EA200100124A1 - Замещенные 1,8-нафтиридин-4(1h)-оны в качестве ингибиторов фосфодиэстеразы 4 - Google Patents

Замещенные 1,8-нафтиридин-4(1h)-оны в качестве ингибиторов фосфодиэстеразы 4

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Publication number
EA200100124A1
EA200100124A1 EA200100124A EA200100124A EA200100124A1 EA 200100124 A1 EA200100124 A1 EA 200100124A1 EA 200100124 A EA200100124 A EA 200100124A EA 200100124 A EA200100124 A EA 200100124A EA 200100124 A1 EA200100124 A1 EA 200100124A1
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EA
Eurasian Patent Office
Prior art keywords
disorders
disease
inflammatory diseases
allergic
ohonid
Prior art date
Application number
EA200100124A
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English (en)
Inventor
Эдуард Фокс Клейнман
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200100124A1 publication Critical patent/EA200100124A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединение формулы (I) или его фармацевтически приемлемая соль, где R, Rи Rявляются такими, как определено в описании изобретения, пригодное для лечения респираторных, аллергических, ревматоидных заболеваний, расстройств регуляции массы тела, воспалительных заболеваний и расстройств центральной нервной системы, таких как астма, хроническое обструктивное заболевание легких, синдром респираторных заболеваний взрослых, токсический шок, фиброз, легочная гиперчувствительность, аллергический ринит, атопический дерматит, псориаз, расстройство регуляции массы, ревматоидный артрит, кахексия, болезнь Крона, неспецифический язвенный колит, артритические состояния и другие воспалительные заболевания, депрессия, мультиинфарктная деменция и СПИД.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100124A 1998-08-11 1999-08-05 Замещенные 1,8-нафтиридин-4(1h)-оны в качестве ингибиторов фосфодиэстеразы 4 EA200100124A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9617698P 1998-08-11 1998-08-11
PCT/IB1999/001390 WO2000009504A1 (en) 1998-08-11 1999-08-05 Substituted 1,8-naphthyridin-4(1h)-ones as phosphodiesterase 4 inhibitors

Publications (1)

Publication Number Publication Date
EA200100124A1 true EA200100124A1 (ru) 2001-10-22

Family

ID=22256080

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100124A EA200100124A1 (ru) 1998-08-11 1999-08-05 Замещенные 1,8-нафтиридин-4(1h)-оны в качестве ингибиторов фосфодиэстеразы 4

Country Status (44)

Country Link
US (1) US6174895B1 (ru)
EP (1) EP1104420B1 (ru)
JP (1) JP2002522541A (ru)
KR (1) KR20010072368A (ru)
CN (1) CN1312810A (ru)
AP (1) AP2001002068A0 (ru)
AR (1) AR015557A1 (ru)
AT (1) ATE229955T1 (ru)
AU (1) AU4924999A (ru)
BG (1) BG105321A (ru)
BR (1) BR9912902A (ru)
CA (1) CA2340180A1 (ru)
CO (1) CO5130004A1 (ru)
CZ (1) CZ2001485A3 (ru)
DE (1) DE69904602T2 (ru)
DK (1) DK1104420T3 (ru)
DZ (1) DZ2866A1 (ru)
EA (1) EA200100124A1 (ru)
EE (1) EE200100085A (ru)
ES (1) ES2188194T3 (ru)
GE (1) GEP20033029B (ru)
GT (1) GT199900128A (ru)
HK (1) HK1038917A1 (ru)
HN (1) HN1999000130A (ru)
HR (1) HRP20010107A2 (ru)
HU (1) HUP0103466A3 (ru)
ID (1) ID27843A (ru)
IL (1) IL140868A0 (ru)
IS (1) IS5815A (ru)
MA (1) MA26669A1 (ru)
NO (1) NO20010684L (ru)
NZ (1) NZ509297A (ru)
OA (1) OA11591A (ru)
PA (1) PA8480001A1 (ru)
PE (1) PE20000950A1 (ru)
PL (1) PL346005A1 (ru)
PT (1) PT1104420E (ru)
SK (1) SK1822001A3 (ru)
SV (1) SV1999000120A (ru)
TN (1) TNSN99155A1 (ru)
TR (1) TR200100433T2 (ru)
TW (1) TW542835B (ru)
WO (1) WO2000009504A1 (ru)
ZA (1) ZA200101040B (ru)

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RU2654216C2 (ru) * 2012-08-08 2018-05-17 Мерк Патент Гмбх Производные (аза-)изохинолинона

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US8815951B2 (en) 1996-08-13 2014-08-26 The Regents Of The University Of California Inhibitors of epoxide hydrolases for the treatment of inflammation
EP1343528A2 (en) * 2000-11-02 2003-09-17 Research Foundation of City University of New York Methods for stimulating nervous system regeneration and repair by inhibition phosphodiesterase type 4
WO2002088079A2 (en) * 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
JO2311B1 (en) * 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
US7323460B2 (en) 2002-03-15 2008-01-29 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
KR100454750B1 (ko) * 2002-06-20 2004-11-03 삼성에스디아이 주식회사 유기 전계 발광 소자용 청색 발광 화합물 및 이를 사용한유기 전계 발광 소자
US20060079540A1 (en) * 2002-11-27 2006-04-13 Altana Pharma Ag Pde4 and pde3/4 inhibitors for use in the treatment of cachexia
US6861422B2 (en) * 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE10349497A1 (de) * 2003-10-23 2005-05-25 Bayer Cropscience Ag N-substituierte Pyrazolylcarboxanilide
JP2007517828A (ja) * 2004-01-17 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 気道の疾患を治療するための置換プテリジンの使用
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
DE102004029784A1 (de) * 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) * 2004-07-09 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US20060058311A1 (en) * 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
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EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
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WO2009019205A1 (en) * 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Crystalline form of a dihydropteridione derivative
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US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
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Publication number Priority date Publication date Assignee Title
RU2654216C2 (ru) * 2012-08-08 2018-05-17 Мерк Патент Гмбх Производные (аза-)изохинолинона

Also Published As

Publication number Publication date
ID27843A (id) 2001-04-26
NZ509297A (en) 2003-11-28
GEP20033029B (en) 2003-07-25
PL346005A1 (en) 2002-01-14
IL140868A0 (en) 2002-02-10
HN1999000130A (es) 2000-11-22
CA2340180A1 (en) 2000-02-24
ES2188194T3 (es) 2003-06-16
PT1104420E (pt) 2003-03-31
OA11591A (en) 2004-07-30
BR9912902A (pt) 2001-05-08
CZ2001485A3 (cs) 2002-05-15
PE20000950A1 (es) 2000-09-27
MA26669A1 (fr) 2004-12-20
TW542835B (en) 2003-07-21
IS5815A (is) 2001-01-16
ATE229955T1 (de) 2003-01-15
DE69904602D1 (en) 2003-01-30
HK1038917A1 (zh) 2002-04-04
HUP0103466A3 (en) 2002-11-28
AU4924999A (en) 2000-03-06
PA8480001A1 (es) 2000-09-29
DE69904602T2 (de) 2003-04-30
DK1104420T3 (da) 2003-01-13
CO5130004A1 (es) 2002-02-27
EP1104420B1 (en) 2002-12-18
HRP20010107A2 (en) 2002-02-28
EE200100085A (et) 2002-08-15
TR200100433T2 (tr) 2001-07-23
HUP0103466A2 (hu) 2002-02-28
DZ2866A1 (fr) 2003-12-01
JP2002522541A (ja) 2002-07-23
BG105321A (en) 2001-12-29
SK1822001A3 (en) 2002-08-06
GT199900128A (es) 2001-01-30
EP1104420A1 (en) 2001-06-06
NO20010684D0 (no) 2001-02-09
WO2000009504A1 (en) 2000-02-24
ZA200101040B (en) 2003-01-07
CN1312810A (zh) 2001-09-12
NO20010684L (no) 2001-04-09
AP2001002068A0 (en) 2001-03-31
AR015557A1 (es) 2001-05-02
KR20010072368A (ko) 2001-07-31
TNSN99155A1 (fr) 2005-11-10
SV1999000120A (es) 2000-09-05
US6174895B1 (en) 2001-01-16

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