MX2021001771A - Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos. - Google Patents
Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos.Info
- Publication number
- MX2021001771A MX2021001771A MX2021001771A MX2021001771A MX2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A
- Authority
- MX
- Mexico
- Prior art keywords
- trans
- combination
- chimeric antigen
- krebs cycle
- antigen receptor
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title abstract 3
- 230000004102 tricarboxylic acid cycle Effects 0.000 title abstract 2
- 230000004060 metabolic process Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 2
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 108700010039 chimeric receptor Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
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Abstract
En el presente documento se describen células hematopoyéticas modificadas genéticamente, que expresan uno o más polipéptidos moduladores del ciclo de Krebs, y opcionalmente un polipéptido del receptor quimérico (p. ej., un polipéptido del receptor de células T acoplado a anticuerpos (ACTR) o un polipéptido del receptor de antígeno quimérico (CAR)) capaces de unirse a un antígeno diana de interés; también se describen en el presente documento los usos de las células hematopoyéticas modificadas para inhibir las células que expresan un antígeno diana en un sujeto que lo necesita.
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US201862718491P | 2018-08-14 | 2018-08-14 | |
US201862718579P | 2018-08-14 | 2018-08-14 | |
PCT/US2019/046550 WO2020037066A1 (en) | 2018-08-14 | 2019-08-14 | Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof |
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US (1) | US20210332334A1 (es) |
EP (1) | EP3837353A4 (es) |
JP (1) | JP7456638B2 (es) |
KR (1) | KR20210045418A (es) |
CN (1) | CN112840019A (es) |
AU (1) | AU2019321540A1 (es) |
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CA (1) | CA3108126A1 (es) |
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SG (1) | SG11202101284UA (es) |
WO (1) | WO2020037066A1 (es) |
ZA (1) | ZA202100993B (es) |
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CA3232833A1 (en) | 2021-09-27 | 2023-03-30 | Kathleen Mcginness | Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof |
AU2022388928A1 (en) | 2021-11-16 | 2024-05-16 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
EP4249588A1 (en) * | 2022-03-22 | 2023-09-27 | Universität Basel Vizerektorat Forschung | Cellular therapy |
WO2024015995A2 (en) * | 2022-07-15 | 2024-01-18 | Albert Einstein College Of Medicine | Chimeric antigen receptors comprising a tmigd2 costimulatory domain and associated methods of using the same |
WO2024040208A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof |
WO2024040207A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof |
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AU2013266243A1 (en) | 2012-05-24 | 2014-12-18 | Beth Israel Deaconess Medical Center, Inc. | Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer |
ES2844700T3 (es) | 2014-09-26 | 2021-07-22 | Baylor College Medicine | Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva |
WO2017079703A1 (en) * | 2015-11-05 | 2017-05-11 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
EP3402571A4 (en) * | 2016-01-15 | 2019-08-28 | The J. David Gladstone Institutes | METHOD FOR THE TREATMENT OF DISORDERS BY METABOLIC CONTROL OF T-CELL DIFFERENTIATION |
WO2020028572A2 (en) * | 2018-08-01 | 2020-02-06 | Unum Therapeutics Inc. | ANTIBODY-COUPLED T CELL RECEPTORS (ACTRs) IN COMBINATION WITH TRANS CO-STIMULATORY MOLECULES AND THERAPEUTIC USES THEREOF |
US20210269794A1 (en) * | 2018-08-17 | 2021-09-02 | Yale University | Compositions and Methods for High-Throughput Activation Screening to Boost T Cell Effector Function |
JP2022512958A (ja) * | 2018-11-07 | 2022-02-07 | ソティオ,リミティド ライアビリティ カンパニー | トランス共刺激分子と組み合わされた抗gpc3キメラ抗原受容体(car)及びその治療的用途 |
EP3942023A1 (en) * | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
EP4157877A2 (en) * | 2020-05-28 | 2023-04-05 | AZTherapies, Inc. | Car-treg-based therapies targeting myelin oligodendrocyte glycoprotein (mog) for treating neurodegenerative diseases |
CA3232833A1 (en) * | 2021-09-27 | 2023-03-30 | Kathleen Mcginness | Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof |
AU2022388928A1 (en) * | 2021-11-16 | 2024-05-16 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
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US20210332334A1 (en) | 2021-10-28 |
CN112840019A (zh) | 2021-05-25 |
ZA202100993B (en) | 2022-09-28 |
EP3837353A1 (en) | 2021-06-23 |
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