AU570935B2 - Purification of anthracyclinonic gylcosides by selective adsorption on resins - Google Patents

Purification of anthracyclinonic gylcosides by selective adsorption on resins

Info

Publication number
AU570935B2
AU570935B2 AU22455/83A AU2245583A AU570935B2 AU 570935 B2 AU570935 B2 AU 570935B2 AU 22455/83 A AU22455/83 A AU 22455/83A AU 2245583 A AU2245583 A AU 2245583A AU 570935 B2 AU570935 B2 AU 570935B2
Authority
AU
Australia
Prior art keywords
anthracyclinonic
gylcosides
resins
purification
selective adsorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU22455/83A
Other languages
English (en)
Other versions
AU2245583A (en
Inventor
Ernesto Oppici
Onorino Giacoma Rosa
Carlo Varesio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of AU2245583A publication Critical patent/AU2245583A/en
Application granted granted Critical
Publication of AU570935B2 publication Critical patent/AU570935B2/en
Assigned to PHARMACIA & UPJOHN S.P.A. reassignment PHARMACIA & UPJOHN S.P.A. Alteration of Name(s) in Register under S187 Assignors: FARMITALIA CARLO ERBA S.P.A.
Assigned to PHARMACIA ITALIA S.P.A. reassignment PHARMACIA ITALIA S.P.A. Alteration of Name(s) in Register under S187 Assignors: PHARMACIA & UPJOHN S.P.A.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU22455/83A 1982-12-23 1983-12-15 Purification of anthracyclinonic gylcosides by selective adsorption on resins Expired AU570935B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT24939/82 1982-12-23
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (2)

Publication Number Publication Date
AU2245583A AU2245583A (en) 1984-06-28
AU570935B2 true AU570935B2 (en) 1988-03-31

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22455/83A Expired AU570935B2 (en) 1982-12-23 1983-12-15 Purification of anthracyclinonic gylcosides by selective adsorption on resins

Country Status (30)

Country Link
US (1) US4861870A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS59118797A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR900008743B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT383601B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU570935B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE898506A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1204738A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH657623A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS258114B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3345445C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK594083A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES528226A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI834650L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2538394B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2133005B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR79135B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK74887A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU197917B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE56678B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL70500A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1155446B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL193108C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO834765L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ206605A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT77883B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE8307134L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG34587G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (6) SU1440350A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU247183A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA839564B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
US6388058B1 (en) 1997-08-28 2002-05-14 Mercian Corporation Method of purifying daunomycin
EP1036797B1 (en) 1997-12-05 2010-11-17 Mercian Corporation Crystalline anthracycline antibiotic and process for producing the same
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
CN1188424C (zh) * 1998-10-16 2005-02-09 美露香株式会社 盐酸阿霉素的结晶
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
CN101331147B (zh) * 2005-12-13 2011-11-30 苏洛克股份有限公司 用于制备4-脱甲基柔红霉素的方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
NZ593649A (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Nucleoside analogs
MX2011006892A (es) 2008-12-23 2011-07-20 Pharmasset Inc Sintesis de nucleosidos de purina.
EP2636676A3 (en) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCl
JP6058528B2 (ja) 2010-03-31 2017-01-11 ギリアド ファーマセット エルエルシー ヌクレオシドホスホルアミデート
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
WO2017075994A1 (zh) * 2015-11-05 2017-05-11 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
AU528439B2 (en) * 1978-05-09 1983-04-28 F.C. Erba S.p.A. Anthracycline glycosides
AU564016B2 (en) * 1981-05-28 1987-07-30 Farmitalia Carlo Erba S.P.A. Anthracycline clycosides

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BE639897A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1968-11-18 1970-05-25
JPS4944347A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1974-07-27 1976-09-29
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
AU528439B2 (en) * 1978-05-09 1983-04-28 F.C. Erba S.p.A. Anthracycline glycosides
AU564016B2 (en) * 1981-05-28 1987-07-30 Farmitalia Carlo Erba S.P.A. Anthracycline clycosides

Also Published As

Publication number Publication date
NL8304327A (nl) 1984-07-16
SU1447287A3 (ru) 1988-12-23
IE56678B1 (en) 1991-11-06
GR79135B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-10-02
KR900008743B1 (ko) 1990-11-29
AU2245583A (en) 1984-06-28
HUT35270A (en) 1985-06-28
NO834765L (no) 1984-06-25
GB2133005A (en) 1984-07-18
FI834650A7 (fi) 1984-06-24
FR2538394A1 (fr) 1984-06-29
US4861870A (en) 1989-08-29
KR840007438A (ko) 1984-12-07
IT1155446B (it) 1987-01-28
IL70500A0 (en) 1984-03-30
CS258114B2 (en) 1988-07-15
NL193108B (nl) 1998-07-01
IT8224939A0 (it) 1982-12-23
ES8504758A1 (es) 1985-05-01
IL70500A (en) 1990-07-12
SE8307134D0 (sv) 1983-12-22
CH657623A5 (it) 1986-09-15
ZA839564B (en) 1984-08-29
FI834650L (fi) 1984-06-24
HK74887A (en) 1987-10-23
GB2133005B (en) 1986-04-30
PT77883B (en) 1986-04-09
SU1450748A3 (ru) 1989-01-07
DK594083D0 (da) 1983-12-22
AT383601B (de) 1987-07-27
DK594083A (da) 1984-06-24
SU1575943A3 (ru) 1990-06-30
ES528226A0 (es) 1985-05-01
YU247183A (en) 1985-10-31
SG34587G (en) 1988-03-04
SU1470197A3 (ru) 1989-03-30
NZ206605A (en) 1987-02-20
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
CA1204738A (en) 1986-05-20
GB8333511D0 (en) 1984-01-25
SU1450747A3 (ru) 1989-01-07
NL193108C (nl) 1998-11-03
JPH07252291A (ja) 1995-10-03
FR2538394B1 (fr) 1986-03-28
CS980283A2 (en) 1987-12-17
HU197917B (en) 1989-06-28
DE3345445C2 (de) 1995-09-21
BE898506A (fr) 1984-04-16
DE3345445A1 (de) 1984-06-28
SU1440350A3 (ru) 1988-11-23
JP2749272B2 (ja) 1998-05-13
ATA440083A (de) 1986-12-15
IE833060L (en) 1984-06-23
JPH0439476B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-06-29
FI834650A0 (fi) 1983-12-16
SE8307134L (sv) 1984-06-24

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: PHARMACIA ITALIA S.P.A.

Free format text: FORMER OWNER WAS: PHARMACIA AND UPJOHN S.P.A.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired