CN110177803A - 用于使用融合蛋白进行tcr重新编程的组合物和方法 - Google Patents

用于使用融合蛋白进行tcr重新编程的组合物和方法 Download PDF

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Publication number
CN110177803A
CN110177803A CN201780083288.5A CN201780083288A CN110177803A CN 110177803 A CN110177803 A CN 110177803A CN 201780083288 A CN201780083288 A CN 201780083288A CN 110177803 A CN110177803 A CN 110177803A
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tcr
tfp
nucleic acid
molecule
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CN201780083288.5A
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帕特里克·博伊尔勒
罗伯特·霍夫梅斯特
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TCR2 Therapeutics Inc
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TCR2 Therapeutics Inc
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CN201780083288.5A 2016-11-22 2017-11-22 用于使用融合蛋白进行tcr重新编程的组合物和方法 Pending CN110177803A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662425407P 2016-11-22 2016-11-22
US201662425535P 2016-11-22 2016-11-22
US62/425,407 2016-11-22
US62/425,535 2016-11-22
US201662425697P 2016-11-23 2016-11-23
US201662425884P 2016-11-23 2016-11-23
US62/425,697 2016-11-23
US62/425,884 2016-11-23
PCT/US2017/063137 WO2018098365A2 (en) 2016-11-22 2017-11-22 Compositions and methods for tcr reprogramming using fusion proteins

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CN110177803A true CN110177803A (zh) 2019-08-27

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CN201780083288.5A Pending CN110177803A (zh) 2016-11-22 2017-11-22 用于使用融合蛋白进行tcr重新编程的组合物和方法

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Country Link
US (1) US11851491B2 (https=)
EP (1) EP3544996A2 (https=)
JP (2) JP7291396B2 (https=)
CN (1) CN110177803A (https=)
AU (1) AU2017363311A1 (https=)
CA (1) CA3044593A1 (https=)
WO (1) WO2018098365A2 (https=)

Cited By (6)

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WO2021249549A1 (zh) * 2019-09-13 2021-12-16 中国科学院分子细胞科学卓越创新中心 一种嵌合抗原受体及其用途
CN113980136A (zh) * 2020-07-27 2022-01-28 中国科学院分子细胞科学卓越创新中心 一种包含具有Y/F突变的CD3ε胞内区的嵌合抗原受体及其用途
WO2022179545A1 (zh) * 2021-02-25 2022-09-01 华夏英泰（北京）生物技术有限公司 针对cd19和cd22的双靶点star
WO2023010436A1 (zh) * 2021-08-05 2023-02-09 卡瑞济(北京)生命科技有限公司 Tcr表达构建体以及其制备方法和用途
CN115989033A (zh) * 2020-05-05 2023-04-18 T细胞受体治疗公司 用于使用cd70特异性融合蛋白进行tcr重编程的组合物和方法
WO2024140981A1 (zh) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 细胞原位分泌抗体及其用途

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CN107995913B (zh) 2015-05-18 2022-02-11 T细胞受体治疗公司 使用融合蛋白对tcr重编程的组合物和方法
EP3494138A1 (en) 2016-08-02 2019-06-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CA3036745A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
US11851491B2 (en) 2016-11-22 2023-12-26 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
SG11201907299XA (en) 2017-02-08 2019-09-27 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
IL268755B2 (en) 2017-02-20 2025-12-01 Dragonfly Therapeutics Inc Proteins that bind her2, nkg2d, and cd16
WO2018200585A1 (en) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Cells expressing chimeric antigen receptors and secondary effectors and uses thereof
IL270138B2 (en) 2017-04-26 2025-08-01 Eureka Therapeutics Inc Structures that specifically recognize glypican 3 and their uses
EP3737692A4 (en) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
EA202091887A1 (ru) 2018-02-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры
DK3749346T3 (da) 2018-02-08 2024-09-09 Dragonfly Therapeutics Inc Antistof variable domænekombinationer rettet mod nkg2d-receptoren
CA3091478A1 (en) 2018-02-17 2019-08-22 Flagship Pioneering Innovations V, Inc. Compositions and methods for membrane protein delivery
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
CA3093449A1 (en) * 2018-03-09 2019-09-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
CN119529091A (zh) * 2018-06-19 2025-02-28 南京传奇生物科技有限公司 工程化的细胞及其用途
EP3818083A2 (en) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
BR112021001338A2 (pt) * 2018-07-26 2021-05-04 TCR2 Therapeutics Inc. composições e métodos para reprogramação de tcr usando proteínas de fusão específicas para o alvo
WO2020033630A1 (en) * 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
US12378318B2 (en) 2018-08-08 2025-08-05 Dragonfly Therapeutics, Inc. Proteins binding NKG2D, CD16 and a tumor-associated antigen
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