HUP0103466A2 - Foszfo-diészteráz-4 gátló hatású helyettesített 1,8-naftiridin-4(1H)-on származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Foszfo-diészteráz-4 gátló hatású helyettesített 1,8-naftiridin-4(1H)-on származékok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0103466A2 HUP0103466A2 HU0103466A HUP0103466A HUP0103466A2 HU P0103466 A2 HUP0103466 A2 HU P0103466A2 HU 0103466 A HU0103466 A HU 0103466A HU P0103466 A HUP0103466 A HU P0103466A HU P0103466 A2 HUP0103466 A2 HU P0103466A2
- Authority
- HU
- Hungary
- Prior art keywords
- naphthyridin
- phosphodiesterase
- ones
- substituted
- pharmaceutical compositions
- Prior art date
Links
- NQUIRWXTTAMWIU-UHFFFAOYSA-N 1h-1,8-naphthyridin-4-one Chemical class C1=CC=C2C(O)=CC=NC2=N1 NQUIRWXTTAMWIU-UHFFFAOYSA-N 0.000 title 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9617698P | 1998-08-11 | 1998-08-11 | |
| PCT/IB1999/001390 WO2000009504A1 (en) | 1998-08-11 | 1999-08-05 | Substituted 1,8-naphthyridin-4(1h)-ones as phosphodiesterase 4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0103466A2 true HUP0103466A2 (hu) | 2002-02-28 |
| HUP0103466A3 HUP0103466A3 (en) | 2002-11-28 |
Family
ID=22256080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103466A HUP0103466A3 (en) | 1998-08-11 | 1999-08-05 | Substituted 1,8-naphthyridin-4(1h)-ones having phosphodiesterase 4 inhibiting activity and pharmaceutical compositions thereof |
Country Status (44)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815951B2 (en) | 1996-08-13 | 2014-08-26 | The Regents Of The University Of California | Inhibitors of epoxide hydrolases for the treatment of inflammation |
| EP1343528A2 (en) * | 2000-11-02 | 2003-09-17 | Research Foundation of City University of New York | Methods for stimulating nervous system regeneration and repair by inhibition phosphodiesterase type 4 |
| WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| JO2311B1 (en) * | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| US7323460B2 (en) | 2002-03-15 | 2008-01-29 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors |
| KR100454750B1 (ko) * | 2002-06-20 | 2004-11-03 | 삼성에스디아이 주식회사 | 유기 전계 발광 소자용 청색 발광 화합물 및 이를 사용한유기 전계 발광 소자 |
| US20060079540A1 (en) * | 2002-11-27 | 2006-04-13 | Altana Pharma Ag | Pde4 and pde3/4 inhibitors for use in the treatment of cachexia |
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE10349497A1 (de) * | 2003-10-23 | 2005-05-25 | Bayer Cropscience Ag | N-substituierte Pyrazolylcarboxanilide |
| JP2007517828A (ja) * | 2004-01-17 | 2007-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 気道の疾患を治療するための置換プテリジンの使用 |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| EP1915155A1 (en) * | 2005-08-03 | 2008-04-30 | Boehringer Ingelheim International GmbH | Dihydropteridinones in the treatment of respiratory diseases |
| US7439358B2 (en) * | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| WO2009019205A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Crystalline form of a dihydropteridione derivative |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| ES2773272T3 (es) * | 2012-08-08 | 2020-07-10 | Merck Patent Gmbh | Derivados de (aza-)isoquinolinona |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| WO2015011236A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU165405B (hu) * | 1972-06-29 | 1974-08-28 | ||
| US3856800A (en) * | 1973-02-26 | 1974-12-24 | Sterling Drug Inc | Process of preparing 1,4-dihydro-4-oxo-7-q-3-unsubstituted-1,8-naphthyridines from cyclic alkylidenyl n-(6-q-2-pyridyl) aminomethylenemalonates |
| US3882132A (en) * | 1973-03-08 | 1975-05-06 | Sterling Drug Inc | Preparation of 1-alkyl-1,4-dihydro-7-substituted-4-oxo-1,8-naphthyridine-3-carboxylic acids via the 3-aminomethyl analogs |
| US5817670A (en) * | 1994-08-29 | 1998-10-06 | Yamanouchi Pharmaceutical Co., Ltd. | Naphthyridine derivatives and pharmaceutical compositions thereof |
| JP4323574B2 (ja) * | 1995-12-13 | 2009-09-02 | 大日本住友製薬株式会社 | 抗腫瘍剤 |
-
1999
- 1999-08-05 CA CA002340180A patent/CA2340180A1/en not_active Abandoned
- 1999-08-05 GE GEAP19995743A patent/GEP20033029B/en unknown
- 1999-08-05 CZ CZ2001485A patent/CZ2001485A3/cs unknown
- 1999-08-05 EA EA200100124A patent/EA200100124A1/ru unknown
- 1999-08-05 JP JP2000564956A patent/JP2002522541A/ja active Pending
- 1999-08-05 CN CN99809505A patent/CN1312810A/zh active Pending
- 1999-08-05 ID IDW20010315A patent/ID27843A/id unknown
- 1999-08-05 WO PCT/IB1999/001390 patent/WO2000009504A1/en not_active Application Discontinuation
- 1999-08-05 SK SK182-2001A patent/SK1822001A3/sk unknown
- 1999-08-05 EE EEP200100085A patent/EE200100085A/xx unknown
- 1999-08-05 PL PL99346005A patent/PL346005A1/xx not_active Application Discontinuation
- 1999-08-05 AT AT99933078T patent/ATE229955T1/de not_active IP Right Cessation
- 1999-08-05 KR KR1020017001718A patent/KR20010072368A/ko not_active Application Discontinuation
- 1999-08-05 EP EP99933078A patent/EP1104420B1/en not_active Expired - Lifetime
- 1999-08-05 OA OA1200100032A patent/OA11591A/en unknown
- 1999-08-05 ES ES99933078T patent/ES2188194T3/es not_active Expired - Lifetime
- 1999-08-05 DE DE69904602T patent/DE69904602T2/de not_active Expired - Fee Related
- 1999-08-05 AU AU49249/99A patent/AU4924999A/en not_active Abandoned
- 1999-08-05 HU HU0103466A patent/HUP0103466A3/hu unknown
- 1999-08-05 DK DK99933078T patent/DK1104420T3/da active
- 1999-08-05 NZ NZ509297A patent/NZ509297A/en not_active Application Discontinuation
- 1999-08-05 AP APAP/P/2001/002068A patent/AP2001002068A0/en unknown
- 1999-08-05 BR BR9912902-7A patent/BR9912902A/pt not_active Application Discontinuation
- 1999-08-05 IL IL14086899A patent/IL140868A0/xx unknown
- 1999-08-05 PT PT99933078T patent/PT1104420E/pt unknown
- 1999-08-05 TR TR2001/00433T patent/TR200100433T2/xx unknown
- 1999-08-06 TW TW088113482A patent/TW542835B/zh active
- 1999-08-09 PE PE1999000802A patent/PE20000950A1/es not_active Application Discontinuation
- 1999-08-09 GT GT199900128A patent/GT199900128A/es unknown
- 1999-08-09 HN HN1999000130A patent/HN1999000130A/es unknown
- 1999-08-10 SV SV1999000120A patent/SV1999000120A/es not_active Application Discontinuation
- 1999-08-10 MA MA25723A patent/MA26669A1/fr unknown
- 1999-08-10 AR ARP990103992A patent/AR015557A1/es not_active Application Discontinuation
- 1999-08-10 PA PA19998480001A patent/PA8480001A1/es unknown
- 1999-08-10 TN TNTNSN99155A patent/TNSN99155A1/fr unknown
- 1999-08-10 DZ DZ990166A patent/DZ2866A1/xx active
- 1999-08-11 CO CO99051075A patent/CO5130004A1/es unknown
- 1999-08-11 US US09/372,735 patent/US6174895B1/en not_active Expired - Fee Related
-
2001
- 2001-01-16 IS IS5815A patent/IS5815A/is unknown
- 2001-02-07 ZA ZA200101040A patent/ZA200101040B/en unknown
- 2001-02-09 NO NO20010684A patent/NO20010684L/no not_active Application Discontinuation
- 2001-02-09 HR HR20010107A patent/HRP20010107A2/hr not_active Application Discontinuation
- 2001-03-09 BG BG105321A patent/BG105321A/xx unknown
-
2002
- 2002-01-18 HK HK02100400.2A patent/HK1038917A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0103466A3 (en) | Substituted 1,8-naphthyridin-4(1h)-ones having phosphodiesterase 4 inhibiting activity and pharmaceutical compositions thereof | |
| HUP0101204A3 (en) | Hiv inhibiting pyrimidine derivatives and pharmaceutical compositions containing them | |
| HUP0101155A3 (en) | Imidazonaphthyridines, pharmaceutical compositions thereof and intermediates | |
| HUP9801900A3 (en) | 2-methoxybenzophenone derivatives, intermediates, preparation thereof and fungicide compositions containing them | |
| HUP0103575A2 (hu) | Kaszpáz inhibitorok peptidek, azokat hatóanyagként tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| AU9297898A (en) | Thioalkyl compounds, methods, and compositions for inhibiting parp activity | |
| IL141445A0 (en) | Benzazine derivatives as phosphodiesterase 4 inhibitors | |
| ZA988010B (en) | Thioalkyl compounds methods and compositions for inhibiting parp activity | |
| HUP0103921A3 (en) | [1,2,4]triazolo[1,5-c]pyrimidine derivatives and pharmaceutical compositions thereof | |
| AU9298198A (en) | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity | |
| HUP0203300A3 (en) | 2,4-diaminopyrimidine compounds useful as immunosuppressants, pharmaceutical compositions containing them and their use | |
| EP1131314A4 (en) | CONNECTIONS WITH CYTOKIN INHIBITOR ACTIVITY | |
| PL338004A1 (en) | Derivatives of azetidinylpropylpiperidine, intermediate compounds and application of such derivatives as antagonists of tachykinins | |
| ZA988018B (en) | Carboxamide compounds, methods, and compositions for inhibiting parp activity. | |
| HUP0102646A3 (en) | Phthalazine derivatives phosphodiesterase 4 inhibitors and pharmaceutical compositions containing the same | |
| HUP0201942A3 (en) | Processes and intermediates for the preparation of 1,3-oxazin-6-ones and uracils | |
| HUP0100832A3 (en) | Quinoxaline and quinoline carboxamide derivatives, their use and the pharmaceutical compositions containing them | |
| HUP9900563A3 (en) | Chinoline-2-(1h)-ones, their production, pharmaceutical compositions and use | |
| HUP0202692A3 (en) | Interleukin-5 inhibiting 6-azauracil derivatives, pharmaceutical compositions containing them and intermediates | |
| IL141446A0 (en) | Benzazine derivatives as phosphodiesterase 4 inhibitors | |
| ZA991232B (en) | New compound and pharmaceutical compositions thereof. | |
| HUP0104146A3 (en) | Pyrano, piperidino, and thiapyrano compounds, pharmaceutical compositions thereof and their intermediates | |
| HUP0001935A3 (en) | Fungicidal compositions containing quinazolinone derivative and use thereof | |
| HUP0004671A3 (en) | 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1h)-one derivatives and pharmaceutical compositions thereof | |
| IL137019A (en) | 2,7 - dimethyl - 4 - (substituted amino) - 8 - arylpyrazolo [1,5-a] triazine derivatives and pharmaceutical compositions containing them |