JP7142569B2 - サンプルの収集、安定化、および保存のためのシステム、方法およびデバイス - Google Patents
サンプルの収集、安定化、および保存のためのシステム、方法およびデバイス Download PDFInfo
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Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| EP2408372B1 (en) | 2009-03-02 | 2019-01-09 | Seventh Sense Biosystems, Inc. | Devices associated with blood sampling |
| US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| EP2954916A3 (en) * | 2010-08-13 | 2016-04-20 | Seventh Sense Biosystems, Inc. | Clinical and/or consumer techniques and devices |
| ES2565805T3 (es) | 2010-11-09 | 2016-04-07 | Seventh Sense Biosystems, Inc. | Sistemas e interfaces para el muestreo de sangre |
| KR102237667B1 (ko) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
| AU2012249683A1 (en) | 2011-04-29 | 2013-11-14 | Seventh Sense Biosystems, Inc. | Devices and methods for collection and/or manipulation of blood spots or other bodily fluids |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| EP3528950A4 (en) * | 2016-10-24 | 2020-05-27 | Biomatrica, INC. | STABILIZATION OF NUCLEIC ACIDS ON PAPER |
| CN210383905U (zh) | 2017-01-10 | 2020-04-24 | 集联健康有限公司 | 一种用于从受试者收集流体样品的装置以及运输套筒 |
| WO2018222709A2 (en) * | 2017-06-01 | 2018-12-06 | Nantomics, Llc | Dna stabilization of rna |
| WO2019067567A1 (en) * | 2017-09-26 | 2019-04-04 | Juno Diagnostics, Inc. | DEVICES, SYSTEMS AND METHODS FOR BIOMARKER ANALYSIS |
| TWI833715B (zh) * | 2017-10-27 | 2024-03-01 | 美商奇諾診療公司 | 用於超低體積液體生物檢體之裝置、系統及方法 |
| US10758866B2 (en) * | 2017-11-30 | 2020-09-01 | Wellsim Biomedical Technologies, Inc | Isolation chip and manufacturing method of the same |
| GB201819134D0 (en) * | 2018-11-23 | 2019-01-09 | Cancer Research Tech Ltd | Improvements in variant detection |
| CA3095030A1 (en) | 2018-03-30 | 2019-10-03 | Juno Diagnostics, Inc. | Deep learning-based methods, devices, and systems for prenatal testing |
| WO2020167746A1 (en) * | 2019-02-14 | 2020-08-20 | Becton, Dickinson And Company | Capillary collector with rotatable connection |
| WO2021046343A1 (en) * | 2019-09-06 | 2021-03-11 | Teleflex Medical Incorporated | Lysing solution for real-time determining the identification and antibiotic resistance of pathogenic microorganisms |
| AU2020354484A1 (en) | 2019-09-23 | 2022-05-19 | Gateway Genomics, Llc | Methods, compositions, and kits for determining the sex of a fetus |
| US20230203586A1 (en) * | 2020-05-29 | 2023-06-29 | The Rockefeller University | Method and system for rna isolation from self-collected and small volume samples |
| JP2023549013A (ja) * | 2020-09-18 | 2023-11-22 | プロコムキュア バイオテック ゲーエムベーハー | 唾液サンプル採取用キット |
| CN112280661A (zh) * | 2020-10-15 | 2021-01-29 | 西咸新区国睿一诺药物安全评价研究有限公司 | 一种胚胎卵黄囊吸收毒性试验用的流水式测试系统 |
| US20220133191A1 (en) * | 2020-11-04 | 2022-05-05 | Verily Life Sciences Llc | Optical methods to modulate local blood perfusion at the skin |
| WO2022192295A1 (en) * | 2021-03-08 | 2022-09-15 | Michael Wohl | Kits and methods for collecting and transporting a pathogen |
| CN112760360B (zh) * | 2021-03-22 | 2023-12-19 | 洛阳赛奥生物工程技术有限公司 | 一种rna保护剂及其应用 |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| CN113349774B (zh) * | 2021-06-07 | 2022-06-24 | 孟斯琴 | 一种心内科临床检验采血用固定装置 |
| CN113462750B (zh) * | 2021-06-29 | 2024-08-27 | 浙江峻山生物科技有限公司 | 一种提高病毒核酸检测灵敏度的样本保存液及其制备方法 |
| JP2024536820A (ja) * | 2021-09-23 | 2024-10-08 | ドローブリッジ ヘルス,インコーポレイテッド | 試料採集のためのシステムおよび方法 |
| CN114426924B (zh) * | 2022-01-26 | 2024-06-04 | 天宫精准医疗技术(上海)有限公司 | 一种多功能干细胞组织采集装置 |
| US11957465B2 (en) | 2022-08-23 | 2024-04-16 | Reddrop Dx, Inc. | Accelerated ergonomic collection of capillary blood |
| JPWO2024042932A1 (enExample) | 2022-08-24 | 2024-02-29 | ||
| CN115628951A (zh) * | 2022-10-18 | 2023-01-20 | 南京火眼金睛安全科技有限公司 | 一种用于痕量毒品检测的人体毛发裂解液及其应用 |
| CN117169519B (zh) * | 2023-10-26 | 2024-01-30 | 艾康生物技术(杭州)有限公司 | 用于检测样本中tt3和/或tt4的解离剂和试剂盒 |
| SE2351278A1 (en) * | 2023-11-08 | 2025-05-09 | Sequrna Ab | Dry storage |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011521709A (ja) | 2008-05-30 | 2011-07-28 | インテュイティ メディカル インコーポレイテッド | 体液採取装置及び採取部位インターフェイス |
| JP2014516644A (ja) | 2011-04-29 | 2014-07-17 | セブンス センス バイオシステムズ,インコーポレーテッド | 血斑または他の体液の収集および/または操作のためのデバイスおよび方法 |
| US20140234942A1 (en) | 2012-04-30 | 2014-08-21 | General Electric Company | Substrates and methods for collection, stabilization and elution of biomolecules |
| WO2014172245A1 (en) | 2013-04-15 | 2014-10-23 | Becton, Dickinson And Company | Biological fluid sampling device |
| WO2015022410A1 (en) | 2013-08-16 | 2015-02-19 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
Family Cites Families (426)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE542544A (enExample) | 1954-11-04 | |||
| US3070486A (en) | 1958-12-15 | 1962-12-25 | Ohio Commw Eng Co | Cigarette paper products comprising water insoluble dextran |
| US3227075A (en) | 1961-04-04 | 1966-01-04 | Fitchburg Paper | Planographic printing plates |
| US3300474A (en) | 1964-02-12 | 1967-01-24 | Pharmacia Ab | Sucrose ether copolymerizates |
| CA928198A (en) | 1968-07-15 | 1973-06-12 | Boehringer Mannheim G.M.B.H. | Storable blood and serum samples and a process for their preparation |
| CH522395A (fr) | 1968-07-26 | 1972-05-15 | Micromedic Systems Inc | Eprouvette destinée à la prise de sang percutanée et digitale |
| AU2919171A (en) | 1970-05-27 | 1972-11-30 | Pharmacia Ab | A method for carrying out tests, a reagent andan additive for carrying out the method |
| JPS5319092A (en) | 1976-11-08 | 1978-02-21 | Shionogi Seiyaku Kk | Composite for liver desease detection |
| CH620300A5 (en) | 1977-04-29 | 1980-11-14 | Miles Lab | Reactive strip for analysis |
| US4257426A (en) | 1979-06-22 | 1981-03-24 | Marquest Medical Products, Inc. | Vacuum assisted anti-coagulant syringe device for taking blood samples |
| US4540506A (en) | 1983-04-15 | 1985-09-10 | Genex Corporation | Composition for cleaning drains clogged with deposits containing hair |
| CA1255197A (en) | 1984-09-24 | 1989-06-06 | Joseph L. Orlik | Leukocyte differentiation composition and method |
| US5173422A (en) | 1986-08-22 | 1992-12-22 | Miles Inc. | Monoclonal antibodies specific for human glycoalbumin |
| SE462464B (sv) | 1987-01-14 | 1990-07-02 | Broden Bengt Inge | Utrustning foer provtagning paa patienter |
| JP2728757B2 (ja) | 1988-02-11 | 1998-03-18 | キューノ,インコーポレーテッド | 変性多糖支持体の親和性マトリックス |
| JPH01291164A (ja) | 1988-05-19 | 1989-11-22 | Fujirebio Inc | 標準瀘紙用組成物 |
| US5807527A (en) | 1991-05-29 | 1998-09-15 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
| US5985327A (en) | 1988-10-05 | 1999-11-16 | Flinders Technologies Pty. Ltd. | Solid medium and method for DNA storage |
| US5972386A (en) | 1995-12-19 | 1999-10-26 | Flinders Technologies Pty, Ltd. | Dry solid medium for storage and analysis of genetic material |
| US6627226B2 (en) | 1988-10-05 | 2003-09-30 | Whatman, Inc. | Dry solid medium for storage and analysis of genetic material |
| US5756126A (en) | 1991-05-29 | 1998-05-26 | Flinders Technologies Pty. Ltd. | Dry solid medium for storage and analysis of genetic material |
| US5496562A (en) | 1988-10-05 | 1996-03-05 | Flinders Technologies Pty Ltd | Solid medium and method for DNA storage |
| US5252489A (en) | 1989-01-17 | 1993-10-12 | Macri James N | Down syndrome screening method utilizing dried blood samples |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| US5054499A (en) | 1989-03-27 | 1991-10-08 | Swierczek Remi D | Disposable skin perforator and blood testing device |
| CA2014119C (en) | 1989-04-07 | 2000-11-21 | Diane L. Aunet | Methods and devices for the separation of plasma or serum from whole blood, collection of plasma or serum, and reagent delivery system |
| US5141850A (en) | 1990-02-07 | 1992-08-25 | Hygeia Sciences, Inc. | Porous strip form assay device method |
| GB9010742D0 (en) | 1990-05-14 | 1990-07-04 | Quadrant Bioresources Ltd | Stabilization of biological macromolecular substances |
| JP2572823Y2 (ja) | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
| US5494646A (en) | 1993-04-14 | 1996-02-27 | Seymour; Eugene H. | Sampling device and sample adequacy system |
| JP3494183B2 (ja) | 1993-08-10 | 2004-02-03 | 株式会社アドバンス | 簡易採血装置 |
| US5756362A (en) | 1993-10-12 | 1998-05-26 | Cornell Research Foundation, Inc. | Liposome-enhanced immunoaggregation assay and test device |
| CA2127605A1 (en) | 1993-12-23 | 1995-06-24 | Peter J. Degen | Affinity separation method |
| ATE208653T1 (de) | 1994-03-04 | 2001-11-15 | Usf Filtration & Separations | Gross-porige membran aus synthetischen polymeren |
| US6277281B1 (en) | 1994-03-04 | 2001-08-21 | Usf Filtration And Separations Group Inc. | Large pore synthetic polymer membranes |
| US5593824A (en) | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| SE9404468D0 (sv) | 1994-12-22 | 1994-12-22 | Astra Ab | Powder formulations |
| US5636640A (en) | 1995-02-06 | 1997-06-10 | Volunteers For Medical Engineering | Liquid sampling and test apparatus |
| US5725774A (en) | 1995-04-07 | 1998-03-10 | Lxn Corp. | Whole blood separation method and devices using the same |
| AU706447B2 (en) | 1995-04-13 | 1999-06-17 | Advanced Cytometrix, Inc. | Aspiration needle apparatus incorporating its own vacuum and method and adapter for use therewith |
| WO1996040421A1 (en) | 1995-06-07 | 1996-12-19 | Memtec America Corporation | Microfiltration membranes having high pore density and mixed isotropic and anisotropic structure |
| CZ391297A3 (cs) * | 1995-06-07 | 1998-05-13 | Quadrant Holdings Cambridge Limited | Způsob přípravy tenké porovité skelné matrice a prostředek tím získaný |
| DE96915910T1 (de) | 1995-06-07 | 2004-04-22 | Whatman Plc, Maidstone | Trockenes festes medium zur lagerung und analyse von genetischem material |
| US5906742A (en) | 1995-07-05 | 1999-05-25 | Usf Filtration And Separations Group Inc. | Microfiltration membranes having high pore density and mixed isotropic and anisotropic structure |
| EP0854923A2 (en) | 1995-08-09 | 1998-07-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis |
| US5804684A (en) | 1995-08-24 | 1998-09-08 | The Theobald Smith Research Institute, Inc. | Method for isolating nucleic acids |
| US5709699A (en) | 1995-09-01 | 1998-01-20 | Biosafe Diagnostics Corporation | Blood collection and testing device |
| US5662127A (en) | 1996-01-17 | 1997-09-02 | Bio-Plas, Inc. | Self-contained blood withdrawal apparatus and method |
| US7828749B2 (en) | 1996-05-17 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
| US7666150B2 (en) | 1996-05-17 | 2010-02-23 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
| US6340354B1 (en) | 1996-05-17 | 2002-01-22 | Christopher L Rambin | Automated compulsory blood extraction system |
| US7235056B2 (en) | 1996-05-17 | 2007-06-26 | Amira Medical | Body fluid sampling device and methods of use |
| US6332871B1 (en) | 1996-05-17 | 2001-12-25 | Amira Medical | Blood and interstitial fluid sampling device |
| WO1998024493A1 (en) | 1996-12-05 | 1998-06-11 | Mdc Investment Holdings, Inc. | Fluid collection device with retractable needle |
| US6004278A (en) | 1996-12-05 | 1999-12-21 | Mdc Investment Holdings, Inc. | Fluid collection device with retractable needle |
| US6071249A (en) | 1996-12-06 | 2000-06-06 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| US6063039A (en) | 1996-12-06 | 2000-05-16 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| US6045899A (en) | 1996-12-12 | 2000-04-04 | Usf Filtration & Separations Group, Inc. | Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters |
| JPH10179722A (ja) | 1996-12-25 | 1998-07-07 | Sumitomo Bakelite Co Ltd | 表面処理 |
| US5939259A (en) | 1997-04-09 | 1999-08-17 | Schleicher & Schuell, Inc. | Methods and devices for collecting and storing clinical samples for genetic analysis |
| US6129710A (en) | 1997-05-12 | 2000-10-10 | Spectrum Biotech Inc. | Needle cannula attachment device for a disposable syringe |
| US5984940A (en) | 1997-05-29 | 1999-11-16 | Atrion Medical Products, Inc. | Lancet device |
| US5938679A (en) | 1997-10-14 | 1999-08-17 | Hewlett-Packard Company | Apparatus and method for minimally invasive blood sampling |
| US6155992A (en) | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
| US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
| US5971941A (en) | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
| JP2000014662A (ja) | 1998-01-22 | 2000-01-18 | Terumo Corp | 体液検査装置 |
| US6309887B1 (en) | 1998-01-27 | 2001-10-30 | Flexsite Diagnostics, Inc. | Filter paper treatment for improved diagnostic assays |
| US7056306B1 (en) | 1998-02-05 | 2006-06-06 | Mdc Investment Holdings, Inc. | Fluid sampling device with retractable needle |
| US6086545A (en) | 1998-04-28 | 2000-07-11 | Amira Medical | Methods and apparatus for suctioning and pumping body fluid from an incision |
| US5951582A (en) | 1998-05-22 | 1999-09-14 | Specialized Health Products, Inc. | Lancet apparatus and methods |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
| US6204375B1 (en) | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
| DE19836559A1 (de) | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| GB9817662D0 (en) | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
| US20010039010A1 (en) | 1998-09-03 | 2001-11-08 | Leigh Alexander Burgoyne | Sample collection medium incorporating material for sample visualization |
| US6036659A (en) | 1998-10-09 | 2000-03-14 | Flexsite Diagnostics, Inc. | Collection device for biological samples and methods of use |
| US6746841B1 (en) | 1999-04-14 | 2004-06-08 | Whatman Inc. | FTA- coated media for use as a molecular diagnostic tool |
| DE19909602A1 (de) | 1999-03-05 | 2000-09-07 | Roche Diagnostics Gmbh | Gerät zur Entnahme von Blut für Diagnosezwecke |
| US7077828B2 (en) | 1999-03-05 | 2006-07-18 | Roche Diagnostics Gmbh | Device for withdrawing blood for diagnostic applications |
| US6132449A (en) | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
| AU6048199A (en) | 1999-03-11 | 2000-09-28 | Whatman, Inc. | Solid medium and process for the storage and rapid purification of nucleic acid |
| ATE347616T1 (de) | 1999-04-30 | 2006-12-15 | Cyclops Genome Sciences Ltd | Ribonukleinsäurederivate |
| EP1175431A4 (en) | 1999-04-30 | 2002-09-11 | Whatman Inc | SUBSTRATE CONTAINING ANIONIC NUCLEIC ACID PURIFICATION DETERGENT |
| US6818185B1 (en) * | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| AU5461300A (en) | 1999-06-04 | 2000-12-28 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6152942A (en) | 1999-06-14 | 2000-11-28 | Bayer Corporation | Vacuum assisted lancing device |
| GB9914355D0 (en) | 1999-06-19 | 1999-08-18 | Owen Mumford Ltd | Improvements relating to blood sampling devices |
| US6531061B1 (en) * | 1999-07-21 | 2003-03-11 | Olivia M. Cholewa | Disposable dialysis cassette |
| WO2001021830A1 (en) | 1999-09-24 | 2001-03-29 | Ambion, Inc. | Nuclease inhibitor cocktail |
| ES2239053T3 (es) | 1999-12-16 | 2005-09-16 | Alza Corporation | Dispositivo para incrementar el flujo transdermico de sustancias de muestreo. |
| DE10006662A1 (de) | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
| US6558361B1 (en) | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US6612111B1 (en) | 2000-03-27 | 2003-09-02 | Lifescan, Inc. | Method and device for sampling and analyzing interstitial fluid and whole blood samples |
| US6506168B1 (en) | 2000-05-26 | 2003-01-14 | Abbott Laboratories | Apparatus and method for obtaining blood for diagnostic tests |
| DE10026172A1 (de) | 2000-05-26 | 2001-11-29 | Roche Diagnostics Gmbh | System zur Entnahme von Körperflüssigkeit |
| US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
| DE10036907B4 (de) | 2000-07-28 | 2012-03-22 | Xantec Bioanalytics Gmbh | Verfahren zur Herstellung einer Beschichtung auf einem mit Gold bedampften Glassubstrat, Beschichtung hergestellt nach diesem Verfahren und deren Verwendung |
| JP4536890B2 (ja) | 2000-09-12 | 2010-09-01 | テルモ株式会社 | 成分測定装置用チップおよび成分測定システム |
| US20080027368A1 (en) | 2000-09-27 | 2008-01-31 | Sorin Group Usa, Inc. | Disposable cartridge for a blood perfusion system |
| US20100261159A1 (en) * | 2000-10-10 | 2010-10-14 | Robert Hess | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| US6602718B1 (en) | 2000-11-08 | 2003-08-05 | Becton, Dickinson And Company | Method and device for collecting and stabilizing a biological sample |
| US7001724B1 (en) | 2000-11-28 | 2006-02-21 | Applera Corporation | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases |
| US7993839B2 (en) | 2001-01-19 | 2011-08-09 | General Electric Company | Methods and kits for reducing non-specific nucleic acid amplification |
| WO2002056751A2 (en) | 2001-01-22 | 2002-07-25 | Roche Diagnostics Gmbh | Lancet device having capillary action |
| US6752817B2 (en) | 2001-03-26 | 2004-06-22 | Bayer Corporation | Split pressure ring for lancing device and method of operation |
| US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
| US7531362B2 (en) | 2001-06-07 | 2009-05-12 | Medmira Inc. | Rapid diagnostic assay |
| US20020188223A1 (en) | 2001-06-08 | 2002-12-12 | Edward Perez | Devices and methods for the expression of bodily fluids from an incision |
| ATE335435T1 (de) | 2001-06-08 | 2006-09-15 | Hoffmann La Roche | Entnahmevorrichtung für körperflüssigkeiten und testmedienskassette |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| CA2448905C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
| EP1436405A4 (en) | 2001-08-20 | 2006-01-04 | Whatman Inc | CLEANING AND OBTAINING DNA FROM HIGH-PARTICLES AND SOLIDS SAMPLES |
| EP1423514A2 (en) | 2001-09-05 | 2004-06-02 | WHATMAN plc | Stable storage of proteins |
| DE60144582D1 (de) | 2001-09-19 | 2011-06-16 | Terumo Corp | Gerät zur messung von komponenten und chips |
| CA2461370A1 (en) | 2001-09-26 | 2003-05-15 | F. Hoffmann-La Roche Ag | Method and apparatus for sampling bodily fluid |
| AU2002365229A1 (en) | 2001-11-15 | 2003-09-02 | Whatman, Inc. | Methods and materials for detecting genetic material |
| GB0129816D0 (en) | 2001-12-13 | 2002-01-30 | The Technology Partnership Plc | Testing device for chemical or biochemical analysis |
| US20030215358A1 (en) | 2002-01-15 | 2003-11-20 | Schulman Lloyd S. | Liquid permeable composition in dry reagent devices |
| US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
| WO2003086443A1 (en) | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| WO2003088824A2 (en) | 2002-04-19 | 2003-10-30 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US6984485B2 (en) | 2002-04-23 | 2006-01-10 | Beckman Coulter, Inc. | Polymer-coated substrates for immobilization of biomolecules and cells |
| US7156945B2 (en) | 2002-04-24 | 2007-01-02 | Sipix Imaging, Inc. | Process for forming a patterned thin film structure for in-mold decoration |
| US6755802B2 (en) | 2002-05-06 | 2004-06-29 | Beckman Coulter, Inc. | Whole blood sampling device |
| US7303726B2 (en) | 2002-05-09 | 2007-12-04 | Lifescan, Inc. | Minimal procedure analyte test system |
| AU2003231824A1 (en) | 2002-05-22 | 2003-12-12 | Spectrx, Inc. | System and method for the extraction and monitoring of a biological fluid |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| US20040126783A1 (en) | 2002-07-10 | 2004-07-01 | Massachusetts Institute Of Technology | Apparatus and method for isolating a nucleic acid from a sample |
| DE10231659B4 (de) | 2002-07-12 | 2006-01-19 | Preanalytix Gmbh | Zusammensetzung zum Binden von Nukleinsäure an eine Festphase |
| GB0217963D0 (en) | 2002-08-02 | 2002-09-11 | Cyclops Genome Sciences Ltd | Purification of nucleic acids |
| US7740600B2 (en) | 2002-08-02 | 2010-06-22 | Candela Corporation | Apparatus and method for inhibiting pain signals transmitted during a skin related medical treatment |
| US7163515B2 (en) | 2002-09-03 | 2007-01-16 | Mcnenny James H | Projectile blood collection device |
| US20040096914A1 (en) | 2002-11-20 | 2004-05-20 | Ye Fang | Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof |
| EP1578286A4 (en) | 2002-12-13 | 2009-01-14 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR MEASURING ANALYTES |
| EP1570783A4 (en) | 2002-12-13 | 2009-09-09 | Arkray Inc | NADELEINFÜHRVORRICHTUNG |
| WO2004060162A1 (en) | 2002-12-30 | 2004-07-22 | Roche Diagnostics Gmbh | Flexible test strip lancet device |
| US7374546B2 (en) | 2003-01-29 | 2008-05-20 | Roche Diagnostics Operations, Inc. | Integrated lancing test strip |
| US7267950B2 (en) | 2003-05-01 | 2007-09-11 | Veridex, Lcc | Rapid extraction of RNA from cells and tissues |
| JP4241183B2 (ja) | 2003-05-19 | 2009-03-18 | 株式会社日立ハイテクノロジーズ | 核酸回収方法及び核酸回収キット |
| EP1628905A1 (en) | 2003-05-23 | 2006-03-01 | Gyros Patent Ab | Hydrophilic/hydrophobic surfaces |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| US7250270B2 (en) | 2003-06-13 | 2007-07-31 | Ambion, Inc. | Methods and compositions for preparing tissue samples for RNA extraction |
| EP1641944B1 (en) | 2003-07-09 | 2011-06-29 | Genvault Corporation | Room temperature elution of nucleic acids |
| US7736593B2 (en) | 2003-08-05 | 2010-06-15 | Becton, Dickinson And Company | Device and methods for collection of biological fluid sample and treatment of selected components |
| BRPI0413538B8 (pt) | 2003-08-12 | 2021-06-22 | Becton Dickison And Company | dispositivo para fornecer um medicamento para o corpo de um paciente por injeção |
| EP1662987B1 (en) | 2003-09-11 | 2011-11-09 | Theranos, Inc. | Medical device for analyte monitoring and drug delivery |
| JP3714940B2 (ja) | 2003-11-07 | 2005-11-09 | 株式会社日立ハイテクノロジーズ | Rna抽出方法、および生体材料の分析方法 |
| US7521021B2 (en) | 2003-11-26 | 2009-04-21 | Leica Biosvstems St. Louis Llc | System for in situ processing of a tissue specimen |
| CN1902492A (zh) | 2003-12-30 | 2007-01-24 | 3M创新有限公司 | 基底及结合到该基底上的化合物 |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| US7354515B2 (en) | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
| US20050222539A1 (en) | 2004-03-30 | 2005-10-06 | Pediamed Pharmaceuticals, Inc. | Automatic injection device |
| EP1732626A1 (en) | 2004-03-30 | 2006-12-20 | Novo Nordisk A/S | Actuator system comprising lever mechanism |
| WO2005095653A2 (en) | 2004-04-02 | 2005-10-13 | Hematologics, Inc. | Method for collecting purified cells |
| BRPI0509694A (pt) | 2004-04-08 | 2007-10-09 | Biomatrica Inc | integração de armazenamento de amostra e administração de amostra para ciências biológicas |
| US20060099567A1 (en) | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20080176209A1 (en) | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| ATE497837T1 (de) | 2004-04-09 | 2011-02-15 | Vivebio Llc | Vorrichtungen und verfahren für abnahme, lagerung und transport von biologischen proben |
| DE102004021780B4 (de) | 2004-04-30 | 2008-10-02 | Siemens Ag | Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien |
| WO2005106463A1 (ja) | 2004-04-30 | 2005-11-10 | Arkray, Inc. | 検体分析用具 |
| US9101302B2 (en) | 2004-05-03 | 2015-08-11 | Abbott Diabetes Care Inc. | Analyte test device |
| US8142723B2 (en) | 2004-05-03 | 2012-03-27 | Chromologic, LLC | Tag free bio sensing micro strip |
| CN1968651A (zh) | 2004-05-07 | 2007-05-23 | 贝克顿·迪金森公司 | 凸轮致动的医疗穿刺装置及方法 |
| WO2005116651A2 (en) | 2004-05-24 | 2005-12-08 | Diasys Corporation | Method and device for testing for bence-jones protein |
| JP2008509226A (ja) | 2004-05-24 | 2008-03-27 | ジェンボールト コーポレイション | 回収可能な形式での安定なタンパク質保管および安定な核酸保管 |
| EP1765195B1 (en) | 2004-06-25 | 2014-07-30 | Facet Technologies, LLC | Low cost safety lancet |
| US7776530B2 (en) | 2004-06-29 | 2010-08-17 | Wallac Oy | Integrated nucleic acid analysis |
| US20060030790A1 (en) | 2004-08-06 | 2006-02-09 | Braig James R | Sample element with barrier material and vacuum |
| US20060068399A1 (en) * | 2004-09-24 | 2006-03-30 | Cepheid | Multiple bead reagent system for protein based assays with optimized matrices |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| AU2005322131B2 (en) | 2004-12-23 | 2011-11-10 | Global Life Sciences Solutions Usa Llc | Ligation-based RNA amplification |
| US20090208919A1 (en) | 2005-01-21 | 2009-08-20 | Argylla Technologies, Llp | Particle matrix for storage of biomolecules |
| WO2006086668A2 (en) | 2005-02-09 | 2006-08-17 | Epicentre Technologies | Compositions and methods employing 5'-phosphate-dependent nucleic acid exonucleases |
| US7695442B2 (en) | 2005-04-12 | 2010-04-13 | Roche Diagnostics Operations, Inc. | Integrated lancing test strip with retractable lancet |
| CN101175853A (zh) | 2005-03-16 | 2008-05-07 | Dna吉诺特克股份有限公司 | 用于保存来自体液的核酸的组合物和方法 |
| GB0505909D0 (en) | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
| US20060234251A1 (en) * | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| US7858384B2 (en) | 2005-04-29 | 2010-12-28 | Kimberly-Clark Worldwide, Inc. | Flow control technique for assay devices |
| US7803319B2 (en) | 2005-04-29 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Metering technique for lateral flow assay devices |
| KR100716015B1 (ko) * | 2005-06-08 | 2007-05-08 | 유재천 | 란셋 장치 및 이를 이용한 혈액의 채취 및 주입 방법 |
| US20070015165A1 (en) | 2005-07-13 | 2007-01-18 | Sigma-Aldrich Co. | Method for the isolation of RNA from biological sources |
| USD548339S1 (en) | 2005-08-09 | 2007-08-07 | Recuperatio Limited | Skin treatment device |
| CN101242869B (zh) | 2005-09-02 | 2010-05-26 | Iomai公司 | 经皮递送疫苗和透皮递送药物的装置及其应用 |
| AU2006292394A1 (en) | 2005-09-15 | 2007-03-29 | Artemis Health, Inc. | Systems and methods for enrichment of analytes |
| USD546440S1 (en) | 2005-09-27 | 2007-07-10 | C.R. Bard, Inc. | Injectable power port |
| US8057404B2 (en) | 2005-10-12 | 2011-11-15 | Panasonic Corporation | Blood sensor, blood testing apparatus, and method for controlling blood testing apparatus |
| US7816122B2 (en) | 2005-10-18 | 2010-10-19 | Idexx Laboratories, Inc. | Lateral flow device with onboard reagents |
| JP4699868B2 (ja) | 2005-11-04 | 2011-06-15 | 株式会社日立ハイテクノロジーズ | 核酸精製方法及び核酸精製器具 |
| DE602006020158D1 (de) | 2005-11-08 | 2011-03-31 | Surmodics Inc | Ultradünne photopolymer-beschichtungen und verwendungen davon |
| WO2007070381A2 (en) | 2005-12-09 | 2007-06-21 | Promega Corporation | Nucleic acid purification with a binding matrix |
| US8333712B2 (en) | 2006-01-11 | 2012-12-18 | Canon Kabushiki Kaisha | Body fluid sampling device |
| WO2007089777A2 (en) | 2006-01-31 | 2007-08-09 | University Of Chicago | Method and apparatus for assaying blood clotting |
| US8979770B2 (en) * | 2006-02-24 | 2015-03-17 | Merck Sharp & Dohme Corp. | Extraction and diagnostic fluid devices, systems and methods of use |
| WO2007108515A1 (ja) | 2006-03-22 | 2007-09-27 | Matsushita Electric Industrial Co., Ltd. | 血液検査装置 |
| US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
| EP1852069B1 (de) | 2006-05-04 | 2015-06-17 | Roche Diagnostics GmbH | Blutentnahmesystem zur Entnahme von Blut aus einem Körperteil für Diagnosezwecke |
| GB0610553D0 (en) | 2006-05-26 | 2006-07-05 | Bakhtyari Nejad Esfahani Arash | Dressing |
| WO2007140417A2 (en) | 2006-05-31 | 2007-12-06 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| JP2008022988A (ja) | 2006-07-19 | 2008-02-07 | Ritsumeikan | 採血装置 |
| US8636041B2 (en) | 2006-08-18 | 2014-01-28 | Roche Diagnostics Operations Inc. | Methods and devices for delivering fluid to a reservoir of a fluid delivery device |
| US7682338B2 (en) | 2006-08-23 | 2010-03-23 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| NZ576003A (en) | 2006-10-06 | 2012-03-30 | Dna Genotek Inc | Stabilizing compositions and methods for extraction of ribonucleic acid |
| DE102006047519A1 (de) | 2006-10-07 | 2008-05-21 | Fresenius Kabi Deutschland Gmbh | Port für einen Katheter |
| EP2081442B1 (en) | 2006-10-10 | 2016-08-10 | TrovaGene, Inc. | Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media |
| US8021324B2 (en) | 2007-07-19 | 2011-09-20 | Medical Components, Inc. | Venous access port assembly with X-ray discernable indicia |
| JP2008099992A (ja) | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置 |
| JP2008099991A (ja) | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置 |
| JP2008099988A (ja) | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置 |
| US7521213B2 (en) | 2006-12-01 | 2009-04-21 | Quest Diagnostics Investments Incorporated | Sample processing for nucleic acid amplification |
| US8377379B2 (en) | 2006-12-15 | 2013-02-19 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device |
| GB0700374D0 (en) | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| WO2009002568A2 (en) | 2007-01-16 | 2008-12-31 | Genvault Corporation | Nanoparticles useful for biomolecule storage |
| US7748283B2 (en) | 2007-02-16 | 2010-07-06 | Whatman, Inc. | Controlled transfer biological sample collection devices and methods of using such devices |
| US8469986B2 (en) | 2007-03-30 | 2013-06-25 | Stat Medical Devices, Inc. | Lancet device with combined trigger and cocking mechanism and method |
| WO2008124936A1 (en) | 2007-04-16 | 2008-10-23 | Mcmaster University | Method of producing bioactive paper |
| CN101674773B (zh) | 2007-04-30 | 2012-07-11 | 霍夫曼-拉罗奇有限公司 | 产生体液样品并对其进行分析的仪器和系统 |
| WO2008144439A1 (en) | 2007-05-16 | 2008-11-27 | Mystic Pharmaceuticals, Inc. | Combination unit dose dispensing containers |
| HUE037759T2 (hu) | 2007-05-17 | 2018-09-28 | Advance Dx Inc | Folyadékelválasztó gyûjtõkártya |
| EP2175999B1 (en) | 2007-06-21 | 2017-01-04 | Gen-Probe Incorporated | Receptacles for use in performing processes |
| US20090053704A1 (en) | 2007-08-24 | 2009-02-26 | Natalia Novoradovskaya | Stabilization of nucleic acids on solid supports |
| CN101795624B (zh) | 2007-08-29 | 2012-09-12 | 百瑞特公司 | 包括采样装置、确定装置和注射装置的便携式医疗设备 |
| JP2009092651A (ja) | 2007-09-20 | 2009-04-30 | Fujifilm Corp | 担体およびその製造方法 |
| FR2923151B1 (fr) | 2007-11-02 | 2010-09-03 | Commissariat Energie Atomique | Dispositif de prelevement sanguin comportant au moins un filtre . |
| JP2011505011A (ja) * | 2007-11-28 | 2011-02-17 | スマート チューブ,インコーポレイテッド | 生体試料の採取、刺激、安定化及び分析のためのデバイス、システム及び方法 |
| JP5726529B2 (ja) | 2007-11-30 | 2015-06-03 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 単一試料からのゲノムdna、rnaおよびタンパク質の単離方法 |
| WO2009081405A2 (en) | 2007-12-25 | 2009-07-02 | Rapidx Ltd. | Devices and methods for reduced-pain blood sampling |
| WO2009117167A1 (en) | 2008-01-02 | 2009-09-24 | Blood Cell Storage, Inc. | Devices and processes for nucleic acid extraction |
| WO2009090174A1 (en) | 2008-01-17 | 2009-07-23 | Whatman Inc | Composite membrane blends comprising ionic branch polymers and methods of use |
| US7766846B2 (en) | 2008-01-28 | 2010-08-03 | Roche Diagnostics Operations, Inc. | Rapid blood expression and sampling |
| JP2011510660A (ja) | 2008-01-30 | 2011-04-07 | ノバルティス アーゲー | 母体血漿中の無細胞胎児dnaの二段階濃縮法 |
| KR20100123711A (ko) | 2008-02-13 | 2010-11-24 | 우노메디컬 에이/에스 | 캐뉼라부와 유체 통로 사이의 밀봉부 |
| WO2009108669A1 (en) | 2008-02-29 | 2009-09-03 | Medical Components, Inc. | Venous access port assembly with push surfaces |
| EP2128169A1 (de) | 2008-05-30 | 2009-12-02 | Qiagen GmbH | Verfahren zur Isolierung von kurzkettigen Nukleinsäuren |
| CA3095014A1 (en) | 2008-06-06 | 2009-12-10 | Intuity Medical, Inc. | Detection meter and mode of operation |
| US20100209957A1 (en) | 2008-06-20 | 2010-08-19 | Genvault Corporation | Biosample storage devices and methods of use thereof |
| US20100099074A1 (en) | 2008-07-25 | 2010-04-22 | Garry Nolan | Collection device and method for stimulating and stabilizing a biological sample |
| CA2734736C (en) | 2008-08-21 | 2017-02-28 | Dna Genotek Inc. | Sample receiving device |
| CN102177237B (zh) | 2008-09-12 | 2013-10-30 | 金沃特公司 | 用于贮存和稳定生物分子的基质和介质 |
| GB0818609D0 (en) | 2008-10-10 | 2008-11-19 | Univ Hull | apparatus and method |
| US8932271B2 (en) | 2008-11-13 | 2015-01-13 | C. R. Bard, Inc. | Implantable medical devices including septum-based indicators |
| US8961787B2 (en) | 2008-12-01 | 2015-02-24 | General Electric Company | Systems and methods for processing complex biological materials |
| BRPI0923565A2 (pt) | 2008-12-23 | 2016-01-26 | 3M Innovative Properties Co | artigo não tecido funcionalizado |
| US8337464B2 (en) | 2009-01-29 | 2012-12-25 | Vital Access Corporation | Vascular access ports and related methods |
| US8663538B2 (en) | 2009-02-12 | 2014-03-04 | Picolife Technologies, Llc | Method of making a membrane for use with a flow control system for a micropump |
| AU2010213510B2 (en) | 2009-02-16 | 2014-05-01 | Epicentre Technologies Corporation | Template-independent ligation of single-stranded DNA |
| EP3290530B1 (en) | 2009-02-18 | 2020-09-02 | Streck Inc. | Preservation of cell-free nucleic acids |
| US20120149128A1 (en) | 2009-02-23 | 2012-06-14 | Victor Manneh | Assays and assay devices |
| US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
| US20110172510A1 (en) | 2010-01-13 | 2011-07-14 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or withdrawal of fluids |
| EP2408372B1 (en) | 2009-03-02 | 2019-01-09 | Seventh Sense Biosystems, Inc. | Devices associated with blood sampling |
| US20110105952A1 (en) | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Relatively small devices applied to the skin, modular systems, and methods of use thereof |
| US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
| WO2010101625A2 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Oxygen sensor |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| US20110105872A1 (en) | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Systems and methods for application to skin and control of actuation, delivery, and/or perception thereof |
| EP2241252A1 (de) | 2009-03-17 | 2010-10-20 | F. Hoffmann-La Roche AG | Testvorrichtung insbesondere für Blutzuckertests |
| US20120100538A1 (en) | 2009-03-24 | 2012-04-26 | Biocept, Inc. | Devices and methods of cell capture and analysis |
| WO2010111265A1 (en) | 2009-03-24 | 2010-09-30 | University Of Chicago | Slip chip device and methods |
| JP2012523888A (ja) | 2009-04-15 | 2012-10-11 | シー・アール・バード・インコーポレーテッド | 統合された流体管理システムを有する生検機器 |
| JP2012526990A (ja) * | 2009-05-11 | 2012-11-01 | ネクサス・ディーエックス・インコーポレイテッド | 検体検出のための方法及び組成 |
| WO2010132508A2 (en) | 2009-05-11 | 2010-11-18 | Biomatrica, Inc. | Compositions and methods for biological sample storage |
| AU2010258715B2 (en) | 2009-06-12 | 2015-04-09 | Revvity Health Sciences, Inc. | Rehydratable matrices for dry storage of TAQ polymerase in a microfluidic device |
| JP6297777B2 (ja) | 2009-07-30 | 2018-03-20 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 鞍状のチップを有する穿刺装置 |
| US20110027771A1 (en) | 2009-07-31 | 2011-02-03 | Artemis Health, Inc. | Methods and compositions for cell stabilization |
| US20110040208A1 (en) | 2009-08-11 | 2011-02-17 | Abbott Diabetes Care Inc. | Integrated lancet and test strip and methods of making and using same |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US20130018279A1 (en) | 2009-09-01 | 2013-01-17 | Pathway Genomics | "blood sample collection apparatus and kits" |
| BR112012004688A2 (pt) | 2009-09-04 | 2019-09-24 | Atomo Diagnostics Pty Ltd | dispositivo de amostragem para coletar um fluido corporal. |
| WO2011053796A2 (en) | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin |
| EP2493536B1 (en) | 2009-10-30 | 2017-09-20 | Seventh Sense Biosystems, Inc. | Relatively small devices applied to the skin, modular systems, and methods of use thereof |
| WO2011062750A1 (en) | 2009-11-17 | 2011-05-26 | C. R. Bard, Inc. | Overmolded access port including anchoring and identification features |
| WO2011065972A2 (en) | 2009-11-24 | 2011-06-03 | Seventh Sense Biosystems, Inc. | Patient-enacted sampling technique |
| JP5899118B2 (ja) | 2009-12-29 | 2016-04-06 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 核酸溶出の改良 |
| EP3243435A1 (en) | 2010-01-13 | 2017-11-15 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
| WO2011088211A2 (en) | 2010-01-13 | 2011-07-21 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
| US8657763B2 (en) | 2010-01-19 | 2014-02-25 | Christopher A. Jacobs | Vacuum assisted lancing system with elective vacuum release and method for blood extraction with minimal pain |
| US20110195425A1 (en) | 2010-02-10 | 2011-08-11 | Selinfreund Richard H | Systems and methods for diagnosing parasite infections |
| US20110224106A1 (en) | 2010-03-10 | 2011-09-15 | Ibis Biosciences, Inc. | Production Of Single-Stranded Circular Nucleic Acid |
| US20110306853A1 (en) | 2010-03-19 | 2011-12-15 | Michael Darryl Black | Body fluid sampling/fluid delivery device |
| EP2555918A1 (en) | 2010-04-06 | 2013-02-13 | Genvault Corporation | Stabilized chemical dehydration of biological material |
| US20130102501A1 (en) | 2010-04-14 | 2013-04-25 | Cornell University | Device for recovery and isolation of biomolecules |
| ES2639641T3 (es) | 2010-04-20 | 2017-10-27 | Octapharma Ag | Nuevo agente estabilizante para proteínas farmacéuticas |
| EP2388312A1 (en) | 2010-05-17 | 2011-11-23 | Curetis AG | Universally applicable lysis buffer and processing methods for the lysis of bodily samples |
| US20120158100A1 (en) | 2010-06-21 | 2012-06-21 | Kevin Schomacker | Driving Microneedle Arrays into Skin and Delivering RF Energy |
| JP5514008B2 (ja) | 2010-06-22 | 2014-06-04 | ニプロ株式会社 | ディスポーザブル型穿刺器具 |
| ES2561824T3 (es) | 2010-07-16 | 2016-03-01 | Seventh Sense Biosystems, Inc. | Ambiente a baja presión para dispositivos de transferencia de fluidos |
| EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| CN103229053B (zh) | 2010-07-27 | 2015-06-24 | 西北大学 | 过滤血浆的装置和方法 |
| EP2954916A3 (en) | 2010-08-13 | 2016-04-20 | Seventh Sense Biosystems, Inc. | Clinical and/or consumer techniques and devices |
| US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| AU2011293832B2 (en) | 2010-08-26 | 2014-07-17 | Spot Bioscience, Llc | Biological fluid sampling and storage apparatus for remote use |
| EA024511B1 (ru) | 2010-10-15 | 2016-09-30 | Атомо Дайагностикс Пти Лимитед | Устройство для взятия проб |
| US8474332B2 (en) | 2010-10-20 | 2013-07-02 | Medtronic Minimed, Inc. | Sensor assembly and medical device incorporating same |
| ES2565805T3 (es) | 2010-11-09 | 2016-04-07 | Seventh Sense Biosystems, Inc. | Sistemas e interfaces para el muestreo de sangre |
| WO2012075471A1 (en) | 2010-12-04 | 2012-06-07 | Hui-Yu Liu | Rna stability enhancer |
| US20120152743A1 (en) | 2010-12-17 | 2012-06-21 | General Electric Company | Method for electroeluting genetic material from dried samples |
| WO2012092260A1 (en) | 2010-12-27 | 2012-07-05 | Ibis Biosciences, Inc. | Compositions and methods for producing single-stranded circular dna |
| US8852123B2 (en) | 2010-12-30 | 2014-10-07 | Roche Diagnostics Operations, Inc. | Handheld medical diagnostic devices housing with sample transfer |
| EP2673031B1 (en) | 2011-02-09 | 2020-07-15 | Becton, Dickinson and Company | Medical infusion device comprising a self-contained torsion spring inserter |
| WO2012154257A1 (en) * | 2011-02-17 | 2012-11-15 | Prometheus Laboratories Inc. | Apparatus and method for isolating leukocytes and tumor cells by filtration |
| GB201103257D0 (en) | 2011-02-25 | 2011-04-13 | Ge Healthcare Uk Ltd | Paper support and method of recovering biological material therefrom |
| GB201103258D0 (en) | 2011-02-25 | 2011-04-13 | Ge Healthcare Uk Ltd | Solid support and method of enhancing the recovery of biological material therefrom |
| GB201103256D0 (en) | 2011-02-25 | 2011-04-13 | Ge Healthcare Uk Ltd | Solid support and method of recovering biological material therefrom |
| AU2012236109A1 (en) | 2011-04-01 | 2013-11-21 | Occam Biolabs, Inc. | Methods and kits for detecting cell-free pathogen-specific nucleic acids |
| WO2012154362A1 (en) | 2011-04-11 | 2012-11-15 | Seventh Sense Biosysems, Inc. | Devices and methods for delivery and/or withdrawal of fluids and preservation of withdrawn fluids |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| KR102237667B1 (ko) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
| JP5559096B2 (ja) | 2011-05-10 | 2014-07-23 | 株式会社堀場製作所 | 血球計数用試薬、及び血液検査方法 |
| CA2843945C (en) | 2011-08-03 | 2022-06-21 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
| ES2574956T3 (es) | 2011-09-26 | 2016-06-23 | Preanalytix Gmbh | Estabilización y aislamiento de ácidos nucleicos extracelulares |
| GB2496122A (en) | 2011-10-31 | 2013-05-08 | Ge Healthcare Bio Sciences Ab | Biological sample preservation on paper |
| US9554736B2 (en) | 2011-11-29 | 2017-01-31 | Teleflex Medical Incorporated | Device with integrated allergy testing |
| AU2012327218C1 (en) * | 2011-11-30 | 2015-12-24 | Wellstat Diagnostics, Llc. | Filtration Module |
| US20130150811A1 (en) | 2011-12-12 | 2013-06-13 | Angiodynamics, Inc. | High-Flow Port Stem |
| CN103173432B (zh) | 2011-12-22 | 2020-08-04 | 通用电气公司 | 分离核酸的方法及装置 |
| US20130211289A1 (en) | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
| DK2814981T3 (en) | 2012-02-13 | 2017-10-16 | Streck Inc | BLOOD COLLECTION UNIT FOR STABILIZING CELL-FREE PLASMA DNA |
| US9353393B2 (en) | 2012-02-15 | 2016-05-31 | General Electric Company | Methods and kits for reducing non-specific nucleic acid amplification |
| US9269873B2 (en) | 2012-03-13 | 2016-02-23 | Citizen Holdings Co., Ltd. | Semiconductor light emitting device and method for manufacturing same |
| US9933343B2 (en) | 2012-03-14 | 2018-04-03 | Chromologic Llc | Integrated membrane for preservation of biomolecules |
| WO2013144743A1 (en) | 2012-03-31 | 2013-10-03 | Dbs System Sàrl | Device and method for dried fluid spot analysis |
| WO2013159116A1 (en) | 2012-04-20 | 2013-10-24 | University Of Chicago | Fluidic devices for biospecimen preservation |
| WO2013159117A1 (en) | 2012-04-20 | 2013-10-24 | SlipChip, LLC | Fluidic devices and systems for sample preparation or autonomous analysis |
| EP2844330B1 (en) | 2012-04-24 | 2020-06-03 | The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust | A device for performing regional anesthesia |
| US9040675B2 (en) | 2012-04-30 | 2015-05-26 | General Electric Company | Formulations for nucleic acid stabilization on solid substrates |
| US9044738B2 (en) | 2012-04-30 | 2015-06-02 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
| US9040679B2 (en) | 2012-04-30 | 2015-05-26 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
| ES2385079B1 (es) | 2012-05-08 | 2013-05-24 | Leventon S.A.U. | Reductor de presión para el suministro de medicamentos a un paciente y procedimiento de fabricación correspondiente |
| US9075042B2 (en) | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US8777170B2 (en) | 2012-06-05 | 2014-07-15 | Lenmark Holdings, Llc | Display article support systems |
| EP2874942B1 (en) | 2012-07-23 | 2018-09-05 | Tasso, Inc. | Methods and devices relating to open microfluidic channels |
| US20150259671A1 (en) | 2012-07-31 | 2015-09-17 | General Electric Company | Devices and systems for isolating biomolecules and associated methods thereof |
| US9399986B2 (en) | 2012-07-31 | 2016-07-26 | General Electric Company | Devices and systems for isolating biomolecules and associated methods thereof |
| US20140038172A1 (en) | 2012-08-06 | 2014-02-06 | Vivebio, Llc | Matrix and System for Preserving Biological Specimens for Qualitative and Quantitative Analysis |
| US9636062B2 (en) | 2012-09-06 | 2017-05-02 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| US9427184B2 (en) | 2012-09-06 | 2016-08-30 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| DE102012019400A1 (de) | 2012-10-04 | 2014-04-10 | Gerresheimer Regensburg Gmbh | Stechhilfevorrichtung zur Blutprobenentnahme |
| US20140358036A1 (en) | 2012-12-05 | 2014-12-04 | Theranos, Inc. | Bodily Fluid Sample Collection and Transport |
| CN104968269B (zh) | 2012-12-05 | 2019-02-15 | 赛拉诺斯知识产权有限责任公司 | 用于体液样品收集、运输和处理的系统、装置和方法 |
| US20140342371A1 (en) | 2012-12-05 | 2014-11-20 | Theranos, Inc. | Bodily Fluid Sample Collection and Transport |
| EP2935583B1 (en) | 2012-12-20 | 2018-09-12 | General Electric Company | Formulations for nucleic acid stabilization on solid substrates |
| US11420033B2 (en) | 2013-01-23 | 2022-08-23 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
| EP2948121B1 (en) | 2013-01-23 | 2017-11-29 | C.R. Bard Inc. | Low-profile access port |
| US9623409B2 (en) | 2013-03-11 | 2017-04-18 | Cue Inc. | Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes |
| WO2014153181A1 (en) | 2013-03-14 | 2014-09-25 | Spot On Sciences, Inc. | Biological sample collection and preservation |
| US20140272925A1 (en) | 2013-03-14 | 2014-09-18 | Chromologic Llc | Plasma Separation Apparatus, Method and System |
| US10238812B2 (en) | 2013-03-15 | 2019-03-26 | Edge Systems Llc | Skin treatment systems and methods using needles |
| US20150273467A1 (en) | 2013-03-15 | 2015-10-01 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| US9795929B2 (en) | 2013-03-15 | 2017-10-24 | Theranos, Inc. | Systems, devices, and methods for bodily fluid separation materials |
| US20140323911A1 (en) | 2013-03-15 | 2014-10-30 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| JP6267319B2 (ja) | 2013-04-15 | 2018-01-24 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 生物学的流体移送デバイスおよび生物学的流体サンプリングシステム |
| ES2748062T3 (es) | 2013-04-15 | 2020-03-12 | Becton Dickinson Co | Dispositivo de transferencia de muestreo de fluido biológico y sistema de separación y ensayo de fluido biológico |
| JP6247380B2 (ja) | 2013-04-15 | 2017-12-13 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 血液採取搬送装置 |
| ES2662110T3 (es) | 2013-04-15 | 2018-04-05 | Becton, Dickinson And Company | Dispositivo de transferencia de muestras de fluidos biológicos y sistema de separación y de análisis de fluidos biológicos |
| BR112015026252B1 (pt) | 2013-04-15 | 2022-03-22 | Becton, Dickinson And Company | Dispositivo de coleta de fluido biológico e sistema de coleta e teste de fluido biológico |
| US9517026B2 (en) | 2013-04-15 | 2016-12-13 | Becton, Dickinson And Company | Biological fluid collection device and biological fluid separation and testing system |
| JP6174785B2 (ja) | 2013-04-15 | 2017-08-02 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 生物学的流体分離デバイスならびに生物学的流体分離および検査システム |
| EP3007556B1 (en) | 2013-06-13 | 2020-05-20 | Biomatrica, INC. | Cell stabilization |
| WO2014198700A1 (en) | 2013-06-13 | 2014-12-18 | Roche Diagnostics Gmbh | Body fluid sampling element |
| ES2676697T3 (es) | 2013-07-16 | 2018-07-24 | Rene La Fontaine | Módulo de aguja e instrumento para perforar la piel |
| US9644232B2 (en) | 2013-07-26 | 2017-05-09 | General Electric Company | Method and device for collection and amplification of circulating nucleic acids |
| US9217167B2 (en) | 2013-07-26 | 2015-12-22 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| US10655167B2 (en) | 2013-07-26 | 2020-05-19 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| US9938568B2 (en) | 2013-07-26 | 2018-04-10 | General Electric Company | Ligase-assisted nucleic acid circularization and amplification |
| EP3038635A4 (en) * | 2013-08-28 | 2017-04-05 | Cytonics Corporation | Systems, compositions, and methods for transplantation and treating conditions |
| WO2015061743A1 (en) | 2013-10-24 | 2015-04-30 | Theranos, Inc. | Systems and methods for ordering laboratory tests and providing results thereof |
| US9534214B2 (en) * | 2013-10-31 | 2017-01-03 | General Electric Company | Substrates and associated methods for elution of nucleic acids |
| US9719082B2 (en) | 2013-10-31 | 2017-08-01 | General Electric Company | Substrates and associated methods for elution of nucleic acids |
| WO2015069789A1 (en) | 2013-11-06 | 2015-05-14 | Becton, Dickinson And Company | Microfluidic devices, and methods of making and using the same |
| CN105899133A (zh) | 2013-11-11 | 2016-08-24 | 赛拉诺斯股份有限公司 | 针对具有新奇外观的样品收集装置的方法和系统 |
| US20150166956A1 (en) | 2013-12-16 | 2015-06-18 | General Electric Company | Devices for separation of particulates, associated methods and systems |
| WO2015091760A1 (en) | 2013-12-20 | 2015-06-25 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with disposable cartridge and disposable injector |
| EP3083056B1 (en) | 2013-12-20 | 2023-04-05 | Spot Bioscience, LLC | Whole blood separation sampling apparatus |
| GB201401133D0 (en) | 2014-01-23 | 2014-03-12 | Renephra Ltd | Fluid extraction device, applicator device and associated methods |
| US20150211967A1 (en) | 2014-01-29 | 2015-07-30 | Trajan Scientific Australia Pty Ltd | Preparation of samples for analysis and sampling device therefor |
| CN106233137A (zh) * | 2014-04-25 | 2016-12-14 | 通用电气公司 | 用于生物分子的收集、稳定和洗脱的基材和方法 |
| JP6669672B2 (ja) | 2014-06-10 | 2020-03-18 | バイオマトリカ,インク. | 周囲温度における血液サンプル中の変性されていないポリペプチド、核酸、およびエキソソームの安定化 |
| EP3616617B1 (en) | 2014-07-18 | 2023-08-30 | Becton, Dickinson and Company | Lancet device with first-drop removal |
| US9901922B2 (en) | 2014-07-25 | 2018-02-27 | General Electric Company | Sample collection and transfer device |
| US9480981B2 (en) | 2014-07-25 | 2016-11-01 | General Electric Company | Sample collection and transfer device |
| WO2016019388A1 (en) | 2014-08-01 | 2016-02-04 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
| US10779757B2 (en) | 2014-08-01 | 2020-09-22 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
| US10335078B2 (en) | 2014-08-04 | 2019-07-02 | General Electric Company | Device for separation and collection of plasma |
| US9950321B2 (en) * | 2014-08-04 | 2018-04-24 | General Electric Company | Device for separation and collection of plasma |
| US11987836B2 (en) | 2014-09-30 | 2024-05-21 | Global Life Sciences Solutions Usa Llc | Method for nucleic acid analysis directly from an unpurified biological sample |
| US10111610B2 (en) * | 2014-11-04 | 2018-10-30 | Wainamics, Inc. | Microscale plasma separator |
| US10287570B2 (en) * | 2014-11-21 | 2019-05-14 | Occam Biolabs, Inc. | System and method for collecting a sample of nucleic acid |
| US20180008183A1 (en) | 2015-01-28 | 2018-01-11 | Seventh Sense Biosystems, Inc. | Devices and methods for delivering and/or receiving fluid |
| US10597697B2 (en) | 2015-02-05 | 2020-03-24 | Ge Healthcare Bio-Sciences Corp. | Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample |
| WO2016134324A1 (en) | 2015-02-20 | 2016-08-25 | Neoteryx, Llc | Method and apparatus for acquiring blood for testing |
| US9730625B2 (en) | 2015-03-02 | 2017-08-15 | Verily Life Sciences Llc | Automated blood sampling device |
| CN107430114B (zh) | 2015-03-31 | 2020-07-24 | 豪夫迈·罗氏有限公司 | 血浆分离卡 |
| JP6758661B2 (ja) | 2015-05-14 | 2020-09-23 | ゼネラル・エレクトリック・カンパニイ | 血漿の分離および回収のためのキット |
| ES2753453T3 (es) | 2015-05-26 | 2020-04-08 | Hoffmann La Roche | Cartucho e insertador para un sistema médico |
| JP6558971B2 (ja) | 2015-06-17 | 2019-08-14 | 株式会社日立ハイテクノロジーズ | 採血装置 |
| EP3325153B1 (en) | 2015-07-17 | 2020-03-18 | Cue Health Inc. | Sample analysis cartridge |
| EP3689238B1 (en) | 2015-08-06 | 2021-09-29 | Becton, Dickinson and Company | Biological fluid collection device |
| WO2017040208A1 (en) | 2015-08-28 | 2017-03-09 | Crisi Medical Systems, Inc. | Flow sensor system with absorber |
| ES2912965T3 (es) * | 2015-09-09 | 2022-05-30 | Drawbridge Health Inc | Dispositivos para la recopilación, estabilización y conservación de muestras |
| WO2017044888A1 (en) | 2015-09-09 | 2017-03-16 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| JP2019500852A (ja) | 2015-11-05 | 2019-01-17 | ゼネラル・エレクトリック・カンパニイ | リガーゼ支援核酸環状化および増幅 |
| US20170128934A1 (en) | 2015-11-10 | 2017-05-11 | Neoteryx, Llc | Plasma extraction device |
| EP3393342B1 (en) | 2015-12-21 | 2020-07-08 | Tasso, Inc. | Devices for actuation and retraction in fluid collection |
| CN108883230B (zh) | 2016-02-12 | 2022-10-04 | 美敦力米尼梅德有限公司 | 便携式输注泵及与其使用的组件 |
| US10610862B2 (en) | 2016-04-04 | 2020-04-07 | Advance Dx, Inc. | Multiple path sample collection card |
| WO2017214338A1 (en) | 2016-06-07 | 2017-12-14 | Drawbridge Health, Inc. | Metods and devices for strong or stabilizing molecules |
| EP4029445A1 (en) | 2016-07-29 | 2022-07-20 | YourBio Health, Inc. | Device for receiving bodily fluid from a subject |
| US11523805B2 (en) | 2016-09-21 | 2022-12-13 | Tasso, Inc. | Methods for delivery of bodily fluids onto a fibrous substrate |
| CN210383905U (zh) | 2017-01-10 | 2020-04-24 | 集联健康有限公司 | 一种用于从受试者收集流体样品的装置以及运输套筒 |
| CN107260186A (zh) | 2017-07-07 | 2017-10-20 | 深圳鹏博威投资控股有限公司 | 负压式采血针头 |
| USD870264S1 (en) | 2017-09-06 | 2019-12-17 | C. R. Bard, Inc. | Implantable apheresis port |
| US12290361B2 (en) | 2018-05-14 | 2025-05-06 | Loop Medical Sa | Sample collection device, system and method for extracting and collecting a sample of a fluid of a user |
| JP7460607B2 (ja) | 2018-09-14 | 2024-04-02 | タッソ インコーポレイテッド | 体液収集装置および関連方法 |
| ES2940212T3 (es) | 2019-11-13 | 2023-05-04 | Loop Medical Sa | Dispositivo de recogida de muestras para extraer y recoger una muestra de un fluido de un usuario |
| EP4121733A4 (en) | 2020-03-18 | 2024-05-22 | Drawbridge Health, Inc. | SAMPLE COLLECTION SYSTEMS AND METHODS |
-
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- 2016-09-09 ES ES20175443T patent/ES2912965T3/es active Active
- 2016-09-09 US US15/261,707 patent/US11266337B2/en active Active
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- 2016-09-09 EP EP16845220.9A patent/EP3347448B1/en active Active
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-
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- 2022-01-21 US US17/581,711 patent/US20220218251A1/en not_active Abandoned
- 2022-04-01 JP JP2022061959A patent/JP7330325B2/ja active Active
-
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- 2023-08-08 JP JP2023129537A patent/JP7454734B2/ja active Active
- 2023-08-11 US US18/233,283 patent/US20230380738A1/en not_active Abandoned
-
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- 2024-03-11 JP JP2024037159A patent/JP2024083344A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011521709A (ja) | 2008-05-30 | 2011-07-28 | インテュイティ メディカル インコーポレイテッド | 体液採取装置及び採取部位インターフェイス |
| JP2014516644A (ja) | 2011-04-29 | 2014-07-17 | セブンス センス バイオシステムズ,インコーポレーテッド | 血斑または他の体液の収集および/または操作のためのデバイスおよび方法 |
| US20140234942A1 (en) | 2012-04-30 | 2014-08-21 | General Electric Company | Substrates and methods for collection, stabilization and elution of biomolecules |
| WO2014172245A1 (en) | 2013-04-15 | 2014-10-23 | Becton, Dickinson And Company | Biological fluid sampling device |
| WO2015022410A1 (en) | 2013-08-16 | 2015-02-19 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022089877A (ja) * | 2015-09-09 | 2022-06-16 | ドローブリッジ ヘルス,インコーポレイテッド | サンプルの収集、安定化、および保存のためのシステム、方法およびデバイス |
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