JP7291396B2 - 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 - Google Patents

融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 Download PDF

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JP7291396B2
JP7291396B2 JP2019527363A JP2019527363A JP7291396B2 JP 7291396 B2 JP7291396 B2 JP 7291396B2 JP 2019527363 A JP2019527363 A JP 2019527363A JP 2019527363 A JP2019527363 A JP 2019527363A JP 7291396 B2 JP7291396 B2 JP 7291396B2
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ボーエルレ，パトリック
ホフマイスター，ロバート
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ティーシーアール２ セラピューティクス インク．
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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JP2019527363A 2016-11-22 2017-11-22 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 Active JP7291396B2 (ja)

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JP2023087484A JP2023109968A (ja) 2016-11-22 2023-05-29 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法

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US201662425407P 2016-11-22 2016-11-22
US201662425535P 2016-11-22 2016-11-22
US62/425,407 2016-11-22
US62/425,535 2016-11-22
US201662425697P 2016-11-23 2016-11-23
US201662425884P 2016-11-23 2016-11-23
US62/425,697 2016-11-23
US62/425,884 2016-11-23
PCT/US2017/063137 WO2018098365A2 (en) 2016-11-22 2017-11-22 Compositions and methods for tcr reprogramming using fusion proteins

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JP2019536452A5 JP2019536452A5 (https=) 2020-12-24
JP7291396B2 true JP7291396B2 (ja) 2023-06-15

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US (1) US11851491B2 (https=)
EP (1) EP3544996A2 (https=)
JP (2) JP7291396B2 (https=)
CN (1) CN110177803A (https=)
AU (1) AU2017363311A1 (https=)
CA (1) CA3044593A1 (https=)
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CA3036745A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
US11851491B2 (en) 2016-11-22 2023-12-26 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
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WO2018200585A1 (en) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Cells expressing chimeric antigen receptors and secondary effectors and uses thereof
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EA202091887A1 (ru) 2018-02-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры
DK3749346T3 (da) 2018-02-08 2024-09-09 Dragonfly Therapeutics Inc Antistof variable domænekombinationer rettet mod nkg2d-receptoren
CA3091478A1 (en) 2018-02-17 2019-08-22 Flagship Pioneering Innovations V, Inc. Compositions and methods for membrane protein delivery
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
CA3093449A1 (en) * 2018-03-09 2019-09-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CN119529091A (zh) * 2018-06-19 2025-02-28 南京传奇生物科技有限公司 工程化的细胞及其用途
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BR112021001338A2 (pt) * 2018-07-26 2021-05-04 TCR2 Therapeutics Inc. composições e métodos para reprogramação de tcr usando proteínas de fusão específicas para o alvo
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