MX2022002984A - Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión. - Google Patents

Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión.

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Publication number
MX2022002984A
MX2022002984A MX2022002984A MX2022002984A MX2022002984A MX 2022002984 A MX2022002984 A MX 2022002984A MX 2022002984 A MX2022002984 A MX 2022002984A MX 2022002984 A MX2022002984 A MX 2022002984A MX 2022002984 A MX2022002984 A MX 2022002984A
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MX
Mexico
Prior art keywords
tcr
fusion proteins
methods
compositions
delta
Prior art date
Application number
MX2022002984A
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English (en)
Inventor
Daniel Getts
Patrick Baeuerle
Julie Donaghey
Robert Hofmeister
Dario Gutierrez
Philippe Kieffer-Kwon
Original Assignee
Tcr2 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tcr2 Therapeutics Inc filed Critical Tcr2 Therapeutics Inc
Publication of MX2022002984A publication Critical patent/MX2022002984A/es

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    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector

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Abstract

En la presente se proporcionan ácidos nucleicos recombinantes que codifican proteínas de fusión del receptor de linfocitos T (TCR) (TFP) y un dominio constante de TCR, linfocitos T modificados que expresan las moléculas codificadas y métodos de uso de estos para el tratamiento de enfermedades, incluido el cáncer. En la presente se describen proteínas de fusión que comprenden linfocitos T de subunidades de TCR, que incluyen las cadenas CD3 épsilon, CD3 gamma, CD3 delta, TCR gamma, TCR delta, TCR alfa y TCR beta con dominios de unión específicos para los antígenos de superficie celular que tienen el potencial de superar las limitaciones de los enfoques existentes.
MX2022002984A 2019-09-12 2020-09-11 Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión. MX2022002984A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962899563P 2019-09-12 2019-09-12
US202062971682P 2020-02-07 2020-02-07
PCT/US2020/050503 WO2021050948A1 (en) 2019-09-12 2020-09-11 Compositions and methods for tcr reprogramming using fusion proteins

Publications (1)

Publication Number Publication Date
MX2022002984A true MX2022002984A (es) 2022-06-16

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MX2022002984A MX2022002984A (es) 2019-09-12 2020-09-11 Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión.

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EP (1) EP4028033A4 (es)
JP (1) JP2022548866A (es)
KR (1) KR20220078607A (es)
CN (1) CN114828862A (es)
AU (1) AU2020344628A1 (es)
BR (1) BR112022004458A2 (es)
CA (1) CA3154287A1 (es)
IL (1) IL291236A (es)
MX (1) MX2022002984A (es)
WO (1) WO2021050948A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023091420A2 (en) * 2021-11-16 2023-05-25 TCR2 Therapeutics Inc. Compositions and methods for t cell engineering
WO2023133296A2 (en) * 2022-01-07 2023-07-13 Sorrento Therapeutics, Inc. Engineered pd-l1-targeting gamma delta t cell receptors
WO2024039576A2 (en) * 2022-08-19 2024-02-22 Memorial Sloan-Kettering Cancer Center T cell receptors targeting ras mutations and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011059836A2 (en) * 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
AU2012327204B2 (en) * 2011-10-28 2016-01-21 Regeneron Pharmaceuticals, Inc. Genetically modified T cell receptor mice
SG10201913245UA (en) * 2015-10-23 2020-02-27 Eureka Therapeutics Inc Antibody/t-cell receptor chimeric constructs and uses thereof
GB201604494D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers
DK3445787T3 (da) * 2016-10-07 2021-03-01 Tcr2 Therapeutics Inc Sammensætninger og fremgangsmåder til omprogrammering af t-cellereceptorer under anvendelse af fusionsproteiner
AU2017363311A1 (en) * 2016-11-22 2019-06-13 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
CA3047999A1 (en) * 2016-12-21 2018-06-28 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
EP3638295A1 (en) * 2017-06-13 2020-04-22 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2019118508A1 (en) * 2017-12-12 2019-06-20 The Trustees Of The University Of Pennsylvania Genetically modified immune cells targeting ny-eso-1 and methods of use thereof
WO2019133443A1 (en) * 2017-12-28 2019-07-04 Janux Therapeutics, Inc. Modified t cell receptors
JP2021515598A (ja) * 2018-03-09 2021-06-24 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒリプログラミングのための組成物及び方法

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JP2022548866A (ja) 2022-11-22
IL291236A (en) 2022-05-01
CA3154287A1 (en) 2021-03-18
WO2021050948A1 (en) 2021-03-18
KR20220078607A (ko) 2022-06-10
BR112022004458A2 (pt) 2022-05-31
EP4028033A1 (en) 2022-07-20
CN114828862A (zh) 2022-07-29
AU2020344628A1 (en) 2022-04-07
EP4028033A4 (en) 2023-10-04

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