Publication Date
ES8702888A1 true ES8702888A1 (es) 1987-01-16
ES548357A0 ES548357A0 (es) 1987-01-16

Family

ID=9309181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548357A Expired ES8702888A1 (es) 1984-10-31 1985-10-30 Procedimiento para preparar derivados de n-(adamantil-1)-pirrolidon-5-carboxamida-2.

Country Status (10)

Country Link
US (1) US4661512A (es)
EP (1) EP0187052B1 (es)
JP (1) JPS61109766A (es)
KR (1) KR920003837B1 (es)
AT (1) ATE49957T1 (es)
AU (1) AU583543B2 (es)
DE (1) DE3575715D1 (es)
ES (1) ES8702888A1 (es)
FR (1) FR2572399B1 (es)
ZA (1) ZA858169B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3609152A1 (de) * 1986-03-19 1987-09-24 Bayer Ag Verfahren zur herstellung des (-)-antipoden des (e)-1-cyclohexyl-4,4-dimethyl- 3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ens
US5236946A (en) * 1986-09-16 1993-08-17 Panmedica S.A. Amino acid esters of cycloaliphatic alcohols and their use in treating lipemic disorders
FR2603888B1 (fr) * 1986-09-16 1990-12-21 Panmedica Sa Esters d'amino acides du trimethyl cyclohexanol, procede de preparation et utilisation comme medicaments
DK0668290T3 (da) * 1990-02-28 1999-07-26 Teikoku Seiyaku Kk Fysiologisk aktiv substans, som er i stand til at gennemtrænge biomembranen
US5652335A (en) * 1990-02-28 1997-07-29 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
AU6391594A (en) * 1994-02-01 1995-08-21 Board Of Regents Of The University Of Nebraska, The Polymeric adamantane analogues
US5880154A (en) * 1994-02-01 1999-03-09 The Board Of Regents Of The University Of Nebraska Polymeric adamantane analogues
US5703104A (en) * 1995-07-07 1997-12-30 Durham Pharmaceuticals Llc Cyclic amides and derivatives thereof
EP0870757B1 (en) * 1997-04-10 2002-06-12 Pfizer Inc. Fluoro-substituted adamantane derivatives
CO5150173A1 (es) * 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6808716B2 (en) * 1999-01-08 2004-10-26 Ruey J. Yu N-acetylamino acids, related N-acetyl compounds and their topical use
US6159485A (en) 1999-01-08 2000-12-12 Yugenic Limited Partnership N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use
KR20050012771A (ko) * 2002-06-03 2005-02-02 노파르티스 아게 치환된 시아노피롤리딘의 용도 및 이들을 함유하는고지혈증 및 관련 질환의 치료를 위한 조합 제제
WO2005108359A1 (en) * 2004-05-06 2005-11-17 Pfizer Inc. Novel compounds of proline and morpholine derivatives
JP2007102047A (ja) * 2005-10-07 2007-04-19 Dainippon Printing Co Ltd 商品管理用タグ

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3152180A (en) * 1960-08-25 1964-10-06 Studiengesellschaft Kohle Mbh Process for the production of nu-tert-alkyl amides and, if desired, nu-tert. alkyl amines
FR2622M (fr) * 1962-12-29 1964-06-29 Mundipharma Ag Nouveaux composés thérapeutiques.
US3345399A (en) * 1965-01-21 1967-10-03 Lilly Co Eli Carbamate esters of adamantane, mono-and di-methyladamantane and homoadamantane
US3374244A (en) * 1966-06-13 1968-03-19 Searle & Co N-(dialkylaminoalkyl)adamantanecarboxamides and related compounds
FR1575518A (es) * 1966-06-15 1969-07-25
US3682922A (en) * 1969-01-16 1972-08-08 Searle & Co N-acyl-n-{8 (n{40 ,n{40 -disubstituted amino)-alkyl{9 -1-adamantylmethylamines
BE754823A (fr) * 1969-08-13 1971-01-18 Merz & Co Derives de l'amonioadamantane et leur procede de preparation
JPS5581857A (en) * 1978-12-15 1980-06-20 Kyowa Hakko Kogyo Co Ltd Modifier of citrus fruit
US4273704A (en) * 1979-12-03 1981-06-16 G. D. Searle & Co. N-Adamantane-substituted tetrapeptide amides
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
JPS5865269A (ja) * 1981-10-12 1983-04-18 Suntory Ltd ４置換（２ｓ，３ｓ，４ｓ）−２−カルボキシピロリジン−３−酢酸およびそのエステル
US4448972A (en) * 1982-02-22 1984-05-15 Smithkline Beckman Corporation Adamantyl containing intermediates
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide

Also Published As

Publication number Publication date
AU4884685A (en) 1986-05-08
FR2572399B1 (fr) 1987-01-16
US4661512A (en) 1987-04-28
AU583543B2 (en) 1989-05-04
ATE49957T1 (de) 1990-02-15
FR2572399A1 (fr) 1986-05-02
ZA858169B (en) 1986-06-25
ES548357A0 (es) 1987-01-16
EP0187052B1 (fr) 1990-01-31
JPS61109766A (ja) 1986-05-28
KR860003219A (ko) 1986-05-21
DE3575715D1 (de) 1990-03-08
KR920003837B1 (ko) 1992-05-15
EP0187052A1 (fr) 1986-07-09

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Legal Events

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FD1A Patent lapsed

Effective date: 19970519