SG11202101284UA - Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof - Google Patents
Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereofInfo
- Publication number
- SG11202101284UA SG11202101284UA SG11202101284UA SG11202101284UA SG11202101284UA SG 11202101284U A SG11202101284U A SG 11202101284UA SG 11202101284U A SG11202101284U A SG 11202101284UA SG 11202101284U A SG11202101284U A SG 11202101284UA SG 11202101284U A SG11202101284U A SG 11202101284UA
- Authority
- SG
- Singapore
- Prior art keywords
- trans
- combination
- antigen receptor
- chimeric antigen
- therapeutic uses
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 230000004060 metabolic process Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 title 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14041—Use of virus, viral particle or viral elements as a vector
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AU2022349103A1 (en) | 2021-09-27 | 2024-03-28 | Sotio Biotech Inc. | Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof |
CA3237201A1 (en) | 2021-11-16 | 2023-05-25 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
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US11020429B2 (en) * | 2015-11-05 | 2021-06-01 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
US11241455B2 (en) * | 2016-01-15 | 2022-02-08 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Methods of treating disease by metabolic control of T-cell differentiation |
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CN113260368B (en) * | 2018-11-07 | 2023-08-29 | 舒迪安生物技术公司 | Combination of anti-GPC 3 Chimeric Antigen Receptor (CAR) and trans-costimulatory molecules and therapeutic uses thereof |
EP3942023A1 (en) * | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
US20230210899A1 (en) * | 2020-05-28 | 2023-07-06 | Aztherapies, Inc. | CAR-Treg-Based Therapies Targeting Myelin Oligodendrocyte Glycoprotein (MOG) for Treating Neurodegenerative Diseases |
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