NZ234143A
(en)
|
1989-06-28 |
1991-10-25 |
Mcneil Ppc Inc |
Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
|
DK0923933T3
(da)
|
1993-11-30 |
2002-10-21 |
Searle & Co |
Substituerede pyrazolyl-benzensulfonamider til anvendelse ved behandling af inflammation
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
US5844092A
(en)
|
1994-03-18 |
1998-12-01 |
Genentech, Inc. |
Human TRK receptors and neurotrophic factor inhibitors
|
US5430021A
(en)
|
1994-03-18 |
1995-07-04 |
Pharmavene, Inc. |
Hydrophobic drug delivery systems
|
CA2206201A1
(en)
|
1996-05-29 |
1997-11-29 |
Yoshiaki Isobe |
Pyrazole derivatives and their pharmaceutical use
|
JP3898296B2
(ja)
|
1996-08-28 |
2007-03-28 |
ポーラ化成工業株式会社 |
ピロロピラゾロピリミジン化合物及びこれを有効成分とする医薬
|
AU7079998A
(en)
|
1997-04-25 |
1998-11-24 |
Takeda Chemical Industries Ltd. |
Condensed pyridazine derivatives, their production and use
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
US6534085B1
(en)
|
1999-09-23 |
2003-03-18 |
Bioresponse L.L.C. |
Phytochemicals for promoting weight loss
|
KR100823764B1
(ko)
|
2000-06-22 |
2008-04-21 |
제넨테크, 인크. |
아고니스트 안티-티알케이-씨 모노클로날 항체
|
TWI312347B
(en)
|
2001-02-08 |
2009-07-21 |
Eisai R&D Man Co Ltd |
Bicyclic nitrogen-containing condensed ring compounds
|
DK1401498T3
(da)
|
2001-05-30 |
2011-11-21 |
Genentech Inc |
Anti-NGF-antistoffer til behandlingen af forskellige sygdomme
|
US7101572B2
(en)
|
2001-12-07 |
2006-09-05 |
Unilab Pharmatech, Ltd. |
Taste masked aqueous liquid pharmaceutical composition
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
MXPA04010441A
(es)
|
2002-04-23 |
2005-02-14 |
Shionogi & Co |
Derivado de pirazolo[1,5-a]pirimidina e inhibidor de nad(p)h oxidasa que contiene el mismo.
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
ITMI20021620A1
(it)
|
2002-07-23 |
2004-01-23 |
Novuspharma Spa |
Composto ad ativita' antitumorale
|
JP4024624B2
(ja)
|
2002-08-26 |
2007-12-19 |
富士通株式会社 |
半導体装置の製造方法及び製造装置
|
US7196078B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corpoartion |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
WO2004022561A1
(en)
|
2002-09-04 |
2004-03-18 |
Schering Corporation |
Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US8580782B2
(en)
|
2002-09-04 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
US7550470B2
(en)
|
2002-12-11 |
2009-06-23 |
Merck & Co. Inc. |
Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors
|
WO2004052286A2
(en)
|
2002-12-11 |
2004-06-24 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
GB0303910D0
(en)
|
2003-02-20 |
2003-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
US20070037150A1
(en)
|
2003-02-21 |
2007-02-15 |
The Johns Hopkins University |
Tyrosine kinome
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ[1,5−a]ピリミジン誘導体
|
EP1608652A1
(en)
|
2003-03-31 |
2005-12-28 |
Vernalis (Cambridge) Limited |
Pyrazolopyrimidine compounds and their use in medicine
|
US20060094699A1
(en)
|
2003-04-11 |
2006-05-04 |
Kampen Gita Camilla T |
Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy
|
WO2004089471A2
(en)
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF
|
EP1615667A2
(en)
|
2003-04-11 |
2006-01-18 |
Novo Nordisk A/S |
Combinations of an 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist
|
CN1795206A
(zh)
|
2003-04-28 |
2006-06-28 |
株式会社嘉尔药物 |
半乳糖凝集素-9诱导因子
|
PA8603801A1
(es)
|
2003-05-27 |
2004-12-16 |
Janssen Pharmaceutica Nv |
Derivados de la quinazolina
|
JP2005008581A
(ja)
|
2003-06-20 |
2005-01-13 |
Kissei Pharmaceut Co Ltd |
新規なピラゾロ[1,5−a]ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
|
EA009517B1
(ru)
|
2003-06-27 |
2008-02-28 |
Байер Кропсайенс Аг |
Пиразолопиримидины
|
MEP31508A
(en)
|
2003-07-15 |
2010-10-10 |
Amgen Inc |
Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
|
US7491794B2
(en)
|
2003-10-14 |
2009-02-17 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
CA2543116A1
(en)
|
2003-10-27 |
2005-05-19 |
Genelabs Technologies, Inc. |
Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
CA2546673A1
(en)
|
2003-11-28 |
2005-06-09 |
Novartis Ag |
Diaryl urea derivatives in the treatment of protein kinase dependent diseases
|
UA83881C2
(en)
|
2003-12-18 |
2008-08-26 |
Янссен Фармацевтика Н.В. |
Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
|
PT1696920E
(pt)
|
2003-12-19 |
2015-01-14 |
Plexxikon Inc |
Compostos e métodos para o desenvolvimento de moduladores de ret
|
WO2005068424A1
(en)
|
2004-01-20 |
2005-07-28 |
Cell Therapeutics Europe S.R.L. |
Indolinone derivatives as receptor tyrosine kinase ihibitors
|
US20050222171A1
(en)
|
2004-01-22 |
2005-10-06 |
Guido Bold |
Organic compounds
|
WO2005099363A2
(en)
|
2004-03-26 |
2005-10-27 |
Whitehead Institute For Biomedical Research |
Methods of diagnosing, preventing and treating cancer metastasis
|
UA91677C2
(ru)
|
2004-03-30 |
2010-08-25 |
Интермюн, Инк. |
Макроциклические соединения как ингибиторы вирусной репликации
|
PE20060664A1
(es)
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
EP1812440B1
(en)
|
2004-11-04 |
2010-09-22 |
Vertex Pharmaceuticals, Inc. |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
|
JO3088B1
(ar)
|
2004-12-08 |
2017-03-15 |
Janssen Pharmaceutica Nv |
مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
|
DE102005003687A1
(de)
|
2005-01-26 |
2006-07-27 |
Sphingo Tec Gmbh |
Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
|
CN101119996A
(zh)
|
2005-02-16 |
2008-02-06 |
阿斯利康(瑞典)有限公司 |
化学化合物
|
CA2598076A1
(en)
|
2005-02-16 |
2006-08-24 |
Astrazeneca Ab |
Chemical compounds
|
DK1869049T3
(da)
|
2005-03-21 |
2009-05-18 |
Lilly Co Eli |
Imidazopyridazinforbindelser
|
JP2008540335A
(ja)
|
2005-04-27 |
2008-11-20 |
アストラゼネカ・アクチエボラーグ |
ピラゾリル・ピリミジン誘導体の疼痛治療における使用
|
US20080287437A1
(en)
|
2005-05-16 |
2008-11-20 |
Astrazeneca Ab |
Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
|
CN100406650C
(zh)
|
2005-06-05 |
2008-07-30 |
徐斌 |
一种抗特大变位的模块式梳型桥梁伸缩缝装置
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
US20070025540A1
(en)
|
2005-07-07 |
2007-02-01 |
Roger Travis |
Call center routing based on talkativeness
|
EP2305697A3
(en)
|
2005-07-25 |
2011-07-27 |
Intermune, Inc. |
Macrocyclic inhibitors of Hepatitis C virus replication
|
JP2009502734A
(ja)
|
2005-07-29 |
2009-01-29 |
アステラス製薬株式会社 |
Lck阻害剤としての縮合複素環
|
JP2009503071A
(ja)
|
2005-08-03 |
2009-01-29 |
イーストマン ケミカル カンパニー |
トコフェリルポリエチレングリコールスクシネート粉末及びその製造方法
|
WO2007024680A1
(en)
|
2005-08-22 |
2007-03-01 |
Amgen Inc. |
Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
|
SI1919979T2
(sl)
|
2005-08-25 |
2017-07-31 |
Creabilis Therapeutics S.P.A. |
Polimerni konjugati K-252A in njihovi derivati
|
WO2007025090A2
(en)
|
2005-08-25 |
2007-03-01 |
Kalypsys, Inc. |
Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
|
DE102005042742A1
(de)
|
2005-09-02 |
2007-03-08 |
Schering Ag |
Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
US20070078136A1
(en)
|
2005-09-22 |
2007-04-05 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
AR057979A1
(es)
|
2005-10-06 |
2008-01-09 |
Schering Corp |
PIRAZOLPIRIMIDINAS COMO INHIBIDORAS DE PROTEíNA QUINASA. COMPOSICIONES FARMACEUTICAS.
|
US20070082900A1
(en)
|
2005-10-06 |
2007-04-12 |
Schering Corporation |
Methods for inhibiting protein kinases
|
JP5030961B2
(ja)
|
2005-10-11 |
2012-09-19 |
サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク |
細胞のアポトーシスの検出および定量化用の化合物およびキット
|
DE602006019323D1
(de)
|
2005-10-11 |
2011-02-10 |
Intermune Inc |
Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus
|
WO2007048065A2
(en)
|
2005-10-21 |
2007-04-26 |
Exelixis, Inc. |
Pyrimidinones as casein kinase ii (ck2) modulators
|
WO2007057399A2
(en)
|
2005-11-15 |
2007-05-24 |
Boehringer Ingelheim International Gmbh |
Treatment of cancer with indole derivatives
|
GB0524436D0
(en)
|
2005-11-30 |
2006-01-11 |
Novartis Ag |
Organic compounds
|
US8399442B2
(en)
|
2005-12-30 |
2013-03-19 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
WO2007084815A2
(en)
|
2006-01-19 |
2007-07-26 |
Janssen Pharmaceutica, N.V. |
Substituted thienopyrimidine kinase inhibitors
|
US20090227598A1
(en)
|
2006-01-24 |
2009-09-10 |
Buser-Doepner Carolyn A |
Ret Tyrosine Kinase Inhibition
|
KR100846988B1
(ko)
|
2006-03-06 |
2008-07-16 |
제일약품주식회사 |
신규한 티에노피리미딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 함유하는 약학조성물
|
AU2007224020A1
(en)
|
2006-03-07 |
2007-09-13 |
Array Biopharma Inc. |
Heterobicyclic pyrazole compounds and methods of use
|
GB0606805D0
(en)
|
2006-04-04 |
2006-05-17 |
Novartis Ag |
Organic compounds
|
AU2007246793B2
(en)
|
2006-04-26 |
2013-02-07 |
F. Hoffmann-La Roche Ag |
Thieno [3, 2-D] pyrimidine derivative useful as PI3K inhibitor
|
JP5190361B2
(ja)
|
2006-05-18 |
2013-04-24 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
甲状腺癌に対する抗腫瘍剤
|
EP1873157A1
(en)
|
2006-06-21 |
2008-01-02 |
Bayer Schering Pharma Aktiengesellschaft |
Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
TWI419889B
(zh)
|
2006-07-05 |
2013-12-21 |
Mitsubishi Tanabe Pharma Corp |
吡唑并〔1,5-a〕嘧啶化合物
|
EP2058309A4
(en)
|
2006-08-04 |
2010-12-22 |
Takeda Pharmaceutical |
CONDENSED HETEROCYCLIC COMPOUND
|
US7531539B2
(en)
|
2006-08-09 |
2009-05-12 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
US20110021513A1
(en)
|
2006-09-07 |
2011-01-27 |
Biogen Idec Ma Inc. |
Modulators of interleukin-1 receptor-associated kinase
|
WO2008031551A2
(en)
|
2006-09-12 |
2008-03-20 |
Novartis Forschungsstiftung, Zweigniederlassung |
Non-neuroendocrine cancer therapy
|
CA2664378A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as pi3k lipid kinase inhibitors
|
CA2667962A1
(en)
|
2006-10-30 |
2008-05-08 |
Novartis Ag |
Heterocyclic compounds as antiinflammatory agents
|
JP5357763B2
(ja)
|
2006-11-06 |
2013-12-04 |
トレロ ファーマシューティカルズ, インコーポレイテッド |
イミダゾ[1,2−b]ピリダジン誘導体およびピラゾロ[1,5−a]ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用
|
US20080234267A1
(en)
|
2007-03-20 |
2008-09-25 |
Karen Elizabeth Lackey |
Compounds and Methods of Treatment
|
US20080234262A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
|
EP2137187A1
(en)
|
2007-03-28 |
2009-12-30 |
Inovacia AB |
Pyrazolo [1,5-a]pyrimidines as inhibitors of stearoyl-coa desaturase
|
WO2008124323A1
(en)
|
2007-04-03 |
2008-10-16 |
Array Biopharma Inc. |
Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
|
CN101720322A
(zh)
|
2007-05-04 |
2010-06-02 |
Irm责任有限公司 |
作为c-kit和pdgfr激酶抑制剂的化合物和组合物
|
DK2170827T3
(da)
|
2007-06-21 |
2013-11-18 |
Janssen Pharmaceutica Nv |
Indolin-2-oner og aza-indolin-2-oner
|
CA2693901C
(en)
|
2007-07-20 |
2015-12-29 |
Nerviano Medical Sciences S.R.L. |
Substituted indazole derivatives active as kinase inhibitors
|
WO2009017838A2
(en)
|
2007-08-01 |
2009-02-05 |
Exelixis, Inc. |
Combinations of jak-2 inhibitors and other agents
|
MX2010001395A
(es)
|
2007-08-10 |
2010-03-10 |
Regeneron Pharma |
Anticuerpos humanos de alta afinidad de factor de crecimiento de nervio humano.
|
US8129371B2
(en)
|
2007-10-16 |
2012-03-06 |
Wyeth Llc |
Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors
|
JP2011501760A
(ja)
|
2007-10-23 |
2011-01-13 |
ノバルティス アーゲー |
呼吸器疾患の処置のためのtrkb抗体の使用
|
EP2217601A1
(en)
|
2007-11-08 |
2010-08-18 |
Centro Nacional de Investigaciones Oncológicas (CNIO) |
Imidazopyridazines for use as protein kinase inhibitors
|
JP2011504931A
(ja)
|
2007-11-28 |
2011-02-17 |
シェーリング コーポレイション |
プロテインキナーゼ阻害剤としての2−フルオロピラゾロ[1,5−a]ピリミジン
|
CL2009000090A1
(es)
|
2008-01-17 |
2009-07-24 |
Irm Llc |
Anticuerpo que se une al receptor de tirosina quinasa b (trkb); composicion que comprende el anticuerpo; metodo para reducir los niveles de glucosa en la sangre y/o el peso corporal en un individuo.
|
US20090227556A1
(en)
|
2008-01-31 |
2009-09-10 |
Eisai R&D Management Co., Ltd. |
Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives
|
MX2010012457A
(es)
|
2008-05-13 |
2010-12-07 |
Irm Llc |
Heterociclos que contienen nitrogeno fusionado y composiciones de los mismos como inhibidores de cinasa.
|
JP5677296B2
(ja)
|
2008-07-29 |
2015-02-25 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
グリオーマの治療のためのcdk阻害剤の使用
|
RS53350B
(en)
|
2008-09-22 |
2014-10-31 |
Array Biopharma, Inc. |
SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS
|
TWI577680B
(zh)
|
2008-10-22 |
2017-04-11 |
亞雷生物製藥股份有限公司 |
作為TRK激酶抑制劑之經取代吡唑并〔1,5-a〕嘧啶化合物
|
CN102271515B
(zh)
|
2008-10-31 |
2014-07-02 |
健泰科生物技术公司 |
吡唑并嘧啶jak抑制剂化合物和方法
|
JP2012509859A
(ja)
|
2008-11-24 |
2012-04-26 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
中皮腫の治療のためのcdk阻害物質
|
EP3266795A1
(en)
|
2009-02-12 |
2018-01-10 |
Cell Signaling Technology, Inc. |
Method for detecting a fig-ros fusion polynucleotide
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
ES2594927T3
(es)
|
2010-02-18 |
2016-12-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Métodos para prevenir las metástasis cancerosas
|
CA2795776A1
(en)
|
2010-04-06 |
2011-10-13 |
Caris Life Sciences Luxembourg Holdings, S.A.R.L. |
Circulating biomarkers for disease
|
US8383793B2
(en)
|
2010-04-15 |
2013-02-26 |
St. Jude Children's Research Hospital |
Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
ES2534335T3
(es)
|
2010-05-20 |
2015-04-21 |
Array Biopharma, Inc. |
Compuestos macrocíclicos como inhibidores de la Trk cinasa
|
ES2910305T3
(es)
|
2010-08-19 |
2022-05-12 |
Zoetis Belgium S A |
Anticuerpos anti-NGF y su uso
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
JP2014005206A
(ja)
|
2010-10-22 |
2014-01-16 |
Astellas Pharma Inc |
アリールアミノヘテロ環カルボキサミド化合物
|
JP6190723B2
(ja)
|
2010-12-01 |
2017-08-30 |
アルダーバイオ ホールディングス エルエルシー |
抗ngf組成物およびその使用
|
SG192795A1
(en)
|
2011-02-25 |
2013-09-30 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
WO2012125668A1
(en)
*
|
2011-03-17 |
2012-09-20 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
WO2012125667A1
(en)
*
|
2011-03-17 |
2012-09-20 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
CN108329246B
(zh)
|
2011-05-13 |
2021-02-26 |
阵列生物制药公司 |
作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
|
US8656365B2
(en)
|
2011-09-01 |
2014-02-18 |
Infosys Limited |
Systems, methods, and computer-readable media for measuring quality of application programming interfaces
|
TW201312526A
(zh)
|
2011-09-02 |
2013-03-16 |
Wintek Corp |
觸控顯示面板
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
BR112014011465A2
(pt)
|
2011-11-14 |
2017-05-09 |
Tesaro Inc |
modulação de determinadas quinases de tirosina
|
BR112014014276A2
(pt)
|
2011-12-12 |
2017-06-13 |
Dr Reddys Laboratories Ltd |
composto, composição farmacêutica, método para inibir uma cinase receptora, e, métodos para tratar condições, doenças e/ou distúrbios, e dor
|
JP6160613B2
(ja)
|
2012-04-26 |
2017-07-12 |
小野薬品工業株式会社 |
Trk阻害化合物
|
NZ716487A
(en)
|
2012-05-23 |
2017-01-27 |
Nerviano Medical Sciences Srl |
Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
|
TWI585088B
(zh)
|
2012-06-04 |
2017-06-01 |
第一三共股份有限公司 |
作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物
|
EP2689778A1
(en)
|
2012-07-27 |
2014-01-29 |
Pierre Fabre Medicament |
Derivatives of azaindoles or diazaindoles for treating pain
|
JP6223451B2
(ja)
|
2012-08-31 |
2017-11-01 |
ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド,ア ボディ コーポレイト |
がんの診断及び治療方法
|
ES2726605T3
(es)
|
2012-09-07 |
2019-10-08 |
Exelixis Inc |
Inhibidores de MET, VEGFR y RET para usar en el tratamiento del adenocarcinoma de pulmón
|
US20140084039A1
(en)
|
2012-09-24 |
2014-03-27 |
Electro Scientific Industries, Inc. |
Method and apparatus for separating workpieces
|
JP2014082984A
(ja)
|
2012-10-23 |
2014-05-12 |
Astellas Pharma Inc |
新規ntrk2活性化変異の検出法
|
AU2013337264B2
(en)
|
2012-11-05 |
2018-03-08 |
Foundation Medicine, Inc. |
Novel fusion molecules and uses thereof
|
CN108047219A
(zh)
|
2012-11-07 |
2018-05-18 |
内尔维阿诺医学科学有限公司 |
取代的嘧啶基和吡啶基吡咯并吡啶酮类、其制备方法及其作为激酶抑制剂的用途
|
WO2014078325A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
US9822118B2
(en)
|
2012-11-13 |
2017-11-21 |
Array Biopharma Inc. |
Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
CN107857755B
(zh)
|
2012-11-13 |
2020-10-27 |
阵列生物制药公司 |
作为trka激酶抑制剂的n-吡咯烷基、n′-吡唑基-脲、硫脲、胍和氰基胍化合物
|
PL2920166T3
(pl)
|
2012-11-13 |
2017-05-31 |
Array Biopharma, Inc. |
Bicykliczne związki mocznika, tiomocznika, guanidyny i cyjanoguanidyny przydatne w leczeniu bólu
|
WO2014078372A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
US9981959B2
(en)
|
2012-11-13 |
2018-05-29 |
Array Biopharma Inc. |
Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
US9546156B2
(en)
|
2012-11-13 |
2017-01-17 |
Array Biopharma Inc. |
N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors
|
US9809578B2
(en)
|
2012-11-13 |
2017-11-07 |
Array Biopharma Inc. |
Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
|
WO2014078331A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
RU2015125332A
(ru)
|
2012-11-29 |
2017-01-10 |
Йеда Ресеарч Энд Девелопмент Ко. Лтд. |
Способы профилактики метастазирования опухолей, лечения и прогнозирования рака и идентификации агентов, которые являются предполагаемыми ингибиторами метастазирования
|
US9127055B2
(en)
|
2013-02-08 |
2015-09-08 |
Astellas Pharma Inc. |
Method of treating pain with anti-human NGF antibody
|
EP3800183A1
(en)
|
2013-02-19 |
2021-04-07 |
ONO Pharmaceutical Co., Ltd. |
Urea derivatives as trk-inhibiting compounds
|
US20160010068A1
(en)
|
2013-02-22 |
2016-01-14 |
Boris C. Bastian |
Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets
|
US20140243332A1
(en)
|
2013-02-27 |
2014-08-28 |
Oregon Health & Science University |
Methods of treating cancers characterized by aberrent ros1 activity
|
WO2014152777A2
(en)
|
2013-03-15 |
2014-09-25 |
Insight Genetics, Inc. |
Methods and compositions for the diagnosis and treatment of cancers resistant to ros1 inhibitors
|
MA38394B1
(fr)
|
2013-03-15 |
2018-04-30 |
Glaxosmithkline Ip Dev Ltd |
Dérivés pyridine utilisés comme inhibiteurs de la kinase réarrangée au cours de la transfection (ret)
|
KR20150129847A
(ko)
|
2013-03-15 |
2015-11-20 |
더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 |
융합 단백질 및 이들의 방법
|
EP4253558A1
(en)
|
2013-03-15 |
2023-10-04 |
The Board of Trustees of the Leland Stanford Junior University |
Identification and use of circulating nucleic acid tumor markers
|
EP2971094B1
(en)
|
2013-03-15 |
2021-09-15 |
Novartis AG |
Biomarkers associated with brm inhibition
|
CN105378110B
(zh)
|
2013-04-17 |
2024-06-25 |
生命技术公司 |
与癌症相关的基因融合体和基因变异体
|
US9682083B2
(en)
|
2013-05-14 |
2017-06-20 |
Nerviano Medical Sciences S.R.L. |
Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
|
RU2656591C2
(ru)
|
2013-07-11 |
2018-06-06 |
Бетта Фармасьютикалз Ко., Лтд |
Модуляторы протеин-тирозинкиназы и способы их применения
|
JP6534930B2
(ja)
|
2013-07-26 |
2019-06-26 |
公益財団法人がん研究会 |
Ntrk3融合体の検出法
|
EP3027655B1
(en)
|
2013-07-30 |
2019-08-21 |
Blueprint Medicines Corporation |
Ntrk2 fusions
|
KR20160065986A
(ko)
|
2013-10-24 |
2016-06-09 |
조지타운 유니버시티 |
암 치료용 방법 및 조성물
|
JPWO2015064621A1
(ja)
|
2013-10-29 |
2017-03-09 |
公益財団法人がん研究会 |
新規融合体及びその検出法
|
PT3636649T
(pt)
|
2014-01-24 |
2024-04-09 |
Turning Point Therapeutics Inc |
Diaril macrociclos como moduladores das proteínas quinases
|
DK3102555T3
(da)
|
2014-02-05 |
2021-08-09 |
VM Oncology LLC |
Sammensætninger af forbindelser og anvendelser deraf
|
US10231965B2
(en)
|
2014-02-20 |
2019-03-19 |
Ignyta, Inc. |
Molecules for administration to ROS1 mutant cancer cells
|
HUE045340T2
(hu)
|
2014-05-15 |
2019-12-30 |
Array Biopharma Inc |
1-((3S,4R)-4-(3-fluorfenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2- metilpirimidin-5-il)-1-fenil-1H-pirazol-5-il)karbamid mint TrkA kináz inhibitor
|
WO2015183837A1
(en)
|
2014-05-27 |
2015-12-03 |
Brian Haynes |
Compositions, methods, and uses related to ntrk2-tert fusions
|
US20170114415A1
(en)
|
2014-05-30 |
2017-04-27 |
The Regents Of The University Of Colorado, A Body Corporate |
Activating ntrk1 gene fusions predictive of kinase inhibitor therapy
|
CN106714804A
(zh)
|
2014-08-01 |
2017-05-24 |
药品循环有限责任公司 |
用于预测dlbcl对用btk抑制剂进行的治疗的响应的生物标志
|
CN110655502A
(zh)
|
2014-08-18 |
2020-01-07 |
小野药品工业株式会社 |
抑制Trk的化合物的酸加成盐
|
BR112017007379A2
(pt)
|
2014-10-14 |
2017-12-19 |
Dana Farber Cancer Inst Inc |
moléculas de anticorpo para pd-l1 e usos das mesmas
|
FI3699181T3
(fi)
|
2014-11-16 |
2023-03-28 |
Array Biopharma Inc |
Kiteinen muoto (s)-n-(5-((r)-2-(2,5-diluorifenyyli)-pyrrolidin-1-yyli)-pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidivetyysulfaatista
|
KR20240055170A
(ko)
|
2014-12-15 |
2024-04-26 |
주식회사 씨엠지제약 |
융합된 고리 헤테로아릴 화합물 및 trk 억제제로서의 이들의 용도
|
CN116196401A
(zh)
|
2015-05-20 |
2023-06-02 |
博德研究所 |
共有的新抗原
|
CN107849113B
(zh)
|
2015-05-29 |
2022-03-22 |
亚尼塔公司 |
用于治疗具有rtk突变细胞的患者的组合物和方法
|
CN107849615A
(zh)
|
2015-06-01 |
2018-03-27 |
洛克索肿瘤学股份有限公司 |
诊断和治疗癌症的方法
|
AU2015101722A4
(en)
|
2015-06-19 |
2016-05-19 |
Macau University Of Science And Technology |
Oncogenic ros1 and alk kinase inhibitor
|
US9782400B2
(en)
|
2015-06-19 |
2017-10-10 |
Macau University Of Science And Technology |
Oncogenic ROS1 and ALK kinase inhibitor
|
GB201511546D0
(en)
|
2015-07-01 |
2015-08-12 |
Immatics Biotechnologies Gmbh |
Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
|
WO2017004342A1
(en)
|
2015-07-02 |
2017-01-05 |
Tp Therapeutics, Inc. |
Chiral diaryl macrocycles as modulators of protein kinases
|
MX2018005087A
(es)
|
2015-10-26 |
2019-05-16 |
Loxo Oncology Inc |
Mutaciones puntuales en cáncer resistente a trk y métodos relacionados con las mismas.
|
US20170224662A1
(en)
|
2016-01-22 |
2017-08-10 |
The Medicines Company |
Aqueous Formulations and Methods of Preparation and Use Thereof
|
WO2017155018A1
(ja)
|
2016-03-11 |
2017-09-14 |
小野薬品工業株式会社 |
Trk阻害剤抵抗性の癌治療剤
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
JP7061602B2
(ja)
|
2016-04-04 |
2022-04-28 |
ロクソ オンコロジー, インコーポレイテッド |
(S)-N-(5-((R)-2-(2,5-ジフルオロフェニル)-ピロリジン-1-イル)-ピラゾロ[1,5-a]ピリミジン-3-イル)-3-ヒドロキシピロリジン-1-カルボキサミドの液体製剤
|
CN109475545A
(zh)
|
2016-04-19 |
2019-03-15 |
埃克塞里艾克西斯公司 |
三阴性乳腺癌治疗方法
|
DK3458456T3
(da)
|
2016-05-18 |
2020-12-14 |
Array Biopharma Inc |
Fremstilling af (s)-n-(5-((r)-2-(2,5-difluorphenyl)pyrrolidin-1-yl)pyrazol[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid
|
WO2017201156A1
(en)
|
2016-05-18 |
2017-11-23 |
Duke University |
Method of treating kras wild-type metastatic colorectal cell carcinoma using cabozantinib plus panitumumab
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
CA3080157A1
(en)
|
2017-10-26 |
2019-05-02 |
Array Biopharma Inc. |
Formulations of a macrocyclic trk kinase inhibitor
|