JPH0439476B2 - - Google Patents
Info
- Publication number
- JPH0439476B2 JPH0439476B2 JP58241118A JP24111883A JPH0439476B2 JP H0439476 B2 JPH0439476 B2 JP H0439476B2 JP 58241118 A JP58241118 A JP 58241118A JP 24111883 A JP24111883 A JP 24111883A JP H0439476 B2 JPH0439476 B2 JP H0439476B2
- Authority
- JP
- Japan
- Prior art keywords
- doxorubicin
- water
- resin
- eluate
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24939A/82 | 1982-12-23 | ||
| IT24939/82A IT1155446B (it) | 1982-12-23 | 1982-12-23 | Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6296499A Division JP2749272B2 (ja) | 1982-12-23 | 1994-11-30 | アントラサイクリノングリコシドの精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59118797A JPS59118797A (ja) | 1984-07-09 |
| JPH0439476B2 true JPH0439476B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-06-29 |
Family
ID=11215200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58241118A Granted JPS59118797A (ja) | 1982-12-23 | 1983-12-22 | アントラサイクリノングリコシドの精製法 |
| JP6296499A Expired - Lifetime JP2749272B2 (ja) | 1982-12-23 | 1994-11-30 | アントラサイクリノングリコシドの精製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6296499A Expired - Lifetime JP2749272B2 (ja) | 1982-12-23 | 1994-11-30 | アントラサイクリノングリコシドの精製法 |
Country Status (30)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| DK356087A (da) * | 1987-07-09 | 1989-01-10 | Biogal Gyogyszergyar | Fremgangsmaade til isolering af et antibiotikum |
| US5188945A (en) * | 1991-09-09 | 1993-02-23 | American Cyanamid Company | Recovery process for antibiotics ll-e19020 alpha and beta |
| US5437861A (en) * | 1993-03-16 | 1995-08-01 | Applied Immune Sciences, Inc. | Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome |
| DE19521419C2 (de) * | 1995-06-14 | 1997-11-27 | Plasma Applikation Mbh Ges | Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen |
| US6388058B1 (en) | 1997-08-28 | 2002-05-14 | Mercian Corporation | Method of purifying daunomycin |
| EP1036797B1 (en) | 1997-12-05 | 2010-11-17 | Mercian Corporation | Crystalline anthracycline antibiotic and process for producing the same |
| KR100274787B1 (ko) * | 1998-05-08 | 2003-10-22 | 보령제약 주식회사 | 독소루비신및이의염산염의제조정제방법 |
| CN1188424C (zh) * | 1998-10-16 | 2005-02-09 | 美露香株式会社 | 盐酸阿霉素的结晶 |
| KR100351718B1 (ko) * | 1999-11-02 | 2002-09-11 | 보령제약 주식회사 | 4'-에피-독소루비신의 정제방법 |
| CN100412084C (zh) * | 2003-07-02 | 2008-08-20 | 獀洛克斯股份有限公司 | 热稳定的结晶盐酸表柔比星及其制造方法 |
| US20090099346A1 (en) * | 2003-07-02 | 2009-04-16 | Victor Matvienko | Thermally stable crystalline epirubicin hydrochloride |
| TW200510719A (en) * | 2003-08-06 | 2005-03-16 | Pharmacia Italia Spa | Method for detecting contaminants in pharmaceutical products |
| US7388083B2 (en) * | 2005-03-07 | 2008-06-17 | Solux Corporation | Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics |
| CN101331147B (zh) * | 2005-12-13 | 2011-11-30 | 苏洛克股份有限公司 | 用于制备4-脱甲基柔红霉素的方法 |
| US8802830B2 (en) * | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
| US8357785B2 (en) * | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| EA019341B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Фосфорамидаты нуклеозидов |
| NZ593649A (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Nucleoside analogs |
| MX2011006892A (es) | 2008-12-23 | 2011-07-20 | Pharmasset Inc | Sintesis de nucleosidos de purina. |
| EP2636676A3 (en) | 2009-09-08 | 2014-01-01 | Heraeus Precious Metals GmbH & Co. KG | Crystallization of epidaunorubicin x HCl |
| JP6058528B2 (ja) | 2010-03-31 | 2017-01-11 | ギリアド ファーマセット エルエルシー | ヌクレオシドホスホルアミデート |
| CN102120750B (zh) * | 2011-01-30 | 2013-04-03 | 山东新时代药业有限公司 | 一种盐酸表柔比星的纯化方法 |
| DE102011103751A1 (de) | 2011-05-31 | 2012-12-06 | Heraeus Precious Metals Gmbh & Co. Kg | Kristallisierung von Epirubicinhydrochlorid |
| CN103087124B (zh) * | 2012-11-21 | 2016-01-13 | 浙江海正药业股份有限公司 | 一种制备阿霉素的方法 |
| EP2778171A1 (en) | 2013-03-15 | 2014-09-17 | Synbias Pharma Ltd. | Crystalline monohydrate of epirubicin hydrochloride |
| WO2017075994A1 (zh) * | 2015-11-05 | 2017-05-11 | 浙江海正药业股份有限公司 | 一种表柔比星或其盐酸盐的分离纯化方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE639897A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | ||||
| US2827417A (en) * | 1954-09-03 | 1958-03-18 | Pfizer & Co C | Ion exchange purification of basic antibiotics |
| US2960437A (en) * | 1954-09-03 | 1960-11-15 | Pfizer & Co C | Ion exchange purification of basic antibiotics |
| US2793978A (en) * | 1955-06-27 | 1957-05-28 | Olin Mathieson | Ion exchange purification of neomycin |
| US3221008A (en) * | 1962-01-30 | 1965-11-30 | Merck & Co Inc | Ion exchange process for the recovery of ionic organic substances |
| FR1533151A (fr) * | 1962-05-18 | 1968-07-19 | Rhone Poulenc Sa | Nouvel antibiotique et sa préparation |
| FR1527892A (fr) * | 1967-03-15 | 1968-06-07 | Rhone Poulenc Sa | Nouveau procédé de préparation de l'antibiotique 13057 r.p. |
| FR1593235A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-11-18 | 1970-05-25 | ||
| JPS4944347A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-09-01 | 1974-04-26 | ||
| US3882195A (en) * | 1973-05-16 | 1975-05-06 | Air Prod & Chem | Pre-emulsification-delayed initiation suspension pearl polymerization process |
| JPS5134915B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-07-27 | 1976-09-29 | ||
| AU519670B2 (en) * | 1975-01-22 | 1981-12-17 | Farmitalia Carlo Erba S.R.L. | Optically active daunosaminyl derivatives of anthracyclin- /nes |
| NL7602342A (nl) * | 1975-03-13 | 1976-09-15 | Rhone Poulenc Ind | Naftaceenderivaat met antibiotische activiteit. |
| US4029548A (en) * | 1976-05-07 | 1977-06-14 | The Upjohn Company | Process for producing antibiotics U-50,147 and U-51,738 |
| IT1098212B (it) * | 1978-05-09 | 1985-09-07 | Farmaceutici Italia | Antracioline antitumorali sostituite |
| JPS5543012A (en) * | 1978-09-20 | 1980-03-26 | Sanraku Inc | Novel anthracycline derivatine and its preparation |
| JPS6023679B2 (ja) * | 1979-07-13 | 1985-06-08 | メルシャン株式会社 | ロドマイシン群抗生物質とその製造法 |
| JPS5750994A (en) * | 1980-09-12 | 1982-03-25 | Microbial Chem Res Found | Novel antibiotic mf266 substance and its preparation |
| JPS57159496A (en) * | 1981-03-28 | 1982-10-01 | Sanraku Inc | Preparation of adriamycin |
| IT1210476B (it) * | 1981-05-28 | 1989-09-14 | Erba Farmitalia | Antracicline. |
-
1982
- 1982-12-23 IT IT24939/82A patent/IT1155446B/it active
-
1983
- 1983-12-15 AU AU22455/83A patent/AU570935B2/en not_active Expired
- 1983-12-15 NL NL8304327A patent/NL193108C/nl not_active IP Right Cessation
- 1983-12-15 DE DE3345445A patent/DE3345445C2/de not_active Expired - Lifetime
- 1983-12-16 AT AT0440083A patent/AT383601B/de not_active IP Right Cessation
- 1983-12-16 FI FI834650A patent/FI834650L/fi not_active Application Discontinuation
- 1983-12-16 NZ NZ206605A patent/NZ206605A/en unknown
- 1983-12-16 SU SU833674607A patent/SU1440350A3/ru active
- 1983-12-16 CA CA000443557A patent/CA1204738A/en not_active Expired
- 1983-12-16 GB GB08333511A patent/GB2133005B/en not_active Expired
- 1983-12-20 FR FR8320378A patent/FR2538394B1/fr not_active Expired
- 1983-12-20 YU YU02471/83A patent/YU247183A/xx unknown
- 1983-12-20 BE BE0/212079A patent/BE898506A/fr not_active IP Right Cessation
- 1983-12-20 GR GR73292A patent/GR79135B/el unknown
- 1983-12-20 ES ES528226A patent/ES528226A0/es active Granted
- 1983-12-20 IL IL70500A patent/IL70500A/xx not_active IP Right Cessation
- 1983-12-20 CH CH6767/83A patent/CH657623A5/it not_active IP Right Cessation
- 1983-12-22 KR KR1019830006090A patent/KR900008743B1/ko not_active Expired
- 1983-12-22 SE SE8307134A patent/SE8307134L/xx not_active Application Discontinuation
- 1983-12-22 ZA ZA839564A patent/ZA839564B/xx unknown
- 1983-12-22 DK DK594083A patent/DK594083A/da not_active Application Discontinuation
- 1983-12-22 CS CS839802A patent/CS258114B2/cs unknown
- 1983-12-22 NO NO834765A patent/NO834765L/no unknown
- 1983-12-22 HU HU834427A patent/HU197917B/hu unknown
- 1983-12-22 PT PT77883A patent/PT77883B/pt unknown
- 1983-12-22 JP JP58241118A patent/JPS59118797A/ja active Granted
- 1983-12-23 IE IE3060/83A patent/IE56678B1/en not_active IP Right Cessation
-
1987
- 1987-01-14 SU SU874028799A patent/SU1450747A3/ru active
- 1987-01-14 SU SU874028798A patent/SU1447287A3/ru active
- 1987-01-20 SU SU874028823A patent/SU1450748A3/ru active
- 1987-01-20 SU SU874028832A patent/SU1470197A3/ru active
- 1987-01-23 SU SU874028858A patent/SU1575943A3/ru active
- 1987-02-02 US US07/009,550 patent/US4861870A/en not_active Expired - Lifetime
- 1987-04-14 SG SG345/87A patent/SG34587G/en unknown
- 1987-10-15 HK HK748/87A patent/HK74887A/xx not_active IP Right Cessation
-
1994
- 1994-11-30 JP JP6296499A patent/JP2749272B2/ja not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |