CN110177803A - 用于使用融合蛋白进行tcr重新编程的组合物和方法 - Google Patents

用于使用融合蛋白进行tcr重新编程的组合物和方法 Download PDF

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Publication number
CN110177803A
CN110177803A CN201780083288.5A CN201780083288A CN110177803A CN 110177803 A CN110177803 A CN 110177803A CN 201780083288 A CN201780083288 A CN 201780083288A CN 110177803 A CN110177803 A CN 110177803A
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tcr
tfp
nucleic acid
molecule
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CN201780083288.5A
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帕特里克·博伊尔勒
罗伯特·霍夫梅斯特
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TCR2 Therapeutics Inc
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TCR2 Therapeutics Inc
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CN201780083288.5A 2016-11-22 2017-11-22 用于使用融合蛋白进行tcr重新编程的组合物和方法 Pending CN110177803A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662425535P 2016-11-22 2016-11-22
US201662425407P 2016-11-22 2016-11-22
US62/425,407 2016-11-22
US62/425,535 2016-11-22
US201662425884P 2016-11-23 2016-11-23
US201662425697P 2016-11-23 2016-11-23
US62/425,884 2016-11-23
US62/425,697 2016-11-23
PCT/US2017/063137 WO2018098365A2 (en) 2016-11-22 2017-11-22 Compositions and methods for tcr reprogramming using fusion proteins

Publications (1)

Publication Number Publication Date
CN110177803A true CN110177803A (zh) 2019-08-27

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CN201780083288.5A Pending CN110177803A (zh) 2016-11-22 2017-11-22 用于使用融合蛋白进行tcr重新编程的组合物和方法

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Country Link
US (1) US11851491B2 (https=)
EP (1) EP3544996A2 (https=)
JP (2) JP7291396B2 (https=)
CN (1) CN110177803A (https=)
AU (1) AU2017363311A1 (https=)
CA (1) CA3044593A1 (https=)
WO (1) WO2018098365A2 (https=)

Cited By (6)

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WO2021249549A1 (zh) * 2019-09-13 2021-12-16 中国科学院分子细胞科学卓越创新中心 一种嵌合抗原受体及其用途
CN113980136A (zh) * 2020-07-27 2022-01-28 中国科学院分子细胞科学卓越创新中心 一种包含具有Y/F突变的CD3ε胞内区的嵌合抗原受体及其用途
WO2022179545A1 (zh) * 2021-02-25 2022-09-01 华夏英泰（北京）生物技术有限公司 针对cd19和cd22的双靶点star
WO2023010436A1 (zh) * 2021-08-05 2023-02-09 卡瑞济(北京)生命科技有限公司 Tcr表达构建体以及其制备方法和用途
CN115989033A (zh) * 2020-05-05 2023-04-18 T细胞受体治疗公司 用于使用cd70特异性融合蛋白进行tcr重编程的组合物和方法
WO2024140981A1 (zh) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 细胞原位分泌抗体及其用途

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PL3298033T5 (pl) 2015-05-18 2023-10-30 TCR2 Therapeutics Inc. Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
CA3032498A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018067993A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
JP7291396B2 (ja) 2016-11-22 2023-06-15 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
AU2018219887B2 (en) 2017-02-08 2024-08-15 Dragonfly Therapeutics, LLC Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CN110944661A (zh) 2017-02-20 2020-03-31 蜻蜓疗法股份有限公司 结合her2、nkg2d和cd16的蛋白质
EP3615574A4 (en) 2017-04-26 2021-02-24 Eureka Therapeutics, Inc. SPECIFIC GLYPICAN 3 RECOGNIZING CONSTRUCTS AND THEIR USE
JP7538601B2 (ja) 2017-04-26 2024-08-22 ユーリカ セラピューティックス， インコーポレイテッド キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
CA3237846A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
AU2019222560B2 (en) 2018-02-17 2025-07-03 Flagship Pioneering Innovations V, Inc. Compositions and methods for membrane protein delivery
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
MX2020009371A (es) * 2018-03-09 2021-01-08 Tcr2 Therapeutics Inc Composiciones y métodos para la reprogramación de tcr mediante el uso de proteínas de fusión.
EP3765517A1 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
SG11202008731XA (en) * 2018-06-19 2020-10-29 Nanjing Legend Biotech Co Ltd Engineered cells and uses thereof
CA3105448A1 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
BR112021001338A2 (pt) * 2018-07-26 2021-05-04 TCR2 Therapeutics Inc. composições e métodos para reprogramação de tcr usando proteínas de fusão específicas para o alvo
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