JP7443057B2 - （Ｓ）－Ｎ－（５－（（Ｒ）－２－（２，５－ジフルオロフェニル）ピロリジン－１－イル）－ピラゾロ［１，５－ａ］ピリミジン－３－イル）－３－ヒドロキシピロリジン－１－カルボキサミドの調製 - Google Patents

（Ｓ）－Ｎ－（５－（（Ｒ）－２－（２，５－ジフルオロフェニル）ピロリジン－１－イル）－ピラゾロ［１，５－ａ］ピリミジン－３－イル）－３－ヒドロキシピロリジン－１－カルボキサミドの調製 Download PDF

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Publication number
JP7443057B2
JP7443057B2 JP2019512951A JP2019512951A JP7443057B2 JP 7443057 B2 JP7443057 B2 JP 7443057B2 JP 2019512951 A JP2019512951 A JP 2019512951A JP 2019512951 A JP2019512951 A JP 2019512951A JP 7443057 B2 JP7443057 B2 JP 7443057B2
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formula
compound
salt
mixture
nitro
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JP2019516795A (ja
JP2019516795A5 (OSRAM
Inventor
マーク レイノルズ
チャールズ トッド アーリー
ステイシー スペンサー
デリク ジュエングスト
ブルーノ アッシュ
ユートン チアン
ジュリア ハース
スティーヴン ダブリュ． アンドリュース
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Loxo Oncology Inc
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Loxo Oncology Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2019512951A 2016-05-18 2017-05-18 （Ｓ）－Ｎ－（５－（（Ｒ）－２－（２，５－ジフルオロフェニル）ピロリジン－１－イル）－ピラゾロ［１，５－ａ］ピリミジン－３－イル）－３－ヒドロキシピロリジン－１－カルボキサミドの調製 Active JP7443057B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662338359P 2016-05-18 2016-05-18
US62/338,359 2016-05-18
PCT/US2017/033257 WO2017201241A1 (en) 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

Publications (3)

Publication Number Publication Date
JP2019516795A JP2019516795A (ja) 2019-06-20
JP2019516795A5 JP2019516795A5 (OSRAM) 2020-07-02
JP7443057B2 true JP7443057B2 (ja) 2024-03-05

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ID=58794189

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JP2019512951A Active JP7443057B2 (ja) 2016-05-18 2017-05-18 （Ｓ）－Ｎ－（５－（（Ｒ）－２－（２，５－ジフルオロフェニル）ピロリジン－１－イル）－ピラゾロ［１，５－ａ］ピリミジン－３－イル）－３－ヒドロキシピロリジン－１－カルボキサミドの調製

Country Status (27)

Country Link
US (1) US11214571B2 (OSRAM)
EP (2) EP3458456B1 (OSRAM)
JP (1) JP7443057B2 (OSRAM)
KR (1) KR102566858B1 (OSRAM)
CN (1) CN110049987B (OSRAM)
AU (1) AU2017268371B2 (OSRAM)
CA (1) CA3024603A1 (OSRAM)
CL (1) CL2018003264A1 (OSRAM)
CO (1) CO2018013015A2 (OSRAM)
DK (2) DK3800189T3 (OSRAM)
ES (2) ES2836222T3 (OSRAM)
FI (1) FI3800189T3 (OSRAM)
HR (2) HRP20201984T1 (OSRAM)
HU (2) HUE063877T2 (OSRAM)
IL (1) IL262964B (OSRAM)
LT (2) LT3800189T (OSRAM)
MX (1) MX392604B (OSRAM)
PE (1) PE20190437A1 (OSRAM)
PL (2) PL3458456T3 (OSRAM)
PT (2) PT3458456T (OSRAM)
RS (2) RS61463B1 (OSRAM)
RU (1) RU2745953C2 (OSRAM)
SG (1) SG11201810245WA (OSRAM)
SI (2) SI3800189T1 (OSRAM)
UA (1) UA127826C2 (OSRAM)
WO (1) WO2017201241A1 (OSRAM)
ZA (1) ZA201808534B (OSRAM)

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CN109232582B (zh) * 2018-11-28 2021-02-05 安礼特（上海）医药科技有限公司 拉洛替尼硫酸氢盐晶型及其制备和应用
CN112457231A (zh) * 2019-09-09 2021-03-09 上海医药工业研究院 一种拉罗替尼（Larotrectinib）中间体的消旋化方法
CN110804059B (zh) * 2019-09-30 2024-03-12 郑州泰基鸿诺医药股份有限公司 氨基甲酸酯类化合物、药物组合物及其应用
CN111138437B (zh) * 2019-12-04 2021-03-05 杭州华东医药集团新药研究院有限公司 取代的吡唑并[1,5-a]嘧啶氨基酸衍生物及其用途
CN112624950A (zh) * 2020-12-10 2021-04-09 北京蓝博特科技有限公司 一种(r)-2-(2,5-二氟苯基)吡咯烷的合成方法
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CN113444070A (zh) * 2021-07-28 2021-09-28 深圳市真味生物科技有限公司 一种由手性叔丁基亚磺酰胺合成手性尼古丁的制备方法
CN115872905B (zh) * 2021-09-29 2024-08-09 凯特立斯（深圳）科技有限公司 一种拉罗替尼中间体的制备方法
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